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Conjunctival icterus

MedGen UID:
537025
Concept ID:
C0240962
Finding
Synonym: Scleral icterus
SNOMED CT: Yellow sclera (246975001); Scleral icterus (246975001)
 
HPO: HP:0032106

Definition

Conjunctival icterus is a condition where there is yellowing of the whites of the eyes. This is most commonly seen in patients who have liver disease. [from HPO]

Term Hierarchy

Conditions with this feature

Johanson-Blizzard syndrome
MedGen UID:
59798
Concept ID:
C0175692
Disease or Syndrome
Johanson-Blizzard syndrome is an autosomal recessive disorder characterized by poor growth, mental retardation, and variable dysmorphic features, including aplasia or hypoplasia of the nasal alae, abnormal hair patterns or scalp defects, and oligodontia. Other features include hypothyroidism, sensorineural hearing loss, imperforate anus, and pancreatic exocrine insufficiency (summary by Al-Dosari et al., 2008).
Fumarase deficiency
MedGen UID:
87458
Concept ID:
C0342770
Disease or Syndrome
Fumarate hydratase (FH) deficiency results in severe neonatal and early infantile encephalopathy that is characterized by poor feeding, failure to thrive, hypotonia, lethargy, and seizures. Dysmorphic facial features include frontal bossing, depressed nasal bridge, and widely spaced eyes. Many affected individuals are microcephalic. A spectrum of brain abnormalities are seen on magnetic resonance imaging, including cerebral atrophy, enlarged ventricles and generous extra-axial cerebral spinal fluid (CSF) spaces, delayed myelination for age, thinning of the corpus callosum, and an abnormally small brain stem. Brain malformations including bilateral polymicrogyria and absence of the corpus callosum can also be observed. Development is severely affected: most affected individuals are nonverbal and nonambulatory, and many die during early childhood. Less severely affected individuals with moderate cognitive impairment and long-term survival have been reported.
Dehydrated hereditary stomatocytosis with or without pseudohyperkalemia and/or perinatal edema
MedGen UID:
1638271
Concept ID:
C4551512
Disease or Syndrome

Professional guidelines

PubMed

Maisels MJ, Coffey MP, Gendelman B, Smyth M, Kendall A, Clune S, Coleman K, McManus S
J Pediatr 2016 May;172:212-214.e1. Epub 2016 Feb 18 doi: 10.1016/j.jpeds.2016.01.032. PMID: 26898809

Recent clinical studies

Etiology

Azzuqa A, Watchko JF
Curr Pediatr Rev 2017;13(3):169-175. doi: 10.2174/1573396313666170718145535. PMID: 28721815
Azzuqa A, Watchko JF
J Pediatr 2015 Oct;167(4):840-4. Epub 2015 Aug 1 doi: 10.1016/j.jpeds.2015.06.065. PMID: 26239927

Diagnosis

Shishido Y, Fujimoto K, Yano Y, Mitsuoka E, Komatsubara T, Shio S, Ishii M, Higashiyama H
BMC Surg 2021 Aug 5;21(1):318. doi: 10.1186/s12893-021-01314-z. PMID: 34353316Free PMC Article
Azzuqa A, Watchko JF
Curr Pediatr Rev 2017;13(3):169-175. doi: 10.2174/1573396313666170718145535. PMID: 28721815
Maisels MJ, Coffey MP, Gendelman B, Smyth M, Kendall A, Clune S, Coleman K, McManus S
J Pediatr 2016 May;172:212-214.e1. Epub 2016 Feb 18 doi: 10.1016/j.jpeds.2016.01.032. PMID: 26898809
Azzuqa A, Watchko JF
J Pediatr 2015 Oct;167(4):840-4. Epub 2015 Aug 1 doi: 10.1016/j.jpeds.2015.06.065. PMID: 26239927
Sideris S, Loizidou A, Georgala A, Lebrun F, Gil T, Awada P, Piccart P, Cardoso F
Acta Clin Belg 2013 Mar-Apr;68(2):135-7. doi: 10.2143/ACB.3149. PMID: 23967725

Therapy

Sideris S, Loizidou A, Georgala A, Lebrun F, Gil T, Awada P, Piccart P, Cardoso F
Acta Clin Belg 2013 Mar-Apr;68(2):135-7. doi: 10.2143/ACB.3149. PMID: 23967725

Prognosis

Azzuqa A, Watchko JF
J Pediatr 2015 Oct;167(4):840-4. Epub 2015 Aug 1 doi: 10.1016/j.jpeds.2015.06.065. PMID: 26239927

Clinical prediction guides

Shishido Y, Fujimoto K, Yano Y, Mitsuoka E, Komatsubara T, Shio S, Ishii M, Higashiyama H
BMC Surg 2021 Aug 5;21(1):318. doi: 10.1186/s12893-021-01314-z. PMID: 34353316Free PMC Article
Azzuqa A, Watchko JF
J Pediatr 2015 Oct;167(4):840-4. Epub 2015 Aug 1 doi: 10.1016/j.jpeds.2015.06.065. PMID: 26239927

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