U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Liver regeneration

MedGen UID:
488965
•Concept ID:
C1318485
•
Disease or Syndrome
SNOMED CT: Liver regeneration (65860006)

Professional guidelines

PubMed

Management of alcoholic hepatitis: A clinical perspective.
Kasper P, Lang S, Steffen HM, Demir M
Liver Int 2023 Oct;43(10):2078-2095. Epub 2023 Aug 22 doi: 10.1111/liv.15701. PMID: 37605624
Mesenchymal stromal cells: promising treatment for liver cirrhosis.
Yao L, Hu X, Dai K, Yuan M, Liu P, Zhang Q, Jiang Y
Stem Cell Res Ther 2022 Jul 15;13(1):308. doi: 10.1186/s13287-022-03001-z. PMID: 35841079Free PMC Article
Molecular pathogenesis of acetaminophen-induced liver injury and its treatment options.
Cai X, Cai H, Wang J, Yang Q, Guan J, Deng J, Chen Z
J Zhejiang Univ Sci B 2022 Apr 15;23(4):265-285. doi: 10.1631/jzus.B2100977. PMID: 35403383Free PMC Article

Recent clinical studies

Etiology

Balance of Gata3 and Ramp2 in hepatocytes regulates hepatic vascular reconstitution in postoperative liver regeneration.
Wang B, Shen H, Wei Y, Liu F, Yang Y, Yu H, Fu J, Cui X, Yu T, Xu Y, Liu Y, Dong H, Shen F, Zhou W, Liu H, Chen Y, Wang H
J Hepatol 2024 Feb;80(2):309-321. Epub 2023 Oct 31 doi: 10.1016/j.jhep.2023.10.016. PMID: 37918568
Magnesium and Liver Metabolism Through the Lifespan.
Bravo M, Simón J, González-Recio I, Martinez-Cruz LA, Goikoetxea-Usandizaga N, Martínez-Chantar ML
Adv Nutr 2023 Jul;14(4):739-751. Epub 2023 May 18 doi: 10.1016/j.advnut.2023.05.009. PMID: 37207838Free PMC Article
Augmenter of liver regeneration: Mitochondrial function and steatohepatitis.
Verma AK, Sharma A, Subramaniyam N, Gandhi CR
J Hepatol 2022 Nov;77(5):1410-1421. Epub 2022 Jun 28 doi: 10.1016/j.jhep.2022.06.019. PMID: 35777586
C-C motif chemokine ligand 5 confines liver regeneration by down-regulating reparative macrophage-derived hepatocyte growth factor in a forkhead box O 3a-dependent manner.
Huang M, Jiao J, Cai H, Zhang Y, Xia Y, Lin J, Shang Z, Qian Y, Wang F, Wu H, Kong X, Gu J
Hepatology 2022 Dec;76(6):1706-1722. Epub 2022 May 5 doi: 10.1002/hep.32458. PMID: 35288960Free PMC Article
Hepatostat: Liver regeneration and normal liver tissue maintenance.
Michalopoulos GK
Hepatology 2017 Apr;65(4):1384-1392. Epub 2017 Mar 6 doi: 10.1002/hep.28988. PMID: 27997988

Diagnosis

Alcohol-Related Liver Disease: Basic Mechanisms and Clinical Perspectives.
Liu SY, Tsai IT, Hsu YC
Int J Mol Sci 2021 May 13;22(10) doi: 10.3390/ijms22105170. PMID: 34068269Free PMC Article
Single-cell genomics and spatial transcriptomics: Discovery of novel cell states and cellular interactions in liver physiology and disease biology.
Saviano A, Henderson NC, Baumert TF
J Hepatol 2020 Nov;73(5):1219-1230. Epub 2020 Jun 10 doi: 10.1016/j.jhep.2020.06.004. PMID: 32534107Free PMC Article
Mesenchymal stromal cells promote liver regeneration through regulation of immune cells.
Hu C, Wu Z, Li L
Int J Biol Sci 2020;16(5):893-903. Epub 2020 Jan 22 doi: 10.7150/ijbs.39725. PMID: 32071558Free PMC Article
Neuropilins and liver.
Elpek GÖ
World J Gastroenterol 2015 Jun 21;21(23):7065-73. doi: 10.3748/wjg.v21.i23.7065. PMID: 26109793Free PMC Article
Hepatocyte transplantation.
Fox IJ, Chowdhury JR
Am J Transplant 2004;4 Suppl 6:7-13. doi: 10.1111/j.1600-6135.2004.0340.x. PMID: 14871269

