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Vaginal adenosis

MedGen UID:
541820
•Concept ID:
C0269214
•
Disease or Syndrome
Synonym: Vaginal Adenosis
SNOMED CT: Vaginal adenosis (37956000)
 
HPO: HP:0025485

Definition

Vaginal adenosis is defined by the presence of metaplastic cervical or endometrial epithelium within the vaginal wall, thought to be derived from persistent Müllerian (synonymous with paramesonephric) epithelium islets in postembryonic life. [from HPO]

Professional guidelines

PubMed

Primary Vaginal Gastric-type Adenocarcinoma and Vaginal Adenosis Exhibiting Gastric Differentiation: Report of a Series With Detailed Immunohistochemical Analysis.
Wong RW, Moore M, Talia KL, Ganesan R, McCluggage WG
Am J Surg Pathol 2018 Jul;42(7):958-970. doi: 10.1097/PAS.0000000000001068. PMID: 29664741
Value of screening procedures for the detection of vaginal adenosis.
Gunning JE, Ostegard DR
Obstet Gynecol 1976 Mar;47(3):268-71. PMID: 55991
Colposcopic aspects of management of vaginal adenosis in DES children.
Scott JW, Seckinger D, Puente-Duany W
J Reprod Med 1974 May;12(5):187-93. PMID: 4838312

Recent clinical studies

Etiology

Management of breast cancer in patients prenatally exposed to diethylstilbestrol: are we prepared?
Mano MS, Kerr J, Kennedy J
Breast 2005 Oct;14(5):408-10. doi: 10.1016/j.breast.2004.11.002. PMID: 16216745
Hormones, medications, and cancer.
Lipsett MB
Cancer 1983 Jun 15;51(12 Suppl):2426-9. doi: 10.1002/1097-0142(19830615)51:12+<2426::aid-cncr2820511307>3.0.co;2-c. PMID: 6850519
Carbon dioxide laser treatment of vaginal adenosis in DES-exposed offspring: a prospective study.
Bellina JH, Ross LF, Hemmings R, Voros JI, Moorehead M
Lasers Surg Med 1983;3(1):23-8. doi: 10.1002/lsm.1900030104. PMID: 6633131
Colposcopic evaluation of DES-exposed progeny at two large medical centers: the squamous neoplasia problem.
Lurain JR, Gallup DG
South Med J 1978 Jul;71(7):809-12. doi: 10.1097/00007611-197807000-00022. PMID: 663728
Vaginal adenosis: a precancerous lesion?
Stafl A, Mattingly RF
Am J Obstet Gynecol 1974 Nov 1;120(5):666-77. doi: 10.1016/0002-9378(74)90610-3. PMID: 4422247

Diagnosis

Primary neuroendocrine carcinoma of the vagina with coexistent atypical vaginal adenosis: a rare entity.
Khurana A, Gupta G, Gupta M, Kaur M
J Cancer Res Ther 2013 Apr-Jun;9(2):328-30. doi: 10.4103/0973-1482.113422. PMID: 23771390
Management of breast cancer in patients prenatally exposed to diethylstilbestrol: are we prepared?
Mano MS, Kerr J, Kennedy J
Breast 2005 Oct;14(5):408-10. doi: 10.1016/j.breast.2004.11.002. PMID: 16216745
Comparison of histologic and colposcopic findings in DES-exposed females.
Welch WR, Robboy SJ, Townsend DE, Barnes AB, Scully RE, Herbst AL
Obstet Gynecol 1978 Oct;52(4):457-61. PMID: 714329
Vaginal adenosis. Case report.
Green TF, Newman RL
Mo Med 1976 Nov;73(11):614-8. PMID: 979946
Carcinoma of the vagina in young adults.
Hilton C
Proc R Soc Med 1973 Dec;66(12):1239. PMID: 4777060Free PMC Article

