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Epithelioid hemangioma

MedGen UID:
61449
Concept ID:
C0205788
Neoplastic Process
Synonyms: Hemangioma, Histiocytoid; Hemangiomas, Histiocytoid; Histiocytoid Hemangioma; Histiocytoid Hemangiomas
SNOMED CT: Angiolymphoid hyperplasia with eosinophilia (125574005); Histiocytoid hemangioma (33929001); Epithelioid hemangioma (189869009); Epithelioid hemangioma (33929001)
 
HPO: HP:0032060
Monarch Initiative: MONDO:0021169

Definition

A benign neoplasm that includes blood vessel proliferation and a dense eosinophilic inflammatory infiltrate, manifesting as flesh/plum-colored pruritic nodules and papules, most commonly affecting the ear and the periauricular area. [from HPO]

Professional guidelines

PubMed

Tortorelli I, Bellan E, Chiusole B, Murtas F, Ruggieri P, Pala E, Cerchiaro M, Buzzaccarini MS, Scarzello G, Krengli M, Bisinella G, Battisti S, Di Maggio A, Zagonel V, Tos APD, Sbaraglia M, Brunello A
Crit Rev Oncol Hematol 2024 Mar;195:104268. Epub 2024 Jan 17 doi: 10.1016/j.critrevonc.2024.104268. PMID: 38237880
Burke AB, Dong C, Chandra SR
Oral Maxillofac Surg Clin North Am 2024 Feb;36(1):93-102. Epub 2023 Oct 29 doi: 10.1016/j.coms.2023.09.004. PMID: 37903662
Abboud S, Bhatt A, Pateva I, Saab S, Hameed M, Healey J, Getty P
Skeletal Radiol 2022 Jul;51(7):1493-1498. Epub 2022 Jan 10 doi: 10.1007/s00256-021-03977-4. PMID: 35001142

Recent clinical studies

Etiology

Tortorelli I, Bellan E, Chiusole B, Murtas F, Ruggieri P, Pala E, Cerchiaro M, Buzzaccarini MS, Scarzello G, Krengli M, Bisinella G, Battisti S, Di Maggio A, Zagonel V, Tos APD, Sbaraglia M, Brunello A
Crit Rev Oncol Hematol 2024 Mar;195:104268. Epub 2024 Jan 17 doi: 10.1016/j.critrevonc.2024.104268. PMID: 38237880
Markidan J, Hardy N, Kallen M, Ma L
J Cutan Pathol 2022 Apr;49(4):377-380. Epub 2021 Nov 18 doi: 10.1111/cup.14166. PMID: 34755378
Liu KX, Duggan EM, Al-Ibraheemi A, Shaikh R, Adams DM
Pediatr Blood Cancer 2019 Jan;66(1):e27451. Epub 2018 Sep 11 doi: 10.1002/pbc.27451. PMID: 30207085
Sidbury R, Heintz PW, Beckstead JH, White CR Jr
Adv Dermatol 1999;14:285-306. PMID: 10643502
Kanik AB, Oh CH, Bhawan J
J Am Acad Dermatol 1996 Nov;35(5 Pt 2):851-3. doi: 10.1016/s0190-9622(96)90102-4. PMID: 8912604

Diagnosis

Tortorelli I, Bellan E, Chiusole B, Murtas F, Ruggieri P, Pala E, Cerchiaro M, Buzzaccarini MS, Scarzello G, Krengli M, Bisinella G, Battisti S, Di Maggio A, Zagonel V, Tos APD, Sbaraglia M, Brunello A
Crit Rev Oncol Hematol 2024 Mar;195:104268. Epub 2024 Jan 17 doi: 10.1016/j.critrevonc.2024.104268. PMID: 38237880
Papke DJ Jr, Hornick JL
Virchows Arch 2020 Jan;476(1):17-28. Epub 2019 Aug 28 doi: 10.1007/s00428-019-02651-4. PMID: 31463731
Sedran L, Bonaso M, Mettus A, Roccia F
J Craniofac Surg 2018 Nov;29(8):e736-e739. doi: 10.1097/SCS.0000000000004645. PMID: 30277937
Wick MR, Santa Cruz DJ, Gru AA
Semin Diagn Pathol 2017 Jan;34(1):99-107. Epub 2016 Nov 29 doi: 10.1053/j.semdp.2016.11.008. PMID: 27979335
Guo R, Gavino AC
Arch Pathol Lab Med 2015 May;139(5):683-6. doi: 10.5858/arpa.2013-0334-RS. PMID: 25927152

