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Lupus erythematosus tumidus

MedGen UID:
590566
Concept ID:
C0406636
Disease or Syndrome
Synonyms: Intermittent cutaneous lupus; intermittent cutaneous lupus; let; Lupus Erythematosus Tumidus; lupus erythematosus tumidus; Tumid Lupus Erythematosus; tumid lupus erythematosus
SNOMED CT: Lupus erythematosus tumidus (200941006)
 
Monarch Initiative: MONDO:0019560
Orphanet: ORPHA90283

Definition

A rare form of chronic cutaneous lupus erythematosus characterized by extreme photosensitivity with intermittent formation of erythematous, edematous, urticarial-like, smooth plaques on sun-exposed skin areas. The lesions heal without scarring. The course of the disease is benign, and development of systemic lupus erythematosus is infrequent. Most patients do not have lupus-related autoantibodies. Skin biopsy shows a perivascular and periadnexal lymphocytic infiltrate and increased dermal mucin deposition without involvement of the dermoepidermal junction. [from ORDO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVLupus erythematosus tumidus
Follow this link to review classifications for Lupus erythematosus tumidus in Orphanet.

Professional guidelines

PubMed

Pona A, Cardenas-de la Garza JA, Broderick A, Sangueza OP, Niehaus AG, Bowers N, Pichardo RO
Cutis 2022 Jun;109(6):330-332. doi: 10.12788/cutis.0544. PMID: 35960984
Okon LG, Werth VP
Best Pract Res Clin Rheumatol 2013 Jun;27(3):391-404. doi: 10.1016/j.berh.2013.07.008. PMID: 24238695Free PMC Article
Sontheimer RD
Arch Dermatol 2000 Aug;136(8):1044-9. doi: 10.1001/archderm.136.8.1044. PMID: 10926741

Recent clinical studies

Etiology

Trčko K, Lukinovič N, Luzar B
Acta Dermatovenerol Croat 2023 Dec;31(3):125-132. PMID: 38439721
Pona A, Cardenas-de la Garza JA, Broderick A, Sangueza OP, Niehaus AG, Bowers N, Pichardo RO
Cutis 2022 Jun;109(6):330-332. doi: 10.12788/cutis.0544. PMID: 35960984
Magaña M, Castellanos G, Meurehg CC, Magaña-Mainero MR
Am J Dermatopathol 2022 Jul 1;44(7):469-477. Epub 2021 Nov 1 doi: 10.1097/DAD.0000000000002019. PMID: 35704910
Rodriguez-Caruncho C, Bielsa I, Fernández-Figueras MT, Roca J, Carrascosa JM, Ferrándiz C
Lupus 2015 Jun;24(7):751-5. Epub 2014 Nov 20 doi: 10.1177/0961203314560204. PMID: 25413356
Choonhakarn C, Poonsriaram A, Chaivoramukul J
Int J Dermatol 2004 Nov;43(11):815-8. doi: 10.1111/j.1365-4632.2004.02073.x. PMID: 15533063

Diagnosis

Trčko K, Lukinovič N, Luzar B
Acta Dermatovenerol Croat 2023 Dec;31(3):125-132. PMID: 38439721
Pona A, Cardenas-de la Garza JA, Broderick A, Sangueza OP, Niehaus AG, Bowers N, Pichardo RO
Cutis 2022 Jun;109(6):330-332. doi: 10.12788/cutis.0544. PMID: 35960984
Magaña M, Castellanos G, Meurehg CC, Magaña-Mainero MR
Am J Dermatopathol 2022 Jul 1;44(7):469-477. Epub 2021 Nov 1 doi: 10.1097/DAD.0000000000002019. PMID: 35704910
Okon LG, Werth VP
Best Pract Res Clin Rheumatol 2013 Jun;27(3):391-404. doi: 10.1016/j.berh.2013.07.008. PMID: 24238695Free PMC Article
Kuhn A, Bein D, Bonsmann G
Autoimmun Rev 2009 May;8(6):441-8. Epub 2009 Jan 20 doi: 10.1016/j.autrev.2008.12.010. PMID: 19162244

