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Coinfection

MedGen UID:
452372
Concept ID:
C0275524
Disease or Syndrome
Synonyms: Co infection; Co-infection; Co-infections; Coinfections; Infection, Mixed; Infection, Polymicrobial; Infections, Mixed; Infections, Polymicrobial; Mixed Infection; Mixed Infections; Polymicrobial Infection; Polymicrobial Infections
SNOMED CT: Polymicrobial infection (4559000); Mixed infectious disease (4559000); Mixed infection (4559000); Polyinfection (4559000)
 
Monarch Initiative: MONDO:0100128

Definition

The simultaneous infection of a host by multiple pathogen species. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVCoinfection

Professional guidelines

PubMed

Yang Q, Han J, Shen J, Peng X, Zhou L, Yin X
Medicine (Baltimore) 2022 Sep 2;101(35):e30405. doi: 10.1097/MD.0000000000030405. PMID: 36107594Free PMC Article
Abu-Freha N, Mathew Jacob B, Elhoashla A, Afawi Z, Abu-Hammad T, Elsana F, Paz S, Etzion O
Eur J Gen Pract 2022 Dec;28(1):102-108. doi: 10.1080/13814788.2022.2056161. PMID: 35579223Free PMC Article
Lantos PM, Rumbaugh J, Bockenstedt LK, Falck-Ytter YT, Aguero-Rosenfeld ME, Auwaerter PG, Baldwin K, Bannuru RR, Belani KK, Bowie WR, Branda JA, Clifford DB, DiMario FJ Jr, Halperin JJ, Krause PJ, Lavergne V, Liang MH, Meissner HC, Nigrovic LE, Nocton JJJ, Osani MC, Pruitt AA, Rips J, Rosenfeld LE, Savoy ML, Sood SK, Steere AC, Strle F, Sundel R, Tsao J, Vaysbrot EE, Wormser GP, Zemel LS
Neurology 2021 Feb 9;96(6):262-273. Epub 2020 Nov 30 doi: 10.1212/WNL.0000000000011151. PMID: 33257476

Recent clinical studies

Etiology

Pearlman B
Semin Liver Dis 2023 Aug;43(3):293-304. Epub 2023 Jul 20 doi: 10.1055/a-2133-8614. PMID: 37473778Free PMC Article
Wu HY, Chang PH, Chen KY, Lin IF, Hsih WH, Tsai WL, Chen JA, Lee SS; GREAT working group
J Microbiol Immunol Infect 2022 Dec;55(6 Pt 1):985-992. Epub 2022 Oct 7 doi: 10.1016/j.jmii.2022.09.006. PMID: 36243668Free PMC Article
Md-Lasim A, Mohd-Taib FS, Abdul-Halim M, Mohd-Ngesom AM, Nathan S, Md-Nor S
Int J Environ Res Public Health 2021 Sep 6;18(17) doi: 10.3390/ijerph18179411. PMID: 34502012Free PMC Article
Cawcutt K, Kalil AC
Curr Opin Crit Care 2017 Oct;23(5):385-390. doi: 10.1097/MCC.0000000000000435. PMID: 28777158
Bruchfeld J, Correia-Neves M, Källenius G
Cold Spring Harb Perspect Med 2015 Feb 26;5(7):a017871. doi: 10.1101/cshperspect.a017871. PMID: 25722472Free PMC Article

Diagnosis

Pearlman B
Semin Liver Dis 2023 Aug;43(3):293-304. Epub 2023 Jul 20 doi: 10.1055/a-2133-8614. PMID: 37473778Free PMC Article
Du Y, Wang C, Zhang Y
Viruses 2022 Nov 26;14(12) doi: 10.3390/v14122645. PMID: 36560647Free PMC Article
Wu HY, Chang PH, Chen KY, Lin IF, Hsih WH, Tsai WL, Chen JA, Lee SS; GREAT working group
J Microbiol Immunol Infect 2022 Dec;55(6 Pt 1):985-992. Epub 2022 Oct 7 doi: 10.1016/j.jmii.2022.09.006. PMID: 36243668Free PMC Article
Aghbash PS, Eslami N, Shirvaliloo M, Baghi HB
J Med Virol 2021 Sep;93(9):5310-5322. Epub 2021 Jun 12 doi: 10.1002/jmv.27102. PMID: 34032294Free PMC Article
McArdle AJ, Turkova A, Cunnington AJ
Curr Opin Infect Dis 2018 Jun;31(3):209-215. doi: 10.1097/QCO.0000000000000447. PMID: 29698255Free PMC Article