Therapy

Intestinal metaplasia in stilboestrol-induced vaginal adenosis.
Merchant WJ, Gale J
Histopathology 1993 Oct;23(4):373-6. doi: 10.1111/j.1365-2559.1993.tb01222.x. PMID: 8300072
Hormones, medications, and cancer.
Lipsett MB
Cancer 1983 Jun 15;51(12 Suppl):2426-9. doi: 10.1002/1097-0142(19830615)51:12+<2426::aid-cncr2820511307>3.0.co;2-c. PMID: 6850519
Prenatal diethylstilbestrol exposure and human genital tract abnormalities.
Herbst AL, Scully RE, Robboy SJ
Natl Cancer Inst Monogr 1979 May;(51):25-35. PMID: 481577
Comparison of histologic and colposcopic findings in DES-exposed females.
Welch WR, Robboy SJ, Townsend DE, Barnes AB, Scully RE, Herbst AL
Obstet Gynecol 1978 Oct;52(4):457-61. PMID: 714329
Vaginal adenosis: a precancerous lesion?
Stafl A, Mattingly RF
Am J Obstet Gynecol 1974 Nov 1;120(5):666-77. doi: 10.1016/0002-9378(74)90610-3. PMID: 4422247

Prognosis

Primary Vaginal Gastric-type Adenocarcinoma and Vaginal Adenosis Exhibiting Gastric Differentiation: Report of a Series With Detailed Immunohistochemical Analysis.
Wong RW, Moore M, Talia KL, Ganesan R, McCluggage WG
Am J Surg Pathol 2018 Jul;42(7):958-970. doi: 10.1097/PAS.0000000000001068. PMID: 29664741
Primary neuroendocrine carcinoma of the vagina with coexistent atypical vaginal adenosis: a rare entity.
Khurana A, Gupta G, Gupta M, Kaur M
J Cancer Res Ther 2013 Apr-Jun;9(2):328-30. doi: 10.4103/0973-1482.113422. PMID: 23771390
Carbon dioxide laser treatment of vaginal adenosis in DES-exposed offspring: a prospective study.
Bellina JH, Ross LF, Hemmings R, Voros JI, Moorehead M
Lasers Surg Med 1983;3(1):23-8. doi: 10.1002/lsm.1900030104. PMID: 6633131
Comparison of histologic and colposcopic findings in DES-exposed females.
Welch WR, Robboy SJ, Townsend DE, Barnes AB, Scully RE, Herbst AL
Obstet Gynecol 1978 Oct;52(4):457-61. PMID: 714329
Management of vaginal adenosis at Beth Israel Hospital, Boston.
Burke L
J Reprod Med 1976 Jun;16(6):291-2. PMID: 957350

Clinical prediction guides

Primary Vaginal Gastric-type Adenocarcinoma and Vaginal Adenosis Exhibiting Gastric Differentiation: Report of a Series With Detailed Immunohistochemical Analysis.
Wong RW, Moore M, Talia KL, Ganesan R, McCluggage WG
Am J Surg Pathol 2018 Jul;42(7):958-970. doi: 10.1097/PAS.0000000000001068. PMID: 29664741
Incidental vaginal müllerianosis.
Val-Bernal JF, Mayorga M
Pathol Res Pract 2016 Jun;212(6):568-72. Epub 2016 Feb 26 doi: 10.1016/j.prp.2016.02.023. PMID: 26970930
Colposcopic findings and intraepithelial neoplasia in diethylstilbestrol-exposed offspring. The Dutch experience.
Helmerhorst TJ, Wijnen HJ, Kenemans P, Tjioe GS, Dijkhuizen HH, Calame JJ, Stolk HG
Am J Obstet Gynecol 1989 Nov;161(5):1191-4. doi: 10.1016/0002-9378(89)90662-5. PMID: 2589438
Comparison of histologic and colposcopic findings in DES-exposed females.
Welch WR, Robboy SJ, Townsend DE, Barnes AB, Scully RE, Herbst AL
Obstet Gynecol 1978 Oct;52(4):457-61. PMID: 714329
Clear cell carcinoma of cervix and vagina in progeny of women who received diethylstilbestrol: three cases with scanning and transmission electron microscopy.
Puri S, Fenoglio CM, Richart RM, Townsend D
Am J Obstet Gynecol 1977 Jul 1;128(5):550-5. doi: 10.1016/0002-9378(77)90040-0. PMID: 879214

Recent systematic reviews

The developmental origin of cervical and vaginal epithelium and their clinical consequences: a systematic review.
Reich O, Fritsch H
J Low Genit Tract Dis 2014 Oct;18(4):358-60. doi: 10.1097/LGT.0000000000000023. PMID: 24977630

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