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Significant Arterial Dissection

MedGen UID:
476507
•Concept ID:
C3274874
•
Disease or Syndrome

Definition

A dissection that impairs flow. This includes Type C (a persisting contrast medium extravasation) in the presence of ischemia, Type D (a spiral filling defect with delayed but complete distal flow), Type E (persistent filling defect with delayed antegrade flow) and Type F (filling defect with impaired flow and total occlusion). [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVSignificant Arterial Dissection

Professional guidelines

PubMed

Antithrombotic Treatment for Cervical Artery Dissection: A Systematic Review and Individual Patient Data Meta-Analysis.
Kaufmann JE, Harshfield EL, Gensicke H, Wegener S, Michel P, Kägi G, Nedeltchev K, Kellert L, Rosenbaum S, Nolte CH, Christensen H, Arnold M, Lyrer P, Levi C, Bath PM, Engelter ST, Traenka C, Markus HS; CADISS and TREAT-CAD Investigators
JAMA Neurol 2024 Jun 1;81(6):630-637. doi: 10.1001/jamaneurol.2024.1141. PMID: 38739383Free PMC Article
Radial Artery Access Complications: Prevention, Diagnosis and Management.
Roy S, Kabach M, Patel DB, Guzman LA, Jovin IS
Cardiovasc Revasc Med 2022 Jul;40:163-171. Epub 2021 Dec 16 doi: 10.1016/j.carrev.2021.12.007. PMID: 34952824
Optimal Treatment of Uncomplicated Type B Aortic Dissection: JACC Review Topic of the Week.
Tadros RO, Tang GHL, Barnes HJ, Mousavi I, Kovacic JC, Faries P, Olin JW, Marin ML, Adams DH
J Am Coll Cardiol 2019 Sep 17;74(11):1494-1504. doi: 10.1016/j.jacc.2019.07.063. PMID: 31514953

Recent clinical studies

Etiology

OPG/TRAIL ratio as a predictive biomarker of mortality in patients with type A acute aortic dissection.
Lu J, Li P, Ma K, Li Y, Yuan H, Zhu J, Duan W, Ou J, Huang Y, Wu L, Pan X, Zhang H, Du J, Li Y
Nat Commun 2021 Jun 7;12(1):3401. doi: 10.1038/s41467-021-23787-5. PMID: 34099729Free PMC Article
Aortic Dissection: A Review of the Pathophysiology, Management and Prospective Advances.
Sayed A, Munir M, Bahbah EI
Curr Cardiol Rev 2021;17(4):e230421186875. doi: 10.2174/1573403X16666201014142930. PMID: 33059568Free PMC Article
Acute type A aortic dissection - a review.
Gudbjartsson T, Ahlsson A, Geirsson A, Gunn J, Hjortdal V, Jeppsson A, Mennander A, Zindovic I, Olsson C
Scand Cardiovasc J 2020 Feb;54(1):1-13. Epub 2019 Sep 23 doi: 10.1080/14017431.2019.1660401. PMID: 31542960
Insights From the International Registry of Acute Aortic Dissection: A 20-Year Experience of Collaborative Clinical Research.
Evangelista A, Isselbacher EM, Bossone E, Gleason TG, Eusanio MD, Sechtem U, Ehrlich MP, Trimarchi S, Braverman AC, Myrmel T, Harris KM, Hutchinson S, O'Gara P, Suzuki T, Nienaber CA, Eagle KA; IRAD Investigators
Circulation 2018 Apr 24;137(17):1846-1860. doi: 10.1161/CIRCULATIONAHA.117.031264. PMID: 29685932
Migraine stroke.
Bogousslavsky J, Regli F, Van Melle G, Payot M, Uske A
Neurology 1988 Feb;38(2):223-7. doi: 10.1212/wnl.38.2.223. PMID: 3340283

Diagnosis

Loeys-Dietz Syndrome.
Velchev JD, Van Laer L, Luyckx I, Dietz H, Loeys B
Adv Exp Med Biol 2021;1348:251-264. doi: 10.1007/978-3-030-80614-9_11. PMID: 34807423
Aortic Dissection: A Review of the Pathophysiology, Management and Prospective Advances.
Sayed A, Munir M, Bahbah EI
Curr Cardiol Rev 2021;17(4):e230421186875. doi: 10.2174/1573403X16666201014142930. PMID: 33059568Free PMC Article
Acute type A aortic dissection - a review.
Gudbjartsson T, Ahlsson A, Geirsson A, Gunn J, Hjortdal V, Jeppsson A, Mennander A, Zindovic I, Olsson C
Scand Cardiovasc J 2020 Feb;54(1):1-13. Epub 2019 Sep 23 doi: 10.1080/14017431.2019.1660401. PMID: 31542960
Antiplatelet Therapy vs Anticoagulation Therapy in Cervical Artery Dissection: The Cervical Artery Dissection in Stroke Study (CADISS) Randomized Clinical Trial Final Results.
Markus HS, Levi C, King A, Madigan J, Norris J; Cervical Artery Dissection in Stroke Study (CADISS) Investigators
JAMA Neurol 2019 Jun 1;76(6):657-664. doi: 10.1001/jamaneurol.2019.0072. PMID: 30801621Free PMC Article
Insights From the International Registry of Acute Aortic Dissection: A 20-Year Experience of Collaborative Clinical Research.
Evangelista A, Isselbacher EM, Bossone E, Gleason TG, Eusanio MD, Sechtem U, Ehrlich MP, Trimarchi S, Braverman AC, Myrmel T, Harris KM, Hutchinson S, O'Gara P, Suzuki T, Nienaber CA, Eagle KA; IRAD Investigators
Circulation 2018 Apr 24;137(17):1846-1860. doi: 10.1161/CIRCULATIONAHA.117.031264. PMID: 29685932

