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Nephropathy caused by heavy metals

MedGen UID:
625180
•Concept ID:
C0451769
•
Disease or Syndrome
Synonyms: Heavy-Metal-Induced Nephropathy; Nephropathy induced by heavy metals
SNOMED CT: Nephropathy induced by heavy metals (197753000); Nephropathy caused by heavy metals (197753000)

Definition

Damage to the kidney and renal tubules resulting from heavy metal exposure. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVNephropathy caused by heavy metals

Professional guidelines

PubMed

Impact of Inflammation on Ferritin, Hepcidin and the Management of Iron Deficiency Anemia in Chronic Kidney Disease.
Ueda N, Takasawa K
Nutrients 2018 Aug 27;10(9) doi: 10.3390/nu10091173. PMID: 30150549Free PMC Article
Anemia, heart failure and evidence-based clinical management.
Pereira CA, Roscani MG, Zanati SG, Matsubara BB
Arq Bras Cardiol 2013 Jul;101(1):87-92. doi: 10.5935/abc.20130126. PMID: 23917508Free PMC Article
Anaemia management and mortality risk in chronic kidney disease.
Hörl WH
Nat Rev Nephrol 2013 May;9(5):291-301. Epub 2013 Feb 26 doi: 10.1038/nrneph.2013.21. PMID: 23438972

Recent clinical studies

Etiology

A network meta-analysis of the efficacy of hypoxia-inducible factor prolyl-hydroxylase inhibitors in dialysis chronic kidney disease.
Chen J, Shou X, Xu Y, Jin L, Zhu C, Ye X, Mei Z, Chen P
Aging (Albany NY) 2023 Mar 27;15(6):2237-2274. doi: 10.18632/aging.204611. PMID: 36988549Free PMC Article
Mesoamerican Nephropathy.
Correa-Rotter R, García-Trabanino R
Semin Nephrol 2019 May;39(3):263-271. doi: 10.1016/j.semnephrol.2019.02.004. PMID: 31054625
Impact of Inflammation on Ferritin, Hepcidin and the Management of Iron Deficiency Anemia in Chronic Kidney Disease.
Ueda N, Takasawa K
Nutrients 2018 Aug 27;10(9) doi: 10.3390/nu10091173. PMID: 30150549Free PMC Article
Renal Anemia and Iron Metabolism.
Ogawa C, Tsuchiya K, Maeda K, Nitta K
Contrib Nephrol 2018;195:62-73. Epub 2018 May 7 doi: 10.1159/000486936. PMID: 29734151
Hazards of heavy metal contamination.
Järup L
Br Med Bull 2003;68:167-82. doi: 10.1093/bmb/ldg032. PMID: 14757716

Diagnosis

Rubrometabolic Syndrome.
Kalra S, Coetzee A, Kalra PA, Saldaña JR, Kilov G
Minerva Endocrinol (Torino) 2023 Mar;48(1):59-75. Epub 2020 Dec 17 doi: 10.23736/S2724-6507.20.03353-2. PMID: 33331741
Mesoamerican Nephropathy.
Correa-Rotter R, García-Trabanino R
Semin Nephrol 2019 May;39(3):263-271. doi: 10.1016/j.semnephrol.2019.02.004. PMID: 31054625
Fanconi Syndrome.
Foreman JW
Pediatr Clin North Am 2019 Feb;66(1):159-167. doi: 10.1016/j.pcl.2018.09.002. PMID: 30454741
Impact of Inflammation on Ferritin, Hepcidin and the Management of Iron Deficiency Anemia in Chronic Kidney Disease.
Ueda N, Takasawa K
Nutrients 2018 Aug 27;10(9) doi: 10.3390/nu10091173. PMID: 30150549Free PMC Article
Ferroptosis: A Regulated Cell Death Nexus Linking Metabolism, Redox Biology, and Disease.
Stockwell BR, Friedmann Angeli JP, Bayir H, Bush AI, Conrad M, Dixon SJ, Fulda S, Gascón S, Hatzios SK, Kagan VE, Noel K, Jiang X, Linkermann A, Murphy ME, Overholtzer M, Oyagi A, Pagnussat GC, Park J, Ran Q, Rosenfeld CS, Salnikow K, Tang D, Torti FM, Torti SV, Toyokuni S, Woerpel KA, Zhang DD
Cell 2017 Oct 5;171(2):273-285. doi: 10.1016/j.cell.2017.09.021. PMID: 28985560Free PMC Article

Therapy

A network meta-analysis of the efficacy of hypoxia-inducible factor prolyl-hydroxylase inhibitors in dialysis chronic kidney disease.
Chen J, Shou X, Xu Y, Jin L, Zhu C, Ye X, Mei Z, Chen P
Aging (Albany NY) 2023 Mar 27;15(6):2237-2274. doi: 10.18632/aging.204611. PMID: 36988549Free PMC Article
Rubrometabolic Syndrome.
Kalra S, Coetzee A, Kalra PA, Saldaña JR, Kilov G
Minerva Endocrinol (Torino) 2023 Mar;48(1):59-75. Epub 2020 Dec 17 doi: 10.23736/S2724-6507.20.03353-2. PMID: 33331741
Mesoamerican Nephropathy.
Correa-Rotter R, García-Trabanino R
Semin Nephrol 2019 May;39(3):263-271. doi: 10.1016/j.semnephrol.2019.02.004. PMID: 31054625
Impact of Inflammation on Ferritin, Hepcidin and the Management of Iron Deficiency Anemia in Chronic Kidney Disease.
Ueda N, Takasawa K
Nutrients 2018 Aug 27;10(9) doi: 10.3390/nu10091173. PMID: 30150549Free PMC Article
Hazards of heavy metal contamination.
Järup L
Br Med Bull 2003;68:167-82. doi: 10.1093/bmb/ldg032. PMID: 14757716

