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Retinopathy of prematurity stage 2

MedGen UID:
473428
Concept ID:
C1443382
Disease or Syndrome
Synonyms: Retinopathy of prematurity stage 2 - intraretinal ridge; Retinopathy of Prematurity Stage 2 Intraretinal Ridge; ROP stage 2
SNOMED CT: Retinopathy of prematurity stage 2 - intraretinal ridge (408848001)
 
HPO: HP:0500051

Definition

The accumulating neovascularization thickens and manifests as a linear bump. The neovascularization remains along the surface of the retina and does not extend off the retina into the cortical vitreous. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVRetinopathy of prematurity stage 2

Professional guidelines

PubMed

Dumbrăveanu L, Cușnir V, Bobescu D
Rom J Ophthalmol 2021 Oct-Dec;65(4):315-329. doi: 10.22336/rjo.2021.66. PMID: 35087972Free PMC Article
Hartnett ME
Curr Opin Ophthalmol 2017 May;28(3):282-288. doi: 10.1097/ICU.0000000000000360. PMID: 28141765Free PMC Article
Stahl A, Göpel W
Dtsch Arztebl Int 2015 Oct 23;112(43):730-5. doi: 10.3238/arztebl.2015.0730. PMID: 26568177Free PMC Article

Recent clinical studies

Etiology

Glaser K, Härtel C, Dammann O, Herting E, Andres O, Speer CP, Göpel W, Stahl A; German Neonatal Network
Acta Paediatr 2023 Dec;112(12):2507-2515. Epub 2023 Sep 4 doi: 10.1111/apa.16965. PMID: 37667535
Ahmed I, Hoyek S, Patel NA
Semin Ophthalmol 2023 Feb;38(2):151-157. Epub 2022 Nov 30 doi: 10.1080/08820538.2022.2152708. PMID: 36448810
Ge G, Zhang Y, Zhang M
Acta Ophthalmol 2021 Dec;99(8):e1263-e1273. Epub 2021 Feb 21 doi: 10.1111/aos.14827. PMID: 33611839
Simkin SK, Misra SL, Han JV, McGhee CNJ, Dai S
Clin Exp Ophthalmol 2019 Dec;47(9):1122-1130. Epub 2019 Aug 7 doi: 10.1111/ceo.13593. PMID: 31313447
Ahmad M, Patnaik J, Thevarajah T, Cathcart J, Jung J, Singh J, Braverman R, Lynch A, McCourt E
J AAPOS 2019 Apr;23(2):90.e1-90.e6. Epub 2019 Feb 14 doi: 10.1016/j.jaapos.2018.10.012. PMID: 30772472

Diagnosis

Dumbrăveanu L, Cușnir V, Bobescu D
Rom J Ophthalmol 2021 Oct-Dec;65(4):315-329. doi: 10.22336/rjo.2021.66. PMID: 35087972Free PMC Article
Chiang MF, Quinn GE, Fielder AR, Ostmo SR, Paul Chan RV, Berrocal A, Binenbaum G, Blair M, Peter Campbell J, Capone A Jr, Chen Y, Dai S, Ells A, Fleck BW, Good WV, Elizabeth Hartnett M, Holmstrom G, Kusaka S, Kychenthal A, Lepore D, Lorenz B, Martinez-Castellanos MA, Özdek Ş, Ademola-Popoola D, Reynolds JD, Shah PK, Shapiro M, Stahl A, Toth C, Vinekar A, Visser L, Wallace DK, Wu WC, Zhao P, Zin A
Ophthalmology 2021 Oct;128(10):e51-e68. Epub 2021 Jul 8 doi: 10.1016/j.ophtha.2021.05.031. PMID: 34247850Free PMC Article
Hellström A, Nilsson AK, Wackernagel D, Pivodic A, Vanpee M, Sjöbom U, Hellgren G, Hallberg B, Domellöf M, Klevebro S, Hellström W, Andersson M, Lund AM, Löfqvist C, Elfvin A, Sävman K, Hansen-Pupp I, Hård AL, Smith LEH, Ley D
JAMA Pediatr 2021 Apr 1;175(4):359-367. doi: 10.1001/jamapediatrics.2020.5653. PMID: 33523106Free PMC Article
Scruggs BA, Chan RVP, Kalpathy-Cramer J, Chiang MF, Campbell JP
Transl Vis Sci Technol 2020 Feb 10;9(2):5. doi: 10.1167/tvst.9.2.5. PMID: 32704411Free PMC Article
Stahl A, Göpel W
Dtsch Arztebl Int 2015 Oct 23;112(43):730-5. doi: 10.3238/arztebl.2015.0730. PMID: 26568177Free PMC Article

