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Herpes labialis

MedGen UID:
5533
•Concept ID:
C0019345
•
Disease or Syndrome
Synonyms: Blister, Fever; Blisters, Fever; Cold Sore; Cold Sores; Fever Blister; Fever Blisters; Herpes Labialis; Herpes Simplex, Labial; Labial Herpes Simplex; Sore, Cold; Sores, Cold
SNOMED CT: Herpes labialis (1475003); Cold sores (1475003); Fever blister (1475003); Herpes simplex labialis (1475003); Cold sore (1475003)
 
Monarch Initiative: MONDO:0043653

Definition

A lesion caused by type 1 or type 2 herpes simplex virus, involving the oralfacial region. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVHerpes labialis

Professional guidelines

PubMed

A Comprehensive Overview of Epidemiology, Pathogenesis and the Management of Herpes Labialis.
Gopinath D, Koe KH, Maharajan MK, Panda S
Viruses 2023 Jan 13;15(1) doi: 10.3390/v15010225. PMID: 36680265Free PMC Article
Prevention and treatment of neonatal herpes simplex virus infection.
Samies NL, James SH
Antiviral Res 2020 Apr;176:104721. Epub 2020 Feb 7 doi: 10.1016/j.antiviral.2020.104721. PMID: 32044154Free PMC Article
Treatment of recurrent herpes labialis.
Sarnoff DS
J Drugs Dermatol 2014 Sep;13(9):1016-8. PMID: 25226000

Recent clinical studies

Etiology

Potential Involvement of Varicella Zoster Virus in Alzheimer's Disease via Reactivation of Quiescent Herpes Simplex Virus Type 1.
Cairns DM, Itzhaki RF, Kaplan DL
J Alzheimers Dis 2022;88(3):1189-1200. doi: 10.3233/JAD-220287. PMID: 35754275
Herpes Labialis: An Update.
Leung AKC, Barankin B
Recent Pat Inflamm Allergy Drug Discov 2017;11(2):107-113. doi: 10.2174/1872213X11666171003151717. PMID: 28971780
Genome-wide association and HLA region fine-mapping studies identify susceptibility loci for multiple common infections.
Tian C, Hromatka BS, Kiefer AK, Eriksson N, Noble SM, Tung JY, Hinds DA
Nat Commun 2017 Sep 19;8(1):599. doi: 10.1038/s41467-017-00257-5. PMID: 28928442Free PMC Article
Interventions for prevention of herpes simplex labialis (cold sores on the lips).
Chi CC, Wang SH, Delamere FM, Wojnarowska F, Peters MC, Kanjirath PP
Cochrane Database Syst Rev 2015 Aug 7;2015(8):CD010095. doi: 10.1002/14651858.CD010095.pub2. PMID: 26252373Free PMC Article
Herpes simplex virus.
Riley LE
Semin Perinatol 1998 Aug;22(4):284-92. doi: 10.1016/s0146-0005(98)80017-7. PMID: 9738993

Diagnosis

A Comprehensive Overview of Epidemiology, Pathogenesis and the Management of Herpes Labialis.
Gopinath D, Koe KH, Maharajan MK, Panda S
Viruses 2023 Jan 13;15(1) doi: 10.3390/v15010225. PMID: 36680265Free PMC Article
Prevention and treatment of neonatal herpes simplex virus infection.
Samies NL, James SH
Antiviral Res 2020 Apr;176:104721. Epub 2020 Feb 7 doi: 10.1016/j.antiviral.2020.104721. PMID: 32044154Free PMC Article
The controversial natural history of oral herpes simplex virus type 1 infection.
Petti S, Lodi G
Oral Dis 2019 Nov;25(8):1850-1865. Epub 2019 Nov 27 doi: 10.1111/odi.13234. PMID: 31733122
Herpes Labialis: An Update.
Leung AKC, Barankin B
Recent Pat Inflamm Allergy Drug Discov 2017;11(2):107-113. doi: 10.2174/1872213X11666171003151717. PMID: 28971780
Herpes Simplex Virus Type 1 infection: overview on relevant clinico-pathological features.
Arduino PG, Porter SR
J Oral Pathol Med 2008 Feb;37(2):107-21. doi: 10.1111/j.1600-0714.2007.00586.x. PMID: 18197856

Therapy

Herpes Virus, Oral Clinical Signs and QoL: Systematic Review of Recent Data.
Crimi S, Fiorillo L, Bianchi A, D'Amico C, Amoroso G, Gorassini F, Mastroieni R, Marino S, Scoglio C, Catalano F, Campagna P, Bocchieri S, De Stefano R, Fiorillo MT, Cicciù M
Viruses 2019 May 21;11(5) doi: 10.3390/v11050463. PMID: 31117264Free PMC Article
Herpes Labialis: An Update.
Leung AKC, Barankin B
Recent Pat Inflamm Allergy Drug Discov 2017;11(2):107-113. doi: 10.2174/1872213X11666171003151717. PMID: 28971780
Interventions for prevention of herpes simplex labialis (cold sores on the lips).
Chi CC, Wang SH, Delamere FM, Wojnarowska F, Peters MC, Kanjirath PP
Cochrane Database Syst Rev 2015 Aug 7;2015(8):CD010095. doi: 10.1002/14651858.CD010095.pub2. PMID: 26252373Free PMC Article
Herpes labialis.
Worrall G
BMJ Clin Evid 2009 Sep 23;2009 PMID: 21726482Free PMC Article
Herpes Simplex Virus Type 1 infection: overview on relevant clinico-pathological features.
Arduino PG, Porter SR
J Oral Pathol Med 2008 Feb;37(2):107-21. doi: 10.1111/j.1600-0714.2007.00586.x. PMID: 18197856

