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Persistent infection

MedGen UID:
688822
Concept ID:
C1264606
Disease or Syndrome
Synonyms: Infection, Long Term; Infection, Persistent; Long Term Infection; Long Term Infections; Persistent Infection; Persistent Infections
SNOMED CT: Persistent infection (115648009)

Definition

Infection which lasts for a long period with continuous display of clinical features. Persistent infection arises due to inability of host cells to clear primary infections completely. When persistent infections are cleared so that infection symptoms are under control they are often referred to as chronic infections. LATENT INFECTIONS are infections in which manifestation of clinical symptoms appear later. [from MeSH]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVPersistent infection

Professional guidelines

PubMed

European Association for the Study of the Liver. Electronic address: easloffice@easloffice.eu; European Association for the Study of the Liver
J Hepatol 2023 Aug;79(2):433-460. Epub 2023 Jun 24 doi: 10.1016/j.jhep.2023.05.001. PMID: 37364791
Lee C, Song M
J Endod 2022 Sep;48(9):1137-1145. Epub 2022 Jun 14 doi: 10.1016/j.joen.2022.06.002. PMID: 35714726
Ntanasis-Stathopoulos I, Kyriazoglou A, Liontos M, A Dimopoulos M, Gavriatopoulou M
J BUON 2020 May-Jun;25(3):1281-1285. PMID: 32862567

Recent clinical studies

Etiology

Metersky ML, Barker AF
Clin Chest Med 2022 Mar;43(1):35-46. doi: 10.1016/j.ccm.2021.11.003. PMID: 35236559
Della Fera AN, Warburton A, Coursey TL, Khurana S, McBride AA
Viruses 2021 Feb 20;13(2) doi: 10.3390/v13020321. PMID: 33672465Free PMC Article
Castanheira CP, Sallas ML, Nunes RAL, Lorenzi NPC, Termini L
Pathobiology 2021;88(2):187-197. Epub 2020 Nov 23 doi: 10.1159/000511477. PMID: 33227782
Camilo V, Sugiyama T, Touati E
Helicobacter 2017 Sep;22 Suppl 1 doi: 10.1111/hel.12405. PMID: 28891130
Eldin C, Mélenotte C, Mediannikov O, Ghigo E, Million M, Edouard S, Mege JL, Maurin M, Raoult D
Clin Microbiol Rev 2017 Jan;30(1):115-190. doi: 10.1128/CMR.00045-16. PMID: 27856520Free PMC Article

Diagnosis

European Association for the Study of the Liver. Electronic address: easloffice@easloffice.eu; European Association for the Study of the Liver
J Hepatol 2023 Aug;79(2):433-460. Epub 2023 Jun 24 doi: 10.1016/j.jhep.2023.05.001. PMID: 37364791
Lamoth F, Calandra T
Eur Respir Rev 2022 Dec 31;31(166) Epub 2022 Nov 29 doi: 10.1183/16000617.0114-2022. PMID: 36450372Free PMC Article
Tuano KS, Seth N, Chinen J
Ann Allergy Asthma Immunol 2021 Dec;127(6):617-626. Epub 2021 Sep 3 doi: 10.1016/j.anai.2021.08.413. PMID: 34481993
Ntanasis-Stathopoulos I, Kyriazoglou A, Liontos M, A Dimopoulos M, Gavriatopoulou M
J BUON 2020 May-Jun;25(3):1281-1285. PMID: 32862567
Eldin C, Mélenotte C, Mediannikov O, Ghigo E, Million M, Edouard S, Mege JL, Maurin M, Raoult D
Clin Microbiol Rev 2017 Jan;30(1):115-190. doi: 10.1128/CMR.00045-16. PMID: 27856520Free PMC Article

Therapy

Hurlow J, Bowler PG
J Wound Care 2022 May 2;31(5):436-445. doi: 10.12968/jowc.2022.31.5.436. PMID: 35579319
Bernard L, Arvieux C, Brunschweiler B, Touchais S, Ansart S, Bru JP, Oziol E, Boeri C, Gras G, Druon J, Rosset P, Senneville E, Bentayeb H, Bouhour D, Le Moal G, Michon J, Aumaître H, Forestier E, Laffosse JM, Begué T, Chirouze C, Dauchy FA, Devaud E, Martha B, Burgot D, Boutoille D, Stindel E, Dinh A, Bemer P, Giraudeau B, Issartel B, Caille A
N Engl J Med 2021 May 27;384(21):1991-2001. doi: 10.1056/NEJMoa2020198. PMID: 34042388
Wang R, Pan W, Jin L, Huang W, Li Y, Wu D, Gao C, Ma D, Liao S
Cancer Lett 2020 Feb 28;471:88-102. Epub 2019 Dec 5 doi: 10.1016/j.canlet.2019.11.039. PMID: 31812696
Arbyn M, Xu L, Simoens C, Martin-Hirsch PP
Cochrane Database Syst Rev 2018 May 9;5(5):CD009069. doi: 10.1002/14651858.CD009069.pub3. PMID: 29740819Free PMC Article
Manresa C, Sanz-Miralles EC, Twigg J, Bravo M
Cochrane Database Syst Rev 2018 Jan 1;1(1):CD009376. doi: 10.1002/14651858.CD009376.pub2. PMID: 29291254Free PMC Article

