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Grade V vesicoureteral reflux

MedGen UID:
475973
•Concept ID:
C3274340
•
Disease or Syndrome
Synonyms: Grade V Vesicoureteral Reflux; Grade V VUR; VUR V
 
HPO: HP:0033740

Definition

Vesicoureteral reflux with massive dilation of the collecting system and severe tortuosity of the ureter. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVGrade V vesicoureteral reflux

Professional guidelines

PubMed

Complete primary repair of bladder exstrophy: a single institution referral experience.
Schaeffer AJ, Stec AA, Purves JT, Cervellione RM, Nelson CP, Gearhart JP
J Urol 2011 Sep;186(3):1041-6. Epub 2011 Jul 23 doi: 10.1016/j.juro.2011.04.099. PMID: 21784464
Total endoscopic and anal irrigation management approach to noncompliant neuropathic bladder in children: a good alternative.
Neel KF
J Urol 2010 Jul;184(1):315-8. Epub 2010 May 20 doi: 10.1016/j.juro.2010.01.058. PMID: 20488484

Recent clinical studies

Etiology

Laparoscopic ureterocystoplasty with Mitrofanoff system.
Landa Juárez S, Fernández AM, Castro NR, De La Cruz Yañez H, Hernández CG
J Laparoendosc Adv Surg Tech A 2014 Jun;24(6):422-7. Epub 2014 Jan 29 doi: 10.1089/lap.2013.0290. PMID: 24475883
Prevalence and predictors of renal functional abnormalities of high grade vesicoureteral reflux.
Hunziker M, Colhoun E, Puri P
J Urol 2013 Oct;190(4 Suppl):1490-4. Epub 2013 Jan 28 doi: 10.1016/j.juro.2013.01.068. PMID: 23369721
Complete primary repair of bladder exstrophy: a single institution referral experience.
Schaeffer AJ, Stec AA, Purves JT, Cervellione RM, Nelson CP, Gearhart JP
J Urol 2011 Sep;186(3):1041-6. Epub 2011 Jul 23 doi: 10.1016/j.juro.2011.04.099. PMID: 21784464
Endoscopic treatment of primary grade V vesicoureteral reflux using hyaluronic acid copolymer (DX/HA).
Hunziker M, Mohanan N, D'Asta F, Puri P
Pediatr Surg Int 2010 Oct;26(10):977-9. doi: 10.1007/s00383-010-2650-1. PMID: 20625750
The role of endoscopic treatment in the management of grade v primary vesicoureteral reflux.
Menezes MN, Puri P
Eur Urol 2007 Nov;52(5):1505-9. Epub 2007 May 7 doi: 10.1016/j.eururo.2007.04.082. PMID: 17517467

Diagnosis

Rare coexistence of Tay-Sachs disease, coarctation of the aorta and grade V vesicoureteral reflux.
Karataş MÇ, Yazıcı H, Bozacı AE, Canda E, Levent E, Uçar SK, Çoker M
Arch Argent Pediatr 2022 Feb;120(1):e25-e28. Epub 2022 Jan 1 doi: 10.5546/aap.2022.eng.e25. PMID: 35068126
A truncating NRIP1 variant in an Arabic family with congenital anomalies of the kidneys and urinary tract.
Zheng B, Wang C, Seltzsam S, Schneider S, Schierbaum L, Wu W, Dai R, Connaughton DM, Nakayama M, Mann N, Bauer SB, Awad HS, Eid LA, Tasic V, Shril S, Hildebrandt F
Am J Med Genet A 2022 Jan;188(1):310-313. Epub 2021 Sep 15 doi: 10.1002/ajmg.a.62502. PMID: 34525250Free PMC Article
Prevalence and predictors of renal functional abnormalities of high grade vesicoureteral reflux.
Hunziker M, Colhoun E, Puri P
J Urol 2013 Oct;190(4 Suppl):1490-4. Epub 2013 Jan 28 doi: 10.1016/j.juro.2013.01.068. PMID: 23369721
The role of endoscopic treatment in the management of grade v primary vesicoureteral reflux.
Menezes MN, Puri P
Eur Urol 2007 Nov;52(5):1505-9. Epub 2007 May 7 doi: 10.1016/j.eururo.2007.04.082. PMID: 17517467
Reflux nephropathy in infancy: a comparison of infants presenting with and without urinary tract infection.
Sweeney B, Cascio S, Velayudham M, Puri P
J Urol 2001 Aug;166(2):648-50. doi: 10.1016/s0022-5347(05)66036-3. PMID: 11458111

