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Colorectal neuroendocrine tumor G1

MedGen UID:
474244
•Concept ID:
C3272611
•
Neoplastic Process
Synonyms: Colorectal Carcinoid Tumor; colorectal carcinoid tumor; colorectal carcinoid tumour; Colorectal NET G1; colorectal NET G1; Colorectal Neuroendocrine Tumor G1; colorectal neuroendocrine tumor G1; colorectum carcinoid tumor; colorectum carcinoid tumour; colorectum NET G1; colorectum neuroendocrine neoplasm G1; colorectum neuroendocrine tumor, well differentiated, low grade; grade 1 neuroendocrine neoplasm of colorectum; Large Intestinal Neuroendocrine Tumor G1; large intestinal neuroendocrine tumor G1; large intestinal neuroendocrine tumour G1
 
Monarch Initiative: MONDO:0006162

Definition

A well differentiated, low grade neuroendocrine neoplasm (carcinoid tumor) that arises from the colon or rectum. The mitotic count is less than 2 per 10 HPF and/or the Ki67 index is equal to or less than 2 percent. [from NCI]

Professional guidelines

PubMed

Small-size (40 µm) Beads Loaded with Irinotecan in the Treatment of Patients with Colorectal Liver Metastases.
Mauri G, Rossi D, Frassoni S, Bonomo G, Camisassi N, Della Vigna P, Bagnardi V, Maiettini D, Varano GM, Zampino MG, Orsi F
Cardiovasc Intervent Radiol 2022 Jun;45(6):770-779. Epub 2022 Jan 14 doi: 10.1007/s00270-021-03039-1. PMID: 35029709
Evaluation of radical surgical treatment in the management of 58 locally advanced rectal neuroendocrine neoplasms, one multicenter retrospective study.
Wang Z, Liu Z, Wen Z, Li R, An K, Mei S, Chen J, Shen H, Li J, Zhao F, Wei F, Xiao T, Liu Q
Eur J Surg Oncol 2021 Dec;47(12):3166-3174. Epub 2021 Jul 15 doi: 10.1016/j.ejso.2021.07.010. PMID: 34294465

Recent clinical studies

Etiology

European Neuroendocrine Tumor Society (ENETS) 2023 guidance paper for colorectal neuroendocrine tumours.
Rinke A, Ambrosini V, Dromain C, Garcia-Carbonero R, Haji A, Koumarianou A, van Dijkum EN, O'Toole D, Rindi G, Scoazec JY, Ramage J
J Neuroendocrinol 2023 Jun;35(6):e13309. Epub 2023 Jun 22 doi: 10.1111/jne.13309. PMID: 37345509
Endoscopically removed rectal NETs: a nationwide cohort study.
Kuiper T, van Oijen MGH, van Velthuysen MF, van Lelyveld N, van Leerdam ME, Vleggaar FD, Klümpen HJ
Int J Colorectal Dis 2021 Mar;36(3):535-541. Epub 2020 Nov 23 doi: 10.1007/s00384-020-03801-w. PMID: 33230657
Detection of NRG1 Gene Fusions in Solid Tumors.
Jonna S, Feldman RA, Swensen J, Gatalica Z, Korn WM, Borghaei H, Ma PC, Nieva JJ, Spira AI, Vanderwalde AM, Wozniak AJ, Kim ES, Liu SV
Clin Cancer Res 2019 Aug 15;25(16):4966-4972. Epub 2019 Apr 15 doi: 10.1158/1078-0432.CCR-19-0160. PMID: 30988082Free PMC Article
Surgical treatment of extra-appendiceal colorectal neuroendocrine tumors.
Maryański J, Cyran-Chlebicka A, Szczepankiewicz B, Cebulski W, Słodkowski M, Wroński M
Pol Przegl Chir 2018 May 16;90(3):7-12. doi: 10.5604/01.3001.0011.8164. PMID: 30015320
Digestive Neuroendocrine Tumor Distribution and Characteristics According to the 2010 WHO Classification: a Single Institution Experience in Lebanon.
Kourie HR, Ghorra C, Rassy M, Kesserouani C, Kattan J
Asian Pac J Cancer Prev 2016;17(5):2679-81. PMID: 27268650

