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Capillary fragility

MedGen UID:
507522
•Concept ID:
C0006905
•
Disease or Syndrome
Synonyms: Capillary fragillity; Fragile capillaries
SNOMED CT: Capillary fragility (248725002); Capillary fragillity (248725002); Fragile capillaries (248726001)
 
HPO: HP:0025017

Definition

Reduced resistance to rupture of capillary blood vessels. Capillary fragility may manifest as a bleeding diathesis with spontaneous ecchymoses (bruises). [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVCapillary fragility

Professional guidelines

PubMed

Update in the management of lipedema.
Forner-Cordero I, Forner-Cordero A, Szolnoky G
Int Angiol 2021 Aug;40(4):345-357. Epub 2021 Apr 19 doi: 10.23736/S0392-9590.21.04604-6. PMID: 33870676
Lymphedema treatment decreases pain intensity in lipedema.
Szolnoky G, Varga E, Varga M, Tuczai M, Dósa-Rácz E, Kemény L
Lymphology 2011 Dec;44(4):178-82. PMID: 22458119
Conservative management of symptomatic and/or complicated haemorrhoids in pregnancy and the puerperium.
Quijano CE, Abalos E
Cochrane Database Syst Rev 2005 Jul 20;2005(3):CD004077. doi: 10.1002/14651858.CD004077.pub2. PMID: 16034920Free PMC Article

Recent clinical studies

Etiology

Thromboembolic and bleeding risk in cardiac amyloidosis.
Tana M, Tana C, Rossi D, Mantini C, Gallina S, Ricci F, Porreca E
J Thromb Haemost 2024 Sep;22(9):2381-2392. Epub 2024 May 27 doi: 10.1016/j.jtha.2024.05.018. PMID: 38810701
Therapeutic Approach in Pigmented Purpuric Dermatoses-A Scoping Review.
Kimak A, Żebrowska A
Int J Mol Sci 2024 Feb 24;25(5) doi: 10.3390/ijms25052644. PMID: 38473891Free PMC Article
Risk factors associated with severe dengue in Latin America: A systematic review and meta-analysis.
Paraná VC, Feitosa CA, da Silva GCS, Gois LL, Santos LA
Trop Med Int Health 2024 Mar;29(3):173-191. Epub 2024 Jan 23 doi: 10.1111/tmi.13968. PMID: 38263345
Update in the management of lipedema.
Forner-Cordero I, Forner-Cordero A, Szolnoky G
Int Angiol 2021 Aug;40(4):345-357. Epub 2021 Apr 19 doi: 10.23736/S0392-9590.21.04604-6. PMID: 33870676
What type of valve is most appropriate for osteogenesis imperfecta patients?
Dimitrakakis G, Challoumas D, von Oppell UO
Interact Cardiovasc Thorac Surg 2014 Sep;19(3):499-504. Epub 2014 May 29 doi: 10.1093/icvts/ivu152. PMID: 24876219

Diagnosis

Thromboembolic and bleeding risk in cardiac amyloidosis.
Tana M, Tana C, Rossi D, Mantini C, Gallina S, Ricci F, Porreca E
J Thromb Haemost 2024 Sep;22(9):2381-2392. Epub 2024 May 27 doi: 10.1016/j.jtha.2024.05.018. PMID: 38810701
Therapeutic Approach in Pigmented Purpuric Dermatoses-A Scoping Review.
Kimak A, Żebrowska A
Int J Mol Sci 2024 Feb 24;25(5) doi: 10.3390/ijms25052644. PMID: 38473891Free PMC Article
Risk factors associated with severe dengue in Latin America: A systematic review and meta-analysis.
Paraná VC, Feitosa CA, da Silva GCS, Gois LL, Santos LA
Trop Med Int Health 2024 Mar;29(3):173-191. Epub 2024 Jan 23 doi: 10.1111/tmi.13968. PMID: 38263345
Update in the management of lipedema.
Forner-Cordero I, Forner-Cordero A, Szolnoky G
Int Angiol 2021 Aug;40(4):345-357. Epub 2021 Apr 19 doi: 10.23736/S0392-9590.21.04604-6. PMID: 33870676
What type of valve is most appropriate for osteogenesis imperfecta patients?
Dimitrakakis G, Challoumas D, von Oppell UO
Interact Cardiovasc Thorac Surg 2014 Sep;19(3):499-504. Epub 2014 May 29 doi: 10.1093/icvts/ivu152. PMID: 24876219

