N4.5

MedGen UID:: 617781
•Concept ID:: C0442784
•: Finding

SNOMED CT:

N4.5 (260263000)

Recent clinical studies

Etiology

Discovery of 5-chloro-N2-[(1S)-1-(5-fluoropyrimidin-2-yl)ethyl]-N4-(5-methyl-1H-pyrazol-3-yl)pyrimidine-2,4-diamine (AZD1480) as a novel inhibitor of the Jak/Stat pathway.

Ioannidis S, Lamb ML, Wang T, Almeida L, Block MH, Davies AM, Peng B, Su M, Zhang HJ, Hoffmann E, Rivard C, Green I, Howard T, Pollard H, Read J, Alimzhanov M, Bebernitz G, Bell K, Ye M, Huszar D, Zinda M
J Med Chem 2011 Jan 13;54(1):262-76. Epub 2010 Dec 7 doi: 10.1021/jm1011319. PMID: 21138246

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Diagnosis

A novel test for hyposalivation using a sugar cube.

Spyraki F, Maniewicz S, Mojon P, Müller F
J Oral Rehabil 2024 Aug;51(8):1433-1439. Epub 2024 Apr 29 doi: 10.1111/joor.13715. PMID: 38685706

Excision of the doubly methylated base N(4),5-dimethylcytosine from DNA by Escherichia coli Nei and Fpg proteins.

Alexeeva M, Guragain P, Tesfahun AN, Tomkuvienė M, Arshad A, Gerasimaitė R, Rukšėnaitė A, Urbanavičiūtė G, Bjørås M, Laerdahl JK, Klungland A, Klimašauskas S, Bjelland S
Philos Trans R Soc Lond B Biol Sci 2018 Jun 5;373(1748) doi: 10.1098/rstb.2017.0337. PMID: 29685966 Free PMC Article

A new ETV6-NTRK3 cell line model reveals MALAT1 as a novel therapeutic target - a short report.

Chen S, Nagel S, Schneider B, Dai H, Geffers R, Kaufmann M, Meyer C, Pommerenke C, Thress KS, Li J, Quentmeier H, Drexler HG, MacLeod RAF
Cell Oncol (Dordr) 2018 Feb;41(1):93-101. Epub 2017 Nov 8 doi: 10.1007/s13402-017-0356-2. PMID: 29119387

Rapid and sensitive quantitative analysis of the new antimalarial N4-[2,6-dimethoxy-4-methyl-5-[(3-trifluoromethyl)phenoxy]-8- quinolinyl]-1,4-pentanediamine in plasma by liquid chromatography and electrochemical detection.

Karle JM, Olmeda R
J Chromatogr 1988 Feb 26;424(2):347-56. doi: 10.1016/s0378-4347(00)81111-1. PMID: 3372627

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Therapy

Discovery of the First Potent, Selective, and Orally Bioavailable Signal Peptide Peptidase-Like 2a (SPPL2a) Inhibitor Displaying Pronounced Immunomodulatory Effects In Vivo.

Velcicky J, Bodendorf U, Rigollier P, Epple R, Beisner DR, Guerini D, Smith P, Liu B, Feifel R, Wipfli P, Aichholz R, Couttet P, Dix I, Widmer T, Wen B, Brandl T
J Med Chem 2018 Feb 8;61(3):865-880. Epub 2018 Jan 23 doi: 10.1021/acs.jmedchem.7b01371. PMID: 29359565

A new ETV6-NTRK3 cell line model reveals MALAT1 as a novel therapeutic target - a short report.

Identification and preclinical characterization of AZ-23, a novel, selective, and orally bioavailable inhibitor of the Trk kinase pathway.

Thress K, Macintyre T, Wang H, Whitston D, Liu ZY, Hoffmann E, Wang T, Brown JL, Webster K, Omer C, Zage PE, Zeng L, Zweidler-McKay PA
Mol Cancer Ther 2009 Jul;8(7):1818-27. Epub 2009 Jun 9 doi: 10.1158/1535-7163.MCT-09-0036. PMID: 19509272

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Clinical prediction guides

A novel test for hyposalivation using a sugar cube.

Spyraki F, Maniewicz S, Mojon P, Müller F
J Oral Rehabil 2024 Aug;51(8):1433-1439. Epub 2024 Apr 29 doi: 10.1111/joor.13715. PMID: 38685706

Excision of the doubly methylated base N(4),5-dimethylcytosine from DNA by Escherichia coli Nei and Fpg proteins.

See all (2)

MedGen

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N4.5

Recent clinical studies

Etiology

Diagnosis

Therapy

Clinical prediction guides

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