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Folliculitis decalvans

MedGen UID:
750617
•Concept ID:
C2608043
•
Disease or Syndrome
Synonyms: Quinquaud folliculitis decalvans; Quinquaud's disease; Quinquaud's folliculitis decalvans
SNOMED CT: Folliculitis depilans (53593008); Folliculitis decalvans (53593008)
Modes of inheritance:
Not genetically inherited
MedGen UID:
988794
•Concept ID:
CN307044
•
Finding
Source: Orphanet
clinical entity without genetic inheritance.
See: This record
Not genetically inherited (Orphanet)
 
Monarch Initiative: MONDO:0018103
Orphanet: ORPHA346

Definition

A rare chronic inflammatory cicatricial alopecia of the scalp occurring in middle-aged adults and characterized by the development of alopecic patches with slowly centrifugal spread predominantly in the vertex and occipital area of the scalp, associated with perifollicular erythema, follicular pustules and hemorrhagic crusts. [from ORDO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVFolliculitis decalvans

Professional guidelines

PubMed

EGFR inhibitor-induced folliculitis decalvans: a case series and management guidelines.
Nowaczyk J, Fret K, Kaminska-Winciorek G, Rudnicka L, Czuwara J
Anticancer Drugs 2023 Sep 1;34(8):942-948. Epub 2023 Jan 24 doi: 10.1097/CAD.0000000000001494. PMID: 36708507Free PMC Article
Oral isotretinoin for the treatment of dermatologic conditions other than acne: a systematic review and discussion of future directions.
Chu S, Michelle L, Ekelem C, Sung CT, Rojek N, Mesinkovska NA
Arch Dermatol Res 2021 Aug;313(6):391-430. Epub 2020 Nov 5 doi: 10.1007/s00403-020-02152-4. PMID: 33151346
The Diagnosis and Treatment of Hair and Scalp Diseases.
Wolff H, Fischer TW, Blume-Peytavi U
Dtsch Arztebl Int 2016 May 27;113(21):377-86. doi: 10.3238/arztebl.2016.0377. PMID: 27504707Free PMC Article

Recent clinical studies

Etiology

Clinical Characterization and Treatment Response of Folliculitis Decalvans Lichen Planopilaris Phenotypic Spectrum: A Unicentre Retrospective Series of 31 Patients.
Melián-Olivera A, Moreno-Arrones Ó, Burgos-Blasco P, Hermosa-Gelbard Á, Jaén-Olasolo P, Vañó-Galván S, Saceda-Corralo D
Acta Derm Venereol 2024 Feb 19;104:adv12373. doi: 10.2340/actadv.v104.12373. PMID: 38372472Free PMC Article
A Review of the Dermatologic Clinical Applications of Topical Photodynamic Therapy.
Luo OD, Bose R, Bawazir MA, Thuraisingam T, Ghazawi FM
J Cutan Med Surg 2024 Jan-Feb;28(1):NP1. Epub 2024 Jan 20 doi: 10.1177/12034754231216969. PMID: 38243786
Tufted hairs: A bouquet of flowers in different hair diseases.
Starace M, Vezzoni R, Alessandrini A, Bruni F, Carpanese M, Melo DF, Piraccini BM
J Cosmet Dermatol 2022 Sep;21(9):3741-3746. Epub 2022 Jan 10 doi: 10.1111/jocd.14712. PMID: 35001495
Histopathologic and dermoscopic features of 42 cases of folliculitis decalvans: A case series.
Uchiyama M, Harada K, Tobita R, Irisawa R, Tsuboi R
J Am Acad Dermatol 2021 Nov;85(5):1185-1193. Epub 2020 Apr 6 doi: 10.1016/j.jaad.2020.03.092. PMID: 32272176
Primary scarring alopecias.
Rigopoulos D, Stamatios G, Ioannides D
Curr Probl Dermatol 2015;47:76-86. Epub 2015 Feb 20 doi: 10.1159/000369407. PMID: 26370646

