U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Benign neoplasm of prostate

MedGen UID:
57577
•Concept ID:
C0154009
•
Neoplastic Process
Synonyms: Benign Neoplasm of Prostate; benign neoplasm of prostate; Benign Neoplasm of the Prostate; benign neoplasm of the prostate; Benign Prostate Neoplasm; benign prostate neoplasm; Benign Prostate Tumor; benign prostate tumor; benign prostate tumour; Benign Prostatic Neoplasm; benign prostatic neoplasm; Benign prostatic tumor; Benign tumor of prostate; Benign Tumor of Prostate; benign tumor of prostate; Benign Tumor of the Prostate; benign tumor of the prostate; benign tumour of prostate; benign tumour of the prostate; prostate gland benign neoplasm
SNOMED CT: Benign prostatic tumor (92308005); Benign tumor of prostate (92308005); Benign neoplasm of prostate (92308005)
 
Monarch Initiative: MONDO:0021510

Definition

A neoplasm that arises from the prostate and is characterized by the absence of atypical or malignant cytological and architectural features, and absence of invasive features or metastatic potential. Representative examples include benign phyllodes tumor, leiomyoma, and fibroma. [from NCI]

Professional guidelines

PubMed

EAU-EANM-ESTRO-ESUR-ISUP-SIOG Guidelines on Prostate Cancer-2024 Update. Part I: Screening, Diagnosis, and Local Treatment with Curative Intent.
Cornford P, van den Bergh RCN, Briers E, Van den Broeck T, Brunckhorst O, Darraugh J, Eberli D, De Meerleer G, De Santis M, Farolfi A, Gandaglia G, Gillessen S, Grivas N, Henry AM, Lardas M, van Leenders GJLH, Liew M, Linares Espinos E, Oldenburg J, van Oort IM, Oprea-Lager DE, Ploussard G, Roberts MJ, Rouvière O, Schoots IG, Schouten N, Smith EJ, Stranne J, Wiegel T, Willemse PM, Tilki D
Eur Urol 2024 Aug;86(2):148-163. Epub 2024 Apr 13 doi: 10.1016/j.eururo.2024.03.027. PMID: 38614820
EAU-EANM-ESTRO-ESUR-SIOG Guidelines on Prostate Cancer-2020 Update. Part 1: Screening, Diagnosis, and Local Treatment with Curative Intent.
Mottet N, van den Bergh RCN, Briers E, Van den Broeck T, Cumberbatch MG, De Santis M, Fanti S, Fossati N, Gandaglia G, Gillessen S, Grivas N, Grummet J, Henry AM, van der Kwast TH, Lam TB, Lardas M, Liew M, Mason MD, Moris L, Oprea-Lager DE, van der Poel HG, Rouvière O, Schoots IG, Tilki D, Wiegel T, Willemse PM, Cornford P
Eur Urol 2021 Feb;79(2):243-262. Epub 2020 Nov 7 doi: 10.1016/j.eururo.2020.09.042. PMID: 33172724
The Diagnosis and Treatment of Prostate Cancer: A Review.
Litwin MS, Tan HJ
JAMA 2017 Jun 27;317(24):2532-2542. doi: 10.1001/jama.2017.7248. PMID: 28655021

Recent clinical studies

Etiology

Prostate Adenocarcinoma Grade Group 1: Rationale for Retaining a Cancer Label in the 2022 World Health Organization Classification.
Netto GJ, Amin MB, Compérat EM, Gill AJ, Hartmann A, Moch H, Menon S, Raspollini MR, Rubin MA, Srigley JR, Hoon Tan P, Tickoo SK, Tsuzuki T, Turajlic S, Cree I, Berney DM
Eur Urol 2023 Apr;83(4):301-303. Epub 2022 Oct 4 doi: 10.1016/j.eururo.2022.09.015. PMID: 36202687
The microbiome in prostate inflammation and prostate cancer.
Porter CM, Shrestha E, Peiffer LB, Sfanos KS
Prostate Cancer Prostatic Dis 2018 Sep;21(3):345-354. Epub 2018 May 23 doi: 10.1038/s41391-018-0041-1. PMID: 29795140
Comprehensive overview of prostatitis.
Khan FU, Ihsan AU, Khan HU, Jana R, Wazir J, Khongorzul P, Waqar M, Zhou X
Biomed Pharmacother 2017 Oct;94:1064-1076. Epub 2017 Aug 16 doi: 10.1016/j.biopha.2017.08.016. PMID: 28813783
Prostatitis: acute and chronic.
Ramakrishnan K, Salinas RC
Prim Care 2010 Sep;37(3):547-63, viii-ix. doi: 10.1016/j.pop.2010.04.007. PMID: 20705198
Inflammation, atrophy, and prostate carcinogenesis.
De Marzo AM, Nakai Y, Nelson WG
Urol Oncol 2007 Sep-Oct;25(5):398-400. doi: 10.1016/j.urolonc.2007.05.007. PMID: 17826659

