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Addictive stimulant use

MedGen UID:: 751384
•Concept ID:: C2711618
•: Mental or Behavioral Dysfunction

Synonyms:	Stimulant addiction; Stimulant dependence
SNOMED CT:	Stimulant dependence (442406005)

HPO:	HP:0033512

Definition

Addiction to a stimulant drug is defined as a drug that typically increases alertness, attention, and energy while also elevating blood pressure, heart rate, and breathing. [from HPO]

Term Hierarchy

GTR
MeSH

CClinical test, RResearch test, OOMIM, GGeneReviews, VClinVar

CROGVAddictive stimulant use

Abnormally increased volition
- Impulse control disorder
  - Impulsivity
    - Compulsive behaviors
      - Addictive behavior
        Drug dependence
        Addictive stimulant use
        Addictive amphetamine use
        Addictive methylphenidate use
        Cocaine dependence
        Cocaine dependence, continuous
        Cocaine dependence, episodic
        Methamphetamine dependence

Professional guidelines

PubMed

Updated European Consensus Statement on diagnosis and treatment of adult ADHD.

Kooij JJS, Bijlenga D, Salerno L, Jaeschke R, Bitter I, Balázs J, Thome J, Dom G, Kasper S, Nunes Filipe C, Stes S, Mohr P, Leppämäki S, Casas M, Bobes J, Mccarthy JM, Richarte V, Kjems Philipsen A, Pehlivanidis A, Niemela A, Styr B, Semerci B, Bolea-Alamanac B, Edvinsson D, Baeyens D, Wynchank D, Sobanski E, Philipsen A, McNicholas F, Caci H, Mihailescu I, Manor I, Dobrescu I, Saito T, Krause J, Fayyad J, Ramos-Quiroga JA, Foeken K, Rad F, Adamou M, Ohlmeier M, Fitzgerald M, Gill M, Lensing M, Motavalli Mukaddes N, Brudkiewicz P, Gustafsson P, Tani P, Oswald P, Carpentier PJ, De Rossi P, Delorme R, Markovska Simoska S, Pallanti S, Young S, Bejerot S, Lehtonen T, Kustow J, Müller-Sedgwick U, Hirvikoski T, Pironti V, Ginsberg Y, Félegyházy Z, Garcia-Portilla MP, Asherson P
Eur Psychiatry 2019 Feb;56:14-34. Epub 2018 Nov 16 doi: 10.1016/j.eurpsy.2018.11.001. PMID: 30453134

Diagnosis and treatment of ADHD in children vs adults: What nurses should know.

Leahy LG
Arch Psychiatr Nurs 2018 Dec;32(6):890-895. Epub 2018 Jun 4 doi: 10.1016/j.apnu.2018.06.013. PMID: 30454634

Methamphetamine: an update on epidemiology, pharmacology, clinical phenomenology, and treatment literature.

Courtney KE, Ray LA
Drug Alcohol Depend 2014 Oct 1;143:11-21. Epub 2014 Aug 17 doi: 10.1016/j.drugalcdep.2014.08.003. PMID: 25176528 Free PMC Article

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Recent clinical studies

Etiology

Risk of Incident Psychosis and Mania With Prescription Amphetamines.

Moran LV, Skinner JP, Shinn AK, Nielsen K, Rao V, Taylor ST, Cohen TR, Erkol C, Merchant J, Mujica CA, Perlis RH, Ongur D
Am J Psychiatry 2024 Oct 1;181(10):901-909. Epub 2024 Sep 12 doi: 10.1176/appi.ajp.20230329. PMID: 39262211

Sleep loss and addiction.

López-Muciño LA, García-García F, Cueto-Escobedo J, Acosta-Hernández M, Venebra-Muñoz A, Rodríguez-Alba JC
Neurosci Biobehav Rev 2022 Oct;141:104832. Epub 2022 Aug 18 doi: 10.1016/j.neubiorev.2022.104832. PMID: 35988803

Pharmacological Treatment of Methamphetamine/Amphetamine Dependence: A Systematic Review.

Siefried KJ, Acheson LS, Lintzeris N, Ezard N
CNS Drugs 2020 Apr;34(4):337-365. doi: 10.1007/s40263-020-00711-x. PMID: 32185696 Free PMC Article

Stimulant Use in Pregnancy: An Under-recognized Epidemic Among Pregnant Women.

