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Kidney papillary necrosis

MedGen UID:
7212
•Concept ID:
C0022667
•
Disease or Syndrome
Synonyms: Kidney Papillary Necrosis; Necrosis, Kidney Papillary; Necrosis, Renal Medullary; Necrotizing Renal Papillitides; Necrotizing Renal Papillitis; Papillary Necrosis, Kidney; Papillitides, Necrotizing Renal; Renal Medullary Necrosis; Renal Papillitides, Necrotizing; Renal Papillitis, Necrotizing
SNOMED CT: Necrotizing papillitis (90241004); Papillary necrosis (90241004); Necrotizing renal papillitis (90241004); Renal papillary necrosis (90241004)
 
HPO: HP:0032632
Monarch Initiative: MONDO:0006821

Definition

Premature death of cells in the renal papilla (the apex of a renal pyramid which projects into the cavity of a calyx of the kidney and through which collecting ducts discharge urine). Histologically, one observes pale tissue with typical appearance of coagulative necrosis, affecting the renal papillae. Necrosis can be identified by pyknotic nuclei and simplified, flattened epithelium of proximal tubules. The tubular and glomerular basement membranes are still visible without viable nuclei. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVKidney papillary necrosis

Professional guidelines

PubMed

PAPILLARY NECROSIS. PATHOLOGY AND MANAGEMENT OF THE ACUTE ATTACK.
BONNIN N
Am Heart J 1964 Dec;68:842-3. doi: 10.1016/0002-8703(64)90137-1. PMID: 14235965

Recent clinical studies

Etiology

An update on sickle cell nephropathy.
Alhwiesh A
Saudi J Kidney Dis Transpl 2014 Mar;25(2):249-65. doi: 10.4103/1319-2442.128495. PMID: 24625990
Over-the-counter analgesic use.
De Broe ME, Elseviers MM
J Am Soc Nephrol 2009 Oct;20(10):2098-103. Epub 2009 May 7 doi: 10.1681/ASN.2008101097. PMID: 19423685
Herbs and the kidney.
Isnard Bagnis C, Deray G, Baumelou A, Le Quintrec M, Vanherweghem JL
Am J Kidney Dis 2004 Jul;44(1):1-11. doi: 10.1053/j.ajkd.2004.02.009. PMID: 15211432
Renal papillary necrosis--40 years on.
Bach PH, Nguyen TK
Toxicol Pathol 1998 Jan-Feb;26(1):73-91. doi: 10.1177/019262339802600110. PMID: 9502390
Interstitial nephritis. A brief review.
Heptinstall RH
Am J Pathol 1976 Apr;83(1):213-36. PMID: 776003Free PMC Article

Diagnosis

Renal Papillary and Calyceal Lesions at CT Urography: Genitourinary Imaging.
Kawamoto S, Duggan P, Sheth S, Miyamoto H, Kazi ZN, Fishman EK
Radiographics 2017 Jan-Feb;37(1):358-359. doi: 10.1148/rg.2017160089. PMID: 28076022
Over-the-counter analgesic use.
De Broe ME, Elseviers MM
J Am Soc Nephrol 2009 Oct;20(10):2098-103. Epub 2009 May 7 doi: 10.1681/ASN.2008101097. PMID: 19423685
Renal papillary necrosis--40 years on.
Bach PH, Nguyen TK
Toxicol Pathol 1998 Jan-Feb;26(1):73-91. doi: 10.1177/019262339802600110. PMID: 9502390
Phenacetin nephritis.
Freeland JP
Urology 1975 Jul;6(1):37-8. doi: 10.1016/0090-4295(75)90589-0. PMID: 1145922
Cryptococcal pyelonephritis.
Randall RE Jr, Stacy WK, Toone EC, Prout GR Jr, Madge GE, Shadomy HJ, Shadomy S, Utz JP
N Engl J Med 1968 Jul 11;279(2):60-5. doi: 10.1056/NEJM196807112790202. PMID: 5657012

Therapy

Nonsteroidal antiinflammatory drugs, cyclooxygenase-2, and the kidneys.
Rahman S, Malcoun A
Prim Care 2014 Dec;41(4):803-21. Epub 2014 Nov 4 doi: 10.1016/j.pop.2014.09.001. PMID: 25439535
Over-the-counter analgesic use.
De Broe ME, Elseviers MM
J Am Soc Nephrol 2009 Oct;20(10):2098-103. Epub 2009 May 7 doi: 10.1681/ASN.2008101097. PMID: 19423685
Herbs and the kidney.
Isnard Bagnis C, Deray G, Baumelou A, Le Quintrec M, Vanherweghem JL
Am J Kidney Dis 2004 Jul;44(1):1-11. doi: 10.1053/j.ajkd.2004.02.009. PMID: 15211432
Renal papillary necrosis.
Lancet 1982 Sep 11;2(8298):588-90. PMID: 6125734
Cryptococcal pyelonephritis.
Randall RE Jr, Stacy WK, Toone EC, Prout GR Jr, Madge GE, Shadomy HJ, Shadomy S, Utz JP
N Engl J Med 1968 Jul 11;279(2):60-5. doi: 10.1056/NEJM196807112790202. PMID: 5657012

Prognosis

An update on sickle cell nephropathy.
Alhwiesh A
Saudi J Kidney Dis Transpl 2014 Mar;25(2):249-65. doi: 10.4103/1319-2442.128495. PMID: 24625990
Analgesic nephropathy.
Henrich WL
Am J Med Sci 1988 Jun;295(6):561-8. doi: 10.1097/00000441-198806000-00012. PMID: 3291614
Chemically induced renal papillary necrosis and upper urothelial carcinoma. Part 1.
Bach PH, Bridges JW
Crit Rev Toxicol 1985;15(3):217-329. doi: 10.3109/10408448509089854. PMID: 3933914
Diabetic nephropathy.
Beyer MM
Pediatr Clin North Am 1984 Jun;31(3):635-51. doi: 10.1016/s0031-3955(16)34611-9. PMID: 6374591
PHENACETIN NEPHROPATHY.
RAMSAY AG, WHITE DF
Can Med Assoc J 1965 Jan 9;92(2):55-9. PMID: 14228236Free PMC Article

Clinical prediction guides

Prevalence and associations of symptomatic renal papillary necrosis in sickle cell anemia patients in South-Eastern Nigeria.
Madu AJ, Okoye AE, Ajuba IC, Madu KA, Anigbo C, Agu K
Niger J Clin Pract 2016 Jul-Aug;19(4):471-4. doi: 10.4103/1119-3077.183299. PMID: 27251962
Obituary to analgesic nephropathy--an autopsy study.
Mihatsch MJ, Khanlari B, Brunner FP
Nephrol Dial Transplant 2006 Nov;21(11):3139-45. Epub 2006 Aug 5 doi: 10.1093/ndt/gfl390. PMID: 16891638
Analgesic nephropathy: is it caused by multi-analgesic abuse or single substance use?
Elseviers MM, De Broe ME
Drug Saf 1999 Jan;20(1):15-24. doi: 10.2165/00002018-199920010-00003. PMID: 9935274
Diabetic nephropathy.
Beyer MM
Pediatr Clin North Am 1984 Jun;31(3):635-51. doi: 10.1016/s0031-3955(16)34611-9. PMID: 6374591
Renal papillary necrosis: an update.
Eknoyan G, Qunibi WY, Grissom RT, Tuma SN, Ayus JC
Medicine (Baltimore) 1982 Mar;61(2):55-73. doi: 10.1097/00005792-198203000-00001. PMID: 7038374

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