Diagnosis

Comprehensive overview of prostatitis.
Khan FU, Ihsan AU, Khan HU, Jana R, Wazir J, Khongorzul P, Waqar M, Zhou X
Biomed Pharmacother 2017 Oct;94:1064-1076. Epub 2017 Aug 16 doi: 10.1016/j.biopha.2017.08.016. PMID: 28813783
The role of the prostate in male fertility, health and disease.
Verze P, Cai T, Lorenzetti S
Nat Rev Urol 2016 Jul;13(7):379-86. Epub 2016 Jun 1 doi: 10.1038/nrurol.2016.89. PMID: 27245504
Prostate specific antigen.
Brett T
Aust Fam Physician 2011 Jul;40(7):497-500. PMID: 21743854
Granulomatous prostatitis.
Uzoh CC, Uff JS, Okeke AA
BJU Int 2007 Mar;99(3):510-2. Epub 2006 Nov 7 doi: 10.1111/j.1464-410X.2006.06585.x. PMID: 17092284
Transrectal prostatic biopsy.
Hendry WF, Williams JP
Br Med J 1971 Dec 4;4(5787):595-7. doi: 10.1136/bmj.4.5787.595. PMID: 5130215Free PMC Article

Therapy

Deciphering Evolutionary Dynamics and Lineage Plasticity in Aggressive Prostate Cancer.
Kyprianou N, Lucien F
Int J Mol Sci 2021 Oct 28;22(21) doi: 10.3390/ijms222111645. PMID: 34769075Free PMC Article
Advanced Prostate Cancer: Treatment Advances and Future Directions.
Swami U, McFarland TR, Nussenzveig R, Agarwal N
Trends Cancer 2020 Aug;6(8):702-715. Epub 2020 Jun 10 doi: 10.1016/j.trecan.2020.04.010. PMID: 32534790
MRI-Targeted or Standard Biopsy for Prostate-Cancer Diagnosis.
Kasivisvanathan V, Rannikko AS, Borghi M, Panebianco V, Mynderse LA, Vaarala MH, Briganti A, Budäus L, Hellawell G, Hindley RG, Roobol MJ, Eggener S, Ghei M, Villers A, Bladou F, Villeirs GM, Virdi J, Boxler S, Robert G, Singh PB, Venderink W, Hadaschik BA, Ruffion A, Hu JC, Margolis D, Crouzet S, Klotz L, Taneja SS, Pinto P, Gill I, Allen C, Giganti F, Freeman A, Morris S, Punwani S, Williams NR, Brew-Graves C, Deeks J, Takwoingi Y, Emberton M, Moore CM; PRECISION Study Group Collaborators
N Engl J Med 2018 May 10;378(19):1767-1777. Epub 2018 Mar 18 doi: 10.1056/NEJMoa1801993. PMID: 29552975Free PMC Article
Inflammation, atrophy, and prostate carcinogenesis.
De Marzo AM, Nakai Y, Nelson WG
Urol Oncol 2007 Sep-Oct;25(5):398-400. doi: 10.1016/j.urolonc.2007.05.007. PMID: 17826659
The prostate--overview: recent insights and speculations.
Gardner WA Jr, Bennett BD
Monogr Pathol 1992;(34):129-48. PMID: 1406739