Therapy

Stewart N, Zagarella S, Mann S
J Dermatol 2013 May;40(5):393-5. Epub 2013 Mar 12 doi: 10.1111/1346-8138.12106. PMID: 23488565
Alder B, Proia A, Liss J
Orbit 2013 Feb;32(1):51-3. doi: 10.3109/01676830.2012.739674. PMID: 23387457
Kahana A, Lee BJ, Flint A, Elner VM
Arch Ophthalmol 2012 Sep;130(9):1209-12. doi: 10.1001/archophthalmol.2012.572. PMID: 22965602Free PMC Article
Moss HB, Sines DT, Blatt J, Dutton JJ, Proia AD
Ophthalmic Plast Reconstr Surg 2012 Jul-Aug;28(4):e88-90. doi: 10.1097/IOP.0b013e31823645f9. PMID: 22186982
López de Blanc S, Sambuelli R, Femopase F, Luna N, Gravotta M, David D, Bistoni A, Criscuolo MI
J Oral Pathol Med 2000 Feb;29(2):91-6. doi: 10.1034/j.1600-0714.2000.290207.x. PMID: 10718405

Prognosis

Tortorelli I, Bellan E, Chiusole B, Murtas F, Ruggieri P, Pala E, Cerchiaro M, Buzzaccarini MS, Scarzello G, Krengli M, Bisinella G, Battisti S, Di Maggio A, Zagonel V, Tos APD, Sbaraglia M, Brunello A
Crit Rev Oncol Hematol 2024 Mar;195:104268. Epub 2024 Jan 17 doi: 10.1016/j.critrevonc.2024.104268. PMID: 38237880
Burke AB, Dong C, Chandra SR
Oral Maxillofac Surg Clin North Am 2024 Feb;36(1):93-102. Epub 2023 Oct 29 doi: 10.1016/j.coms.2023.09.004. PMID: 37903662
Kallen ME, Hornick JL
Am J Surg Pathol 2021 Jan;45(1):e1-e23. doi: 10.1097/PAS.0000000000001552. PMID: 32796172
Liu KX, Duggan EM, Al-Ibraheemi A, Shaikh R, Adams DM
Pediatr Blood Cancer 2019 Jan;66(1):e27451. Epub 2018 Sep 11 doi: 10.1002/pbc.27451. PMID: 30207085
Hui PK, Chan JK, Ng CS, Kung IT, Gwi E
Am J Surg Pathol 1989 Mar;13(3):177-86. doi: 10.1097/00000478-198903000-00001. PMID: 2919716

Clinical prediction guides

Luzar B, Ieremia E, Antonescu CR, Zhang L, Calonje E
Mod Pathol 2020 Aug;33(8):1527-1536. Epub 2020 Feb 24 doi: 10.1038/s41379-020-0505-4. PMID: 32094426Free PMC Article
Schaefer IM, Hornick JL
Adv Anat Pathol 2018 Nov;25(6):400-412. doi: 10.1097/PAP.0000000000000204. PMID: 30134255Free PMC Article
van IJzendoorn DG, de Jong D, Romagosa C, Picci P, Benassi MS, Gambarotti M, Daugaard S, van de Sande M, Szuhai K, Bovée JV
Genes Chromosomes Cancer 2015 Sep;54(9):565-74. Epub 2015 Jul 14 doi: 10.1002/gcc.22269. PMID: 26173738
Antonescu C
Mod Pathol 2014 Jan;27 Suppl 1:S30-8. doi: 10.1038/modpathol.2013.176. PMID: 24384851
Pavlidakey PG, Burroughs C, Karrs T, Somach SC
Am J Dermatopathol 2011 Dec;33(8):831-4. doi: 10.1097/DAD.0b013e3181fef12c. PMID: 21931284

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