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Chronic respiratory acidosis

MedGen UID:
541160
•Concept ID:
C0268048
•
Disease or Syndrome
SNOMED CT: Chronic respiratory acidosis (8764008)
 
HPO: HP:0012466

Definition

Longstanding impairment in ventilation such that the partial pressure of carbon dioxide (PaCO2) is elevated above the upper limit of the reference range (more than 45 mm Hg), with a normal or near-normal pH secondary to renal compensation and an elevated serum bicarbonate levels (more than30 mEq/L). [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVChronic respiratory acidosis

Professional guidelines

PubMed

High flow nasal cannula versus noninvasive ventilation in the treatment of acute hypercapnic respiratory failure: A systematic review and meta-analysis.
Fahey AC, O'Connell M, Cornally N, Saab MM
Clin Respir J 2023 Nov;17(11):1091-1102. Epub 2023 Sep 12 doi: 10.1111/crj.13695. PMID: 37700578Free PMC Article
Home NIV treatment quality in patients with chronic respiratory failure having participated to the French nationwide telemonitoring experimental program (The TELVENT study).
Pontier-Marchandise S, Texereau J, Prigent A, Gonzalez-Bermejo J, Rabec C, Gagnadoux F, Letierce A, Winck JC
Respir Med Res 2023 Nov;84:101028. Epub 2023 May 25 doi: 10.1016/j.resmer.2023.101028. PMID: 37683442
Non-invasive ventilation for the management of acute hypercapnic respiratory failure due to exacerbation of chronic obstructive pulmonary disease.
Osadnik CR, Tee VS, Carson-Chahhoud KV, Picot J, Wedzicha JA, Smith BJ
Cochrane Database Syst Rev 2017 Jul 13;7(7):CD004104. doi: 10.1002/14651858.CD004104.pub4. PMID: 28702957Free PMC Article

Recent clinical studies

Etiology

Characteristics of pulse oximetry and arterial blood gas in patients with fibrotic interstitial lung disease.
Donaldson MA, Donohoe K, Assayag D, Durand C, Fisher JH, Johannson K, Kolb M, Lok SD, Manganas H, Marcoux V, Min B, Morisset J, Marinescu DC, Ryerson CJ
BMJ Open Respir Res 2024 Mar 13;11(1) doi: 10.1136/bmjresp-2023-002250. PMID: 38479819Free PMC Article
Myasthenic crisis treated in a Chinese neurological intensive care unit: clinical features, mortality, outcomes, and predictors of survival.
Liu F, Wang Q, Chen X
BMC Neurol 2019 Jul 19;19(1):172. doi: 10.1186/s12883-019-1384-5. PMID: 31324153Free PMC Article
Effect of arterial puncture on ventilation.
Sahni AS, Gonzalez H, Tulaimat A
Heart Lung 2017 May-Jun;46(3):149-152. Epub 2017 Apr 6 doi: 10.1016/j.hrtlng.2017.01.011. PMID: 28392039
Usefulness of pulmonary function tests and blood gases in acute neuromuscular respiratory failure.
Cabrera Serrano M, Rabinstein AA
Eur J Neurol 2012 Mar;19(3):452-6. Epub 2011 Oct 4 doi: 10.1111/j.1468-1331.2011.03539.x. PMID: 21974753
Respiratory acidosis.
Epstein SK, Singh N
Respir Care 2001 Apr;46(4):366-83. PMID: 11262556

Diagnosis

Characteristics of pulse oximetry and arterial blood gas in patients with fibrotic interstitial lung disease.
Donaldson MA, Donohoe K, Assayag D, Durand C, Fisher JH, Johannson K, Kolb M, Lok SD, Manganas H, Marcoux V, Min B, Morisset J, Marinescu DC, Ryerson CJ
BMJ Open Respir Res 2024 Mar 13;11(1) doi: 10.1136/bmjresp-2023-002250. PMID: 38479819Free PMC Article
Osteoarthrosis causing altered mental status: a case report.
Reddy YN, Josephson RA
J Med Case Rep 2014 Dec 3;8:401. doi: 10.1186/1752-1947-8-401. PMID: 25464859Free PMC Article
Acid-base disorders in patients with chronic obstructive pulmonary disease: a pathophysiological review.
Bruno CM, Valenti M
J Biomed Biotechnol 2012;2012:915150. Epub 2012 Feb 1 doi: 10.1155/2012/915150. PMID: 22500110Free PMC Article
The caudal solitary complex is a site of central CO(2) chemoreception and integration of multiple systems that regulate expired CO(2).
Dean JB, Putnam RW
Respir Physiol Neurobiol 2010 Oct 31;173(3):274-87. Epub 2010 Jul 27 doi: 10.1016/j.resp.2010.07.002. PMID: 20670695
Respiratory acidosis.
Epstein SK, Singh N
Respir Care 2001 Apr;46(4):366-83. PMID: 11262556

