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Neonatal thyrotoxicosis

MedGen UID:
510684
•Concept ID:
C0158983
•
Disease or Syndrome
Synonyms: infantile hyperthyroidism; Neonatal Thyrotoxicosis; neonatal thyrotoxicosis
SNOMED CT: Neonatal thyrotoxicosis (13795004)
 
Monarch Initiative: MONDO:0001555

Definition

A hypermetabolic syndrome characterized by tachycardia, palpitations, tremor, weight loss, and moist skin that is caused by the elevation of thyroid hormone levels in the serum of the newborn infant or thyroid-axis receptor activation, most commonly due to transplacental passage of thyroid stimulating globulins. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVNeonatal thyrotoxicosis

Professional guidelines

PubMed

Neonatal Screening for Hyperthyroidism Proof of Concept.
Banigé M, Kariyawasam D, Gauthereau V, Luton D, Polak M
J Clin Endocrinol Metab 2022 Mar 24;107(4):e1374-e1381. doi: 10.1210/clinem/dgab890. PMID: 34894265
Measuring TSH receptor antibody to influence treatment choices in Graves' disease.
Hesarghatta Shyamasunder A, Abraham P
Clin Endocrinol (Oxf) 2017 May;86(5):652-657. doi: 10.1111/cen.13327. PMID: 28295509
Clinical review: Clinical utility of TSH receptor antibodies.
Barbesino G, Tomer Y
J Clin Endocrinol Metab 2013 Jun;98(6):2247-55. Epub 2013 Mar 28 doi: 10.1210/jc.2012-4309. PMID: 23539719Free PMC Article

Recent clinical studies

Etiology

Neonatal Outcomes of Pregnancies Complicated by Maternal Hyperthyroidism.
Abdullah AA, Ramli N, Yaacob NM, Hussain S
J ASEAN Fed Endocr Soc 2022;37(2):15-22. Epub 2022 Aug 6 doi: 10.15605/jafes.037.02.03. PMID: 36578895Free PMC Article
Neonatal Screening for Hyperthyroidism Proof of Concept.
Banigé M, Kariyawasam D, Gauthereau V, Luton D, Polak M
J Clin Endocrinol Metab 2022 Mar 24;107(4):e1374-e1381. doi: 10.1210/clinem/dgab890. PMID: 34894265
Thyrotropin Receptor Antibodies-An Overview.
Kotwal A, Stan M
Ophthalmic Plast Reconstr Surg 2018 Jul/Aug;34(4S Suppl 1):S20-S27. doi: 10.1097/IOP.0000000000001052. PMID: 29771756
Measuring TSH receptor antibody to influence treatment choices in Graves' disease.
Hesarghatta Shyamasunder A, Abraham P
Clin Endocrinol (Oxf) 2017 May;86(5):652-657. doi: 10.1111/cen.13327. PMID: 28295509
Thyroid hyperfunction during pregnancy.
Glinoer D
Thyroid 1998 Sep;8(9):859-64. doi: 10.1089/thy.1998.8.859. PMID: 9777758

Diagnosis

Diagnosis and Management of Fetal and Neonatal Thyrotoxicosis.
Bohîlțea RE, Mihai BM, Szini E, Șucaliuc IA, Badiu C
Medicina (Kaunas) 2022 Dec 23;59(1) doi: 10.3390/medicina59010036. PMID: 36676660Free PMC Article
Thyrotropin Receptor Antibodies-An Overview.
Kotwal A, Stan M
Ophthalmic Plast Reconstr Surg 2018 Jul/Aug;34(4S Suppl 1):S20-S27. doi: 10.1097/IOP.0000000000001052. PMID: 29771756
Measuring TSH receptor antibody to influence treatment choices in Graves' disease.
Hesarghatta Shyamasunder A, Abraham P
Clin Endocrinol (Oxf) 2017 May;86(5):652-657. doi: 10.1111/cen.13327. PMID: 28295509
Hyperthyroidism in pregnancy.
Cooper DS, Laurberg P
Lancet Diabetes Endocrinol 2013 Nov;1(3):238-49. Epub 2013 Oct 18 doi: 10.1016/S2213-8587(13)70086-X. PMID: 24622372
Thyroid hyperfunction during pregnancy.
Glinoer D
Thyroid 1998 Sep;8(9):859-64. doi: 10.1089/thy.1998.8.859. PMID: 9777758

