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Addictive benzodiazepine use

MedGen UID:
572757
•Concept ID:
C0338768
•
Mental or Behavioral Dysfunction
Synonym: Benzodiazepine addiction
SNOMED CT: Benzodiazepine dependence (231473004)
 
HPO: HP:0033516

Definition

Addiction to a benzodiazepine. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAddictive benzodiazepine use

Professional guidelines

PubMed

The Spectrum of Alcohol Use: Epidemiology, Diagnosis, and Treatment.
Cohen SM, Alexander RS, Holt SR
Med Clin North Am 2022 Jan;106(1):43-60. doi: 10.1016/j.mcna.2021.08.003. PMID: 34823734
Clinical management of the alcohol withdrawal syndrome.
Day E, Daly C
Addiction 2022 Mar;117(3):804-814. Epub 2021 Aug 22 doi: 10.1111/add.15647. PMID: 34288186
Canadian Network for Mood and Anxiety Treatments (CANMAT) and International Society for Bipolar Disorders (ISBD) recommendations for the management of patients with bipolar disorder with mixed presentations.
Yatham LN, Chakrabarty T, Bond DJ, Schaffer A, Beaulieu S, Parikh SV, McIntyre RS, Milev RV, Alda M, Vazquez G, Ravindran AV, Frey BN, Sharma V, Goldstein BI, Rej S, O'Donovan C, Tourjman V, Kozicky JM, Kauer-Sant'Anna M, Malhi G, Suppes T, Vieta E, Kapczinski F, Kanba S, Lam RW, Kennedy SH, Calabrese J, Berk M, Post R
Bipolar Disord 2021 Dec;23(8):767-788. Epub 2021 Nov 1 doi: 10.1111/bdi.13135. PMID: 34599629

Recent clinical studies

Etiology

Comparative efficacy and safety of pharmacotherapies for alcohol withdrawal: a systematic review and network meta-analysis.
Bahji A, Bach P, Danilewitz M, Crockford D, El-Guebaly N, Devoe DJ, Saitz R
Addiction 2022 Oct;117(10):2591-2601. Epub 2022 Mar 15 doi: 10.1111/add.15853. PMID: 35194860Free PMC Article
Benzodiazepines and Related Sedatives.
Peng L, Morford KL, Levander XA
Med Clin North Am 2022 Jan;106(1):113-129. doi: 10.1016/j.mcna.2021.08.012. PMID: 34823725
Cognitive Behavioral Therapy and Acceptance and Commitment Therapy for the Discontinuation of Long-Term Benzodiazepine Use in Insomnia and Anxiety Disorders.
Chapoutot M, Peter-Derex L, Bastuji H, Leslie W, Schoendorff B, Heinzer R, Siclari F, Nicolas A, Lemoine P, Higgins S, Bourgeois A, Vallet GT, Anders R, Ounnoughene M, Spencer J, Meloni F, Putois B
Int J Environ Res Public Health 2021 Sep 28;18(19) doi: 10.3390/ijerph181910222. PMID: 34639523Free PMC Article
Benzodiazepine harm: how can it be reduced?
Lader M
Br J Clin Pharmacol 2014 Feb;77(2):295-301. doi: 10.1111/j.1365-2125.2012.04418.x. PMID: 22882333Free PMC Article
The benzodiazepine withdrawal syndrome.
Pétursson H
Addiction 1994 Nov;89(11):1455-9. doi: 10.1111/j.1360-0443.1994.tb03743.x. PMID: 7841856

Diagnosis

The Spectrum of Alcohol Use: Epidemiology, Diagnosis, and Treatment.
Cohen SM, Alexander RS, Holt SR
Med Clin North Am 2022 Jan;106(1):43-60. doi: 10.1016/j.mcna.2021.08.003. PMID: 34823734
Canadian Network for Mood and Anxiety Treatments (CANMAT) and International Society for Bipolar Disorders (ISBD) recommendations for the management of patients with bipolar disorder with mixed presentations.
Yatham LN, Chakrabarty T, Bond DJ, Schaffer A, Beaulieu S, Parikh SV, McIntyre RS, Milev RV, Alda M, Vazquez G, Ravindran AV, Frey BN, Sharma V, Goldstein BI, Rej S, O'Donovan C, Tourjman V, Kozicky JM, Kauer-Sant'Anna M, Malhi G, Suppes T, Vieta E, Kapczinski F, Kanba S, Lam RW, Kennedy SH, Calabrese J, Berk M, Post R
Bipolar Disord 2021 Dec;23(8):767-788. Epub 2021 Nov 1 doi: 10.1111/bdi.13135. PMID: 34599629
Acute and Persistent Withdrawal Syndromes Following Discontinuation of Psychotropic Medications.
Cosci F, Chouinard G
Psychother Psychosom 2020;89(5):283-306. Epub 2020 Apr 7 doi: 10.1159/000506868. PMID: 32259826
A Review of Alprazolam Use, Misuse, and Withdrawal.
Ait-Daoud N, Hamby AS, Sharma S, Blevins D
J Addict Med 2018 Jan/Feb;12(1):4-10. doi: 10.1097/ADM.0000000000000350. PMID: 28777203Free PMC Article
Benzodiazepine use, abuse, and dependence.
O'brien CP
J Clin Psychiatry 2005;66 Suppl 2:28-33. PMID: 15762817