Diagnosis

European Neuroendocrine Tumor Society (ENETS) 2023 guidance paper for colorectal neuroendocrine tumours.
Rinke A, Ambrosini V, Dromain C, Garcia-Carbonero R, Haji A, Koumarianou A, van Dijkum EN, O'Toole D, Rindi G, Scoazec JY, Ramage J
J Neuroendocrinol 2023 Jun;35(6):e13309. Epub 2023 Jun 22 doi: 10.1111/jne.13309. PMID: 37345509
Development of novel prediction models for nodal and distant metastasis in G1 and G2 colorectal neuroendocrine tumors.
Wang Z, Liu Q
Int J Colorectal Dis 2023 Feb 13;38(1):37. doi: 10.1007/s00384-023-04331-x. PMID: 36781493
Colorectal Neuroendocrine Neoplasms: Areas of Unmet Need.
Ramage JK, Valle JW, Nieveen van Dijkum EJM, Sundin A, Pascher A, Couvelard A, Kloeppel G; the ENETS 2016 Munich Advisory Board Participants; ENETS 2016 Munich Advisory Board Participants
Neuroendocrinology 2019;108(1):45-53. Epub 2018 Sep 16 doi: 10.1159/000493767. PMID: 30219817
Surgical treatment of extra-appendiceal colorectal neuroendocrine tumors.
Maryański J, Cyran-Chlebicka A, Szczepankiewicz B, Cebulski W, Słodkowski M, Wroński M
Pol Przegl Chir 2018 May 16;90(3):7-12. doi: 10.5604/01.3001.0011.8164. PMID: 30015320
Progress in new diagnosis and therapeutic strategy for gastrointestinal malignancy: focus on new molecular-targeted treatments.
Sugiyama T
Digestion 2015;91(1):7-12. Epub 2015 Jan 20 doi: 10.1159/000368762. PMID: 25632910

Therapy

Final results of urelumab, an anti-CD137 agonist monoclonal antibody, in combination with cetuximab or nivolumab in patients with advanced solid tumors.
Khushalani NI, Ott PA, Ferris RL, Cascone T, Schadendorf D, Le DT, Sharma MR, Barlesi F, Sharfman W, Luke JJ, Melero I, Lathers D, Neely J, Suryawanshi S, Sanyal A, Holloway JL, Suryawanshi R, Ely S, Segal NH
J Immunother Cancer 2024 Mar 7;12(3) doi: 10.1136/jitc-2023-007364. PMID: 38458639Free PMC Article
First-in-human, open-label, phase 1/2 study of the monoclonal antibody programmed cell death protein-1 (PD-1) inhibitor cetrelimab (JNJ-63723283) in patients with advanced cancers.
Felip E, Moreno V, Morgensztern D, Curigliano G, Rutkowski P, Trigo JM, Calvo A, Kowalski D, Cortinovis D, Plummer R, Maio M, Ascierto PA, Vladimirov VI, Cervantes A, Zudaire E, Hazra A, T'jollyn H, Bandyopadhyay N, Greger JG, Attiyeh E, Xie H, Calvo E
Cancer Chemother Pharmacol 2022 Apr;89(4):499-514. Epub 2022 Mar 17 doi: 10.1007/s00280-022-04414-6. PMID: 35298698Free PMC Article
BRAF(V600E) mutation: A promising target in colorectal neuroendocrine carcinoma.
Dizdar L, Werner TA, Drusenheimer JC, Möhlendick B, Raba K, Boeck I, Anlauf M, Schott M, Göring W, Esposito I, Stoecklein NH, Knoefel WT, Krieg A
Int J Cancer 2019 Mar 15;144(6):1379-1390. Epub 2018 Oct 30 doi: 10.1002/ijc.31828. PMID: 30144031
Digestive Neuroendocrine Tumor Distribution and Characteristics According to the 2010 WHO Classification: a Single Institution Experience in Lebanon.
Kourie HR, Ghorra C, Rassy M, Kesserouani C, Kattan J
Asian Pac J Cancer Prev 2016;17(5):2679-81. PMID: 27268650
Phase I study of every 2- or 3-week dosing of ramucirumab, a human immunoglobulin G1 monoclonal antibody targeting the vascular endothelial growth factor receptor-2 in patients with advanced solid tumors.
Chiorean EG, Hurwitz HI, Cohen RB, Schwartz JD, Dalal RP, Fox FE, Gao L, Sweeney CJ
Ann Oncol 2015 Jun;26(6):1230-1237. Epub 2015 Mar 18 doi: 10.1093/annonc/mdv144. PMID: 25787923