Diagnosis

Scarring Alopecia.
Larrondo J, McMichael AJ
Dermatol Clin 2023 Jul;41(3):519-537. Epub 2023 Apr 14 doi: 10.1016/j.det.2023.02.007. PMID: 37236719
Update on trichoscopy: Integration of the terminology by systematic approach and a proposal of a diagnostic flowchart.
Kinoshita-Ise M, Sachdeva M
J Dermatol 2022 Jan;49(1):4-18. Epub 2021 Nov 22 doi: 10.1111/1346-8138.16233. PMID: 34806223
The Diagnosis and Treatment of Hair and Scalp Diseases.
Wolff H, Fischer TW, Blume-Peytavi U
Dtsch Arztebl Int 2016 May 27;113(21):377-86. doi: 10.3238/arztebl.2016.0377. PMID: 27504707Free PMC Article
Histopathology of alopecia: a clinicopathological approach to diagnosis.
Stefanato CM
Histopathology 2010 Jan;56(1):24-38. doi: 10.1111/j.1365-2559.2009.03439.x. PMID: 20055903
Folliculitis decalvans.
Otberg N, Kang H, Alzolibani AA, Shapiro J
Dermatol Ther 2008 Jul-Aug;21(4):238-44. doi: 10.1111/j.1529-8019.2008.00204.x. PMID: 18715292

Therapy

Recalcitrant Folliculitis Decalvans Treatment Outcomes With Biologics and Small Molecule Inhibitors.
Fakhoury T, Urban K, Ettefagh L, Nami N
Cutis 2024 May;113(5):E32-E34. doi: 10.12788/cutis.1023. PMID: 39042121
Photodynamic therapy should be considered for the treatment of folliculitis decalvans.
Yang L, Chen J, Tong X, Gao L, Ding S, Guo A
Photodiagnosis Photodyn Ther 2021 Sep;35:102356. Epub 2021 May 25 doi: 10.1016/j.pdpdt.2021.102356. PMID: 34048971
Oral isotretinoin for the treatment of dermatologic conditions other than acne: a systematic review and discussion of future directions.
Chu S, Michelle L, Ekelem C, Sung CT, Rojek N, Mesinkovska NA
Arch Dermatol Res 2021 Aug;313(6):391-430. Epub 2020 Nov 5 doi: 10.1007/s00403-020-02152-4. PMID: 33151346
The Diagnosis and Treatment of Hair and Scalp Diseases.
Wolff H, Fischer TW, Blume-Peytavi U
Dtsch Arztebl Int 2016 May 27;113(21):377-86. doi: 10.3238/arztebl.2016.0377. PMID: 27504707Free PMC Article
Folliculitis decalvans.
Brooke RC, Griffiths CE
Clin Exp Dermatol 2001 Jan;26(1):120-2. doi: 10.1046/j.1365-2230.2001.00746.x. PMID: 11260200

Prognosis

Histopathology in the Diagnosis of Tinea Capitis: When to Do, How to Interpret?
Elmas ÖF, Durdu M
Mycopathologia 2023 Oct;188(5):545-552. Epub 2023 Mar 28 doi: 10.1007/s11046-023-00711-7. PMID: 36976441
Folliculitis Decalvans Has a Heterogeneous Microbiological Signature and Impaired Immunological Response.
Moreno-Arrones OM, Garcia-Hoz C, Del Campo R, Roy G, Saceda-Corralo D, Jimenez-Cauhe J, Ponce-Alonso M, Serrano-Villar S, Jaen P, Paoli J, Vano-Galvan S
Dermatology 2023;239(3):454-461. Epub 2023 Jan 30 doi: 10.1159/000529301. PMID: 36716709
EGFR inhibitor-induced folliculitis decalvans: a case series and management guidelines.
Nowaczyk J, Fret K, Kaminska-Winciorek G, Rudnicka L, Czuwara J
Anticancer Drugs 2023 Sep 1;34(8):942-948. Epub 2023 Jan 24 doi: 10.1097/CAD.0000000000001494. PMID: 36708507Free PMC Article
Update on trichoscopy: Integration of the terminology by systematic approach and a proposal of a diagnostic flowchart.
Kinoshita-Ise M, Sachdeva M
J Dermatol 2022 Jan;49(1):4-18. Epub 2021 Nov 22 doi: 10.1111/1346-8138.16233. PMID: 34806223
Red face revisited: Disorders of hair growth and the pilosebaceous unit.
Ramos-e-Silva M, Pirmez R
Clin Dermatol 2014 Nov-Dec;32(6):784-99. Epub 2014 Mar 1 doi: 10.1016/j.clindermatol.2014.02.018. PMID: 25441472