Prognosis

On the Role of Psychoneuroimmunology in Oral Medicine.
Seizer L, Schubert C
Int Dent J 2022 Dec;72(6):765-772. Epub 2022 Sep 30 doi: 10.1016/j.identj.2022.07.002. PMID: 36184323Free PMC Article
The origins of oral medicine in the Hippocratic collected works.
Askitopoulou H, Nyktari V, Papaioannou A, Stefanakis G, Konsolaki E
J Oral Pathol Med 2017 Oct;46(9):689-694. Epub 2017 Aug 9 doi: 10.1111/jop.12615. PMID: 28715092
An update on short-course intermittent and prevention therapies for herpes labialis.
Gilbert S, Corey L, Cunningham A, Malkin JE, Stanberry L, Whitley R, Spruance S
Herpes 2007 Jun;14 Suppl 1:13A-18A. PMID: 17877887
Short-course therapy for recurrent genital herpes and herpes labialis.
Spruance S, Aoki FY, Tyring S, Stanberry L, Whitley R, Hamed K
J Fam Pract 2007 Jan;56(1):30-6. PMID: 17217895
Herpes simplex virus.
Waggoner-Fountain LA, Grossman LB
Pediatr Rev 2004 Mar;25(3):86-93. doi: 10.1542/pir.25-3-86. PMID: 14993516

Clinical prediction guides

Causal associations between prodromal infection and neuromyelitis optica spectrum disorder: A Mendelian randomization study.
Wang L, Zhou L, ZhangBao J, Huang W, Tan H, Fan Y, Lu C, Yu J, Wang M, Lu J, Zhao C, Zhang T, Quan C
Eur J Neurol 2023 Dec;30(12):3819-3827. Epub 2023 Aug 16 doi: 10.1111/ene.16014. PMID: 37540821
Doxycycline: An option in the treatment of ulcerated oral lesions?
Piacentini M, Borghetti RL, Zancanaro de Figueiredo MA, Cherubini K, Gonçalves Salum F
J Clin Pharm Ther 2019 Dec;44(6):838-843. Epub 2019 Aug 10 doi: 10.1111/jcpt.13022. PMID: 31400293
Herpes labialis.
Worrall G
BMJ Clin Evid 2009 Sep 23;2009 PMID: 21726482Free PMC Article
Cutaneous effects of smoking.
Freiman A, Bird G, Metelitsa AI, Barankin B, Lauzon GJ
J Cutan Med Surg 2004 Nov-Dec;8(6):415-23. doi: 10.1007/s10227-005-0020-8. PMID: 15988548
Acyclovir in the management of herpes labialis.
Yeo JM, Fiddian AP
J Antimicrob Chemother 1983 Sep;12 Suppl B:95-103. doi: 10.1093/jac/12.suppl_b.95. PMID: 6355056

Recent systematic reviews

Herpes Virus, Oral Clinical Signs and QoL: Systematic Review of Recent Data.
Crimi S, Fiorillo L, Bianchi A, D'Amico C, Amoroso G, Gorassini F, Mastroieni R, Marino S, Scoglio C, Catalano F, Campagna P, Bocchieri S, De Stefano R, Fiorillo MT, Cicciù M
Viruses 2019 May 21;11(5) doi: 10.3390/v11050463. PMID: 31117264Free PMC Article
Efficacy of low-level laser therapy in management of recurrent herpes labialis: a systematic review.
Al-Maweri SA, Kalakonda B, AlAizari NA, Al-Soneidar WA, Ashraf S, Abdulrab S, Al-Mawri ES
Lasers Med Sci 2018 Sep;33(7):1423-1430. Epub 2018 May 25 doi: 10.1007/s10103-018-2542-5. PMID: 29802585
Efficacy and safety of nucleoside antiviral drugs for treatment of recurrent herpes labialis: a systematic review and meta-analysis.
Chen F, Xu H, Liu J, Cui Y, Luo X, Zhou Y, Chen Q, Jiang L
J Oral Pathol Med 2017 Sep;46(8):561-568. Epub 2017 Jan 25 doi: 10.1111/jop.12534. PMID: 27935123
Interventions for prevention of herpes simplex labialis (cold sores on the lips).
Chi CC, Wang SH, Delamere FM, Wojnarowska F, Peters MC, Kanjirath PP
Cochrane Database Syst Rev 2015 Aug 7;2015(8):CD010095. doi: 10.1002/14651858.CD010095.pub2. PMID: 26252373Free PMC Article
Herpes labialis.
Worrall G
BMJ Clin Evid 2009 Sep 23;2009 PMID: 21726482Free PMC Article

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