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Occult blood detected in feces

MedGen UID:
540186
•Concept ID:
C0266813
•
Finding
Synonyms: Fecal Occult Blood; Fecal occult blood positive; Occult blood in stool
SNOMED CT: Occult blood in stool (59614000); Fecal occult blood positive (59614000); Occult blood detected in feces (59614000)

Definition

Blood in the feces that is not visibly apparent. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVOccult blood detected in feces

Professional guidelines

PubMed

Faecal immunochemical test: challenges and opportunities for cancer diagnosis in primary care.
Craig M, Turner J, Torkington J, Crosby T
Br J Gen Pract 2022 Aug;72(721):366-367. Epub 2022 Jul 28 doi: 10.3399/bjgp22X720209. PMID: 35902254Free PMC Article
Colorectal Cancer Screening: Recommendations for Physicians and Patients From the U.S. Multi-Society Task Force on Colorectal Cancer.
Rex DK, Boland CR, Dominitz JA, Giardiello FM, Johnson DA, Kaltenbach T, Levin TR, Lieberman D, Robertson DJ
Gastroenterology 2017 Jul;153(1):307-323. Epub 2017 Jun 9 doi: 10.1053/j.gastro.2017.05.013. PMID: 28600072
Hot Topics in Primary Care: Colorectal Cancer Screening.
Elfant AB
J Fam Pract 2015 Dec;64(12 Suppl):S10-5. PMID: 26845007

Recent clinical studies

Etiology

Multitarget Stool RNA Test for Colorectal Cancer Screening.
Barnell EK, Wurtzler EM, La Rocca J, Fitzgerald T, Petrone J, Hao Y, Kang Y, Holmes FL, Lieberman DA
JAMA 2023 Nov 14;330(18):1760-1768. doi: 10.1001/jama.2023.22231. PMID: 37870871Free PMC Article
Use of Fecal Occult Blood Testing as a Diagnostic Tool for Clinical Indications: A Systematic Review and Meta-Analysis.
Lee MW, Pourmorady JS, Laine L
Am J Gastroenterol 2020 May;115(5):662-670. doi: 10.14309/ajg.0000000000000495. PMID: 31972617
Screening for colorectal cancer.
Choi Y, Sateia HF, Peairs KS, Stewart RW
Semin Oncol 2017 Feb;44(1):34-44. Epub 2017 Feb 10 doi: 10.1053/j.seminoncol.2017.02.002. PMID: 28395761
Accuracy of fecal immunochemical tests for colorectal cancer: systematic review and meta-analysis.
Lee JK, Liles EG, Bent S, Levin TR, Corley DA
Ann Intern Med 2014 Feb 4;160(3):171. doi: 10.7326/M13-1484. PMID: 24658694Free PMC Article
Multitarget stool DNA testing for colorectal-cancer screening.
Imperiale TF, Ransohoff DF, Itzkowitz SH, Levin TR, Lavin P, Lidgard GP, Ahlquist DA, Berger BM
N Engl J Med 2014 Apr 3;370(14):1287-97. Epub 2014 Mar 19 doi: 10.1056/NEJMoa1311194. PMID: 24645800

Diagnosis

Comparison of Colonoscopy, Fecal Immunochemical Test, and Risk-Adapted Approach in a Colorectal Cancer Screening Trial (TARGET-C).
Chen H, Shi J, Lu M, Li Y, Du L, Liao X, Wei D, Dong D, Gao Y, Zhu C, Ying R, Zheng W, Yan S, Xiao H, Zhang J, Kong Y, Li F, Zou S, Liu C, Wang H, Zhang Y, Lu B, Luo C, Cai J, Tian J, Miao X, Ding K, Brenner H, Dai M
Clin Gastroenterol Hepatol 2023 Mar;21(3):808-818. Epub 2022 Aug 11 doi: 10.1016/j.cgh.2022.08.003. PMID: 35964896
Use of Fecal Occult Blood Testing as a Diagnostic Tool for Clinical Indications: A Systematic Review and Meta-Analysis.
Lee MW, Pourmorady JS, Laine L
Am J Gastroenterol 2020 May;115(5):662-670. doi: 10.14309/ajg.0000000000000495. PMID: 31972617
Screening for colorectal cancer.
Choi Y, Sateia HF, Peairs KS, Stewart RW
Semin Oncol 2017 Feb;44(1):34-44. Epub 2017 Feb 10 doi: 10.1053/j.seminoncol.2017.02.002. PMID: 28395761
Potential of fecal microbiota for early-stage detection of colorectal cancer.
Zeller G, Tap J, Voigt AY, Sunagawa S, Kultima JR, Costea PI, Amiot A, Böhm J, Brunetti F, Habermann N, Hercog R, Koch M, Luciani A, Mende DR, Schneider MA, Schrotz-King P, Tournigand C, Tran Van Nhieu J, Yamada T, Zimmermann J, Benes V, Kloor M, Ulrich CM, von Knebel Doeberitz M, Sobhani I, Bork P
Mol Syst Biol 2014 Nov 28;10(11):766. doi: 10.15252/msb.20145645. PMID: 25432777Free PMC Article
Accuracy of fecal immunochemical tests for colorectal cancer: systematic review and meta-analysis.
Lee JK, Liles EG, Bent S, Levin TR, Corley DA
Ann Intern Med 2014 Feb 4;160(3):171. doi: 10.7326/M13-1484. PMID: 24658694Free PMC Article

