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Stiff neck

MedGen UID:
57464
Concept ID:
C0151315
Sign or Symptom
Synonym: Neck stiffness
SNOMED CT: Stiff neck (161882006); NS - Neck stiffness (161882006); Neck stiffness (161882006)
 
HPO: HP:0025258

Definition

A sensation of tightness in the neck when attempting to move it, especially after a period of inactivity. Neck stiffness often involves soreness and difficulty moving the neck, especially when trying to turn the head to the side. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVStiff neck

Conditions with this feature

Spondyloepiphyseal dysplasia, Stanescu type
MedGen UID:
905084
Concept ID:
C4225273
Disease or Syndrome
Spondyloepiphyseal dysplasia with accumulation of glycoprotein in chondrocytes has been designated the 'Stanescu type.' Clinical hallmarks include progressive joint contracture with premature degenerative joint disease, particularly in the knee, hip, and finger joints. Interphalangeal joints of the hands are swollen due to osseous distention of the metaphyseal ends of the phalanges. Affected individuals may be relatively tall despite the presence of a short trunk. Radiologically, there is generalized platyspondyly with mild modification of the endplates, hypoplastic pelvis, epiphyseal flattening with metaphyseal splaying of the long bones, and enlarged phalangeal epimetaphyses of the hands. In addition, the proximal femora are characteristically broad and elongated with striking coxa valga (summary by Nishimura et al., 1998).
Mitochondrial complex 1 deficiency, nuclear type 8
MedGen UID:
1648411
Concept ID:
C4748766
Disease or Syndrome
NEK9-related lethal skeletal dysplasia
MedGen UID:
1799564
Concept ID:
C5568141
Disease or Syndrome
Lethal congenital contracture syndrome-10 (LCCS10) is an autosomal recessive disorder characterized by fetal akinesia, multiple contractures, shortening of upper and lower limbs, and narrow chest and thorax. Death occurs in utero or soon after birth (Casey et al., 2016). For a general phenotypic description and a discussion of genetic heterogeneity of lethal congenital contracture syndrome, see LCCS1 (253310).

Professional guidelines

PubMed

Odagiri K, Yamauchi K, Toda M, Uchida A, Tsubota H, Zenba K, Okawai H, Eda H, Mizuno S, Yokota H
PLoS One 2022;17(10):e0276320. Epub 2022 Oct 17 doi: 10.1371/journal.pone.0276320. PMID: 36251669Free PMC Article
Shukla B, Aguilera EA, Salazar L, Wootton SH, Kaewpoowat Q, Hasbun R
J Clin Virol 2017 Sep;94:110-114. Epub 2017 Aug 4 doi: 10.1016/j.jcv.2017.07.016. PMID: 28806629Free PMC Article
Peigue-Lafeuille H, Croquez N, Laurichesse H, Clavelou P, Aumaître O, Schmidt J, Maillet-Vioud M, Henquell C, Archimbaud C, Bailly JL, Chambon M
J Med Virol 2002 May;67(1):47-53. doi: 10.1002/jmv.2191. PMID: 11920817

Recent clinical studies

Etiology

Hasbun R
JAMA 2022 Dec 6;328(21):2147-2154. doi: 10.1001/jama.2022.20521. PMID: 36472590
Donà D, Gastaldi A, Campagna M, Montagnani C, Galli L, Trapani S, Pierossi N, De Luca M, D'Argenio P, Tucci FM, De Vincentiis G, Grotto P, Da Mosto MC, Frigo AC, Volo T, Emanuelli E, Martini A, Da Dalt L
Pediatr Emerg Care 2021 Dec 1;37(12):e1358-e1365. doi: 10.1097/PEC.0000000000002037. PMID: 32097379
Shukla B, Aguilera EA, Salazar L, Wootton SH, Kaewpoowat Q, Hasbun R
J Clin Virol 2017 Sep;94:110-114. Epub 2017 Aug 4 doi: 10.1016/j.jcv.2017.07.016. PMID: 28806629Free PMC Article
Auriel E, Regev K, Korczyn AD
Handb Clin Neurol 2014;119:577-84. doi: 10.1016/B978-0-7020-4086-3.00038-2. PMID: 24365321
Gubin AV, Ulrich EV, Taschilkin AI, Yalfimov AN
Spine (Phila Pa 1976) 2009 Aug 15;34(18):1906-9. doi: 10.1097/BRS.0b013e3181abbf3d. PMID: 19680099