Therapy

Neonatal Thyrotoxicosis.
Samuels SL, Namoc SM, Bauer AJ
Clin Perinatol 2018 Mar;45(1):31-40. Epub 2017 Dec 16 doi: 10.1016/j.clp.2017.10.001. PMID: 29406005
Measuring TSH receptor antibody to influence treatment choices in Graves' disease.
Hesarghatta Shyamasunder A, Abraham P
Clin Endocrinol (Oxf) 2017 May;86(5):652-657. doi: 10.1111/cen.13327. PMID: 28295509
Hyperthyroidism in pregnancy.
Cooper DS, Laurberg P
Lancet Diabetes Endocrinol 2013 Nov;1(3):238-49. Epub 2013 Oct 18 doi: 10.1016/S2213-8587(13)70086-X. PMID: 24622372
Neonatal thyrotoxicosis.
Robards GJ, Davis JR
Med J Aust 1973 Sep 1;2(9):432-4. doi: 10.5694/j.1326-5377.1973.tb115207.x. PMID: 4800423
Neonatal thyrotoxicosis.
Hopton DS, Wade JS
Proc R Soc Med 1969 Aug;62(8):817. PMID: 4185737Free PMC Article

Prognosis

Diagnosis and Management of Fetal and Neonatal Thyrotoxicosis.
Bohîlțea RE, Mihai BM, Szini E, Șucaliuc IA, Badiu C
Medicina (Kaunas) 2022 Dec 23;59(1) doi: 10.3390/medicina59010036. PMID: 36676660Free PMC Article
Neonatal thyrotoxicosis with maternal hypothyroidism.
Ravindra S, Shetty S
BMJ Case Rep 2022 Mar 9;15(3) doi: 10.1136/bcr-2021-247865. PMID: 35264385Free PMC Article
Neonatal Screening for Hyperthyroidism Proof of Concept.
Banigé M, Kariyawasam D, Gauthereau V, Luton D, Polak M
J Clin Endocrinol Metab 2022 Mar 24;107(4):e1374-e1381. doi: 10.1210/clinem/dgab890. PMID: 34894265
Thyrotropin Receptor Antibodies-An Overview.
Kotwal A, Stan M
Ophthalmic Plast Reconstr Surg 2018 Jul/Aug;34(4S Suppl 1):S20-S27. doi: 10.1097/IOP.0000000000001052. PMID: 29771756
Measuring TSH receptor antibody to influence treatment choices in Graves' disease.
Hesarghatta Shyamasunder A, Abraham P
Clin Endocrinol (Oxf) 2017 May;86(5):652-657. doi: 10.1111/cen.13327. PMID: 28295509

Clinical prediction guides

Neonatal Screening for Hyperthyroidism Proof of Concept.
Banigé M, Kariyawasam D, Gauthereau V, Luton D, Polak M
J Clin Endocrinol Metab 2022 Mar 24;107(4):e1374-e1381. doi: 10.1210/clinem/dgab890. PMID: 34894265
Thyrotropin Receptor Antibodies-An Overview.
Kotwal A, Stan M
Ophthalmic Plast Reconstr Surg 2018 Jul/Aug;34(4S Suppl 1):S20-S27. doi: 10.1097/IOP.0000000000001052. PMID: 29771756
Measuring TSH receptor antibody to influence treatment choices in Graves' disease.
Hesarghatta Shyamasunder A, Abraham P
Clin Endocrinol (Oxf) 2017 May;86(5):652-657. doi: 10.1111/cen.13327. PMID: 28295509
Clinical review: Clinical utility of TSH receptor antibodies.
Barbesino G, Tomer Y
J Clin Endocrinol Metab 2013 Jun;98(6):2247-55. Epub 2013 Mar 28 doi: 10.1210/jc.2012-4309. PMID: 23539719Free PMC Article
Thyroid hyperfunction during pregnancy.
Glinoer D
Thyroid 1998 Sep;8(9):859-64. doi: 10.1089/thy.1998.8.859. PMID: 9777758

Recent systematic reviews

Maternal Thyrotropin Receptor Antibody Concentration and the Risk of Fetal and Neonatal Thyrotoxicosis: A Systematic Review.
van Dijk MM, Smits IH, Fliers E, Bisschop PH
Thyroid 2018 Feb;28(2):257-264. doi: 10.1089/thy.2017.0413. PMID: 29325496

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