Therapy

European Psychiatric Association guidance on treatment of cognitive impairment in schizophrenia.
Vita A, Gaebel W, Mucci A, Sachs G, Barlati S, Giordano GM, Nibbio G, Nordentoft M, Wykes T, Galderisi S
Eur Psychiatry 2022 Sep 5;65(1):e57. doi: 10.1192/j.eurpsy.2022.2315. PMID: 36059103Free PMC Article
Benzodiazepines and Related Sedatives.
Peng L, Morford KL, Levander XA
Med Clin North Am 2022 Jan;106(1):113-129. doi: 10.1016/j.mcna.2021.08.012. PMID: 34823725
Clinical management of the alcohol withdrawal syndrome.
Day E, Daly C
Addiction 2022 Mar;117(3):804-814. Epub 2021 Aug 22 doi: 10.1111/add.15647. PMID: 34288186
A Review of Alprazolam Use, Misuse, and Withdrawal.
Ait-Daoud N, Hamby AS, Sharma S, Blevins D
J Addict Med 2018 Jan/Feb;12(1):4-10. doi: 10.1097/ADM.0000000000000350. PMID: 28777203Free PMC Article
Benzodiazepine use, abuse, and dependence.
O'brien CP
J Clin Psychiatry 2005;66 Suppl 2:28-33. PMID: 15762817

Prognosis

New Australian guidelines for the treatment of alcohol problems: an overview of recommendations.
Haber PS, Riordan BC, Winter DT, Barrett L, Saunders J, Hides L, Gullo M, Manning V, Day CA, Bonomo Y, Burns L, Assan R, Curry K, Mooney-Somers J, Demirkol A, Monds L, McDonough M, Baillie AJ, Clark P, Ritter A, Quinn C, Cunningham J, Lintzeris N, Rombouts S, Savic M, Norman A, Reid S, Hutchinson D, Zheng C, Iese Y, Black N, Draper B, Ridley N, Gowing L, Stapinski L, Taye B, Lancaster K, Stjepanović D, Kay-Lambkin F, Jamshidi N, Lubman D, Pastor A, White N, Wilson S, Jaworski AL, Memedovic S, Logge W, Mills K, Seear K, Freeburn B, Lea T, Withall A, Marel C, Boffa J, Roxburgh A, Purcell-Khodr G, Doyle M, Conigrave K, Teesson M, Butler K, Connor J, Morley KC
Med J Aust 2021 Oct 4;215 Suppl 7:S3-S32. doi: 10.5694/mja2.51254. PMID: 34601742
Evaluation of the course and treatment of Alcohol Withdrawal Syndrome with the Clinical Institute Withdrawal Assessment for Alcohol - Revised: A systematic review-based meta-analysis.
Pribék IK, Kovács I, Kádár BK, Kovács CS, Richman MJ, Janka Z, Andó B, Lázár BA
Drug Alcohol Depend 2021 Mar 1;220:108536. Epub 2021 Jan 19 doi: 10.1016/j.drugalcdep.2021.108536. PMID: 33503582
Acute and Persistent Withdrawal Syndromes Following Discontinuation of Psychotropic Medications.
Cosci F, Chouinard G
Psychother Psychosom 2020;89(5):283-306. Epub 2020 Apr 7 doi: 10.1159/000506868. PMID: 32259826
Vascular disease in cocaine addiction.
Bachi K, Mani V, Jeyachandran D, Fayad ZA, Goldstein RZ, Alia-Klein N
Atherosclerosis 2017 Jul;262:154-162. Epub 2017 Mar 14 doi: 10.1016/j.atherosclerosis.2017.03.019. PMID: 28363516Free PMC Article
Benzodiazepine use, abuse, and dependence.
O'brien CP
J Clin Psychiatry 2005;66 Suppl 2:28-33. PMID: 15762817

