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Heroin dependence

MedGen UID:
5532
•Concept ID:
C0019337
•
Mental or Behavioral Dysfunction
Synonyms: Addiction, Heroin; Dependence, Heroin; Heroin Addiction; Heroin Dependence
SNOMED CT: Heroin dependence (231477003); Heroin addiction (231477003); Dependence on diamorphine (231477003)
 
HPO: HP:0033517
Monarch Initiative: MONDO:0005367

Definition

Addiction to heroin. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVHeroin dependence

Professional guidelines

PubMed

Treatment of Adolescent Heroin Dependence: The End of an Era.
Smyth BP, McCarney G
Ir Med J 2020 Jan 16;113(1):2. PMID: 32298556
Heroin-assisted treatment: has a controversial treatment come of age?†.
Farrell M, Hall W
Br J Psychiatry 2015 Jul;207(1):3-4. doi: 10.1192/bjp.bp.114.160986. PMID: 26135569
Pharmacogenetics of alcohol, nicotine and drug addiction treatments.
Sturgess JE, George TP, Kennedy JL, Heinz A, Müller DJ
Addict Biol 2011 Jul;16(3):357-76. Epub 2011 Mar 1 doi: 10.1111/j.1369-1600.2010.00287.x. PMID: 21362114

Recent clinical studies

Etiology

Risk of Heroin Dependence in Newly Incident Heroin Users.
Santiago Rivera OJ, Havens JR, Parker MA, Anthony JC
JAMA Psychiatry 2018 Aug 1;75(8):863-864. doi: 10.1001/jamapsychiatry.2018.1214. PMID: 29847618Free PMC Article
Lee Robins' studies of heroin use among US Vietnam veterans.
Hall W, Weier M
Addiction 2017 Jan;112(1):176-180. Epub 2016 Sep 20 doi: 10.1111/add.13584. PMID: 27650054
GABRB2 Haplotype Association with Heroin Dependence in Chinese Population.
Kim YS, Yang M, Mat WK, Tsang SY, Su Z, Jiang X, Ng SK, Liu S, Hu T, Pun F, Liao Y, Tang J, Chen X, Hao W, Xue H
PLoS One 2015;10(11):e0142049. Epub 2015 Nov 12 doi: 10.1371/journal.pone.0142049. PMID: 26561861Free PMC Article
Heroin dependence.
Brown R
WMJ 2004;103(4):20-6. PMID: 15481866
The resurgence and abuse of heroin by children in the United States.
Tarabar AF, Nelson LS
Curr Opin Pediatr 2003 Apr;15(2):210-5. doi: 10.1097/00008480-200304000-00013. PMID: 12640281

Diagnosis

DRD2 and ANKK1 genes associate with late-onset heroin dependence in men.
Tsou CC, Chou HW, Ho PS, Kuo SC, Chen CY, Huang CC, Liang CS, Lu RB, Huang SY
World J Biol Psychiatry 2019 Oct;20(8):605-615. Epub 2017 Sep 25 doi: 10.1080/15622975.2017.1372630. PMID: 28854834
Risk of Heroin Dependence in Newly Incident Heroin Users.
Santiago Rivera OJ, Havens JR, Parker MA, Anthony JC
JAMA Psychiatry 2018 Aug 1;75(8):863-864. doi: 10.1001/jamapsychiatry.2018.1214. PMID: 29847618Free PMC Article
Heroin in Malaysia and Singapore.
Sulaiman M, Kunalan V, Yap ATW, Lim WJL, Ng JJY, Loh SWX, Chan KB
Drug Test Anal 2018 Jan;10(1):109-119. Epub 2017 Aug 24 doi: 10.1002/dta.2238. PMID: 28670869
The resurgence and abuse of heroin by children in the United States.
Tarabar AF, Nelson LS
Curr Opin Pediatr 2003 Apr;15(2):210-5. doi: 10.1097/00008480-200304000-00013. PMID: 12640281
Acute heroin overdose.
Sporer KA
Ann Intern Med 1999 Apr 6;130(7):584-90. doi: 10.7326/0003-4819-130-7-199904060-00019. PMID: 10189329

Therapy

Overdose prevention sites and heroin assisted treatment.
Sherman S
BMJ 2019 Sep 9;366:l5437. doi: 10.1136/bmj.l5437. PMID: 31501227
Anticonvulsants for cocaine dependence.
Minozzi S, Cinquini M, Amato L, Davoli M, Farrell MF, Pani PP, Vecchi S
Cochrane Database Syst Rev 2015 Apr 17;2015(4):CD006754. doi: 10.1002/14651858.CD006754.pub4. PMID: 25882271Free PMC Article
Buprenorphine maintenance versus placebo or methadone maintenance for opioid dependence.
Mattick RP, Breen C, Kimber J, Davoli M
Cochrane Database Syst Rev 2014 Feb 6;2014(2):CD002207. doi: 10.1002/14651858.CD002207.pub4. PMID: 24500948Free PMC Article
Prescription of heroin for the management of heroin dependence: current status.
Lintzeris N
CNS Drugs 2009;23(6):463-76. doi: 10.2165/00023210-200923060-00002. PMID: 19480466
Anticonvulsants for cocaine dependence.
Minozzi S, Amato L, Davoli M, Farrell M, Lima Reisser AA, Pani PP, Silva de Lima M, Soares B, Vecchi S
Cochrane Database Syst Rev 2008 Apr 16;(2):CD006754. doi: 10.1002/14651858.CD006754.pub2. PMID: 18425968