Smid MC, Metz TD, Gordon AJ
Clin Obstet Gynecol 2019 Mar;62(1):168-184. doi: 10.1097/GRF.0000000000000418. PMID: 30601144 Free PMC Article

Pharmacology of nicotine: addiction, smoking-induced disease, and therapeutics.

Benowitz NL
Annu Rev Pharmacol Toxicol 2009;49:57-71. doi: 10.1146/annurev.pharmtox.48.113006.094742. PMID: 18834313 Free PMC Article

See all (1841)

Diagnosis

Updated European Consensus Statement on diagnosis and treatment of adult ADHD.

Diagnosis and treatment of ADHD in children vs adults: What nurses should know.

Leahy LG
Arch Psychiatr Nurs 2018 Dec;32(6):890-895. Epub 2018 Jun 4 doi: 10.1016/j.apnu.2018.06.013. PMID: 30454634

International Consensus Statement on Screening, Diagnosis and Treatment of Substance Use Disorder Patients with Comorbid Attention Deficit/Hyperactivity Disorder.

Crunelle CL, van den Brink W, Moggi F, Konstenius M, Franck J, Levin FR, van de Glind G, Demetrovics Z, Coetzee C, Luderer M, Schellekens A; ICASA consensus group, Matthys F
Eur Addict Res 2018;24(1):43-51. Epub 2018 Mar 6 doi: 10.1159/000487767. PMID: 29510390 Free PMC Article

The dopamine theory of addiction: 40 years of highs and lows.

Nutt DJ, Lingford-Hughes A, Erritzoe D, Stokes PR
Nat Rev Neurosci 2015 May;16(5):305-12. Epub 2015 Apr 15 doi: 10.1038/nrn3939. PMID: 25873042

Methamphetamine: an update on epidemiology, pharmacology, clinical phenomenology, and treatment literature.

Courtney KE, Ray LA
Drug Alcohol Depend 2014 Oct 1;143:11-21. Epub 2014 Aug 17 doi: 10.1016/j.drugalcdep.2014.08.003. PMID: 25176528 Free PMC Article

See all (818)

Therapy

Benefits and Harms of 'Smart Drugs' (Nootropics) in Healthy Individuals.

Schifano F, Catalani V, Sharif S, Napoletano F, Corkery JM, Arillotta D, Fergus S, Vento A, Guirguis A
Drugs 2022 Apr;82(6):633-647. Epub 2022 Apr 2 doi: 10.1007/s40265-022-01701-7. PMID: 35366192

Cognition and addiction .

Verdejo-Garcia A, Garcia-Fernandez G, Dom G
Dialogues Clin Neurosci 2019 Sep;21(3):281-290. doi: 10.31887/DCNS.2019.21.3/gdom. PMID: 31749652 Free PMC Article

Stimulant Use in Pregnancy: An Under-recognized Epidemic Among Pregnant Women.

Smid MC, Metz TD, Gordon AJ
Clin Obstet Gynecol 2019 Mar;62(1):168-184. doi: 10.1097/GRF.0000000000000418. PMID: 30601144 Free PMC Article

Diagnosis and treatment of ADHD in children vs adults: What nurses should know.

Leahy LG
Arch Psychiatr Nurs 2018 Dec;32(6):890-895. Epub 2018 Jun 4 doi: 10.1016/j.apnu.2018.06.013. PMID: 30454634

Methamphetamine: an update on epidemiology, pharmacology, clinical phenomenology, and treatment literature.

Courtney KE, Ray LA
Drug Alcohol Depend 2014 Oct 1;143:11-21. Epub 2014 Aug 17 doi: 10.1016/j.drugalcdep.2014.08.003. PMID: 25176528 Free PMC Article

See all (2197)

Prognosis

The e-psychonaut drugs' psychopharmacology.

Schifano F, Chiappini S, Corkery JM, Scherbaum N, Guirguis A
Curr Opin Pharmacol 2021 Apr;57:165-174. Epub 2021 Mar 25 doi: 10.1016/j.coph.2021.02.008. PMID: 33774473

Substance-induced Psychosis in Youth.

Beckmann D, Lowman KL, Nargiso J, McKowen J, Watt L, Yule AM
Child Adolesc Psychiatr Clin N Am 2020 Jan;29(1):131-143. Epub 2019 Sep 23 doi: 10.1016/j.chc.2019.08.006. PMID: 31708042 Free PMC Article

Cognition and addiction .

Verdejo-Garcia A, Garcia-Fernandez G, Dom G
Dialogues Clin Neurosci 2019 Sep;21(3):281-290. doi: 10.31887/DCNS.2019.21.3/gdom. PMID: 31749652 Free PMC Article

Vascular disease in cocaine addiction.