Prognosis

Bowden SJ, Doulgeraki T, Bouras E, Markozannes G, Athanasiou A, Grout-Smith H, Kechagias KS, Ellis LB, Zuber V, Chadeau-Hyam M, Flanagan JM, Tsilidis KK, Kalliala I, Kyrgiou M
BMC Med 2023 Jul 27;21(1):274. doi: 10.1186/s12916-023-02965-w. PMID: 37501128Free PMC Article
Quinlan JD
Am Fam Physician 2021 Aug 1;104(2):152-159. PMID: 34383440
Choi IJ, Kim CG, Lee JY, Kim YI, Kook MC, Park B, Joo J
N Engl J Med 2020 Jan 30;382(5):427-436. doi: 10.1056/NEJMoa1909666. PMID: 31995688
Giuliano AR, Palefsky JM, Goldstone S, Moreira ED Jr, Penny ME, Aranda C, Vardas E, Moi H, Jessen H, Hillman R, Chang YH, Ferris D, Rouleau D, Bryan J, Marshall JB, Vuocolo S, Barr E, Radley D, Haupt RM, Guris D
N Engl J Med 2011 Feb 3;364(5):401-11. doi: 10.1056/NEJMoa0909537. PMID: 21288094Free PMC Article
Kwiatkowska B, Filipowicz-Sosnowska A
Pol Arch Med Wewn 2009 Jan-Feb;119(1-2):60-5. PMID: 19341180

Clinical prediction guides

Gao X, Shen Q, Roco JA, Dalton B, Frith K, Munier CML, Ballard FD, Wang K, Kelly HG, Nekrasov M, He JS, Jaeger R, Carreira P, Ellyard JI, Beattie L, Enders A, Cook MC, Zaunders JJ, Cockburn IA
Sci Immunol 2024 Mar 29;9(93):eadj4748. doi: 10.1126/sciimmunol.adj4748. PMID: 38330097
Geng Y, Shi T, Wang Y
Adv Exp Med Biol 2023;1417:33-48. doi: 10.1007/978-981-99-1304-6_3. PMID: 37223857
Ntanasis-Stathopoulos I, Kyriazoglou A, Liontos M, A Dimopoulos M, Gavriatopoulou M
J BUON 2020 May-Jun;25(3):1281-1285. PMID: 32862567
Bellinghausen C, Rohde GGU, Savelkoul PHM, Wouters EFM, Stassen FRM
J Gen Virol 2016 Dec;97(12):3089-3102. Epub 2016 Oct 18 doi: 10.1099/jgv.0.000627. PMID: 27902340
Geng Y, Wang Y
Adv Exp Med Biol 2016;948:39-59. doi: 10.1007/978-94-024-0942-0_3. PMID: 27738978

Recent systematic reviews

Main E, Rand S
Cochrane Database Syst Rev 2023 May 5;5(5):CD002011. doi: 10.1002/14651858.CD002011.pub3. PMID: 37144842Free PMC Article
Norenhag J, Du J, Olovsson M, Verstraelen H, Engstrand L, Brusselaers N
BJOG 2020 Jan;127(2):171-180. Epub 2019 Jul 17 doi: 10.1111/1471-0528.15854. PMID: 31237400
Tamarelle J, Thiébaut ACM, de Barbeyrac B, Bébéar C, Ravel J, Delarocque-Astagneau E
Clin Microbiol Infect 2019 Jan;25(1):35-47. Epub 2018 May 3 doi: 10.1016/j.cmi.2018.04.019. PMID: 29729331Free PMC Article
Arbyn M, Xu L, Simoens C, Martin-Hirsch PP
Cochrane Database Syst Rev 2018 May 9;5(5):CD009069. doi: 10.1002/14651858.CD009069.pub3. PMID: 29740819Free PMC Article
Manresa C, Sanz-Miralles EC, Twigg J, Bravo M
Cochrane Database Syst Rev 2018 Jan 1;1(1):CD009376. doi: 10.1002/14651858.CD009376.pub2. PMID: 29291254Free PMC Article

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