Therapy

First-in-class MKK4 inhibitors enhance liver regeneration and prevent liver failure.
Zwirner S, Abu Rmilah AA, Klotz S, Pfaffenroth B, Kloevekorn P, Moschopoulou AA, Schuette S, Haag M, Selig R, Li K, Zhou W, Nelson E, Poso A, Chen H, Amiot B, Jia Y, Minshew A, Michalak G, Cui W, Rist E, Longerich T, Jung B, Felgendreff P, Trompak O, Premsrirut PK, Gries K, Muerdter TE, Heinkele G, Wuestefeld T, Shapiro D, Weissbach M, Koenigsrainer A, Sipos B, Ab E, Zacarias MO, Theisgen S, Gruenheit N, Biskup S, Schwab M, Albrecht W, Laufer S, Nyberg S, Zender L
Cell 2024 Mar 28;187(7):1666-1684.e26. Epub 2024 Mar 14 doi: 10.1016/j.cell.2024.02.023. PMID: 38490194Free PMC Article
YAP-TEAD mediates PPAR α-induced hepatomegaly and liver regeneration in mice.
Fan S, Gao Y, Qu A, Jiang Y, Li H, Xie G, Yao X, Yang X, Zhu S, Yagai T, Tian J, Wang R, Gonzalez FJ, Huang M, Bi H
Hepatology 2022 Jan;75(1):74-88. Epub 2021 Dec 15 doi: 10.1002/hep.32105. PMID: 34387904Free PMC Article
Interleukin-22 ameliorates acute-on-chronic liver failure by reprogramming impaired regeneration pathways in mice.
Xiang X, Feng D, Hwang S, Ren T, Wang X, Trojnar E, Matyas C, Mo R, Shang D, He Y, Seo W, Shah VH, Pacher P, Xie Q, Gao B
J Hepatol 2020 Apr;72(4):736-745. Epub 2019 Nov 29 doi: 10.1016/j.jhep.2019.11.013. PMID: 31786256Free PMC Article
Artificial liver support in acute and acute-on-chronic liver failure.
Larsen FS
Curr Opin Crit Care 2019 Apr;25(2):187-191. doi: 10.1097/MCC.0000000000000584. PMID: 30672818
Pharmacological Studies of Artichoke Leaf Extract and Their Health Benefits.
Ben Salem M, Affes H, Ksouda K, Dhouibi R, Sahnoun Z, Hammami S, Zeghal KM
Plant Foods Hum Nutr 2015 Dec;70(4):441-53. doi: 10.1007/s11130-015-0503-8. PMID: 26310198

Prognosis

Balance of Gata3 and Ramp2 in hepatocytes regulates hepatic vascular reconstitution in postoperative liver regeneration.
Wang B, Shen H, Wei Y, Liu F, Yang Y, Yu H, Fu J, Cui X, Yu T, Xu Y, Liu Y, Dong H, Shen F, Zhou W, Liu H, Chen Y, Wang H
J Hepatol 2024 Feb;80(2):309-321. Epub 2023 Oct 31 doi: 10.1016/j.jhep.2023.10.016. PMID: 37918568
Liver Regeneration in Acute on Chronic Liver Failure.
Blake MJ, Steer CJ
Clin Liver Dis 2023 Aug;27(3):595-616. Epub 2023 Apr 23 doi: 10.1016/j.cld.2023.03.005. PMID: 37380285
Orosomucoid in liver diseases.
Elpek GO
World J Gastroenterol 2021 Dec 7;27(45):7739-7747. doi: 10.3748/wjg.v27.i45.7739. PMID: 34963738Free PMC Article
Hepatostat: Liver regeneration and normal liver tissue maintenance.
Michalopoulos GK
Hepatology 2017 Apr;65(4):1384-1392. Epub 2017 Mar 6 doi: 10.1002/hep.28988. PMID: 27997988
alpha-Fetoprotein.
Sell S, Becker FF
J Natl Cancer Inst 1978 Jan;60(1):19-26. doi: 10.1093/jnci/60.1.19. PMID: 75267

