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Neonatal encephalopathy

MedGen UID:
536453
•Concept ID:
C0235820
•
Disease or Syndrome
Synonym: Neonatal Encephalopathy
SNOMED CT: Neonatal encephalopathy (95628005)

Definition

Abnormal functioning of the central nervous system in the newborn period that may be due to a variety of etiologies including hypoxia/ischemia, metabolic disturbance, or infection. [from NCI]

Professional guidelines

PubMed

Therapeutic hypothermia for neonatal encephalopathy: importance of early management.
Austin T, Chakkarapani E
Arch Dis Child Fetal Neonatal Ed 2022 Jan;107(1):2-3. Epub 2021 Nov 9 doi: 10.1136/archdischild-2021-322563. PMID: 34753784
Pharmacologic Prevention and Treatment of Neonatal Brain Injury.
McNally MA, Soul JS
Clin Perinatol 2019 Jun;46(2):311-325. Epub 2019 Mar 26 doi: 10.1016/j.clp.2019.02.006. PMID: 31010562
Neonatal Encephalopathy: Current Management and Future Trends.
Schump EA
Crit Care Nurs Clin North Am 2018 Dec;30(4):509-521. doi: 10.1016/j.cnc.2018.07.007. PMID: 30447810

Recent clinical studies

Etiology

The Term Newborn: Evaluation for Hypoxic-Ischemic Encephalopathy.
Bonifacio SL, Hutson S
Clin Perinatol 2021 Aug;48(3):681-695. doi: 10.1016/j.clp.2021.05.014. PMID: 34353587
How to use the Bayley Scales of Infant and Toddler Development.
Del Rosario C, Slevin M, Molloy EJ, Quigley J, Nixon E
Arch Dis Child Educ Pract Ed 2021 Apr;106(2):108-112. Epub 2020 Aug 28 doi: 10.1136/archdischild-2020-319063. PMID: 32859738
Inborn errors of metabolism.
Ferreira CR, van Karnebeek CDM
Handb Clin Neurol 2019;162:449-481. doi: 10.1016/B978-0-444-64029-1.00022-9. PMID: 31324325
Therapeutic Hypothermia in Neonatal Hypoxic-Ischemic Encephalopathy.
Wassink G, Davidson JO, Dhillon SK, Zhou K, Bennet L, Thoresen M, Gunn AJ
Curr Neurol Neurosci Rep 2019 Jan 14;19(2):2. doi: 10.1007/s11910-019-0916-0. PMID: 30637551
Pathophysiology of cerebral palsy.
Marret S, Vanhulle C, Laquerriere A
Handb Clin Neurol 2013;111:169-76. doi: 10.1016/B978-0-444-52891-9.00016-6. PMID: 23622161

Diagnosis

MECP2-Related Disorders in Males.
Pascual-Alonso A, Martínez-Monseny AF, Xiol C, Armstrong J
Int J Mol Sci 2021 Sep 4;22(17) doi: 10.3390/ijms22179610. PMID: 34502518Free PMC Article
The Term Newborn: Evaluation for Hypoxic-Ischemic Encephalopathy.
Bonifacio SL, Hutson S
Clin Perinatol 2021 Aug;48(3):681-695. doi: 10.1016/j.clp.2021.05.014. PMID: 34353587
Neonatal Encephalopathy: Beyond Hypoxic-Ischemic Encephalopathy.
Russ JB, Simmons R, Glass HC
Neoreviews 2021 Mar;22(3):e148-e162. doi: 10.1542/neo.22-3-e148. PMID: 33649088
Inborn errors of metabolism.
Ferreira CR, van Karnebeek CDM
Handb Clin Neurol 2019;162:449-481. doi: 10.1016/B978-0-444-64029-1.00022-9. PMID: 31324325
Therapeutic Hypothermia in Neonatal Hypoxic-Ischemic Encephalopathy.
Wassink G, Davidson JO, Dhillon SK, Zhou K, Bennet L, Thoresen M, Gunn AJ
Curr Neurol Neurosci Rep 2019 Jan 14;19(2):2. doi: 10.1007/s11910-019-0916-0. PMID: 30637551

Therapy

Therapeutic hypothermia in neonatal hypoxic encephalopathy: A systematic review and meta-analysis.
Mathew JL, Kaur N, Dsouza JM
J Glob Health 2022;12:04030. Epub 2022 Apr 9 doi: 10.7189/jogh.12.04030. PMID: 35444799Free PMC Article
The Term Newborn: Evaluation for Hypoxic-Ischemic Encephalopathy.
Bonifacio SL, Hutson S
Clin Perinatol 2021 Aug;48(3):681-695. doi: 10.1016/j.clp.2021.05.014. PMID: 34353587
Therapeutic hypothermia for mild neonatal encephalopathy: a systematic review and meta-analysis.
Kariholu U, Montaldo P, Markati T, Lally PJ, Pryce R, Teiserskas J, Liow N, Oliveira V, Soe A, Shankaran S, Thayyil S
Arch Dis Child Fetal Neonatal Ed 2020 Mar;105(2):225-228. Epub 2018 Dec 19 doi: 10.1136/archdischild-2018-315711. PMID: 30567775
Neonatal encephalopathy and hypoxic-ischemic encephalopathy.
Gunn AJ, Thoresen M
Handb Clin Neurol 2019;162:217-237. doi: 10.1016/B978-0-444-64029-1.00010-2. PMID: 31324312
Therapeutic Hypothermia in Neonatal Hypoxic-Ischemic Encephalopathy.
Wassink G, Davidson JO, Dhillon SK, Zhou K, Bennet L, Thoresen M, Gunn AJ
Curr Neurol Neurosci Rep 2019 Jan 14;19(2):2. doi: 10.1007/s11910-019-0916-0. PMID: 30637551