Therapy

White-nose syndrome initiates a cascade of physiologic disturbances in the hibernating bat host.
Verant ML, Meteyer CU, Speakman JR, Cryan PM, Lorch JM, Blehert DS
BMC Physiol 2014 Dec 9;14:10. doi: 10.1186/s12899-014-0010-4. PMID: 25487871Free PMC Article
Life-threatening hypokalemia following rapid correction of respiratory acidosis.
Hammond K, You D, Collins EG, Leehey DJ, Laghi F
Heart Lung 2013 Jul-Aug;42(4):287-9. Epub 2013 May 11 doi: 10.1016/j.hrtlng.2013.03.004. PMID: 23669409
Respiratory acidosis.
Epstein SK, Singh N
Respir Care 2001 Apr;46(4):366-83. PMID: 11262556
Fluid and electrolyte considerations in diuretic therapy for hypertensive patients with chronic obstructive pulmonary disease.
Hill NS
Arch Intern Med 1986 Jan;146(1):129-33. PMID: 2867747
Ammonia and acid-base homeostasis.
Tannen RL
Med Clin North Am 1983 Jul;67(4):781-98. doi: 10.1016/s0025-7125(16)31177-4. PMID: 6135827

Prognosis

Characteristics of pulse oximetry and arterial blood gas in patients with fibrotic interstitial lung disease.
Donaldson MA, Donohoe K, Assayag D, Durand C, Fisher JH, Johannson K, Kolb M, Lok SD, Manganas H, Marcoux V, Min B, Morisset J, Marinescu DC, Ryerson CJ
BMJ Open Respir Res 2024 Mar 13;11(1) doi: 10.1136/bmjresp-2023-002250. PMID: 38479819Free PMC Article
Myasthenic crisis treated in a Chinese neurological intensive care unit: clinical features, mortality, outcomes, and predictors of survival.
Liu F, Wang Q, Chen X
BMC Neurol 2019 Jul 19;19(1):172. doi: 10.1186/s12883-019-1384-5. PMID: 31324153Free PMC Article
Hypercapnia impairs lung neutrophil function and increases mortality in murine pseudomonas pneumonia.
Gates KL, Howell HA, Nair A, Vohwinkel CU, Welch LC, Beitel GJ, Hauser AR, Sznajder JI, Sporn PH
Am J Respir Cell Mol Biol 2013 Nov;49(5):821-8. doi: 10.1165/rcmb.2012-0487OC. PMID: 23777386Free PMC Article
Usefulness of pulmonary function tests and blood gases in acute neuromuscular respiratory failure.
Cabrera Serrano M, Rabinstein AA
Eur J Neurol 2012 Mar;19(3):452-6. Epub 2011 Oct 4 doi: 10.1111/j.1468-1331.2011.03539.x. PMID: 21974753
Re-evaluation of acid-base prediction rules in patients with chronic respiratory acidosis.
Martinu T, Menzies D, Dial S
Can Respir J 2003 Sep;10(6):311-5. doi: 10.1155/2003/818404. PMID: 14530822

Clinical prediction guides

Characteristics of pulse oximetry and arterial blood gas in patients with fibrotic interstitial lung disease.
Donaldson MA, Donohoe K, Assayag D, Durand C, Fisher JH, Johannson K, Kolb M, Lok SD, Manganas H, Marcoux V, Min B, Morisset J, Marinescu DC, Ryerson CJ
BMJ Open Respir Res 2024 Mar 13;11(1) doi: 10.1136/bmjresp-2023-002250. PMID: 38479819Free PMC Article
Myasthenic crisis treated in a Chinese neurological intensive care unit: clinical features, mortality, outcomes, and predictors of survival.
Liu F, Wang Q, Chen X
BMC Neurol 2019 Jul 19;19(1):172. doi: 10.1186/s12883-019-1384-5. PMID: 31324153Free PMC Article
Effects of seasonal vitamin D deficiency and respiratory acidosis on bone metabolism markers in submarine crewmembers during prolonged patrols.
Holy X, Collombet JM, Labarthe F, Granger-Veyron N, Bégot L
J Appl Physiol (1985) 2012 Feb;112(4):587-96. Epub 2011 Dec 1 doi: 10.1152/japplphysiol.00608.2011. PMID: 22134698
Usefulness of pulmonary function tests and blood gases in acute neuromuscular respiratory failure.
Cabrera Serrano M, Rabinstein AA
Eur J Neurol 2012 Mar;19(3):452-6. Epub 2011 Oct 4 doi: 10.1111/j.1468-1331.2011.03539.x. PMID: 21974753
Re-evaluation of acid-base prediction rules in patients with chronic respiratory acidosis.
Martinu T, Menzies D, Dial S
Can Respir J 2003 Sep;10(6):311-5. doi: 10.1155/2003/818404. PMID: 14530822

Recent systematic reviews

High flow through nasal cannula in exacerbated COPD patients: a systematic review.
Pisani L, Astuto M, Prediletto I, Longhini F
Pulmonology 2019 Nov-Dec;25(6):348-354. Epub 2019 Oct 5 doi: 10.1016/j.pulmoe.2019.08.001. PMID: 31591056

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