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Kidney papillary necrosis

MedGen UID:
7212
Concept ID:
C0022667
Disease or Syndrome
Synonyms: Kidney Papillary Necrosis; Necrosis, Kidney Papillary; Necrosis, Renal Medullary; Necrotizing Renal Papillitides; Necrotizing Renal Papillitis; Papillary Necrosis, Kidney; Papillitides, Necrotizing Renal; Renal Medullary Necrosis; Renal Papillitides, Necrotizing; Renal Papillitis, Necrotizing
SNOMED CT: Necrotizing papillitis (90241004); Papillary necrosis (90241004); Necrotizing renal papillitis (90241004); Renal papillary necrosis (90241004)
 
HPO: HP:0032632
Monarch Initiative: MONDO:0006821

Definition

Premature death of cells in the renal papilla (the apex of a renal pyramid which projects into the cavity of a calyx of the kidney and through which collecting ducts discharge urine). Histologically, one observes pale tissue with typical appearance of coagulative necrosis, affecting the renal papillae. Necrosis can be identified by pyknotic nuclei and simplified, flattened epithelium of proximal tubules. The tubular and glomerular basement membranes are still visible without viable nuclei. [from HPO]

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PubMed

BONNIN N
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Recent clinical studies

Etiology

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Diagnosis

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Radiographics 2017 Jan-Feb;37(1):358-359. doi: 10.1148/rg.2017160089. PMID: 28076022
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J Am Soc Nephrol 2009 Oct;20(10):2098-103. Epub 2009 May 7 doi: 10.1681/ASN.2008101097. PMID: 19423685
Bach PH, Nguyen TK
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Therapy

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De Broe ME, Elseviers MM
J Am Soc Nephrol 2009 Oct;20(10):2098-103. Epub 2009 May 7 doi: 10.1681/ASN.2008101097. PMID: 19423685
Isnard Bagnis C, Deray G, Baumelou A, Le Quintrec M, Vanherweghem JL
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Prognosis

Li EJ, Carroll VG
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Clinical prediction guides

Madu AJ, Okoye AE, Ajuba IC, Madu KA, Anigbo C, Agu K
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