Prognosis

Neuroimaging in the term newborn with neonatal encephalopathy.
Wisnowski JL, Wintermark P, Bonifacio SL, Smyser CD, Barkovich AJ, Edwards AD, de Vries LS, Inder TE, Chau V; Newborn Brain Society Guidelines and Publications Committee
Semin Fetal Neonatal Med 2021 Oct;26(5):101304. Epub 2021 Oct 29 doi: 10.1016/j.siny.2021.101304. PMID: 34736808Free PMC Article
The Term Newborn: Evaluation for Hypoxic-Ischemic Encephalopathy.
Bonifacio SL, Hutson S
Clin Perinatol 2021 Aug;48(3):681-695. doi: 10.1016/j.clp.2021.05.014. PMID: 34353587
How to use the Bayley Scales of Infant and Toddler Development.
Del Rosario C, Slevin M, Molloy EJ, Quigley J, Nixon E
Arch Dis Child Educ Pract Ed 2021 Apr;106(2):108-112. Epub 2020 Aug 28 doi: 10.1136/archdischild-2020-319063. PMID: 32859738
Epidemiology of neonatal encephalopathy and hypoxic-ischaemic encephalopathy.
Kurinczuk JJ, White-Koning M, Badawi N
Early Hum Dev 2010 Jun;86(6):329-38. Epub 2010 Jun 16 doi: 10.1016/j.earlhumdev.2010.05.010. PMID: 20554402
Neonatal encephalopathy following fetal distress. A clinical and electroencephalographic study.
Sarnat HB, Sarnat MS
Arch Neurol 1976 Oct;33(10):696-705. doi: 10.1001/archneur.1976.00500100030012. PMID: 987769

Clinical prediction guides

Neuroimaging in the term newborn with neonatal encephalopathy.
Wisnowski JL, Wintermark P, Bonifacio SL, Smyser CD, Barkovich AJ, Edwards AD, de Vries LS, Inder TE, Chau V; Newborn Brain Society Guidelines and Publications Committee
Semin Fetal Neonatal Med 2021 Oct;26(5):101304. Epub 2021 Oct 29 doi: 10.1016/j.siny.2021.101304. PMID: 34736808Free PMC Article
How to use the Bayley Scales of Infant and Toddler Development.
Del Rosario C, Slevin M, Molloy EJ, Quigley J, Nixon E
Arch Dis Child Educ Pract Ed 2021 Apr;106(2):108-112. Epub 2020 Aug 28 doi: 10.1136/archdischild-2020-319063. PMID: 32859738
The fetal inflammatory response syndrome: the origins of a concept, pathophysiology, diagnosis, and obstetrical implications.
Jung E, Romero R, Yeo L, Diaz-Primera R, Marin-Concha J, Para R, Lopez AM, Pacora P, Gomez-Lopez N, Yoon BH, Kim CJ, Berry SM, Hsu CD
Semin Fetal Neonatal Med 2020 Aug;25(4):101146. Epub 2020 Oct 23 doi: 10.1016/j.siny.2020.101146. PMID: 33164775Free PMC Article
Global, regional, and national age-sex specific mortality for 264 causes of death, 1980-2016: a systematic analysis for the Global Burden of Disease Study 2016.
GBD 2016 Causes of Death Collaborators
Lancet 2017 Sep 16;390(10100):1151-1210. doi: 10.1016/S0140-6736(17)32152-9. PMID: 28919116Free PMC Article
Pathophysiology of cerebral palsy.
Marret S, Vanhulle C, Laquerriere A
Handb Clin Neurol 2013;111:169-76. doi: 10.1016/B978-0-444-52891-9.00016-6. PMID: 23622161

Recent systematic reviews

Therapeutic hypothermia in neonatal hypoxic encephalopathy: A systematic review and meta-analysis.
Mathew JL, Kaur N, Dsouza JM
J Glob Health 2022;12:04030. Epub 2022 Apr 9 doi: 10.7189/jogh.12.04030. PMID: 35444799Free PMC Article
Induction of labour at or beyond 37 weeks' gestation.
Middleton P, Shepherd E, Morris J, Crowther CA, Gomersall JC
Cochrane Database Syst Rev 2020 Jul 15;7(7):CD004945. doi: 10.1002/14651858.CD004945.pub5. PMID: 32666584Free PMC Article
Membrane sweeping for induction of labour.
Finucane EM, Murphy DJ, Biesty LM, Gyte GM, Cotter AM, Ryan EM, Boulvain M, Devane D
Cochrane Database Syst Rev 2020 Feb 27;2(2):CD000451. doi: 10.1002/14651858.CD000451.pub3. PMID: 32103497Free PMC Article
Therapeutic hypothermia for mild neonatal encephalopathy: a systematic review and meta-analysis.
Kariholu U, Montaldo P, Markati T, Lally PJ, Pryce R, Teiserskas J, Liow N, Oliveira V, Soe A, Shankaran S, Thayyil S
Arch Dis Child Fetal Neonatal Ed 2020 Mar;105(2):225-228. Epub 2018 Dec 19 doi: 10.1136/archdischild-2018-315711. PMID: 30567775
Planned early birth versus expectant management (waiting) for prelabour rupture of membranes at term (37 weeks or more).
Middleton P, Shepherd E, Flenady V, McBain RD, Crowther CA
Cochrane Database Syst Rev 2017 Jan 4;1(1):CD005302. doi: 10.1002/14651858.CD005302.pub3. PMID: 28050900Free PMC Article

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