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Bronchiolitis, Viral

MedGen UID:
666
•Concept ID:
C0006274
•
Disease or Syndrome
Synonyms: Bronchiolitides, Viral; Viral Bronchiolitides; Viral Bronchiolitis

Definition

An acute inflammatory disease of the lower RESPIRATORY TRACT, caused by paramyxoviruses, occurring primarily in infants and young children; the viruses most commonly implicated are PARAINFLUENZA VIRUS TYPE 3; RESPIRATORY SYNCYTIAL VIRUS, HUMAN; and METAPNEUMOVIRUS. [from MeSH]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVBronchiolitis, Viral

Professional guidelines

PubMed

Bronchiolitis guidelines: what about the Italian situation in a primary care setting?
Porcaro F, Cutrera R, Vittucci AC, Villani A
Ital J Pediatr 2023 Sep 19;49(1):123. doi: 10.1186/s13052-023-01527-3. PMID: 37726761Free PMC Article
Viral bronchiolitis in young infants: new perspectives for management and treatment.
Caballero MT, Polack FP, Stein RT
J Pediatr (Rio J) 2017 Nov-Dec;93 Suppl 1:75-83. Epub 2017 Aug 30 doi: 10.1016/j.jped.2017.07.003. PMID: 28859915
Inter-society consensus document on treatment and prevention of bronchiolitis in newborns and infants.
Baraldi E, Lanari M, Manzoni P, Rossi GA, Vandini S, Rimini A, Romagnoli C, Colonna P, Biondi A, Biban P, Chiamenti G, Bernardini R, Picca M, Cappa M, Magazzù G, Catassi C, Urbino AF, Memo L, Donzelli G, Minetti C, Paravati F, Di Mauro G, Festini F, Esposito S, Corsello G
Ital J Pediatr 2014 Oct 24;40:65. doi: 10.1186/1824-7288-40-65. PMID: 25344148Free PMC Article

Recent clinical studies

Etiology

Bronchiolitis therapies and misadventures.
Linssen RSN, Schechter MS, Rubin BK
Paediatr Respir Rev 2023 Jun;46:49-56. Epub 2022 Sep 29 doi: 10.1016/j.prrv.2022.09.003. PMID: 36280580
Identifying and managing bronchiolitis.
Paluch L
JAAPA 2020 Sep;33(9):12-15. doi: 10.1097/01.JAA.0000694944.22382.39. PMID: 32841971
Viral Bronchiolitis in Children.
Meissner HC
N Engl J Med 2016 Jan 7;374(1):62-72. doi: 10.1056/NEJMra1413456. PMID: 26735994
Acute bronchiolitis.
Teshome G, Gattu R, Brown R
Pediatr Clin North Am 2013 Oct;60(5):1019-34. Epub 2013 Jul 24 doi: 10.1016/j.pcl.2013.06.005. PMID: 24093893
Bronchiolitis: update 2001.
Schlesinger C, Koss MN
Curr Opin Pulm Med 2002 Mar;8(2):112-6. doi: 10.1097/00063198-200203000-00006. PMID: 11845006

Diagnosis

Bronchiolitis.
Dalziel SR, Haskell L, O'Brien S, Borland ML, Plint AC, Babl FE, Oakley E
Lancet 2022 Jul 30;400(10349):392-406. Epub 2022 Jul 1 doi: 10.1016/S0140-6736(22)01016-9. PMID: 35785792
Identifying and managing bronchiolitis.
Paluch L
JAAPA 2020 Sep;33(9):12-15. doi: 10.1097/01.JAA.0000694944.22382.39. PMID: 32841971
Viral bronchiolitis.
Florin TA, Plint AC, Zorc JJ
Lancet 2017 Jan 14;389(10065):211-224. Epub 2016 Aug 20 doi: 10.1016/S0140-6736(16)30951-5. PMID: 27549684Free PMC Article
Respiratory syncytial virus infection and bronchiolitis.
Piedimonte G, Perez MK
Pediatr Rev 2014 Dec;35(12):519-30. doi: 10.1542/pir.35-12-519. PMID: 25452661Free PMC Article
Acute bronchiolitis.
Teshome G, Gattu R, Brown R
Pediatr Clin North Am 2013 Oct;60(5):1019-34. Epub 2013 Jul 24 doi: 10.1016/j.pcl.2013.06.005. PMID: 24093893

Therapy

Bronchiolitis.
Dalziel SR, Haskell L, O'Brien S, Borland ML, Plint AC, Babl FE, Oakley E
Lancet 2022 Jul 30;400(10349):392-406. Epub 2022 Jul 1 doi: 10.1016/S0140-6736(22)01016-9. PMID: 35785792
Identifying and managing bronchiolitis.
Paluch L
JAAPA 2020 Sep;33(9):12-15. doi: 10.1097/01.JAA.0000694944.22382.39. PMID: 32841971
Viral bronchiolitis.
Florin TA, Plint AC, Zorc JJ
Lancet 2017 Jan 14;389(10065):211-224. Epub 2016 Aug 20 doi: 10.1016/S0140-6736(16)30951-5. PMID: 27549684Free PMC Article
Bronchiolitis: update 2001.
Schlesinger C, Koss MN
Curr Opin Pulm Med 2002 Mar;8(2):112-6. doi: 10.1097/00063198-200203000-00006. PMID: 11845006
Bronchiolitis.
Welliver JR, Welliver RC
Pediatr Rev 1993 Apr;14(4):134-9. doi: 10.1542/pir.14-4-134. PMID: 8516237