Clinical prediction guides

Clinical Characterization and Treatment Response of Folliculitis Decalvans Lichen Planopilaris Phenotypic Spectrum: A Unicentre Retrospective Series of 31 Patients.
Melián-Olivera A, Moreno-Arrones Ó, Burgos-Blasco P, Hermosa-Gelbard Á, Jaén-Olasolo P, Vañó-Galván S, Saceda-Corralo D
Acta Derm Venereol 2024 Feb 19;104:adv12373. doi: 10.2340/actadv.v104.12373. PMID: 38372472Free PMC Article
Folliculitis Decalvans Has a Heterogeneous Microbiological Signature and Impaired Immunological Response.
Moreno-Arrones OM, Garcia-Hoz C, Del Campo R, Roy G, Saceda-Corralo D, Jimenez-Cauhe J, Ponce-Alonso M, Serrano-Villar S, Jaen P, Paoli J, Vano-Galvan S
Dermatology 2023;239(3):454-461. Epub 2023 Jan 30 doi: 10.1159/000529301. PMID: 36716709
Tufted hairs: A bouquet of flowers in different hair diseases.
Starace M, Vezzoni R, Alessandrini A, Bruni F, Carpanese M, Melo DF, Piraccini BM
J Cosmet Dermatol 2022 Sep;21(9):3741-3746. Epub 2022 Jan 10 doi: 10.1111/jocd.14712. PMID: 35001495
Update on trichoscopy: Integration of the terminology by systematic approach and a proposal of a diagnostic flowchart.
Kinoshita-Ise M, Sachdeva M
J Dermatol 2022 Jan;49(1):4-18. Epub 2021 Nov 22 doi: 10.1111/1346-8138.16233. PMID: 34806223
Histopathologic and dermoscopic features of 42 cases of folliculitis decalvans: A case series.
Uchiyama M, Harada K, Tobita R, Irisawa R, Tsuboi R
J Am Acad Dermatol 2021 Nov;85(5):1185-1193. Epub 2020 Apr 6 doi: 10.1016/j.jaad.2020.03.092. PMID: 32272176

Recent systematic reviews

Recalcitrant Folliculitis Decalvans Treatment Outcomes With Biologics and Small Molecule Inhibitors.
Fakhoury T, Urban K, Ettefagh L, Nami N
Cutis 2024 May;113(5):E32-E34. doi: 10.12788/cutis.1023. PMID: 39042121
Confocal microscopy and optical coherence tomography of inflammatory skin diseases in hairs and pilosebaceous units: A systematic review.
Al-Chaer RN, Bouazzi D, Jemec G, Mogensen M
Exp Dermatol 2023 Jul;32(7):945-954. Epub 2023 May 4 doi: 10.1111/exd.14830. PMID: 37140216
Update on trichoscopy: Integration of the terminology by systematic approach and a proposal of a diagnostic flowchart.
Kinoshita-Ise M, Sachdeva M
J Dermatol 2022 Jan;49(1):4-18. Epub 2021 Nov 22 doi: 10.1111/1346-8138.16233. PMID: 34806223
Oral isotretinoin for the treatment of dermatologic conditions other than acne: a systematic review and discussion of future directions.
Chu S, Michelle L, Ekelem C, Sung CT, Rojek N, Mesinkovska NA
Arch Dermatol Res 2021 Aug;313(6):391-430. Epub 2020 Nov 5 doi: 10.1007/s00403-020-02152-4. PMID: 33151346

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