Therapy

Laparoscopic ureterocystoplasty with Mitrofanoff system.
Landa Juárez S, Fernández AM, Castro NR, De La Cruz Yañez H, Hernández CG
J Laparoendosc Adv Surg Tech A 2014 Jun;24(6):422-7. Epub 2014 Jan 29 doi: 10.1089/lap.2013.0290. PMID: 24475883
Endoscopic treatment of primary grade V vesicoureteral reflux using hyaluronic acid copolymer (DX/HA).
Hunziker M, Mohanan N, D'Asta F, Puri P
Pediatr Surg Int 2010 Oct;26(10):977-9. doi: 10.1007/s00383-010-2650-1. PMID: 20625750
Total endoscopic and anal irrigation management approach to noncompliant neuropathic bladder in children: a good alternative.
Neel KF
J Urol 2010 Jul;184(1):315-8. Epub 2010 May 20 doi: 10.1016/j.juro.2010.01.058. PMID: 20488484
The role of endoscopic treatment in the management of grade v primary vesicoureteral reflux.
Menezes MN, Puri P
Eur Urol 2007 Nov;52(5):1505-9. Epub 2007 May 7 doi: 10.1016/j.eururo.2007.04.082. PMID: 17517467
Urinary N-acetyl-beta-glucosaminidase as a screening technique for vesicoureteral reflux.
Williams MA, Jones D, Noe HN
Urology 1994 Apr;43(4):528-30. doi: 10.1016/0090-4295(94)90248-8. PMID: 8154076

Prognosis

Rare coexistence of Tay-Sachs disease, coarctation of the aorta and grade V vesicoureteral reflux.
Karataş MÇ, Yazıcı H, Bozacı AE, Canda E, Levent E, Uçar SK, Çoker M
Arch Argent Pediatr 2022 Feb;120(1):e25-e28. Epub 2022 Jan 1 doi: 10.5546/aap.2022.eng.e25. PMID: 35068126
Prevalence and predictors of renal functional abnormalities of high grade vesicoureteral reflux.
Hunziker M, Colhoun E, Puri P
J Urol 2013 Oct;190(4 Suppl):1490-4. Epub 2013 Jan 28 doi: 10.1016/j.juro.2013.01.068. PMID: 23369721
Endoscopic treatment of primary grade V vesicoureteral reflux using hyaluronic acid copolymer (DX/HA).
Hunziker M, Mohanan N, D'Asta F, Puri P
Pediatr Surg Int 2010 Oct;26(10):977-9. doi: 10.1007/s00383-010-2650-1. PMID: 20625750
The role of endoscopic treatment in the management of grade v primary vesicoureteral reflux.
Menezes MN, Puri P
Eur Urol 2007 Nov;52(5):1505-9. Epub 2007 May 7 doi: 10.1016/j.eururo.2007.04.082. PMID: 17517467

Clinical prediction guides

Prevalence and predictors of renal functional abnormalities of high grade vesicoureteral reflux.
Hunziker M, Colhoun E, Puri P
J Urol 2013 Oct;190(4 Suppl):1490-4. Epub 2013 Jan 28 doi: 10.1016/j.juro.2013.01.068. PMID: 23369721
Endoscopic treatment of primary grade V vesicoureteral reflux using hyaluronic acid copolymer (DX/HA).
Hunziker M, Mohanan N, D'Asta F, Puri P
Pediatr Surg Int 2010 Oct;26(10):977-9. doi: 10.1007/s00383-010-2650-1. PMID: 20625750

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