Prognosis

Salvianolic acid A attenuates arsenic-induced ferroptosis and kidney injury via HIF-2α/DUOX1/GPX4 and iron homeostasis.
Yang D, Xia X, Xi S
Sci Total Environ 2024 Jan 10;907:168073. Epub 2023 Oct 23 doi: 10.1016/j.scitotenv.2023.168073. PMID: 37879473
Impact of Inflammation on Ferritin, Hepcidin and the Management of Iron Deficiency Anemia in Chronic Kidney Disease.
Ueda N, Takasawa K
Nutrients 2018 Aug 27;10(9) doi: 10.3390/nu10091173. PMID: 30150549Free PMC Article
Iron status in the elderly: A review of recent evidence.
Wawer AA, Jennings A, Fairweather-Tait SJ
Mech Ageing Dev 2018 Oct;175:55-73. Epub 2018 Jul 21 doi: 10.1016/j.mad.2018.07.003. PMID: 30040993
Dysregulated iron metabolism in patients on hemodialysis.
Nakanishi T, Hasuike Y, Otaki Y, Nanami M, Kuragano T
Contrib Nephrol 2015;185:22-31. Epub 2015 May 19 doi: 10.1159/000380967. PMID: 26023012
Iron, hemochromatosis, and hepatocellular carcinoma.
Kowdley KV
Gastroenterology 2004 Nov;127(5 Suppl 1):S79-86. doi: 10.1016/j.gastro.2004.09.019. PMID: 15508107

Clinical prediction guides

Evidence on Neurotoxicity after Intrauterine and Childhood Exposure to Organomercurials.
Azevedo LF, Karpova N, Rocha BA, Barbosa Junior F, Gobe GC, Hornos Carneiro MF
Int J Environ Res Public Health 2023 Jan 7;20(2) doi: 10.3390/ijerph20021070. PMID: 36673825Free PMC Article
Renal damage induced by cadmium and its possible therapy by mitochondrial transplantation.
Hernández-Cruz EY, Amador-Martínez I, Aranda-Rivera AK, Cruz-Gregorio A, Pedraza Chaverri J
Chem Biol Interact 2022 Jul 1;361:109961. Epub 2022 Apr 30 doi: 10.1016/j.cbi.2022.109961. PMID: 35500868
Impact of Inflammation on Ferritin, Hepcidin and the Management of Iron Deficiency Anemia in Chronic Kidney Disease.
Ueda N, Takasawa K
Nutrients 2018 Aug 27;10(9) doi: 10.3390/nu10091173. PMID: 30150549Free PMC Article
Hazards of heavy metal contamination.
Järup L
Br Med Bull 2003;68:167-82. doi: 10.1093/bmb/ldg032. PMID: 14757716
Metals and kidney autoimmunity.
Bigazzi PE
Environ Health Perspect 1999 Oct;107 Suppl 5(Suppl 5):753-65. doi: 10.1289/ehp.99107s5753. PMID: 10502542Free PMC Article

Recent systematic reviews

The general external exposome and the development or progression of chronic kidney disease: A systematic review and meta-analyses.
Liang KH, Colombijn JMT, Verhaar MC, Ghannoum M, Timmermans EJ, Vernooij RWM
Environ Pollut 2024 Oct 1;358:124509. Epub 2024 Jul 4 doi: 10.1016/j.envpol.2024.124509. PMID: 38968981
CKD of Uncertain Etiology: A Systematic Review.
Lunyera J, Mohottige D, Von Isenburg M, Jeuland M, Patel UD, Stanifer JW
Clin J Am Soc Nephrol 2016 Mar 7;11(3):379-85. Epub 2015 Dec 28 doi: 10.2215/CJN.07500715. PMID: 26712810Free PMC Article
Cadmium or cadmium compounds and chronic kidney disease in workers and the general population: a systematic review.
Byber K, Lison D, Verougstraete V, Dressel H, Hotz P
Crit Rev Toxicol 2016;46(3):191-240. Epub 2015 Oct 29 doi: 10.3109/10408444.2015.1076375. PMID: 26513605
Escalating chronic kidney diseases of multi-factorial origin in Sri Lanka: causes, solutions, and recommendations.
Wimalawansa SJ
Environ Health Prev Med 2014 Nov;19(6):375-94. Epub 2014 Sep 20 doi: 10.1007/s12199-014-0395-5. PMID: 25239006Free PMC Article
Cadmium and renal cancer.
Il'yasova D, Schwartz GG
Toxicol Appl Pharmacol 2005 Sep 1;207(2):179-86. doi: 10.1016/j.taap.2004.12.005. PMID: 16102569

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