Prognosis

Risk of Heroin Dependence in Newly Incident Heroin Users.
Santiago Rivera OJ, Havens JR, Parker MA, Anthony JC
JAMA Psychiatry 2018 Aug 1;75(8):863-864. doi: 10.1001/jamapsychiatry.2018.1214. PMID: 29847618Free PMC Article
Spare change.
Katers L
JAAPA 2014 May;27(5) doi: 10.1097/01.JAA.0000445914.04183.ad. PMID: 24758971
Opioid dependence.
Praveen KT, Law F, O'Shea J, Melichar J
BMJ Clin Evid 2011 Sep 20;2011 PMID: 21929827Free PMC Article
Opioid dependence.
O'Shea J, Law F, Melichar J
BMJ Clin Evid 2009 Jul 24;2009 PMID: 21696648Free PMC Article
Fatal heroin 'overdose': a review.
Darke S, Zador D
Addiction 1996 Dec;91(12):1765-72. doi: 10.1046/j.1360-0443.1996.911217652.x. PMID: 8997759

Clinical prediction guides

Heroin use and neuropsychological impairments: comparison of intravenous and inhalational use.
Ghosh A, Shaktan A, Nehra R, Basu D, Verma A, Rana DK, Modi M, Ahuja CK
Psychopharmacology (Berl) 2023 Apr;240(4):909-920. Epub 2023 Feb 13 doi: 10.1007/s00213-023-06332-8. PMID: 36779990
Impulsivity in heroin-dependent individuals: structural and functional abnormalities within frontostriatal circuits.
Wang S, Zhang M, Liu S, Xu Y, Shao Z, Chen L, Li J, Yang W, Liu J, Yuan K
Brain Imaging Behav 2021 Oct;15(5):2454-2463. Epub 2021 Feb 1 doi: 10.1007/s11682-020-00445-w. PMID: 33528803
Association between stress pathway gene (CRHR1⧹CRHBP) polymorphisms and heroin dependence.
Su H, Wang Z, Zhao M
J Clin Neurosci 2018 Aug;54:33-38. Epub 2018 May 28 doi: 10.1016/j.jocn.2018.05.009. PMID: 29853227
Depression and severity of substance dependence among heroin dependent patients with ADHD symptoms.
Liao YT, Chen CY, Ng MH, Huang KY, Shao WC, Lin TY, Chen VC, Gossop M
Am J Addict 2017 Jan;26(1):26-33. Epub 2016 Dec 20 doi: 10.1111/ajad.12487. PMID: 27997065
GABRB2 Haplotype Association with Heroin Dependence in Chinese Population.
Kim YS, Yang M, Mat WK, Tsang SY, Su Z, Jiang X, Ng SK, Liu S, Hu T, Pun F, Liao Y, Tang J, Chen X, Hao W, Xue H
PLoS One 2015;10(11):e0142049. Epub 2015 Nov 12 doi: 10.1371/journal.pone.0142049. PMID: 26561861Free PMC Article

Recent systematic reviews

Anticonvulsants for cocaine dependence.
Minozzi S, Cinquini M, Amato L, Davoli M, Farrell MF, Pani PP, Vecchi S
Cochrane Database Syst Rev 2015 Apr 17;2015(4):CD006754. doi: 10.1002/14651858.CD006754.pub4. PMID: 25882271Free PMC Article
Buprenorphine maintenance versus placebo or methadone maintenance for opioid dependence.
Mattick RP, Breen C, Kimber J, Davoli M
Cochrane Database Syst Rev 2014 Feb 6;2014(2):CD002207. doi: 10.1002/14651858.CD002207.pub4. PMID: 24500948Free PMC Article
Opioid dependence.
Praveen KT, Law F, O'Shea J, Melichar J
BMJ Clin Evid 2011 Sep 20;2011 PMID: 21929827Free PMC Article
Opioid dependence.
O'Shea J, Law F, Melichar J
BMJ Clin Evid 2009 Jul 24;2009 PMID: 21696648Free PMC Article
Anticonvulsants for cocaine dependence.
Minozzi S, Amato L, Davoli M, Farrell M, Lima Reisser AA, Pani PP, Silva de Lima M, Soares B, Vecchi S
Cochrane Database Syst Rev 2008 Apr 16;(2):CD006754. doi: 10.1002/14651858.CD006754.pub2. PMID: 18425968

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