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Increased body mass index

MedGen UID:
472957
•Concept ID:
C0231254
•
Finding
Synonym: Increased BMI
SNOMED CT: Body mass index above normal parameters (48499001); Increased body mass index (48499001)
 
HPO: HP:0031418

Definition

Abnormally increased weight-to-height squared ratio, calculated by dividing the individual's weight in kilograms by the square of the individual's height in meters and used as an indicator of overweight compared to averages. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVIncreased body mass index

Conditions with this feature

X-linked intellectual disability-short stature-overweight syndrome
MedGen UID:
901885
•Concept ID:
C0796218
•
Disease or Syndrome
X-linked intellectual developmental disorder-12 (XLID12) is characterized by borderline to severe intellectual disability with variable neurologic features, short stature, and elevated body mass index (BMI) (Kumar et al., 2015).
See: Condition Record
Congenital nongoitrous hypothyroidism 6
MedGen UID:
482447
•Concept ID:
C3280817
•
Disease or Syndrome
Any hypothyroidism, congenital, nongoitrous in which the cause of the disease is a mutation in the THRA gene.
See: Condition Record
Congenital nongoitrous hypothyroidism 6
X-linked intellectual disability-short stature-overweight syndrome

Professional guidelines

PubMed

Economic burden of nonoperative treatment of adult spinal deformity.
Passias PG, Ahmad W, Dave P, Lafage R, Lafage V, Mir J, Klineberg EO, Kabeish KM, Gum JL, Line BG, Hart R, Burton D, Smith JS, Ames CP, Shaffrey CI, Schwab F, Hostin R, Buell T, Hamilton DK, Bess S
J Neurosurg Spine 2023 Dec 1;39(6):751-756. Epub 2023 Sep 15 doi: 10.3171/2023.7.SPINE23195. PMID: 37728175
Identification and Management of Night Eating Syndrome in the Adolescent and Young Adult Population.
Lepley T, Schwager Z, Khalid Z
Prim Care Companion CNS Disord 2022 Feb 17;24(1) doi: 10.4088/PCC.21r03062. PMID: 35180815
Esophageal hiatal hernia: risk, diagnosis and management.
Yu HX, Han CS, Xue JR, Han ZF, Xin H
Expert Rev Gastroenterol Hepatol 2018 Apr;12(4):319-329. Epub 2018 Feb 22 doi: 10.1080/17474124.2018.1441711. PMID: 29451037

Recent clinical studies

Etiology

Obesity, metabolic syndrome, and primary hypertension.
Litwin M, Kułaga Z
Pediatr Nephrol 2021 Apr;36(4):825-837. Epub 2020 May 9 doi: 10.1007/s00467-020-04579-3. PMID: 32388582Free PMC Article
Skin changes in the obese patient.
Hirt PA, Castillo DE, Yosipovitch G, Keri JE
J Am Acad Dermatol 2019 Nov;81(5):1037-1057. doi: 10.1016/j.jaad.2018.12.070. PMID: 31610857
Plantar Fasciitis.
Trojian T, Tucker AK
Am Fam Physician 2019 Jun 15;99(12):744-750. PMID: 31194492
The Impact of Childhood and Adolescent Obesity on Cardiovascular Risk in Adulthood: a Systematic Review.
Sommer A, Twig G
Curr Diab Rep 2018 Aug 30;18(10):91. doi: 10.1007/s11892-018-1062-9. PMID: 30167798
Esophageal hiatal hernia: risk, diagnosis and management.
Yu HX, Han CS, Xue JR, Han ZF, Xin H
Expert Rev Gastroenterol Hepatol 2018 Apr;12(4):319-329. Epub 2018 Feb 22 doi: 10.1080/17474124.2018.1441711. PMID: 29451037