Bachi K, Mani V, Jeyachandran D, Fayad ZA, Goldstein RZ, Alia-Klein N
Atherosclerosis 2017 Jul;262:154-162. Epub 2017 Mar 14 doi: 10.1016/j.atherosclerosis.2017.03.019. PMID: 28363516 Free PMC Article

Phenibut dependence.

Samokhvalov AV, Paton-Gay CL, Balchand K, Rehm J
BMJ Case Rep 2013 Feb 6;2013 doi: 10.1136/bcr-2012-008381. PMID: 23391959 Free PMC Article

See all (626)

Clinical prediction guides

Risk of Incident Psychosis and Mania With Prescription Amphetamines.

The Crosstalk Between Neurons and Glia in Methamphetamine-Induced Neuroinflammation.

Shi S, Chen T, Zhao M
Neurochem Res 2022 Apr;47(4):872-884. Epub 2022 Jan 4 doi: 10.1007/s11064-021-03513-9. PMID: 34982394

Cognition and addiction .

Verdejo-Garcia A, Garcia-Fernandez G, Dom G
Dialogues Clin Neurosci 2019 Sep;21(3):281-290. doi: 10.31887/DCNS.2019.21.3/gdom. PMID: 31749652 Free PMC Article

BDNF During Withdrawal.

Geoffroy H, Noble F
Vitam Horm 2017;104:475-496. Epub 2016 Dec 1 doi: 10.1016/bs.vh.2016.10.009. PMID: 28215305

The dopamine theory of addiction: 40 years of highs and lows.

Nutt DJ, Lingford-Hughes A, Erritzoe D, Stokes PR
Nat Rev Neurosci 2015 May;16(5):305-12. Epub 2015 Apr 15 doi: 10.1038/nrn3939. PMID: 25873042

See all (1046)

Recent systematic reviews

A systematic review and meta-analysis of neuromodulation therapies for substance use disorders.

Mehta DD, Praecht A, Ward HB, Sanches M, Sorkhou M, Tang VM, Steele VR, Hanlon CA, George TP
Neuropsychopharmacology 2024 Mar;49(4):649-680. Epub 2023 Dec 12 doi: 10.1038/s41386-023-01776-0. PMID: 38086901 Free PMC Article

Methamphetamine exposure and depression-A systematic review and meta-analysis.

Leung J, Mekonen T, Wang X, Arunogiri S, Degenhardt L, McKetin R
Drug Alcohol Rev 2023 Sep;42(6):1438-1449. Epub 2023 May 1 doi: 10.1111/dar.13670. PMID: 37126460

Practitioner Review: Pharmacological treatment of attention-deficit/hyperactivity disorder symptoms in children and youth with autism spectrum disorder: a systematic review and meta-analysis.

Rodrigues R, Lai MC, Beswick A, Gorman DA, Anagnostou E, Szatmari P, Anderson KK, Ameis SH
J Child Psychol Psychiatry 2021 Jun;62(6):680-700. Epub 2020 Aug 26 doi: 10.1111/jcpp.13305. PMID: 32845025

Pharmacological Treatment of Methamphetamine/Amphetamine Dependence: A Systematic Review.

Siefried KJ, Acheson LS, Lintzeris N, Ezard N
CNS Drugs 2020 Apr;34(4):337-365. doi: 10.1007/s40263-020-00711-x. PMID: 32185696 Free PMC Article

Global prevalence of injecting drug use and sociodemographic characteristics and prevalence of HIV, HBV, and HCV in people who inject drugs: a multistage systematic review.

Degenhardt L, Peacock A, Colledge S, Leung J, Grebely J, Vickerman P, Stone J, Cunningham EB, Trickey A, Dumchev K, Lynskey M, Griffiths P, Mattick RP, Hickman M, Larney S
Lancet Glob Health 2017 Dec;5(12):e1192-e1207. Epub 2017 Oct 23 doi: 10.1016/S2214-109X(17)30375-3. PMID: 29074409 Free PMC Article

See all (104)

MedGen

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Addictive stimulant use

Definition

Term Hierarchy

Professional guidelines

PubMed

Recent clinical studies

Etiology

Diagnosis

Therapy

Prognosis

Clinical prediction guides

Recent systematic reviews

Supplemental Content

Table of contents

Clinical resources

Practice guidelines

Consumer resources

Reviews

Related information

Recent activity