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Precocious puberty in females

MedGen UID:
543449
•Concept ID:
C0271616
•
Disease or Syndrome
Synonym: Precocious puberty, females
SNOMED CT: Precocious female puberty (19911007)
 
HPO: HP:0010465
Monarch Initiative: MONDO:0018561
Orphanet: ORPHA435561

Definition

The onset of puberty before the age of 8 years in girls. [from HPO]

Conditions with this feature

Intellectual developmental disorder, autosomal recessive 76
MedGen UID:
1808571
•Concept ID:
C5677007
•
Mental or Behavioral Dysfunction
Autosomal recessive intellectual developmental disorder-76 (MRT76) is characterized by impaired intellectual development, absent speech, poor sleep, abnormal EEG with seizures, normal brain imaging, and precocious puberty (Ismail et al., 2022).
See: Condition Record
Premature ovarian failure 21
MedGen UID:
1841035
•Concept ID:
C5830399
•
Disease or Syndrome
Premature ovarian failure-21 (POF21) is characterized by female infertility due to primary or secondary amenorrhea. Ovaries are small, atrophic, or nonvisualized on ultrasound (Tucker et al., 2019; Tucker et al., 2022). For a general phenotypic description and a discussion of genetic heterogeneity of POF, see POF1 (311360).
See: Condition Record
Intellectual developmental disorder, autosomal recessive 76
Premature ovarian failure 21

Professional guidelines

PubMed

Central precocious puberty: a review of diagnosis, treatment, and outcomes.
Zevin EL, Eugster EA
Lancet Child Adolesc Health 2023 Dec;7(12):886-896. doi: 10.1016/S2352-4642(23)00237-7. PMID: 37973253
Central precocious puberty: From genetics to treatment.
Aguirre RS, Eugster EA
Best Pract Res Clin Endocrinol Metab 2018 Aug;32(4):343-354. Epub 2018 May 26 doi: 10.1016/j.beem.2018.05.008. PMID: 30086862
Causes, diagnosis, and treatment of central precocious puberty.
Latronico AC, Brito VN, Carel JC
Lancet Diabetes Endocrinol 2016 Mar;4(3):265-274. Epub 2016 Feb 4 doi: 10.1016/S2213-8587(15)00380-0. PMID: 26852255

Recent clinical studies

Etiology

Central precocious puberty: a review of diagnosis, treatment, and outcomes.
Zevin EL, Eugster EA
Lancet Child Adolesc Health 2023 Dec;7(12):886-896. doi: 10.1016/S2352-4642(23)00237-7. PMID: 37973253
Rare variants in the MECP2 gene in girls with central precocious puberty: a translational cohort study.
Canton APM, Tinano FR, Guasti L, Montenegro LR, Ryan F, Shears D, de Melo ME, Gomes LG, Piana MP, Brauner R, Espino-Aguilar R, Escribano-Muñoz A, Paganoni A, Read JE, Korbonits M, Seraphim CE, Costa SS, Krepischi AC, Jorge AAL, David A, Kaisinger LR, Ong KK, Perry JRB, Abreu AP, Kaiser UB, Argente J, Mendonca BB, Brito VN, Howard SR, Latronico AC
Lancet Diabetes Endocrinol 2023 Aug;11(8):545-554. Epub 2023 Jun 26 doi: 10.1016/S2213-8587(23)00131-6. PMID: 37385287Free PMC Article
Approach to the Patient: Central Precocious Puberty.
Kilberg MJ, Vogiatzi MG
J Clin Endocrinol Metab 2023 Jul 14;108(8):2115-2123. doi: 10.1210/clinem/dgad081. PMID: 36916130
Normal and Premature Adrenarche.
Rosenfield RL
Endocr Rev 2021 Nov 16;42(6):783-814. doi: 10.1210/endrev/bnab009. PMID: 33788946Free PMC Article
Consensus statement on the use of gonadotropin-releasing hormone analogs in children.
Carel JC, Eugster EA, Rogol A, Ghizzoni L, Palmert MR; ESPE-LWPES GnRH Analogs Consensus Conference Group, Antoniazzi F, Berenbaum S, Bourguignon JP, Chrousos GP, Coste J, Deal S, de Vries L, Foster C, Heger S, Holland J, Jahnukainen K, Juul A, Kaplowitz P, Lahlou N, Lee MM, Lee P, Merke DP, Neely EK, Oostdijk W, Phillip M, Rosenfield RL, Shulman D, Styne D, Tauber M, Wit JM
Pediatrics 2009 Apr;123(4):e752-62. Epub 2009 Mar 30 doi: 10.1542/peds.2008-1783. PMID: 19332438