Diagnosis

Li H, Wen J, Zhou JL, Chen B, Wu XR
Am J Emerg Med 2023 Jun;68:215.e3-215.e7. Epub 2023 Mar 30 doi: 10.1016/j.ajem.2023.03.040. PMID: 37024323
Hasbun R
JAMA 2022 Dec 6;328(21):2147-2154. doi: 10.1001/jama.2022.20521. PMID: 36472590
Shukla B, Aguilera EA, Salazar L, Wootton SH, Kaewpoowat Q, Hasbun R
J Clin Virol 2017 Sep;94:110-114. Epub 2017 Aug 4 doi: 10.1016/j.jcv.2017.07.016. PMID: 28806629Free PMC Article
Sakakibara R, Kishi M, Tsuyusaki Y, Tateno A, Tateno F, Uchiyama T, Yamamoto T, Yamanishi T, Yano M
Neurourol Urodyn 2013 Jan;32(1):19-23. Epub 2012 Jun 5 doi: 10.1002/nau.22279. PMID: 22674777
Stein RW, Kase CS, Hier DB, Caplan LR, Mohr JP, Hemmati M, Henderson K
Neurology 1984 Dec;34(12):1549-54. doi: 10.1212/wnl.34.12.1549. PMID: 6504325

Therapy

Hasbun R
JAMA 2022 Dec 6;328(21):2147-2154. doi: 10.1001/jama.2022.20521. PMID: 36472590
Bradshaw BT, Jones KM, Westerdale-McInnis JM, Gaff HD
J Dent Hyg 2021 Aug;95(4):23-31. PMID: 34376541
Donà D, Gastaldi A, Campagna M, Montagnani C, Galli L, Trapani S, Pierossi N, De Luca M, D'Argenio P, Tucci FM, De Vincentiis G, Grotto P, Da Mosto MC, Frigo AC, Volo T, Emanuelli E, Martini A, Da Dalt L
Pediatr Emerg Care 2021 Dec 1;37(12):e1358-e1365. doi: 10.1097/PEC.0000000000002037. PMID: 32097379
Auriel E, Regev K, Korczyn AD
Handb Clin Neurol 2014;119:577-84. doi: 10.1016/B978-0-7020-4086-3.00038-2. PMID: 24365321
Iplikcioglu AC, Bek S, Bikmaz K, Ceylan D, Gökduman CA
Acta Neurochir (Wien) 2004 May;146(5):521-4. Epub 2004 Apr 8 doi: 10.1007/s00701-004-0256-x. PMID: 15118891

Prognosis

Bradshaw BT, Jones KM, Westerdale-McInnis JM, Gaff HD
J Dent Hyg 2021 Aug;95(4):23-31. PMID: 34376541
Ozge A, Bolay H
Curr Pain Headache Rep 2014 Jul;18(7):430. doi: 10.1007/s11916-014-0430-7. PMID: 24880802
Auriel E, Regev K, Korczyn AD
Handb Clin Neurol 2014;119:577-84. doi: 10.1016/B978-0-7020-4086-3.00038-2. PMID: 24365321
Sakakibara R, Kishi M, Tsuyusaki Y, Tateno A, Tateno F, Uchiyama T, Yamamoto T, Yamanishi T, Yano M
Neurourol Urodyn 2013 Jan;32(1):19-23. Epub 2012 Jun 5 doi: 10.1002/nau.22279. PMID: 22674777
Stein RW, Kase CS, Hier DB, Caplan LR, Mohr JP, Hemmati M, Henderson K
Neurology 1984 Dec;34(12):1549-54. doi: 10.1212/wnl.34.12.1549. PMID: 6504325

Clinical prediction guides

Hasbun R
JAMA 2022 Dec 6;328(21):2147-2154. doi: 10.1001/jama.2022.20521. PMID: 36472590
Tani N, Ohta M, Higuchi Y, Yamamoto R, Akatsu J
BMJ Open 2022 Mar 22;12(3):e053360. doi: 10.1136/bmjopen-2021-053360. PMID: 35318231Free PMC Article
Donà D, Gastaldi A, Campagna M, Montagnani C, Galli L, Trapani S, Pierossi N, De Luca M, D'Argenio P, Tucci FM, De Vincentiis G, Grotto P, Da Mosto MC, Frigo AC, Volo T, Emanuelli E, Martini A, Da Dalt L
Pediatr Emerg Care 2021 Dec 1;37(12):e1358-e1365. doi: 10.1097/PEC.0000000000002037. PMID: 32097379
Abdelrahim NA, Fadl-Elmula IM, Ali HM
BMC Pediatr 2019 Sep 6;19(1):319. doi: 10.1186/s12887-019-1684-3. PMID: 31492124Free PMC Article
Kelberman D, Dattani MT
Horm Res 2007;68 Suppl 5:138-44. Epub 2007 Dec 10 doi: 10.1159/000110610. PMID: 18174732

Recent systematic reviews

Baklizi N, Raswoli M, Burges M, Moreira DC, Qaddoumi I
Semin Oncol 2022 Oct;49(5):419-425. Epub 2022 Sep 21 doi: 10.1053/j.seminoncol.2022.09.003. PMID: 36180292
Bradshaw BT, Jones KM, Westerdale-McInnis JM, Gaff HD
J Dent Hyg 2021 Aug;95(4):23-31. PMID: 34376541
Sakakibara R, Kishi M, Tsuyusaki Y, Tateno A, Tateno F, Uchiyama T, Yamamoto T, Yamanishi T, Yano M
Neurourol Urodyn 2013 Jan;32(1):19-23. Epub 2012 Jun 5 doi: 10.1002/nau.22279. PMID: 22674777

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