Clinical prediction guides

Balance of Gata3 and Ramp2 in hepatocytes regulates hepatic vascular reconstitution in postoperative liver regeneration.
Wang B, Shen H, Wei Y, Liu F, Yang Y, Yu H, Fu J, Cui X, Yu T, Xu Y, Liu Y, Dong H, Shen F, Zhou W, Liu H, Chen Y, Wang H
J Hepatol 2024 Feb;80(2):309-321. Epub 2023 Oct 31 doi: 10.1016/j.jhep.2023.10.016. PMID: 37918568
Single-cell spatial transcriptomics reveals a dynamic control of metabolic zonation and liver regeneration by endothelial cell Wnt2 and Wnt9b.
Hu S, Liu S, Bian Y, Poddar M, Singh S, Cao C, McGaughey J, Bell A, Blazer LL, Adams JJ, Sidhu SS, Angers S, Monga SP
Cell Rep Med 2022 Oct 18;3(10):100754. Epub 2022 Oct 10 doi: 10.1016/j.xcrm.2022.100754. PMID: 36220068Free PMC Article
Hepatectomy-induced apoptotic extracellular vesicles stimulate neutrophils to secrete regenerative growth factors.
Brandel V, Schimek V, Göber S, Hammond T, Brunnthaler L, Schrottmaier WC, Mussbacher M, Sachet M, Liang YY, Reipert S, Ortmayr G, Pereyra D, Santol J, Rainer M, Walterskirchen N, Ramos C, Gerakopoulos V, Rainer C, Spittler A, Weiss T, Kain R, Messner B, Gruenberger T, Assinger A, Oehler R, Starlinger P
J Hepatol 2022 Dec;77(6):1619-1630. Epub 2022 Aug 17 doi: 10.1016/j.jhep.2022.07.027. PMID: 35985549
Endothelial GATA4 controls liver fibrosis and regeneration by preventing a pathogenic switch in angiocrine signaling.
Winkler M, Staniczek T, Kürschner SW, Schmid CD, Schönhaber H, Cordero J, Kessler L, Mathes A, Sticht C, Neßling M, Uvarovskii A, Anders S, Zhang XJ, von Figura G, Hartmann D, Mogler C, Dobreva G, Schledzewski K, Géraud C, Koch PS, Goerdt S
J Hepatol 2021 Feb;74(2):380-393. Epub 2020 Sep 9 doi: 10.1016/j.jhep.2020.08.033. PMID: 32916216
The interaction of hepatic lipid and glucose metabolism in liver diseases.
Bechmann LP, Hannivoort RA, Gerken G, Hotamisligil GS, Trauner M, Canbay A
J Hepatol 2012 Apr;56(4):952-64. Epub 2011 Dec 13 doi: 10.1016/j.jhep.2011.08.025. PMID: 22173168

Recent systematic reviews

Extended liver resection in mice: state of the art and pitfalls-a systematic review.
Kamali C, Kamali K, Brunnbauer P, Splith K, Pratschke J, Schmelzle M, Krenzien F
Eur J Med Res 2021 Jan 9;26(1):6. doi: 10.1186/s40001-020-00478-3. PMID: 33422147Free PMC Article
Clinical Implications of Augmenter of Liver Regeneration in Cancer: A Systematic Review.
Nguyen KH, Nguyen AH, Dabir DV
Anticancer Res 2017 Jul;37(7):3379-3383. doi: 10.21873/anticanres.11704. PMID: 28668825
ALPPS: challenging the concept of unresectability--a systematic review.
Bertens KA, Hawel J, Lung K, Buac S, Pineda-Solis K, Hernandez-Alejandro R
Int J Surg 2015 Jan;13:280-287. Epub 2014 Dec 11 doi: 10.1016/j.ijsu.2014.12.008. PMID: 25496851
Systematic review of pathophysiological changes following hepatic resection.
Siu J, McCall J, Connor S
HPB (Oxford) 2014 May;16(5):407-21. Epub 2013 Aug 29 doi: 10.1111/hpb.12164. PMID: 23991862Free PMC Article
Liver regeneration in surgical animal models - a historical perspective and clinical implications.
Mortensen KE, Revhaug A
Eur Surg Res 2011;46(1):1-18. Epub 2010 Dec 7 doi: 10.1159/000321361. PMID: 21135558

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Consumer resources

    Reviews

    Related information

    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...