Prognosis

Cancer Progress and Priorities: Prostate Cancer.
Kensler KH, Rebbeck TR
Cancer Epidemiol Biomarkers Prev 2020 Feb;29(2):267-277. doi: 10.1158/1055-9965.EPI-19-0412. PMID: 32024765Free PMC Article
Radical Prostatectomy or Watchful Waiting in Prostate Cancer - 29-Year Follow-up.
Bill-Axelson A, Holmberg L, Garmo H, Taari K, Busch C, Nordling S, Häggman M, Andersson SO, Andrén O, Steineck G, Adami HO, Johansson JE
N Engl J Med 2018 Dec 13;379(24):2319-2329. doi: 10.1056/NEJMoa1807801. PMID: 30575473
Cytoreductive prostatectomy in metastatic prostate cancer: a systematic review.
Becker JA, Berg KD, Røder MA, Brasso K, Iversen P
Scand J Urol 2018 Feb;52(1):1-7. Epub 2017 Aug 18 doi: 10.1080/21681805.2017.1363816. PMID: 28818014
Genitourinary problems in bicyclists.
Asplund C, Barkdull T, Weiss BD
Curr Sports Med Rep 2007 Oct;6(5):333-9. PMID: 17883970
Benign positive margins after radical prostatectomy means a poor prognosis--pro.
Djavan B, Milani S, Fong YK
Urology 2005 Feb;65(2):218-20. doi: 10.1016/j.urology.2004.08.001. PMID: 15708025

Clinical prediction guides

Association between cathepsins and benign prostate diseases: a bidirectional two-sample Mendelian randomization study.
Cao H, Liu B, Gong K, Wu H, Wang Y, Zhang H, Shi C, Wang P, Du H, Zhou H, Wang S
Front Endocrinol (Lausanne) 2024;15:1348310. Epub 2024 Jun 5 doi: 10.3389/fendo.2024.1348310. PMID: 38904040Free PMC Article
Pitfalls in interpreting positive and negative predictive values: Application to prostate multiparametric magnetic resonance imaging.
Rouvière O, Souchon R, Melodelima C
Diagn Interv Imaging 2018 Sep;99(9):515-518. Epub 2018 Aug 31 doi: 10.1016/j.diii.2018.07.008. PMID: 30177449
Changes observed in multiparametric prostate magnetic resonance imaging characteristics correlate with histopathological development of chronic granulomatous prostatitis after intravesical Bacillus Calmette-Guerin therapy.
Logan JK, Walton-Diaz A, Rais-Bahrami S, Merino MJ, Turkbey B, Choyke PL, Pinto PA
J Comput Assist Tomogr 2014 Mar-Apr;38(2):274-6. doi: 10.1097/RCT.0b013e3182aac58a. PMID: 24637671Free PMC Article
Cholesterol and benign prostate disease.
Freeman MR, Solomon KR
Differentiation 2011 Nov-Dec;82(4-5):244-52. Epub 2011 Aug 20 doi: 10.1016/j.diff.2011.04.005. PMID: 21862201Free PMC Article
Color Doppler ultrasonographic scanning in prostatitis: clinical correlation.
Veneziano S, Pavlica P, Mannini D
Eur Urol 1995;28(1):6-9. doi: 10.1159/000475011. PMID: 8521897

Recent systematic reviews

2022 Update on Prostate Cancer Epidemiology and Risk Factors-A Systematic Review.
Bergengren O, Pekala KR, Matsoukas K, Fainberg J, Mungovan SF, Bratt O, Bray F, Brawley O, Luckenbaugh AN, Mucci L, Morgan TM, Carlsson SV
Eur Urol 2023 Aug;84(2):191-206. Epub 2023 May 16 doi: 10.1016/j.eururo.2023.04.021. PMID: 37202314Free PMC Article
Lutetium-177 PSMA for the treatment of metastatic castrate resistant prostate cancer: a systematic review.
Patell K, Kurian M, Garcia JA, Mendiratta P, Barata PC, Jia AY, Spratt DE, Brown JR
Expert Rev Anticancer Ther 2023 Jul;23(7):731-744. Epub 2023 May 24 doi: 10.1080/14737140.2023.2213892. PMID: 37194261
Radiotherapy of oligometastatic prostate cancer: a systematic review.
Rogowski P, Roach M 3rd, Schmidt-Hegemann NS, Trapp C, von Bestenbostel R, Shi R, Buchner A, Stief C, Belka C, Li M
Radiat Oncol 2021 Mar 9;16(1):50. doi: 10.1186/s13014-021-01776-8. PMID: 33750437Free PMC Article
Developments in oligometastatic hormone-sensitive prostate cancer.
Tran PT, Ost P
World J Urol 2019 Dec;37(12):2545-2547. doi: 10.1007/s00345-019-03009-w. PMID: 31705198
Cytoreductive prostatectomy in metastatic prostate cancer: a systematic review.
Becker JA, Berg KD, Røder MA, Brasso K, Iversen P
Scand J Urol 2018 Feb;52(1):1-7. Epub 2017 Aug 18 doi: 10.1080/21681805.2017.1363816. PMID: 28818014

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Consumer resources

    Reviews

    Related information

    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...