Diagnosis

Sarcopenic obesity is associated with cognitive impairment in community-dwelling older adults: The Bunkyo Health Study.
Someya Y, Tamura Y, Kaga H, Sugimoto D, Kadowaki S, Suzuki R, Aoki S, Hattori N, Motoi Y, Shimada K, Daida H, Ishijima M, Kaneko K, Nojiri S, Kawamori R, Watada H
Clin Nutr 2022 May;41(5):1046-1051. Epub 2022 Mar 16 doi: 10.1016/j.clnu.2022.03.017. PMID: 35390728
Overweight, obesity and assisted reproduction: A systematic review and meta-analysis.
Ribeiro LM, Sasaki LMP, Silva AA, Souza ES, Oliveira Lyrio A, C M G Figueiredo A, Gottems LBD
Eur J Obstet Gynecol Reprod Biol 2022 Apr;271:117-127. Epub 2022 Jan 31 doi: 10.1016/j.ejogrb.2022.01.019. PMID: 35183001
Skin changes in the obese patient.
Hirt PA, Castillo DE, Yosipovitch G, Keri JE
J Am Acad Dermatol 2019 Nov;81(5):1037-1057. doi: 10.1016/j.jaad.2018.12.070. PMID: 31610857
Plantar Fasciitis.
Trojian T, Tucker AK
Am Fam Physician 2019 Jun 15;99(12):744-750. PMID: 31194492
Esophageal hiatal hernia: risk, diagnosis and management.
Yu HX, Han CS, Xue JR, Han ZF, Xin H
Expert Rev Gastroenterol Hepatol 2018 Apr;12(4):319-329. Epub 2018 Feb 22 doi: 10.1080/17474124.2018.1441711. PMID: 29451037

Therapy

Myocardial Tissue-Level Characteristics of Adults With Metabolically Healthy Obesity.
Zhao H, Huang R, Jiang M, Wang W, Chai Y, Liu Q, Zhang W, Han Y, Yan F, Lu Q, Tao Z, Wu Q, Yue J, Ma J, Pu J
JACC Cardiovasc Imaging 2023 Jul;16(7):889-901. Epub 2023 Apr 12 doi: 10.1016/j.jcmg.2023.01.022. PMID: 37052557
Overweight, obesity and assisted reproduction: A systematic review and meta-analysis.
Ribeiro LM, Sasaki LMP, Silva AA, Souza ES, Oliveira Lyrio A, C M G Figueiredo A, Gottems LBD
Eur J Obstet Gynecol Reprod Biol 2022 Apr;271:117-127. Epub 2022 Jan 31 doi: 10.1016/j.ejogrb.2022.01.019. PMID: 35183001
Esophageal hiatal hernia: risk, diagnosis and management.
Yu HX, Han CS, Xue JR, Han ZF, Xin H
Expert Rev Gastroenterol Hepatol 2018 Apr;12(4):319-329. Epub 2018 Feb 22 doi: 10.1080/17474124.2018.1441711. PMID: 29451037
Chemistry behind Vegetarianism.
Li D
J Agric Food Chem 2011 Feb 9;59(3):777-84. Epub 2011 Jan 4 doi: 10.1021/jf103846u. PMID: 21204526
Body-mass index and incidence of cancer: a systematic review and meta-analysis of prospective observational studies.
Renehan AG, Tyson M, Egger M, Heller RF, Zwahlen M
Lancet 2008 Feb 16;371(9612):569-78. doi: 10.1016/S0140-6736(08)60269-X. PMID: 18280327

Prognosis

Contributors to impaired bone health in type 2 diabetes.
Sheu A, Greenfield JR, White CP, Center JR
Trends Endocrinol Metab 2023 Jan;34(1):34-48. Epub 2022 Nov 23 doi: 10.1016/j.tem.2022.11.003. PMID: 36435679
Obesity, metabolic syndrome, and cancer: pathophysiological and therapeutic associations.
Mili N, Paschou SA, Goulis DG, Dimopoulos MA, Lambrinoudaki I, Psaltopoulou T
Endocrine 2021 Dec;74(3):478-497. Epub 2021 Oct 8 doi: 10.1007/s12020-021-02884-x. PMID: 34625915
Epidemiology of meningiomas.
Walsh KM
Handb Clin Neurol 2020;169:3-15. doi: 10.1016/B978-0-12-804280-9.00001-9. PMID: 32553297
Short sleep duration is associated with reduced leptin, elevated ghrelin, and increased body mass index.
Taheri S, Lin L, Austin D, Young T, Mignot E
PLoS Med 2004 Dec;1(3):e62. Epub 2004 Dec 7 doi: 10.1371/journal.pmed.0010062. PMID: 15602591Free PMC Article
Obesity and the risk of heart failure.
Kenchaiah S, Evans JC, Levy D, Wilson PW, Benjamin EJ, Larson MG, Kannel WB, Vasan RS
N Engl J Med 2002 Aug 1;347(5):305-13. doi: 10.1056/NEJMoa020245. PMID: 12151467