Therapy

Schmitz T, Doret-Dion M, Sentilhes L, Parant O, Claris O, Renesme L, Abbal J, Girault A, Torchin H, Houllier M, Le Saché N, Vivanti AJ, De Luca D, Winer N, Flamant C, Thuillier C, Boileau P, Blanc J, Brevaut V, Bouet PE, Gascoin G, Beucher G, Datin-Dorriere V, Bounan S, Bolot P, Poncelet C, Alberti C, Ursino M, Aupiais C, Baud O; BETADOSE trial study group; Groupe de Recherche en Obstétrique et Gynécologie
Lancet 2022 Aug 20;400(10352):592-604. doi: 10.1016/S0140-6736(22)01535-5. PMID: 35988568
Stahl A, Sukgen EA, Wu WC, Lepore D, Nakanishi H, Mazela J, Moshfeghi DM, Vitti R, Athanikar A, Chu K, Iveli P, Zhao F, Schmelter T, Leal S, Köfüncü E, Azuma N; FIREFLEYE Study Group
JAMA 2022 Jul 26;328(4):348-359. doi: 10.1001/jama.2022.10564. PMID: 35881122Free PMC Article
Dumbrăveanu L, Cușnir V, Bobescu D
Rom J Ophthalmol 2021 Oct-Dec;65(4):315-329. doi: 10.22336/rjo.2021.66. PMID: 35087972Free PMC Article
Hellström A, Nilsson AK, Wackernagel D, Pivodic A, Vanpee M, Sjöbom U, Hellgren G, Hallberg B, Domellöf M, Klevebro S, Hellström W, Andersson M, Lund AM, Löfqvist C, Elfvin A, Sävman K, Hansen-Pupp I, Hård AL, Smith LEH, Ley D
JAMA Pediatr 2021 Apr 1;175(4):359-367. doi: 10.1001/jamapediatrics.2020.5653. PMID: 33523106Free PMC Article
Stahl A, Göpel W
Dtsch Arztebl Int 2015 Oct 23;112(43):730-5. doi: 10.3238/arztebl.2015.0730. PMID: 26568177Free PMC Article