Therapy

Trčko K, Lukinovič N, Luzar B
Acta Dermatovenerol Croat 2023 Dec;31(3):125-132. PMID: 38439721
Umeda Y, Ito K, Ansai S, Hoashi T, Saeki H, Kanda N
J Nippon Med Sch 2020;87(2):100-103. doi: 10.1272/jnms.JNMS.2020_87-208. PMID: 32418941
Rodriguez-Caruncho C, Bielsa I, Fernández-Figueras MT, Roca J, Carrascosa JM, Ferrándiz C
Lupus 2015 Jun;24(7):751-5. Epub 2014 Nov 20 doi: 10.1177/0961203314560204. PMID: 25413356
Okon LG, Werth VP
Best Pract Res Clin Rheumatol 2013 Jun;27(3):391-404. doi: 10.1016/j.berh.2013.07.008. PMID: 24238695Free PMC Article
Cozzani E, Christana K, Rongioletti F, Rebora A, Parodi A
Eur J Dermatol 2010 Nov-Dec;20(6):797-801. Epub 2010 Oct 28 doi: 10.1684/ejd.2010.1098. PMID: 21030340

Prognosis

Trčko K, Lukinovič N, Luzar B
Acta Dermatovenerol Croat 2023 Dec;31(3):125-132. PMID: 38439721
Pona A, Cardenas-de la Garza JA, Broderick A, Sangueza OP, Niehaus AG, Bowers N, Pichardo RO
Cutis 2022 Jun;109(6):330-332. doi: 10.12788/cutis.0544. PMID: 35960984
Rodriguez-Caruncho C, Bielsa I, Fernández-Figueras MT, Roca J, Carrascosa JM, Ferrándiz C
Lupus 2015 Jun;24(7):751-5. Epub 2014 Nov 20 doi: 10.1177/0961203314560204. PMID: 25413356
Kuhn A, Bein D, Bonsmann G
Autoimmun Rev 2009 May;8(6):441-8. Epub 2009 Jan 20 doi: 10.1016/j.autrev.2008.12.010. PMID: 19162244
Choonhakarn C, Poonsriaram A, Chaivoramukul J
Int J Dermatol 2004 Nov;43(11):815-8. doi: 10.1111/j.1365-4632.2004.02073.x. PMID: 15533063

Clinical prediction guides

Rodriguez-Caruncho C, Bielsa I, Fernández-Figueras MT, Roca J, Carrascosa JM, Ferrándiz C
Lupus 2015 Jun;24(7):751-5. Epub 2014 Nov 20 doi: 10.1177/0961203314560204. PMID: 25413356
Cozzani E, Christana K, Rongioletti F, Rebora A, Parodi A
Eur J Dermatol 2010 Nov-Dec;20(6):797-801. Epub 2010 Oct 28 doi: 10.1684/ejd.2010.1098. PMID: 21030340
Schmitt V, Meuth AM, Amler S, Kuehn E, Haust M, Messer G, Bekou V, Sauerland C, Metze D, Köpcke W, Bonsmann G, Kuhn A
Br J Dermatol 2010 Jan;162(1):64-73. Epub 2009 Jul 7 doi: 10.1111/j.1365-2133.2009.09401.x. PMID: 19712116
Nishiyama M, Kanazawa N, Hiroi A, Furukawa F
Mod Rheumatol 2009;19(5):567-72. Epub 2009 Jun 27 doi: 10.1007/s10165-009-0192-y. PMID: 19562251
Kuhn A, Richter-Hintz D, Oslislo C, Ruzicka T, Megahed M, Lehmann P
Arch Dermatol 2000 Aug;136(8):1033-41. doi: 10.1001/archderm.136.8.1033. PMID: 10926740

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