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Extraosseous Calcification

MedGen UID:
575156
•Concept ID:
C0342648
•
Pathologic Function

Definition

Deposition of calcium in tissues outside of bone. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVExtraosseous Calcification

Professional guidelines

PubMed

Hyperphosphataemia: treatment options.
Malberti F
Drugs 2013 May;73(7):673-88. doi: 10.1007/s40265-013-0054-y. PMID: 23625273
Mechanisms and treatment of extraosseous calcification in chronic kidney disease.
Ketteler M, Rothe H, Krüger T, Biggar PH, Schlieper G
Nat Rev Nephrol 2011 Jul 19;7(9):509-16. doi: 10.1038/nrneph.2011.91. PMID: 21769106
Effect of uremia and its treatment on pulmonary function.
Prezant DJ
Lung 1990;168(1):1-14. doi: 10.1007/BF02719668. PMID: 2105408

Recent clinical studies

Etiology

Extraosseous calcification in kidney disease.
Bartolomeo K, Tan XY, Fatica R
Cleve Clin J Med 2022 Feb 1;89(2):81-90. doi: 10.3949/ccjm.89a.21073. PMID: 35105696
Extraosseous calcification in end-stage renal disease: from visceral organs to vasculature.
Molenaar FM, van Reekum FE, Rookmaaker MB, Abrahams AC, van Jaarsveld BC
Semin Dial 2014 Sep-Oct;27(5):477-87. Epub 2014 Jan 20 doi: 10.1111/sdi.12177. PMID: 24438042
Mechanisms and treatment of extraosseous calcification in chronic kidney disease.
Ketteler M, Rothe H, Krüger T, Biggar PH, Schlieper G
Nat Rev Nephrol 2011 Jul 19;7(9):509-16. doi: 10.1038/nrneph.2011.91. PMID: 21769106
Novel insights into vascular calcification.
Ketteler M, Giachelli C
Kidney Int Suppl 2006 Dec;(105):S5-9. doi: 10.1038/sj.ki.5001996. PMID: 17136112
Fetuin-A and extraosseous calcification in uremia.
Ketteler M
Curr Opin Nephrol Hypertens 2005 Jul;14(4):337-42. doi: 10.1097/01.mnh.0000172719.26606.6f. PMID: 15931001

Diagnosis

Extraosseous calcification in kidney disease.
Bartolomeo K, Tan XY, Fatica R
Cleve Clin J Med 2022 Feb 1;89(2):81-90. doi: 10.3949/ccjm.89a.21073. PMID: 35105696
Extraosseous calcification in end-stage renal disease: from visceral organs to vasculature.
Molenaar FM, van Reekum FE, Rookmaaker MB, Abrahams AC, van Jaarsveld BC
Semin Dial 2014 Sep-Oct;27(5):477-87. Epub 2014 Jan 20 doi: 10.1111/sdi.12177. PMID: 24438042
Mechanisms and treatment of extraosseous calcification in chronic kidney disease.
Ketteler M, Rothe H, Krüger T, Biggar PH, Schlieper G
Nat Rev Nephrol 2011 Jul 19;7(9):509-16. doi: 10.1038/nrneph.2011.91. PMID: 21769106
Sodium thiosulfate, bisphosphonates, and cinacalcet for treatment of calciphylaxis.
Raymond CB, Wazny LD
Am J Health Syst Pharm 2008 Aug 1;65(15):1419-29. doi: 10.2146/ajhp070546. PMID: 18653812
MR imaging of periosteal and cortical changes of bone.
Greenfield GB, Warren DL, Clark RA
Radiographics 1991 Jul;11(4):611-23; discussion 624. doi: 10.1148/radiographics.11.4.1887116. PMID: 1887116

Therapy

Hyperphosphataemia: treatment options.
Malberti F
Drugs 2013 May;73(7):673-88. doi: 10.1007/s40265-013-0054-y. PMID: 23625273
Dialysate calcium concentration and mineral metabolism in long and long-frequent hemodialysis: a systematic review and meta-analysis for a Canadian Society of Nephrology clinical practice guideline.
Zimmerman DL, Nesrallah GE, Chan CT, Copland M, Komenda P, McFarlane PA, Gangji A, Lindsay R, MacRae J, Pauly RP, Perkins DN, Pierratos A, Rioux JP, Steele A, Suri RS, Mustafa RA
Am J Kidney Dis 2013 Jul;62(1):97-111. Epub 2013 Apr 13 doi: 10.1053/j.ajkd.2013.02.357. PMID: 23591289
Sodium thiosulfate: new hope for the treatment of calciphylaxis.
Hayden MR, Goldsmith DJ
Semin Dial 2010 May-Jun;23(3):258-62. doi: 10.1111/j.1525-139X.2010.00738.x. PMID: 20636917
Current issues of continuous ambulatory peritoneal dialysis.
Kawaguchi Y, Hasegawa T, Kubo H, Yamamoto H, Nakayama M, Shigematsu T
Artif Organs 1995 Dec;19(12):1204-9. doi: 10.1111/j.1525-1594.1995.tb02286.x. PMID: 8967875
Skeletal hyperostosis and extraosseous calcification in patients receiving long-term etretinate (Tigason).
Wilson DJ, Kay V, Charig M, Hughes DG, Creasy TS
Br J Dermatol 1988 Nov;119(5):597-607. doi: 10.1111/j.1365-2133.1988.tb03470.x. PMID: 3207613