Therapy

Thromboembolic and bleeding risk in cardiac amyloidosis.
Tana M, Tana C, Rossi D, Mantini C, Gallina S, Ricci F, Porreca E
J Thromb Haemost 2024 Sep;22(9):2381-2392. Epub 2024 May 27 doi: 10.1016/j.jtha.2024.05.018. PMID: 38810701
Update in the management of lipedema.
Forner-Cordero I, Forner-Cordero A, Szolnoky G
Int Angiol 2021 Aug;40(4):345-357. Epub 2021 Apr 19 doi: 10.23736/S0392-9590.21.04604-6. PMID: 33870676
What type of valve is most appropriate for osteogenesis imperfecta patients?
Dimitrakakis G, Challoumas D, von Oppell UO
Interact Cardiovasc Thorac Surg 2014 Sep;19(3):499-504. Epub 2014 May 29 doi: 10.1093/icvts/ivu152. PMID: 24876219
Negative pressure pulmonary edema.
Louis PJ, Fernandes R
Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2002 Jan;93(1):4-6. doi: 10.1067/moe.2002.119909. PMID: 11805770
Bleeding in uremia.
Rabiner SF
Med Clin North Am 1972 Jan;56(1):221-33. doi: 10.1016/s0025-7125(16)32437-3. PMID: 4550291

Prognosis

Does a negative correlation of heme oxygenase-1 with hematoma thickness in chronic subdural hematomas affect neovascularization and microvascular leakage? A retrospective study with preliminary validation.
Luh HT, Chen KW, Yang LY, Chen YT, Lin SH, Wang KC, Lai DM, Hsieh ST
J Neurosurg 2023 Aug 1;139(2):536-543. Epub 2023 Jan 6 doi: 10.3171/2022.11.JNS221790. PMID: 36609367
Lymphedema treatment decreases pain intensity in lipedema.
Szolnoky G, Varga E, Varga M, Tuczai M, Dósa-Rácz E, Kemény L
Lymphology 2011 Dec;44(4):178-82. PMID: 22458119
Management of the oral manifestations of senile purpura in an edentulous patient: a case report.
da Rosa RS, Garcia RC, Cury AA, Faot F
Spec Care Dentist 2011 May-Jun;31(3):111-3. doi: 10.1111/j.1754-4505.2011.00186.x. PMID: 21592165
Pathogenesis, early diagnosis, and prophylaxis for chronic hemophilic synovitis.
Rodríguez-Merchán EC
Clin Orthop Relat Res 1997 Oct;(343):6-11. PMID: 9345198
Capillary fragility studies in diabetes.
Hart A, Cohen H
Br Med J 1969 Apr 12;2(5649):89-91. doi: 10.1136/bmj.2.5649.89. PMID: 5775455Free PMC Article

Clinical prediction guides

Fragility of pulmonary capillaries.
West JB
J Appl Physiol (1985) 2013 Jul 1;115(1):1-15. Epub 2013 May 2 doi: 10.1152/japplphysiol.00229.2013. PMID: 23640584
Lymphedema treatment decreases pain intensity in lipedema.
Szolnoky G, Varga E, Varga M, Tuczai M, Dósa-Rácz E, Kemény L
Lymphology 2011 Dec;44(4):178-82. PMID: 22458119
Bleeding and bruising in patients with Ehlers-Danlos syndrome and other collagen vascular disorders.
De Paepe A, Malfait F
Br J Haematol 2004 Dec;127(5):491-500. doi: 10.1111/j.1365-2141.2004.05220.x. PMID: 15566352
Bleeding time at altitude.
Doughty HA, Beardmore C
J R Soc Med 1994 Jun;87(6):317-9. doi: 10.1177/014107689408700605. PMID: 7605410Free PMC Article
Haemostatic studies in osteogenesis imperfecta.
Evensen SA, Myhre L, Stormorken H
Scand J Haematol 1984 Aug;33(2):177-9. doi: 10.1111/j.1600-0609.1984.tb02393.x. PMID: 6474094

Recent systematic reviews

Risk factors associated with severe dengue in Latin America: A systematic review and meta-analysis.
Paraná VC, Feitosa CA, da Silva GCS, Gois LL, Santos LA
Trop Med Int Health 2024 Mar;29(3):173-191. Epub 2024 Jan 23 doi: 10.1111/tmi.13968. PMID: 38263345
Calcium dobesilate for diabetic retinopathy: a systematic review and meta-analysis.
Zhang X, Liu W, Wu S, Jin J, Li W, Wang N
Sci China Life Sci 2015 Jan;58(1):101-7. Epub 2014 Dec 20 doi: 10.1007/s11427-014-4792-1. PMID: 25528255
Conservative management of symptomatic and/or complicated haemorrhoids in pregnancy and the puerperium.
Quijano CE, Abalos E
Cochrane Database Syst Rev 2005 Jul 20;2005(3):CD004077. doi: 10.1002/14651858.CD004077.pub2. PMID: 16034920Free PMC Article

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