Therapy

Wedemeyer H, Aleman S, Brunetto MR, Blank A, Andreone P, Bogomolov P, Chulanov V, Mamonova N, Geyvandova N, Morozov V, Sagalova O, Stepanova T, Berger A, Manuilov D, Suri V, An Q, Da B, Flaherty J, Osinusi A, Liu Y, Merle U, Schulze Zur Wiesch J, Zeuzem S, Ciesek S, Cornberg M, Lampertico P; MYR 301 Study Group
N Engl J Med 2023 Jul 6;389(1):22-32. Epub 2023 Jun 22 doi: 10.1056/NEJMoa2213429. PMID: 37345876
Kaul S, Jakhar D, Mehta S, Singal A
J Am Acad Dermatol 2023 Dec;89(6):1107-1119. Epub 2022 Feb 8 doi: 10.1016/j.jaad.2021.12.064. PMID: 35149148
WHO Rapid Evidence Appraisal for COVID-19 Therapies (REACT) Working Group, Shankar-Hari M, Vale CL, Godolphin PJ, Fisher D, Higgins JPT, Spiga F, Savovic J, Tierney J, Baron G, Benbenishty JS, Berry LR, Broman N, Cavalcanti AB, Colman R, De Buyser SL, Derde LPG, Domingo P, Omar SF, Fernandez-Cruz A, Feuth T, Garcia F, Garcia-Vicuna R, Gonzalez-Alvaro I, Gordon AC, Haynes R, Hermine O, Horby PW, Horick NK, Kumar K, Lambrecht BN, Landray MJ, Leal L, Lederer DJ, Lorenzi E, Mariette X, Merchante N, Misnan NA, Mohan SV, Nivens MC, Oksi J, Perez-Molina JA, Pizov R, Porcher R, Postma S, Rajasuriar R, Ramanan AV, Ravaud P, Reid PD, Rutgers A, Sancho-Lopez A, Seto TB, Sivapalasingam S, Soin AS, Staplin N, Stone JH, Strohbehn GW, Sunden-Cullberg J, Torre-Cisneros J, Tsai LW, van Hoogstraten H, van Meerten T, Veiga VC, Westerweel PE, Murthy S, Diaz JV, Marshall JC, Sterne JAC
JAMA 2021 Aug 10;326(6):499-518. doi: 10.1001/jama.2021.11330. PMID: 34228774Free PMC Article
Cornberg M, Lok AS, Terrault NA, Zoulim F; 2019 EASL-AASLD HBV Treatment Endpoints Conference Faculty
J Hepatol 2020 Mar;72(3):539-557. Epub 2019 Nov 12 doi: 10.1016/j.jhep.2019.11.003. PMID: 31730789
Chakrabarti B, Davies PD
Monaldi Arch Chest Dis 2006 Mar;65(1):26-33. doi: 10.4081/monaldi.2006.582. PMID: 16700190

Prognosis

Bisht MK, Dahiya P, Ghosh S, Mukhopadhyay S
Front Cell Infect Microbiol 2023;13:1134036. Epub 2023 Jun 26 doi: 10.3389/fcimb.2023.1134036. PMID: 37434784Free PMC Article
Wu HY, Chang PH, Chen KY, Lin IF, Hsih WH, Tsai WL, Chen JA, Lee SS; GREAT working group
J Microbiol Immunol Infect 2022 Dec;55(6 Pt 1):985-992. Epub 2022 Oct 7 doi: 10.1016/j.jmii.2022.09.006. PMID: 36243668Free PMC Article
Harries AD, Dye C
Ann Trop Med Parasitol 2006 Jul-Sep;100(5-6):415-31. doi: 10.1179/136485906X91477. PMID: 16899146
Chakrabarti B, Davies PD
Monaldi Arch Chest Dis 2006 Mar;65(1):26-33. doi: 10.4081/monaldi.2006.582. PMID: 16700190
Gaeta GB, Precone DF, Cozzi-Lepri A, Cicconi P, D'Arminio Monforte A
J Hepatol 2006;44(1 Suppl):S108-13. Epub 2005 Nov 28 doi: 10.1016/j.jhep.2005.11.023. PMID: 16352369