Prognosis

Viral bronchiolitis for the clinician.
Fitzgerald DA
J Paediatr Child Health 2011 Apr;47(4):160-6. doi: 10.1111/j.1440-1754.2010.01735.x. PMID: 20500436Free PMC Article
The treatment of bronchiolitis.
Yanney M, Vyas H
Arch Dis Child 2008 Sep;93(9):793-8. Epub 2008 Jun 6 doi: 10.1136/adc.2007.128736. PMID: 18539685
Bronchiolitis: update 2001.
Schlesinger C, Koss MN
Curr Opin Pulm Med 2002 Mar;8(2):112-6. doi: 10.1097/00063198-200203000-00006. PMID: 11845006
Bronchiolitis.
Welliver JR, Welliver RC
Pediatr Rev 1993 Apr;14(4):134-9. doi: 10.1542/pir.14-4-134. PMID: 8516237
Bronchiolitis or asthma?
Wittig HJ, Chang CH
Pediatr Clin North Am 1969 Feb;16(1):55-66. doi: 10.1016/s0031-3955(16)32234-9. PMID: 4885829

Clinical prediction guides

Nirsevimab Effectiveness Against Cases of Respiratory Syncytial Virus Bronchiolitis Hospitalised in Paediatric Intensive Care Units in France, September 2023-January 2024.
Paireau J, Durand C, Raimbault S, Cazaubon J, Mortamet G, Viriot D, Milesi C, Daudens-Vaysse E, Ploin D, Tessier S, Vanel N, Chappert JL, Levieux K, Ollivier R, Daoudi J, Coignard B, Leteurtre S, Parent-du-Châtelet I, Vaux S
Influenza Other Respir Viruses 2024 Jun;18(6):e13311. doi: 10.1111/irv.13311. PMID: 38840301Free PMC Article
Respiratory Syncytial Virus is the Most Common Causative Agent of Viral Bronchiolitis in Young Children: An Updated Review.
Hon KL, Leung AKC, Wong AHC, Dudi A, Leung KKY
Curr Pediatr Rev 2023;19(2):139-149. doi: 10.2174/1573396318666220810161945. PMID: 35950255
Risk Factors for Respiratory Syncytial Virus Bronchiolitis Admissions.
Meenaghan S, Breatnach C, Smith H
Ir Med J 2020 Jan 16;113(1):9. PMID: 32298565
Respiratory syncytial virus infections: old challenges and new opportunities.
Mejías A, Chávez-Bueno S, Jafri HS, Ramilo O
Pediatr Infect Dis J 2005 Nov;24(11 Suppl):S189-96, discussion S196-7. doi: 10.1097/01.inf.0000188196.87969.9a. PMID: 16378045
Bronchiolitis: a clinical review.
Tercier JA
J Emerg Med 1983;1(2):119-23. doi: 10.1016/0736-4679(83)90044-6. PMID: 6389670

Recent systematic reviews

High flow nasal cannula as respiratory support in treating infant bronchiolitis: a systematic review.
Moreel L, Proesmans M
Eur J Pediatr 2020 May;179(5):711-718. Epub 2020 Mar 31 doi: 10.1007/s00431-020-03637-0. PMID: 32232547
Safety of corticosteroids in young children with acute respiratory conditions: a systematic review and meta-analysis.
Fernandes RM, Wingert A, Vandermeer B, Featherstone R, Ali S, Plint AC, Stang AS, Rowe BH, Johnson DW, Allain D, Klassen TP, Hartling L
BMJ Open 2019 Aug 1;9(8):e028511. doi: 10.1136/bmjopen-2018-028511. PMID: 31375615Free PMC Article
Viral bronchiolitis in young infants: new perspectives for management and treatment.
Caballero MT, Polack FP, Stein RT
J Pediatr (Rio J) 2017 Nov-Dec;93 Suppl 1:75-83. Epub 2017 Aug 30 doi: 10.1016/j.jped.2017.07.003. PMID: 28859915
Respiratory syncytial virus infection and chronic respiratory morbidity - is there a functional or genetic predisposition?
Drysdale SB, Milner AD, Greenough A
Acta Paediatr 2012 Nov;101(11):1114-20. Epub 2012 Sep 11 doi: 10.1111/j.1651-2227.2012.02825.x. PMID: 22963586
Incidence of apnea in infants hospitalized with respiratory syncytial virus bronchiolitis: a systematic review.
Ralston S, Hill V
J Pediatr 2009 Nov;155(5):728-33. Epub 2009 Aug 3 doi: 10.1016/j.jpeds.2009.04.063. PMID: 19647839

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