Prognosis

Development of novel prediction models for nodal and distant metastasis in G1 and G2 colorectal neuroendocrine tumors.
Wang Z, Liu Q
Int J Colorectal Dis 2023 Feb 13;38(1):37. doi: 10.1007/s00384-023-04331-x. PMID: 36781493
Rectal neuroendocrine tumor with extracapsular lymph node metastasis: a case report.
Sakamoto A, Nozawa H, Sonoda H, Hinata M, Ishii H, Emoto S, Anzai H, Yokoyama Y, Murono K, Sasaki K, Kawai K, Ushiku T, Ishihara S
Clin J Gastroenterol 2021 Oct;14(5):1426-1430. Epub 2021 May 24 doi: 10.1007/s12328-021-01447-x. PMID: 34028785
BRAF(V600E) mutation: A promising target in colorectal neuroendocrine carcinoma.
Dizdar L, Werner TA, Drusenheimer JC, Möhlendick B, Raba K, Boeck I, Anlauf M, Schott M, Göring W, Esposito I, Stoecklein NH, Knoefel WT, Krieg A
Int J Cancer 2019 Mar 15;144(6):1379-1390. Epub 2018 Oct 30 doi: 10.1002/ijc.31828. PMID: 30144031
Surgical treatment of extra-appendiceal colorectal neuroendocrine tumors.
Maryański J, Cyran-Chlebicka A, Szczepankiewicz B, Cebulski W, Słodkowski M, Wroński M
Pol Przegl Chir 2018 May 16;90(3):7-12. doi: 10.5604/01.3001.0011.8164. PMID: 30015320
Digestive Neuroendocrine Tumor Distribution and Characteristics According to the 2010 WHO Classification: a Single Institution Experience in Lebanon.
Kourie HR, Ghorra C, Rassy M, Kesserouani C, Kattan J
Asian Pac J Cancer Prev 2016;17(5):2679-81. PMID: 27268650

Clinical prediction guides

Lateral pelvic lymph nodes dissection of rectal neuroendocrine neoplasms: A prospective case-series and literature review.
Zhang Y, Yang Y, Gao C, Zhao H, Zhou H
Surgery 2024 Nov;176(5):1360-1365. Epub 2024 Aug 14 doi: 10.1016/j.surg.2024.07.004. PMID: 39147667
Final results of urelumab, an anti-CD137 agonist monoclonal antibody, in combination with cetuximab or nivolumab in patients with advanced solid tumors.
Khushalani NI, Ott PA, Ferris RL, Cascone T, Schadendorf D, Le DT, Sharma MR, Barlesi F, Sharfman W, Luke JJ, Melero I, Lathers D, Neely J, Suryawanshi S, Sanyal A, Holloway JL, Suryawanshi R, Ely S, Segal NH
J Immunother Cancer 2024 Mar 7;12(3) doi: 10.1136/jitc-2023-007364. PMID: 38458639Free PMC Article
Development of novel prediction models for nodal and distant metastasis in G1 and G2 colorectal neuroendocrine tumors.
Wang Z, Liu Q
Int J Colorectal Dis 2023 Feb 13;38(1):37. doi: 10.1007/s00384-023-04331-x. PMID: 36781493
The ENETS TNM staging and grading system accurately predict prognosis in patients with rectal NENs.
Capurso G, Gaujoux S, Pescatori LC, Panzuto F, Panis Y, Pilozzi E, Terris B, de Mestier L, Prat F, Rinzivillo M, Coriat R, Coulevard A, Delle Fave G, Ruszniewski P
Dig Liver Dis 2019 Dec;51(12):1725-1730. Epub 2019 Aug 9 doi: 10.1016/j.dld.2019.07.011. PMID: 31405587
The clinicopathological significance of angiogenesis in hindgut neuroendocrine tumors obtained via an endoscopic procedure.
Okubo Y, Motohashi O, Nakayama N, Nishimura K, Kasajima R, Miyagi Y, Shiozawa M, Yoshioka E, Suzuki M, Washimi K, Kawachi K, Nito M, Kameda Y, Yokose T
Diagn Pathol 2016 Nov 8;11(1):128. doi: 10.1186/s13000-016-0580-5. PMID: 27821179Free PMC Article

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