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Enlarged ovaries

MedGen UID:
488884
•Concept ID:
C0392039
•
Finding
Synonyms: Large ovary; Ovarian enlargement
SNOMED CT: Ovarian enlargement (66998000); Large ovary (66998000)
 
HPO: HP:0100879

Professional guidelines

PubMed

Do we more often opt for conservative management of ovarian tumors after changing the Dutch national guideline on enlarged ovaries? A nationwide cohort study.
Lems E, Koch AH, Armbrust S, Leemans JC, Bongers MY, Leon-Castillo A, Lok CAR, Geomini PMAJ
Acta Obstet Gynecol Scand 2024 Nov;103(11):2183-2192. Epub 2024 Jul 29 doi: 10.1111/aogs.14912. PMID: 39075824Free PMC Article
Image guided biopsy in the management of cancer of the ovary.
Spencer JA, Anderson K, Weston M, Wilkinson N, Hewitt M
Cancer Imaging 2006 Sep 7;6(1):144-7. doi: 10.1102/1470-7330.2006.0022. PMID: 16966069Free PMC Article
Treatment of true precocious puberty with a potent luteinizing hormone-releasing factor agonist: effect on growth, sexual maturation, pelvic sonography, and the hypothalamic-pituitary-gonadal axis.
Styne DM, Harris DA, Egli CA, Conte FA, Kaplan SL, Rivier J, Vale W, Grumbach MM
J Clin Endocrinol Metab 1985 Jul;61(1):142-51. doi: 10.1210/jcem-61-1-142. PMID: 3923027

Recent clinical studies

Etiology

Dopamine agonists for preventing ovarian hyperstimulation syndrome.
Tang H, Mourad SM, Wang A, Zhai SD, Hart RJ
Cochrane Database Syst Rev 2021 Apr 14;4(4):CD008605. doi: 10.1002/14651858.CD008605.pub4. PMID: 33851429Free PMC Article
2-D and 3-D ultrasonographic characteristics of the ovary in women with PCOS and multifollicular ovaries.
Bozkurt M, Kara Bozkurt D, Kurban D, Takmaz T, Sevket O, Ozcan P
J Obstet Gynaecol 2021 Aug;41(6):920-926. Epub 2020 Oct 16 doi: 10.1080/01443615.2020.1803244. PMID: 33064032
Defining polycystic ovary syndrome phenotype in Vietnamese women.
Cao NT, Le MT, Nguyen VQH, Pilgrim J, Le VNS, Le DD, Pham CK, Aharon D, Hill MJ
J Obstet Gynaecol Res 2019 Nov;45(11):2209-2219. Epub 2019 Aug 21 doi: 10.1111/jog.14097. PMID: 31435998
Dopamine agonists for preventing ovarian hyperstimulation syndrome.
Tang H, Mourad S, Zhai SD, Hart RJ
Cochrane Database Syst Rev 2016 Nov 30;11(11):CD008605. doi: 10.1002/14651858.CD008605.pub3. PMID: 27901279Free PMC Article
Adnexal masses in postmenopausal women.
Rulin MC, Preston AL
Obstet Gynecol 1987 Oct;70(4):578-81. PMID: 3627627

Diagnosis

2-D and 3-D ultrasonographic characteristics of the ovary in women with PCOS and multifollicular ovaries.
Bozkurt M, Kara Bozkurt D, Kurban D, Takmaz T, Sevket O, Ozcan P
J Obstet Gynaecol 2021 Aug;41(6):920-926. Epub 2020 Oct 16 doi: 10.1080/01443615.2020.1803244. PMID: 33064032
Polycystic Ovary Syndrome among Obese Adolescents.
Ybarra M, Franco RR, Cominato L, Sampaio RB, Sucena da Rocha SM, Damiani D
Gynecol Endocrinol 2018 Jan;34(1):45-48. Epub 2017 Jul 29 doi: 10.1080/09513590.2017.1359250. PMID: 28758509
Hyperreactio luteinalis (enlarged ovaries) during the second and third trimesters of pregnancy: common clinical associations.
Lynn KN, Steinkeler JA, Wilkins-Haug LE, Benson CB
J Ultrasound Med 2013 Jul;32(7):1285-9. doi: 10.7863/ultra.32.7.1285. PMID: 23804351
Inactivating mutations of the human luteinizing hormone receptor in both sexes.
Latronico AC, Arnhold IJ
Semin Reprod Med 2012 Oct;30(5):382-6. Epub 2012 Oct 8 doi: 10.1055/s-0032-1324721. PMID: 23044874
Krukenberg's tumour.
Mijinyawa MS, Sani MU, Yusuf SM, Mohammed AZ, Alhassan SU
Niger J Med 2009 Oct-Dec;18(4):416-9. doi: 10.4314/njm.v18i4.51255. PMID: 20120149