Therapy

Multitarget Stool RNA Test for Colorectal Cancer Screening.
Barnell EK, Wurtzler EM, La Rocca J, Fitzgerald T, Petrone J, Hao Y, Kang Y, Holmes FL, Lieberman DA
JAMA 2023 Nov 14;330(18):1760-1768. doi: 10.1001/jama.2023.22231. PMID: 37870871Free PMC Article
Comparison of Colonoscopy, Fecal Immunochemical Test, and Risk-Adapted Approach in a Colorectal Cancer Screening Trial (TARGET-C).
Chen H, Shi J, Lu M, Li Y, Du L, Liao X, Wei D, Dong D, Gao Y, Zhu C, Ying R, Zheng W, Yan S, Xiao H, Zhang J, Kong Y, Li F, Zou S, Liu C, Wang H, Zhang Y, Lu B, Luo C, Cai J, Tian J, Miao X, Ding K, Brenner H, Dai M
Clin Gastroenterol Hepatol 2023 Mar;21(3):808-818. Epub 2022 Aug 11 doi: 10.1016/j.cgh.2022.08.003. PMID: 35964896
Controversies in colorectal cancer screening.
Pox CP
Digestion 2014;89(4):274-81. Epub 2014 Jul 11 doi: 10.1159/000363287. PMID: 25034478
Colorectal cancer: from prevention to personalized medicine.
Binefa G, Rodríguez-Moranta F, Teule A, Medina-Hayas M
World J Gastroenterol 2014 Jun 14;20(22):6786-808. doi: 10.3748/wjg.v20.i22.6786. PMID: 24944469Free PMC Article
Multitarget stool DNA testing for colorectal-cancer screening.
Imperiale TF, Ransohoff DF, Itzkowitz SH, Levin TR, Lavin P, Lidgard GP, Ahlquist DA, Berger BM
N Engl J Med 2014 Apr 3;370(14):1287-97. Epub 2014 Mar 19 doi: 10.1056/NEJMoa1311194. PMID: 24645800

Prognosis

Comparative Effectiveness and Cost-Effectiveness of Colorectal Cancer Screening With Blood-Based Biomarkers (Liquid Biopsy) vs Fecal Tests or Colonoscopy.
Ladabaum U, Mannalithara A, Weng Y, Schoen RE, Dominitz JA, Desai M, Lieberman D
Gastroenterology 2024 Jul;167(2):378-391. Epub 2024 Mar 26 doi: 10.1053/j.gastro.2024.03.011. PMID: 38552670
Colonoscopy vs the Fecal Immunochemical Test: Which is Best?
Robertson DJ, Rex DK, Ciani O, Drummond MF
Gastroenterology 2024 May;166(5):758-771. Epub 2024 Feb 9 doi: 10.1053/j.gastro.2023.12.027. PMID: 38342196
Multitarget Stool RNA Test for Colorectal Cancer Screening.
Barnell EK, Wurtzler EM, La Rocca J, Fitzgerald T, Petrone J, Hao Y, Kang Y, Holmes FL, Lieberman DA
JAMA 2023 Nov 14;330(18):1760-1768. doi: 10.1001/jama.2023.22231. PMID: 37870871Free PMC Article
Use of Fecal Occult Blood Testing as a Diagnostic Tool for Clinical Indications: A Systematic Review and Meta-Analysis.
Lee MW, Pourmorady JS, Laine L
Am J Gastroenterol 2020 May;115(5):662-670. doi: 10.14309/ajg.0000000000000495. PMID: 31972617
The toll of not screening for colorectal cancer.
Chen C, Hoffmeister M, Brenner H
Expert Rev Gastroenterol Hepatol 2017 Jan;11(1):1-3. Epub 2016 Nov 29 doi: 10.1080/17474124.2017.1264269. PMID: 27897033