Prognosis

Extraosseous calcification in end-stage renal disease: from visceral organs to vasculature.
Molenaar FM, van Reekum FE, Rookmaaker MB, Abrahams AC, van Jaarsveld BC
Semin Dial 2014 Sep-Oct;27(5):477-87. Epub 2014 Jan 20 doi: 10.1111/sdi.12177. PMID: 24438042
Sodium thiosulfate: new hope for the treatment of calciphylaxis.
Hayden MR, Goldsmith DJ
Semin Dial 2010 May-Jun;23(3):258-62. doi: 10.1111/j.1525-139X.2010.00738.x. PMID: 20636917
Subclinical vitamin K deficiency in hemodialysis patients.
Pilkey RM, Morton AR, Boffa MB, Noordhof C, Day AG, Su Y, Miller LM, Koschinsky ML, Booth SL
Am J Kidney Dis 2007 Mar;49(3):432-9. doi: 10.1053/j.ajkd.2006.11.041. PMID: 17336705
Fetuin-A and extraosseous calcification in uremia.
Ketteler M
Curr Opin Nephrol Hypertens 2005 Jul;14(4):337-42. doi: 10.1097/01.mnh.0000172719.26606.6f. PMID: 15931001
Calcification and cardiovascular problems in renal failure.
Ketteler M, Gross ML, Ritz E
Kidney Int Suppl 2005 Apr;(94):S120-7. doi: 10.1111/j.1523-1755.2005.09428.x. PMID: 15752228

Clinical prediction guides

Dialysate calcium concentration and mineral metabolism in long and long-frequent hemodialysis: a systematic review and meta-analysis for a Canadian Society of Nephrology clinical practice guideline.
Zimmerman DL, Nesrallah GE, Chan CT, Copland M, Komenda P, McFarlane PA, Gangji A, Lindsay R, MacRae J, Pauly RP, Perkins DN, Pierratos A, Rioux JP, Steele A, Suri RS, Mustafa RA
Am J Kidney Dis 2013 Jul;62(1):97-111. Epub 2013 Apr 13 doi: 10.1053/j.ajkd.2013.02.357. PMID: 23591289
Pathogenesis of vascular calcification in dialysis patients.
Ketteler M, Westenfeld R, Schlieper G, Brandenburg V
Clin Exp Nephrol 2005 Dec;9(4):265-270. doi: 10.1007/s10157-005-0385-4. PMID: 16362152
Fetuin-A and extraosseous calcification in uremia.
Ketteler M
Curr Opin Nephrol Hypertens 2005 Jul;14(4):337-42. doi: 10.1097/01.mnh.0000172719.26606.6f. PMID: 15931001
Current issues of continuous ambulatory peritoneal dialysis.
Kawaguchi Y, Hasegawa T, Kubo H, Yamamoto H, Nakayama M, Shigematsu T
Artif Organs 1995 Dec;19(12):1204-9. doi: 10.1111/j.1525-1594.1995.tb02286.x. PMID: 8967875
Effect of uremia and its treatment on pulmonary function.
Prezant DJ
Lung 1990;168(1):1-14. doi: 10.1007/BF02719668. PMID: 2105408

Recent systematic reviews

Dialysate calcium concentration and mineral metabolism in long and long-frequent hemodialysis: a systematic review and meta-analysis for a Canadian Society of Nephrology clinical practice guideline.
Zimmerman DL, Nesrallah GE, Chan CT, Copland M, Komenda P, McFarlane PA, Gangji A, Lindsay R, MacRae J, Pauly RP, Perkins DN, Pierratos A, Rioux JP, Steele A, Suri RS, Mustafa RA
Am J Kidney Dis 2013 Jul;62(1):97-111. Epub 2013 Apr 13 doi: 10.1053/j.ajkd.2013.02.357. PMID: 23591289

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