Clinical prediction guides

Mao S, Wu L
BMC Pediatr 2024 Jul 16;24(1):457. doi: 10.1186/s12887-024-04939-0. PMID: 39014398Free PMC Article
Galli F, Bindo F, Motos A, Fernández-Barat L, Barbeta E, Gabarrús A, Ceccato A, Bermejo-Martin JF, Ferrer R, Riera J, Peñuelas O, Lorente JÁ, de Gonzalo-Calvo D, Menéndez R, Gonzalez J, Misuraca S, Palomeque A, Amaya-Villar R, Añón JM, Balan Mariño A, Barberà C, Barberán J, Blandino Ortiz A, Bustamante-Munguira E, Caballero J, Cantón-Bulnes ML, Carbajales Pérez C, Carbonell N, Catalán-González M, de Frutos R, Franco N, Galbán C, Lopez Lago A, Gumucio-Sanguino VD, de la Torre MDC, Díaz E, Estella Á, Gallego Curto E, García-Garmendia JL, Gómez JM, Huerta A, Jorge García RN, Loza-Vázquez A, Marin-Corral J, Martin Delgado MC, Martínez de la Gándara A, Martínez Varela I, Lopez Messa J, M Albaiceta G, Nieto MT, Novo MA, Peñasco Y, Pérez-García F, Pozo-Laderas JC, Ricart P, Sagredo V, Sánchez-Miralles A, Sancho Chinesta S, Roche-Campo F, Socias L, Solé-Violan J, Suarez-Sipmann F, Tamayo Lomas L, Trenado J, Úbeda A, Valdivia LJ, Vidal P, Boado MV, Rodríguez A, Antonelli M, Blasi F, Barbé F, Torres A; CIBERESUCICOVID Project investigators (COV20/00110, ISCIII)
Intensive Care Med 2023 Aug;49(8):934-945. Epub 2023 Jul 28 doi: 10.1007/s00134-023-07161-1. PMID: 37507573Free PMC Article
Hu C, Zeng Y, Zhong Z, Yang L, Li H, Zhang HM, Xia H, Jiang MY
PLoS One 2023;18(2):e0281590. Epub 2023 Feb 16 doi: 10.1371/journal.pone.0281590. PMID: 36795764Free PMC Article
Park SY, Yoon JA, Kim SH
Korean J Intern Med 2017 Sep;32(5):805-812. Epub 2017 Aug 24 doi: 10.3904/kjim.2017.109. PMID: 28835093Free PMC Article
Hagan LM, Schinazi RF
Liver Int 2013 Feb;33 Suppl 1(0 1):68-79. doi: 10.1111/liv.12063. PMID: 23286849Free PMC Article

Recent systematic reviews

Özbek L, Topçu U, Manay M, Esen BH, Bektas SN, Aydın S, Özdemir B, Khostelidi SN, Klimko N, Cornely O, Zakhour J, Kanj SS, Seidel D, Hoenigl M, Ergönül Ö
Clin Microbiol Infect 2023 Jun;29(6):722-731. Epub 2023 Mar 13 doi: 10.1016/j.cmi.2023.03.008. PMID: 36921716Free PMC Article
Krumbein H, Kümmel LS, Fragkou PC, Thölken C, Hünerbein BL, Reiter R, Papathanasiou KA, Renz H, Skevaki C
Rev Med Virol 2023 Jan;33(1):e2365. Epub 2022 Jun 10 doi: 10.1002/rmv.2365. PMID: 35686619Free PMC Article
Lansbury L, Lim B, Baskaran V, Lim WS
J Infect 2020 Aug;81(2):266-275. Epub 2020 May 27 doi: 10.1016/j.jinf.2020.05.046. PMID: 32473235Free PMC Article
Stockdale AJ, Kreuels B, Henrion MYR, Giorgi E, Kyomuhangi I, de Martel C, Hutin Y, Geretti AM
J Hepatol 2020 Sep;73(3):523-532. Epub 2020 Apr 23 doi: 10.1016/j.jhep.2020.04.008. PMID: 32335166Free PMC Article
Klein EY, Monteforte B, Gupta A, Jiang W, May L, Hsieh YH, Dugas A
Influenza Other Respir Viruses 2016 Sep;10(5):394-403. Epub 2016 Jun 24 doi: 10.1111/irv.12398. PMID: 27232677Free PMC Article

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