Therapy

Antithrombotic Treatment for Cervical Artery Dissection: A Systematic Review and Individual Patient Data Meta-Analysis.
Kaufmann JE, Harshfield EL, Gensicke H, Wegener S, Michel P, Kägi G, Nedeltchev K, Kellert L, Rosenbaum S, Nolte CH, Christensen H, Arnold M, Lyrer P, Levi C, Bath PM, Engelter ST, Traenka C, Markus HS; CADISS and TREAT-CAD Investigators
JAMA Neurol 2024 Jun 1;81(6):630-637. doi: 10.1001/jamaneurol.2024.1141. PMID: 38739383Free PMC Article
Diagnostic biomarkers and aortic dissection: a systematic review and meta-analysis.
Chen H, Li Y, Li Z, Shi Y, Zhu H
BMC Cardiovasc Disord 2023 Oct 10;23(1):497. doi: 10.1186/s12872-023-03448-9. PMID: 37817089Free PMC Article
Acute type A aortic dissection - a review.
Gudbjartsson T, Ahlsson A, Geirsson A, Gunn J, Hjortdal V, Jeppsson A, Mennander A, Zindovic I, Olsson C
Scand Cardiovasc J 2020 Feb;54(1):1-13. Epub 2019 Sep 23 doi: 10.1080/14017431.2019.1660401. PMID: 31542960
Antiplatelet Therapy vs Anticoagulation Therapy in Cervical Artery Dissection: The Cervical Artery Dissection in Stroke Study (CADISS) Randomized Clinical Trial Final Results.
Markus HS, Levi C, King A, Madigan J, Norris J; Cervical Artery Dissection in Stroke Study (CADISS) Investigators
JAMA Neurol 2019 Jun 1;76(6):657-664. doi: 10.1001/jamaneurol.2019.0072. PMID: 30801621Free PMC Article
Acute Aortic Dissection and Intramural Hematoma: A Systematic Review.
Mussa FF, Horton JD, Moridzadeh R, Nicholson J, Trimarchi S, Eagle KA
JAMA 2016 Aug 16;316(7):754-63. doi: 10.1001/jama.2016.10026. PMID: 27533160

Prognosis

OPG/TRAIL ratio as a predictive biomarker of mortality in patients with type A acute aortic dissection.
Lu J, Li P, Ma K, Li Y, Yuan H, Zhu J, Duan W, Ou J, Huang Y, Wu L, Pan X, Zhang H, Du J, Li Y
Nat Commun 2021 Jun 7;12(1):3401. doi: 10.1038/s41467-021-23787-5. PMID: 34099729Free PMC Article
Acute type A aortic dissection - a review.
Gudbjartsson T, Ahlsson A, Geirsson A, Gunn J, Hjortdal V, Jeppsson A, Mennander A, Zindovic I, Olsson C
Scand Cardiovasc J 2020 Feb;54(1):1-13. Epub 2019 Sep 23 doi: 10.1080/14017431.2019.1660401. PMID: 31542960
Antiplatelet Therapy vs Anticoagulation Therapy in Cervical Artery Dissection: The Cervical Artery Dissection in Stroke Study (CADISS) Randomized Clinical Trial Final Results.
Markus HS, Levi C, King A, Madigan J, Norris J; Cervical Artery Dissection in Stroke Study (CADISS) Investigators
JAMA Neurol 2019 Jun 1;76(6):657-664. doi: 10.1001/jamaneurol.2019.0072. PMID: 30801621Free PMC Article
Insights From the International Registry of Acute Aortic Dissection: A 20-Year Experience of Collaborative Clinical Research.
Evangelista A, Isselbacher EM, Bossone E, Gleason TG, Eusanio MD, Sechtem U, Ehrlich MP, Trimarchi S, Braverman AC, Myrmel T, Harris KM, Hutchinson S, O'Gara P, Suzuki T, Nienaber CA, Eagle KA; IRAD Investigators
Circulation 2018 Apr 24;137(17):1846-1860. doi: 10.1161/CIRCULATIONAHA.117.031264. PMID: 29685932
Presentation, Diagnosis, and Outcomes of Acute Aortic Dissection: 17-Year Trends From the International Registry of Acute Aortic Dissection.
Pape LA, Awais M, Woznicki EM, Suzuki T, Trimarchi S, Evangelista A, Myrmel T, Larsen M, Harris KM, Greason K, Di Eusanio M, Bossone E, Montgomery DG, Eagle KA, Nienaber CA, Isselbacher EM, O'Gara P
J Am Coll Cardiol 2015 Jul 28;66(4):350-8. doi: 10.1016/j.jacc.2015.05.029. PMID: 26205591

