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Treatment resistant depression

MedGen UID:
453214
Concept ID:
C2063866
Mental or Behavioral Dysfunction
Synonyms: Depression, Refractory; Depression, Therapy-Resistant; Depression, Treatment Resistant; Depressions, Refractory; Depressions, Therapy-Resistant; Depressions, Treatment Resistant; Depressive Disorder, Treatment Resistant; Depressive Disorder, Treatment-Resistant; Depressive Disorders, Treatment-Resistant; Disorder, Treatment-Resistant Depressive; Disorders, Treatment-Resistant Depressive; Refractory Depression; Refractory Depressions; Resistant Depression, Treatment; Resistant Depressions, Treatment; Therapy Resistant Depression; Therapy-Resistant Depression; Therapy-Resistant Depressions; Treatment Resistant Depression; Treatment Resistant Depressions; Treatment-Resistant Depressive Disorder; Treatment-Resistant Depressive Disorders
SNOMED CT: Treatment resistant depression (1153570009)

Definition

Failure to respond to two or more trials of antidepressant monotherapy or failure to respond to four or more trials of different antidepressant therapies. (Campbell''s Psychiatric Dictionary, 9th ed.) [from MeSH]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVTreatment resistant depression

Professional guidelines

PubMed

Kverno KS, Mangano E
J Psychosoc Nurs Ment Health Serv 2021 Sep;59(9):7-11. Epub 2021 Sep 1 doi: 10.3928/02793695-20210816-01. PMID: 34459676
Swainson J, Thomas RK, Archer S, Chrenek C, MacKay MA, Baker G, Dursun S, Klassen LJ, Chokka P, Demas ML
Expert Rev Neurother 2019 Oct;19(10):899-911. Epub 2019 Jul 16 doi: 10.1080/14737175.2019.1640604. PMID: 31282772
Pandarakalam JP
Psychiatr Danub 2018 Sep;30(3):273-284. doi: 10.24869/psyd.2018.273. PMID: 30267518

Recent clinical studies

Etiology

Vas C, Jain A, Trivedi M, Jha MK, Mathew SJ
Psychiatr Clin North Am 2023 Jun;46(2):261-275. Epub 2023 Mar 25 doi: 10.1016/j.psc.2023.02.012. PMID: 37149344
Meshkat S, Haikazian S, Di Vincenzo JD, Fancy F, Johnson D, Chen-Li D, McIntyre RS, Mansur R, Rosenblat JD
World J Biol Psychiatry 2023 Sep-Oct;24(7):545-557. Epub 2023 Jan 31 doi: 10.1080/15622975.2023.2169349. PMID: 36651238
Cole EJ, Phillips AL, Bentzley BS, Stimpson KH, Nejad R, Barmak F, Veerapal C, Khan N, Cherian K, Felber E, Brown R, Choi E, King S, Pankow H, Bishop JH, Azeez A, Coetzee J, Rapier R, Odenwald N, Carreon D, Hawkins J, Chang M, Keller J, Raj K, DeBattista C, Jo B, Espil FM, Schatzberg AF, Sudheimer KD, Williams NR
Am J Psychiatry 2022 Feb;179(2):132-141. Epub 2021 Oct 29 doi: 10.1176/appi.ajp.2021.20101429. PMID: 34711062
Kverno KS, Mangano E
J Psychosoc Nurs Ment Health Serv 2021 Sep;59(9):7-11. Epub 2021 Sep 1 doi: 10.3928/02793695-20210816-01. PMID: 34459676
Carhart-Harris RL, Bolstridge M, Day CMJ, Rucker J, Watts R, Erritzoe DE, Kaelen M, Giribaldi B, Bloomfield M, Pilling S, Rickard JA, Forbes B, Feilding A, Taylor D, Curran HV, Nutt DJ
Psychopharmacology (Berl) 2018 Feb;235(2):399-408. Epub 2017 Nov 8 doi: 10.1007/s00213-017-4771-x. PMID: 29119217Free PMC Article