Diagnosis

Central precocious puberty: a review of diagnosis, treatment, and outcomes.
Zevin EL, Eugster EA
Lancet Child Adolesc Health 2023 Dec;7(12):886-896. doi: 10.1016/S2352-4642(23)00237-7. PMID: 37973253
Precocious Puberty.
Banerjee S, Bajpai A
Indian J Pediatr 2023 Jun;90(6):582-589. Epub 2023 Apr 19 doi: 10.1007/s12098-023-04554-4. PMID: 37074536
Precocious puberty.
Gangat M, Radovick S
Minerva Pediatr 2020 Dec;72(6):491-500. Epub 2020 Aug 4 doi: 10.23736/S0026-4946.20.05970-8. PMID: 32748611
Central precocious puberty: From genetics to treatment.
Aguirre RS, Eugster EA
Best Pract Res Clin Endocrinol Metab 2018 Aug;32(4):343-354. Epub 2018 May 26 doi: 10.1016/j.beem.2018.05.008. PMID: 30086862
Causes, diagnosis, and treatment of central precocious puberty.
Latronico AC, Brito VN, Carel JC
Lancet Diabetes Endocrinol 2016 Mar;4(3):265-274. Epub 2016 Feb 4 doi: 10.1016/S2213-8587(15)00380-0. PMID: 26852255

Therapy

Central precocious puberty: a review of diagnosis, treatment, and outcomes.
Zevin EL, Eugster EA
Lancet Child Adolesc Health 2023 Dec;7(12):886-896. doi: 10.1016/S2352-4642(23)00237-7. PMID: 37973253
Precocious Puberty.
Banerjee S, Bajpai A
Indian J Pediatr 2023 Jun;90(6):582-589. Epub 2023 Apr 19 doi: 10.1007/s12098-023-04554-4. PMID: 37074536
Diet and Nutrients Intakes during Infancy and Childhood in Relation to Early Puberty: A Systematic Review and Meta-Analysis.
Tang J, Xue P, Huang X, Lin C, Liu S
Nutrients 2022 Nov 24;14(23) doi: 10.3390/nu14235004. PMID: 36501034Free PMC Article
Use of Gonadotropin-Releasing Hormone Analogs in Children: Update by an International Consortium.
Bangalore Krishna K, Fuqua JS, Rogol AD, Klein KO, Popovic J, Houk CP, Charmandari E, Lee PA, Freire AV, Ropelato MG, Yazid Jalaludin M, Mbogo J, Kanaka-Gantenbein C, Luo X, Eugster EA, Klein KO, Vogiatzi MG, Reifschneider K, Bamba V, Garcia Rudaz C, Kaplowitz P, Backeljauw P, Allen DB, Palmert MR, Harrington J, Guerra-Junior G, Stanley T, Torres Tamayo M, Miranda Lora AL, Bajpai A, Silverman LA, Miller BS, Dayal A, Horikawa R, Oberfield S, Rogol AD, Tajima T, Popovic J, Witchel SF, Rosenthal SM, Finlayson C, Hannema SE, Castilla-Peon MF, Mericq V, Medina Bravo PG
Horm Res Paediatr 2019;91(6):357-372. Epub 2019 Jul 18 doi: 10.1159/000501336. PMID: 31319416
Precocious puberty.
Neely EK, Crossen SS
Curr Opin Obstet Gynecol 2014 Oct;26(5):332-8. doi: 10.1097/GCO.0000000000000099. PMID: 25144596