Prognosis

Ling XC, Kang EY, Chen KJ, Wang NK, Liu L, Chen YP, Hwang YS, Lai CC, Yang SF, Wu WC
Invest Ophthalmol Vis Sci 2023 Jun 1;64(7):11. doi: 10.1167/iovs.64.7.11. PMID: 37272765Free PMC Article
Dumbrăveanu L, Cușnir V, Bobescu D
Rom J Ophthalmol 2021 Oct-Dec;65(4):315-329. doi: 10.22336/rjo.2021.66. PMID: 35087972Free PMC Article
Cao Y, Jiang S, Sun J, Hei M, Wang L, Zhang H, Ma X, Wu H, Li X, Sun H, Zhou W, Shi Y, Wang Y, Gu X, Yang T, Lu Y, Du L, Chen C, Lee SK, Zhou W; Chinese Neonatal Network
JAMA Netw Open 2021 Aug 2;4(8):e2118904. doi: 10.1001/jamanetworkopen.2021.18904. PMID: 34338792Free PMC Article
Ge G, Zhang Y, Zhang M
Acta Ophthalmol 2021 Dec;99(8):e1263-e1273. Epub 2021 Feb 21 doi: 10.1111/aos.14827. PMID: 33611839
Ancel PY, Goffinet F; EPIPAGE-2 Writing Group, Kuhn P, Langer B, Matis J, Hernandorena X, Chabanier P, Joly-Pedespan L, Lecomte B, Vendittelli F, Dreyfus M, Guillois B, Burguet A, Sagot P, Sizun J, Beuchée A, Rouget F, Favreau A, Saliba E, Bednarek N, Morville P, Thiriez G, Marpeau L, Marret S, Kayem G, Durrmeyer X, Granier M, Baud O, Jarreau PH, Mitanchez D, Boileau P, Boulot P, Cambonie G, Daudé H, Bédu A, Mons F, Fresson J, Vieux R, Alberge C, Arnaud C, Vayssière C, Truffert P, Pierrat V, Subtil D, D'Ercole C, Gire C, Simeoni U, Bongain A, Sentilhes L, Rozé JC, Gondry J, Leke A, Deiber M, Claris O, Picaud JC, Ego A, Debillon T, Poulichet A, Coliné E, Favre A, Fléchelles O, Samperiz S, Ramful D, Branger B, Benhammou V, Foix-L'Hélias L, Marchand-Martin L, Kaminski M
JAMA Pediatr 2015 Mar;169(3):230-8. doi: 10.1001/jamapediatrics.2014.3351. PMID: 25621457

Clinical prediction guides

Ling XC, Kang EY, Chen KJ, Wang NK, Liu L, Chen YP, Hwang YS, Lai CC, Yang SF, Wu WC
Invest Ophthalmol Vis Sci 2023 Jun 1;64(7):11. doi: 10.1167/iovs.64.7.11. PMID: 37272765Free PMC Article
Zimmermann DL, Schned H, Unterasinger L, Kirchner L, Fuiko R, Olischar M, Klebermass-Schrehof K, Berger A, Weninger M, Giordano V
Neonatology 2023;120(3):317-324. Epub 2023 Mar 30 doi: 10.1159/000529594. PMID: 36996795
Boskabadi H, Shoeibi N, Bagheri F, Pourbadakhshan N, Moradi A, Zakerihamidi M
Curr Pediatr Rev 2023;19(2):197-202. doi: 10.2174/1573396318666220819151154. PMID: 35986544
Padidam S, Le K, Lin X
J Pediatr Ophthalmol Strabismus 2018 Nov 19;55(6):403-406. doi: 10.3928/01913913-20180905-02. PMID: 30452767
Cayabyab R, Ramanathan R
Neonatology 2016;109(4):369-76. Epub 2016 Jun 3 doi: 10.1159/000444901. PMID: 27251645

Recent systematic reviews

Shafique MA, Haseeb A, Uddin MMN, Asghar B, Chaudhry ER, Raqib MA, Ali SMS, Mustafa MS
Am J Ophthalmol 2024 Mar;259:141-150. Epub 2023 Nov 17 doi: 10.1016/j.ajo.2023.11.012. PMID: 37979602
Albertella M, Gentyala RR, Paraskevas T, Ehret D, Bruschettini M, Soll R
Cochrane Database Syst Rev 2023 Oct 9;10(10):CD013232. doi: 10.1002/14651858.CD013232.pub2. PMID: 37811631Free PMC Article
Wang X, Tang K, Chen L, Cheng S, Xu H
BMJ Open 2019 May 24;9(5):e025440. doi: 10.1136/bmjopen-2018-025440. PMID: 31129577Free PMC Article
Azami M, Jaafari Z, Rahmati S, Farahani AD, Badfar G
BMC Ophthalmol 2018 Apr 2;18(1):83. doi: 10.1186/s12886-018-0732-3. PMID: 29606108Free PMC Article
Kaempfen S, Neumann RP, Jost K, Schulzke SM
Cochrane Database Syst Rev 2018 Mar 2;3(3):CD011893. doi: 10.1002/14651858.CD011893.pub2. PMID: 29499081Free PMC Article

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