Clinical prediction guides

A pilot randomized controlled trial of ketamine in Borderline Personality Disorder.
Fineberg SK, Choi EY, Shapiro-Thompson R, Dhaliwal K, Neustadter E, Sakheim M, Null K, Trujillo-Diaz D, Rondeau J, Pittaro GF, Peters JR, Corlett PR, Krystal JH
Neuropsychopharmacology 2023 Jun;48(7):991-999. Epub 2023 Feb 17 doi: 10.1038/s41386-023-01540-4. PMID: 36804489Free PMC Article
Comparative efficacy and safety of pharmacotherapies for alcohol withdrawal: a systematic review and network meta-analysis.
Bahji A, Bach P, Danilewitz M, Crockford D, El-Guebaly N, Devoe DJ, Saitz R
Addiction 2022 Oct;117(10):2591-2601. Epub 2022 Mar 15 doi: 10.1111/add.15853. PMID: 35194860Free PMC Article
Evaluation of the course and treatment of Alcohol Withdrawal Syndrome with the Clinical Institute Withdrawal Assessment for Alcohol - Revised: A systematic review-based meta-analysis.
Pribék IK, Kovács I, Kádár BK, Kovács CS, Richman MJ, Janka Z, Andó B, Lázár BA
Drug Alcohol Depend 2021 Mar 1;220:108536. Epub 2021 Jan 19 doi: 10.1016/j.drugalcdep.2021.108536. PMID: 33503582
Olanzapine Versus Placebo in Adult Outpatients With Anorexia Nervosa: A Randomized Clinical Trial.
Attia E, Steinglass JE, Walsh BT, Wang Y, Wu P, Schreyer C, Wildes J, Yilmaz Z, Guarda AS, Kaplan AS, Marcus MD
Am J Psychiatry 2019 Jun 1;176(6):449-456. Epub 2019 Jan 18 doi: 10.1176/appi.ajp.2018.18101125. PMID: 30654643Free PMC Article
Benzodiazepine use, abuse, and dependence.
O'brien CP
J Clin Psychiatry 2005;66 Suppl 2:28-33. PMID: 15762817

Recent systematic reviews

Buprenorphine versus methadone for the treatment of opioid dependence: a systematic review and meta-analysis of randomised and observational studies.
Degenhardt L, Clark B, Macpherson G, Leppan O, Nielsen S, Zahra E, Larance B, Kimber J, Martino-Burke D, Hickman M, Farrell M
Lancet Psychiatry 2023 Jun;10(6):386-402. Epub 2023 May 8 doi: 10.1016/S2215-0366(23)00095-0. PMID: 37167985
Comparative efficacy and safety of pharmacotherapies for alcohol withdrawal: a systematic review and network meta-analysis.
Bahji A, Bach P, Danilewitz M, Crockford D, El-Guebaly N, Devoe DJ, Saitz R
Addiction 2022 Oct;117(10):2591-2601. Epub 2022 Mar 15 doi: 10.1111/add.15853. PMID: 35194860Free PMC Article
Evaluation of the course and treatment of Alcohol Withdrawal Syndrome with the Clinical Institute Withdrawal Assessment for Alcohol - Revised: A systematic review-based meta-analysis.
Pribék IK, Kovács I, Kádár BK, Kovács CS, Richman MJ, Janka Z, Andó B, Lázár BA
Drug Alcohol Depend 2021 Mar 1;220:108536. Epub 2021 Jan 19 doi: 10.1016/j.drugalcdep.2021.108536. PMID: 33503582
Benzodiazepines for antipsychotic-induced tardive dyskinesia.
Bergman H, Bhoopathi PS, Soares-Weiser K
Cochrane Database Syst Rev 2018 Jan 20;1(1):CD000205. doi: 10.1002/14651858.CD000205.pub3. PMID: 29352477Free PMC Article
Antipsychotic medications for cocaine dependence.
Indave BI, Minozzi S, Pani PP, Amato L
Cochrane Database Syst Rev 2016 Mar 19;3(3):CD006306. doi: 10.1002/14651858.CD006306.pub3. PMID: 26992929Free PMC Article

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