Therapy

A promising treatment for spontaneous ovarian hyperstimulation syndrome due to familial partial lipodystrophy: GnRH analogs combined with cyst aspiration.
Gökçay Canpolat A, Aslan B, Şükür YE
Hormones (Athens) 2023 Dec;22(4):741-745. Epub 2023 Jul 25 doi: 10.1007/s42000-023-00469-z. PMID: 37491654
Dopamine agonists for preventing ovarian hyperstimulation syndrome.
Tang H, Mourad SM, Wang A, Zhai SD, Hart RJ
Cochrane Database Syst Rev 2021 Apr 14;4(4):CD008605. doi: 10.1002/14651858.CD008605.pub4. PMID: 33851429Free PMC Article
Dopamine agonists for preventing ovarian hyperstimulation syndrome.
Tang H, Mourad S, Zhai SD, Hart RJ
Cochrane Database Syst Rev 2016 Nov 30;11(11):CD008605. doi: 10.1002/14651858.CD008605.pub3. PMID: 27901279Free PMC Article
Unusual presentations of a girl with Down syndrome: Van Wyk-Grumbach syndrome.
Lim HH, Kil HR, Kim JY
J Pediatr Endocrinol Metab 2012;25(11-12):1209-12. doi: 10.1515/jpem-2012-0195. PMID: 23329774
Inactivating mutations of luteinizing hormone beta-subunit or luteinizing hormone receptor cause oligo-amenorrhea and infertility in women.
Arnhold IJ, Lofrano-Porto A, Latronico AC
Horm Res 2009;71(2):75-82. Epub 2009 Jan 8 doi: 10.1159/000183895. PMID: 19129711

Prognosis

Pediatric ovarian torsion: Follow- up after preservation of ovarian tissue.
Geimanaite L, Trainavicius K
J Pediatr Surg 2019 Jul;54(7):1453-1456. Epub 2019 Feb 22 doi: 10.1016/j.jpedsurg.2019.02.004. PMID: 30851955
Prognostic significance of normal-sized ovary in advanced serous epithelial ovarian cancer.
Paik ES, Kim JH, Kim TJ, Lee JW, Kim BG, Bae DS, Choi CH
J Gynecol Oncol 2018 Jan;29(1):e13. doi: 10.3802/jgo.2018.29.e13. PMID: 29185271Free PMC Article
Krukenberg's tumour.
Mijinyawa MS, Sani MU, Yusuf SM, Mohammed AZ, Alhassan SU
Niger J Med 2009 Oct-Dec;18(4):416-9. doi: 10.4314/njm.v18i4.51255. PMID: 20120149
Adnexal masses in postmenopausal women.
Rulin MC, Preston AL
Obstet Gynecol 1987 Oct;70(4):578-81. PMID: 3627627
A clinical test for prenancy.
Graber EA, Barber HR, O'Rourke JJ
Am J Obstet Gynecol 1970 Nov 15;108(6):991-2. doi: 10.1016/0002-9378(70)90349-2. PMID: 4320999

Clinical prediction guides

2-D and 3-D ultrasonographic characteristics of the ovary in women with PCOS and multifollicular ovaries.
Bozkurt M, Kara Bozkurt D, Kurban D, Takmaz T, Sevket O, Ozcan P
J Obstet Gynaecol 2021 Aug;41(6):920-926. Epub 2020 Oct 16 doi: 10.1080/01443615.2020.1803244. PMID: 33064032
Pediatric ovarian torsion: Follow- up after preservation of ovarian tissue.
Geimanaite L, Trainavicius K
J Pediatr Surg 2019 Jul;54(7):1453-1456. Epub 2019 Feb 22 doi: 10.1016/j.jpedsurg.2019.02.004. PMID: 30851955
Prognostic significance of normal-sized ovary in advanced serous epithelial ovarian cancer.
Paik ES, Kim JH, Kim TJ, Lee JW, Kim BG, Bae DS, Choi CH
J Gynecol Oncol 2018 Jan;29(1):e13. doi: 10.3802/jgo.2018.29.e13. PMID: 29185271Free PMC Article
Polycystic Ovary Syndrome among Obese Adolescents.
Ybarra M, Franco RR, Cominato L, Sampaio RB, Sucena da Rocha SM, Damiani D
Gynecol Endocrinol 2018 Jan;34(1):45-48. Epub 2017 Jul 29 doi: 10.1080/09513590.2017.1359250. PMID: 28758509
Adnexal masses in postmenopausal women.
Rulin MC, Preston AL
Obstet Gynecol 1987 Oct;70(4):578-81. PMID: 3627627

Recent systematic reviews

Dopamine agonists for preventing ovarian hyperstimulation syndrome.
Tang H, Mourad SM, Wang A, Zhai SD, Hart RJ
Cochrane Database Syst Rev 2021 Apr 14;4(4):CD008605. doi: 10.1002/14651858.CD008605.pub4. PMID: 33851429Free PMC Article
Dopamine agonists for preventing ovarian hyperstimulation syndrome.
Tang H, Mourad S, Zhai SD, Hart RJ
Cochrane Database Syst Rev 2016 Nov 30;11(11):CD008605. doi: 10.1002/14651858.CD008605.pub3. PMID: 27901279Free PMC Article

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