Clinical prediction guides

Breakfast skipping and traits of cardiometabolic health: A mendelian randomization study.
Xia M, Zhong Y, Peng Y, Qian C
Clin Nutr ESPEN 2024 Feb;59:328-333. Epub 2023 Dec 30 doi: 10.1016/j.clnesp.2023.12.149. PMID: 38220394
Myocardial Tissue-Level Characteristics of Adults With Metabolically Healthy Obesity.
Zhao H, Huang R, Jiang M, Wang W, Chai Y, Liu Q, Zhang W, Han Y, Yan F, Lu Q, Tao Z, Wu Q, Yue J, Ma J, Pu J
JACC Cardiovasc Imaging 2023 Jul;16(7):889-901. Epub 2023 Apr 12 doi: 10.1016/j.jcmg.2023.01.022. PMID: 37052557
Obesity, metabolic syndrome, and primary hypertension.
Litwin M, Kułaga Z
Pediatr Nephrol 2021 Apr;36(4):825-837. Epub 2020 May 9 doi: 10.1007/s00467-020-04579-3. PMID: 32388582Free PMC Article
Diabetes in HFE Hemochromatosis.
Barton JC, Acton RT
J Diabetes Res 2017;2017:9826930. Epub 2017 Feb 26 doi: 10.1155/2017/9826930. PMID: 28331855Free PMC Article
Short sleep duration is associated with reduced leptin, elevated ghrelin, and increased body mass index.
Taheri S, Lin L, Austin D, Young T, Mignot E
PLoS Med 2004 Dec;1(3):e62. Epub 2004 Dec 7 doi: 10.1371/journal.pmed.0010062. PMID: 15602591Free PMC Article

Recent systematic reviews

Overweight, obesity and assisted reproduction: A systematic review and meta-analysis.
Ribeiro LM, Sasaki LMP, Silva AA, Souza ES, Oliveira Lyrio A, C M G Figueiredo A, Gottems LBD
Eur J Obstet Gynecol Reprod Biol 2022 Apr;271:117-127. Epub 2022 Jan 31 doi: 10.1016/j.ejogrb.2022.01.019. PMID: 35183001
Obesity and anxiety symptoms: a systematic review and meta-analysis.
Amiri S, Behnezhad S
Neuropsychiatr 2019 Jun;33(2):72-89. Epub 2019 Feb 18 doi: 10.1007/s40211-019-0302-9. PMID: 30778841
The Impact of Childhood and Adolescent Obesity on Cardiovascular Risk in Adulthood: a Systematic Review.
Sommer A, Twig G
Curr Diab Rep 2018 Aug 30;18(10):91. doi: 10.1007/s11892-018-1062-9. PMID: 30167798
"Generalized osteoarthritis": a systematic review.
Nelson AE, Smith MW, Golightly YM, Jordan JM
Semin Arthritis Rheum 2014 Jun;43(6):713-20. Epub 2013 Dec 31 doi: 10.1016/j.semarthrit.2013.12.007. PMID: 24461078Free PMC Article
Body-mass index and incidence of cancer: a systematic review and meta-analysis of prospective observational studies.
Renehan AG, Tyson M, Egger M, Heller RF, Zwahlen M
Lancet 2008 Feb 16;371(9612):569-78. doi: 10.1016/S0140-6736(08)60269-X. PMID: 18280327

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