Diagnosis

Borbély É, Simon M, Fuchs E, Wiborg O, Czéh B, Helyes Z
Br J Pharmacol 2022 Mar;179(6):1146-1186. Epub 2022 Jan 26 doi: 10.1111/bph.15753. PMID: 34822719Free PMC Article
Cole EJ, Stimpson KH, Bentzley BS, Gulser M, Cherian K, Tischler C, Nejad R, Pankow H, Choi E, Aaron H, Espil FM, Pannu J, Xiao X, Duvio D, Solvason HB, Hawkins J, Guerra A, Jo B, Raj KS, Phillips AL, Barmak F, Bishop JH, Coetzee JP, DeBattista C, Keller J, Schatzberg AF, Sudheimer KD, Williams NR
Am J Psychiatry 2020 Aug 1;177(8):716-726. Epub 2020 Apr 7 doi: 10.1176/appi.ajp.2019.19070720. PMID: 32252538
Pandarakalam JP
Psychiatr Danub 2018 Sep;30(3):273-284. doi: 10.24869/psyd.2018.273. PMID: 30267518
Carhart-Harris RL, Bolstridge M, Day CMJ, Rucker J, Watts R, Erritzoe DE, Kaelen M, Giribaldi B, Bloomfield M, Pilling S, Rickard JA, Forbes B, Feilding A, Taylor D, Curran HV, Nutt DJ
Psychopharmacology (Berl) 2018 Feb;235(2):399-408. Epub 2017 Nov 8 doi: 10.1007/s00213-017-4771-x. PMID: 29119217Free PMC Article
Fava M
Biol Psychiatry 2003 Apr 15;53(8):649-59. doi: 10.1016/s0006-3223(03)00231-2. PMID: 12706951

Therapy

Zhou X, Teng T, Zhang Y, Del Giovane C, Furukawa TA, Weisz JR, Li X, Cuijpers P, Coghill D, Xiang Y, Hetrick SE, Leucht S, Qin M, Barth J, Ravindran AV, Yang L, Curry J, Fan L, Silva SG, Cipriani A, Xie P
Lancet Psychiatry 2020 Jul;7(7):581-601. doi: 10.1016/S2215-0366(20)30137-1. PMID: 32563306Free PMC Article
Swainson J, Thomas RK, Archer S, Chrenek C, MacKay MA, Baker G, Dursun S, Klassen LJ, Chokka P, Demas ML
Expert Rev Neurother 2019 Oct;19(10):899-911. Epub 2019 Jul 16 doi: 10.1080/14737175.2019.1640604. PMID: 31282772
Cipriani A, Furukawa TA, Salanti G, Chaimani A, Atkinson LZ, Ogawa Y, Leucht S, Ruhe HG, Turner EH, Higgins JPT, Egger M, Takeshima N, Hayasaka Y, Imai H, Shinohara K, Tajika A, Ioannidis JPA, Geddes JR
Lancet 2018 Apr 7;391(10128):1357-1366. Epub 2018 Feb 21 doi: 10.1016/S0140-6736(17)32802-7. PMID: 29477251Free PMC Article
Carhart-Harris RL, Bolstridge M, Day CMJ, Rucker J, Watts R, Erritzoe DE, Kaelen M, Giribaldi B, Bloomfield M, Pilling S, Rickard JA, Forbes B, Feilding A, Taylor D, Curran HV, Nutt DJ
Psychopharmacology (Berl) 2018 Feb;235(2):399-408. Epub 2017 Nov 8 doi: 10.1007/s00213-017-4771-x. PMID: 29119217Free PMC Article
Fava M
Biol Psychiatry 2003 Apr 15;53(8):649-59. doi: 10.1016/s0006-3223(03)00231-2. PMID: 12706951

Prognosis

Hsieh MH
Prog Brain Res 2023;281:69-90. Epub 2023 Mar 10 doi: 10.1016/bs.pbr.2023.01.004. PMID: 37806717
Jha MK, Mathew SJ
Am J Psychiatry 2023 Mar 1;180(3):190-199. doi: 10.1176/appi.ajp.20230025. PMID: 36855876
Davis AK, Barrett FS, May DG, Cosimano MP, Sepeda ND, Johnson MW, Finan PH, Griffiths RR
JAMA Psychiatry 2021 May 1;78(5):481-489. doi: 10.1001/jamapsychiatry.2020.3285. PMID: 33146667Free PMC Article
Carhart-Harris RL, Bolstridge M, Day CMJ, Rucker J, Watts R, Erritzoe DE, Kaelen M, Giribaldi B, Bloomfield M, Pilling S, Rickard JA, Forbes B, Feilding A, Taylor D, Curran HV, Nutt DJ
Psychopharmacology (Berl) 2018 Feb;235(2):399-408. Epub 2017 Nov 8 doi: 10.1007/s00213-017-4771-x. PMID: 29119217Free PMC Article
Carhart-Harris RL, Roseman L, Bolstridge M, Demetriou L, Pannekoek JN, Wall MB, Tanner M, Kaelen M, McGonigle J, Murphy K, Leech R, Curran HV, Nutt DJ
Sci Rep 2017 Oct 13;7(1):13187. doi: 10.1038/s41598-017-13282-7. PMID: 29030624Free PMC Article