Prognosis

Precocious puberty and microbiota: The role of the sex hormone-gut microbiome axis.
Calcaterra V, Rossi V, Massini G, Regalbuto C, Hruby C, Panelli S, Bandi C, Zuccotti G
Front Endocrinol (Lausanne) 2022;13:1000919. Epub 2022 Oct 21 doi: 10.3389/fendo.2022.1000919. PMID: 36339428Free PMC Article
Premature Thelarche.
Khokhar A, Mojica A
Pediatr Ann 2018 Jan 1;47(1):e12-e15. doi: 10.3928/19382359-20171214-01. PMID: 29323691
Premature Adrenarche.
Novello L, Speiser PW
Pediatr Ann 2018 Jan 1;47(1):e7-e11. doi: 10.3928/19382359-20171214-04. PMID: 29323690
Precocious puberty.
Neely EK, Crossen SS
Curr Opin Obstet Gynecol 2014 Oct;26(5):332-8. doi: 10.1097/GCO.0000000000000099. PMID: 25144596
Precocious puberty.
Colaco P
Indian J Pediatr 1997 Mar-Apr;64(2):165-75. doi: 10.1007/BF02752439. PMID: 10771833

Clinical prediction guides

Premature Thelarche: An Updated Review.
Leung AKC, Lam JM, Hon KL
Curr Pediatr Rev 2024;20(4):500-509. doi: 10.2174/1573396320666230726110658. PMID: 37496240
Precocious puberty and microbiota: The role of the sex hormone-gut microbiome axis.
Calcaterra V, Rossi V, Massini G, Regalbuto C, Hruby C, Panelli S, Bandi C, Zuccotti G
Front Endocrinol (Lausanne) 2022;13:1000919. Epub 2022 Oct 21 doi: 10.3389/fendo.2022.1000919. PMID: 36339428Free PMC Article
Obesity is a risk factor for central precocious puberty: a case-control study.
Liu G, Guo J, Zhang X, Lu Y, Miao J, Xue H
BMC Pediatr 2021 Nov 16;21(1):509. doi: 10.1186/s12887-021-02936-1. PMID: 34784914Free PMC Article
Long-term effects and significant Adverse Drug Reactions (ADRs) associated with the use of Gonadotropin-Releasing Hormone analogs (GnRHa) for central precocious puberty: a brief review of literature.
De Sanctis V, Soliman AT, Di Maio S, Soliman N, Elsedfy H
Acta Biomed 2019 Sep 6;90(3):345-359. doi: 10.23750/abm.v90i3.8736. PMID: 31580327Free PMC Article
Premature Adrenarche.
Novello L, Speiser PW
Pediatr Ann 2018 Jan 1;47(1):e7-e11. doi: 10.3928/19382359-20171214-04. PMID: 29323690

Recent systematic reviews

An updated meta-analysis of the relationship between vitamin D levels and precocious puberty.
Cheng H, Chen D, Gao H
Front Endocrinol (Lausanne) 2023;14:1298374. Epub 2023 Dec 5 doi: 10.3389/fendo.2023.1298374. PMID: 38116317Free PMC Article
Long-term health consequences of central precocious/early puberty (CPP) and treatment with Gn-RH analogue: a short update.
Soliman AT, Alaaraj N, De Sanctis V, Hamed N, Alyafei F, Ahmed S
Acta Biomed 2023 Dec 5;94(6):e2023222. doi: 10.23750/abm.v94i6.15316. PMID: 38054666Free PMC Article
Lipid profile in girls with precocious puberty: a systematic review and meta-analysis.
Jiang M, Gao Y, Wang K, Huang L
BMC Endocr Disord 2023 Oct 18;23(1):225. doi: 10.1186/s12902-023-01470-8. PMID: 37848909Free PMC Article
Diet and Nutrients Intakes during Infancy and Childhood in Relation to Early Puberty: A Systematic Review and Meta-Analysis.
Tang J, Xue P, Huang X, Lin C, Liu S
Nutrients 2022 Nov 24;14(23) doi: 10.3390/nu14235004. PMID: 36501034Free PMC Article
Worldwide Secular Trends in Age at Pubertal Onset Assessed by Breast Development Among Girls: A Systematic Review and Meta-analysis.
Eckert-Lind C, Busch AS, Petersen JH, Biro FM, Butler G, Bräuner EV, Juul A
JAMA Pediatr 2020 Apr 1;174(4):e195881. Epub 2020 Apr 6 doi: 10.1001/jamapediatrics.2019.5881. PMID: 32040143Free PMC Article

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