Clinical prediction guides

Colonoscopy vs the Fecal Immunochemical Test: Which is Best?
Robertson DJ, Rex DK, Ciani O, Drummond MF
Gastroenterology 2024 May;166(5):758-771. Epub 2024 Feb 9 doi: 10.1053/j.gastro.2023.12.027. PMID: 38342196
Multitarget Stool RNA Test for Colorectal Cancer Screening.
Barnell EK, Wurtzler EM, La Rocca J, Fitzgerald T, Petrone J, Hao Y, Kang Y, Holmes FL, Lieberman DA
JAMA 2023 Nov 14;330(18):1760-1768. doi: 10.1001/jama.2023.22231. PMID: 37870871Free PMC Article
Comparison of Colonoscopy, Fecal Immunochemical Test, and Risk-Adapted Approach in a Colorectal Cancer Screening Trial (TARGET-C).
Chen H, Shi J, Lu M, Li Y, Du L, Liao X, Wei D, Dong D, Gao Y, Zhu C, Ying R, Zheng W, Yan S, Xiao H, Zhang J, Kong Y, Li F, Zou S, Liu C, Wang H, Zhang Y, Lu B, Luo C, Cai J, Tian J, Miao X, Ding K, Brenner H, Dai M
Clin Gastroenterol Hepatol 2023 Mar;21(3):808-818. Epub 2022 Aug 11 doi: 10.1016/j.cgh.2022.08.003. PMID: 35964896
Use of Fecal Occult Blood Testing as a Diagnostic Tool for Clinical Indications: A Systematic Review and Meta-Analysis.
Lee MW, Pourmorady JS, Laine L
Am J Gastroenterol 2020 May;115(5):662-670. doi: 10.14309/ajg.0000000000000495. PMID: 31972617
Potential of fecal microbiota for early-stage detection of colorectal cancer.
Zeller G, Tap J, Voigt AY, Sunagawa S, Kultima JR, Costea PI, Amiot A, Böhm J, Brunetti F, Habermann N, Hercog R, Koch M, Luciani A, Mende DR, Schneider MA, Schrotz-King P, Tournigand C, Tran Van Nhieu J, Yamada T, Zimmermann J, Benes V, Kloor M, Ulrich CM, von Knebel Doeberitz M, Sobhani I, Bork P
Mol Syst Biol 2014 Nov 28;10(11):766. doi: 10.15252/msb.20145645. PMID: 25432777Free PMC Article

Recent systematic reviews

Replicate and repeat faecal immunochemical tests in symptomatic patients: A systematic review.
Farkas NG, Fraser CG, Maclean W, Jourdan I, Rockall T, Benton SC
Ann Clin Biochem 2023 Jan;60(1):27-36. Epub 2022 May 5 doi: 10.1177/00045632221096036. PMID: 35394384
Use of Fecal Occult Blood Testing as a Diagnostic Tool for Clinical Indications: A Systematic Review and Meta-Analysis.
Lee MW, Pourmorady JS, Laine L
Am J Gastroenterol 2020 May;115(5):662-670. doi: 10.14309/ajg.0000000000000495. PMID: 31972617
Noninvasive DNA methylation biomarkers in colorectal cancer: A systematic review.
Xue M, Lai SC, Xu ZP, Wang LJ
J Dig Dis 2015 Dec;16(12):699-712. doi: 10.1111/1751-2980.12299. PMID: 26565661
Tests and investigations for colorectal cancer screening.
Carroll MR, Seaman HE, Halloran SP
Clin Biochem 2014 Jul;47(10-11):921-39. Epub 2014 Apr 24 doi: 10.1016/j.clinbiochem.2014.04.019. PMID: 24769265
Accuracy of fecal immunochemical tests for colorectal cancer: systematic review and meta-analysis.
Lee JK, Liles EG, Bent S, Levin TR, Corley DA
Ann Intern Med 2014 Feb 4;160(3):171. doi: 10.7326/M13-1484. PMID: 24658694Free PMC Article

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