Clinical prediction guides

Steffens DC
N Engl J Med 2024 Feb 15;390(7):630-639. doi: 10.1056/NEJMcp2305428. PMID: 38354142Free PMC Article
Goodwin GM, Aaronson ST, Alvarez O, Arden PC, Baker A, Bennett JC, Bird C, Blom RE, Brennan C, Brusch D, Burke L, Campbell-Coker K, Carhart-Harris R, Cattell J, Daniel A, DeBattista C, Dunlop BW, Eisen K, Feifel D, Forbes M, Haumann HM, Hellerstein DJ, Hoppe AI, Husain MI, Jelen LA, Kamphuis J, Kawasaki J, Kelly JR, Key RE, Kishon R, Knatz Peck S, Knight G, Koolen MHB, Lean M, Licht RW, Maples-Keller JL, Mars J, Marwood L, McElhiney MC, Miller TL, Mirow A, Mistry S, Mletzko-Crowe T, Modlin LN, Nielsen RE, Nielson EM, Offerhaus SR, O'Keane V, Páleníček T, Printz D, Rademaker MC, van Reemst A, Reinholdt F, Repantis D, Rucker J, Rudow S, Ruffell S, Rush AJ, Schoevers RA, Seynaeve M, Shao S, Soares JC, Somers M, Stansfield SC, Sterling D, Strockis A, Tsai J, Visser L, Wahba M, Williams S, Young AH, Ywema P, Zisook S, Malievskaia E
N Engl J Med 2022 Nov 3;387(18):1637-1648. doi: 10.1056/NEJMoa2206443. PMID: 36322843
Davis AK, Barrett FS, May DG, Cosimano MP, Sepeda ND, Johnson MW, Finan PH, Griffiths RR
JAMA Psychiatry 2021 May 1;78(5):481-489. doi: 10.1001/jamapsychiatry.2020.3285. PMID: 33146667Free PMC Article
Cole EJ, Stimpson KH, Bentzley BS, Gulser M, Cherian K, Tischler C, Nejad R, Pankow H, Choi E, Aaron H, Espil FM, Pannu J, Xiao X, Duvio D, Solvason HB, Hawkins J, Guerra A, Jo B, Raj KS, Phillips AL, Barmak F, Bishop JH, Coetzee JP, DeBattista C, Keller J, Schatzberg AF, Sudheimer KD, Williams NR
Am J Psychiatry 2020 Aug 1;177(8):716-726. Epub 2020 Apr 7 doi: 10.1176/appi.ajp.2019.19070720. PMID: 32252538
Carhart-Harris RL, Bolstridge M, Day CMJ, Rucker J, Watts R, Erritzoe DE, Kaelen M, Giribaldi B, Bloomfield M, Pilling S, Rickard JA, Forbes B, Feilding A, Taylor D, Curran HV, Nutt DJ
Psychopharmacology (Berl) 2018 Feb;235(2):399-408. Epub 2017 Nov 8 doi: 10.1007/s00213-017-4771-x. PMID: 29119217Free PMC Article

Recent systematic reviews

Smith-Apeldoorn SY, Veraart JK, Spijker J, Kamphuis J, Schoevers RA
Lancet Psychiatry 2022 Nov;9(11):907-921. doi: 10.1016/S2215-0366(22)00317-0. PMID: 36244360
Alnefeesi Y, Chen-Li D, Krane E, Jawad MY, Rodrigues NB, Ceban F, Di Vincenzo JD, Meshkat S, Ho RCM, Gill H, Teopiz KM, Cao B, Lee Y, McIntyre RS, Rosenblat JD
J Psychiatr Res 2022 Jul;151:693-709. Epub 2022 May 25 doi: 10.1016/j.jpsychires.2022.04.037. PMID: 35688035
Nuñez NA, Joseph B, Pahwa M, Kumar R, Resendez MG, Prokop LJ, Veldic M, Seshadri A, Biernacka JM, Frye MA, Wang Z, Singh B
J Affect Disord 2022 Apr 1;302:385-400. Epub 2022 Jan 2 doi: 10.1016/j.jad.2021.12.134. PMID: 34986373Free PMC Article
Zhou X, Teng T, Zhang Y, Del Giovane C, Furukawa TA, Weisz JR, Li X, Cuijpers P, Coghill D, Xiang Y, Hetrick SE, Leucht S, Qin M, Barth J, Ravindran AV, Yang L, Curry J, Fan L, Silva SG, Cipriani A, Xie P
Lancet Psychiatry 2020 Jul;7(7):581-601. doi: 10.1016/S2215-0366(20)30137-1. PMID: 32563306Free PMC Article
Cipriani A, Furukawa TA, Salanti G, Chaimani A, Atkinson LZ, Ogawa Y, Leucht S, Ruhe HG, Turner EH, Higgins JPT, Egger M, Takeshima N, Hayasaka Y, Imai H, Shinohara K, Tajika A, Ioannidis JPA, Geddes JR
Lancet 2018 Apr 7;391(10128):1357-1366. Epub 2018 Feb 21 doi: 10.1016/S0140-6736(17)32802-7. PMID: 29477251Free PMC Article

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