Clinical prediction guides

Association Between Autoimmune Diseases and Spontaneous Cervicocranial Arterial Dissection.
Li H, Song P, Yang W, Yang L, Diao S, Huang S, Wang Y, Xu X, Yang Y
Front Immunol 2021;12:820039. Epub 2022 Jan 21 doi: 10.3389/fimmu.2021.820039. PMID: 35126376Free PMC Article
OPG/TRAIL ratio as a predictive biomarker of mortality in patients with type A acute aortic dissection.
Lu J, Li P, Ma K, Li Y, Yuan H, Zhu J, Duan W, Ou J, Huang Y, Wu L, Pan X, Zhang H, Du J, Li Y
Nat Commun 2021 Jun 7;12(1):3401. doi: 10.1038/s41467-021-23787-5. PMID: 34099729Free PMC Article
Aortic dissection during pregnancy and postpartum.
Meng X, Han J, Wang L, Wu Q
J Card Surg 2021 Jul;36(7):2510-2517. Epub 2021 Apr 29 doi: 10.1111/jocs.15575. PMID: 33928681
Antiplatelet Therapy vs Anticoagulation Therapy in Cervical Artery Dissection: The Cervical Artery Dissection in Stroke Study (CADISS) Randomized Clinical Trial Final Results.
Markus HS, Levi C, King A, Madigan J, Norris J; Cervical Artery Dissection in Stroke Study (CADISS) Investigators
JAMA Neurol 2019 Jun 1;76(6):657-664. doi: 10.1001/jamaneurol.2019.0072. PMID: 30801621Free PMC Article
Insights From the International Registry of Acute Aortic Dissection: A 20-Year Experience of Collaborative Clinical Research.
Evangelista A, Isselbacher EM, Bossone E, Gleason TG, Eusanio MD, Sechtem U, Ehrlich MP, Trimarchi S, Braverman AC, Myrmel T, Harris KM, Hutchinson S, O'Gara P, Suzuki T, Nienaber CA, Eagle KA; IRAD Investigators
Circulation 2018 Apr 24;137(17):1846-1860. doi: 10.1161/CIRCULATIONAHA.117.031264. PMID: 29685932

Recent systematic reviews

Antithrombotic Treatment for Cervical Artery Dissection: A Systematic Review and Individual Patient Data Meta-Analysis.
Kaufmann JE, Harshfield EL, Gensicke H, Wegener S, Michel P, Kägi G, Nedeltchev K, Kellert L, Rosenbaum S, Nolte CH, Christensen H, Arnold M, Lyrer P, Levi C, Bath PM, Engelter ST, Traenka C, Markus HS; CADISS and TREAT-CAD Investigators
JAMA Neurol 2024 Jun 1;81(6):630-637. doi: 10.1001/jamaneurol.2024.1141. PMID: 38739383Free PMC Article
Diagnostic biomarkers and aortic dissection: a systematic review and meta-analysis.
Chen H, Li Y, Li Z, Shi Y, Zhu H
BMC Cardiovasc Disord 2023 Oct 10;23(1):497. doi: 10.1186/s12872-023-03448-9. PMID: 37817089Free PMC Article
Blood Pressure, Hypertension, and the Risk of Aortic Dissection Incidence and Mortality: Results From the J-SCH Study, the UK Biobank Study, and a Meta-Analysis of Cohort Studies.
Hibino M, Otaki Y, Kobeissi E, Pan H, Hibino H, Taddese H, Majeed A, Verma S, Konta T, Yamagata K, Fujimoto S, Tsuruya K, Narita I, Kasahara M, Shibagaki Y, Iseki K, Moriyama T, Kondo M, Asahi K, Watanabe T, Watanabe T, Watanabe M, Aune D
Circulation 2022 Mar;145(9):633-644. Epub 2021 Nov 8 doi: 10.1161/CIRCULATIONAHA.121.056546. PMID: 34743557
Aortic dissection during pregnancy and postpartum.
Meng X, Han J, Wang L, Wu Q
J Card Surg 2021 Jul;36(7):2510-2517. Epub 2021 Apr 29 doi: 10.1111/jocs.15575. PMID: 33928681
Acute Aortic Dissection and Intramural Hematoma: A Systematic Review.
Mussa FF, Horton JD, Moridzadeh R, Nicholson J, Trimarchi S, Eagle KA
JAMA 2016 Aug 16;316(7):754-63. doi: 10.1001/jama.2016.10026. PMID: 27533160

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