U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Nicotine dependence

MedGen UID:
45086
•Concept ID:
C0028043
•
Mental or Behavioral Dysfunction
Synonyms: Addictive nicotine use; Nicotine addiction
SNOMED CT: Nicotine dependence (56294008)
 
Related genes: GABBR2, SLC6A3, CYP2A6, CHRNA4
 
HPO: HP:0033543
Monarch Initiative: MONDO:0008575

Definition

Nicotine addiction can be defined as a chronic, compulsive craving for nicotine and continued usage despite harmful consequences. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  

Professional guidelines

PubMed

Clinical Practice Guideline of Spanish Society of Pneumology and Thoracic Surgery (SEPAR) on Pharmacological Treatment of Tobacco Dependence 2023.
Rábade-Castedo C, de Granda-Orive JI, Riesco-Miranda JA, De Higes-Martínez E, Ramos-Pinedo Á, Cabrera-César E, Signes-Costa Miñana J, García Rueda M, Pastor-Esplá E, Jiménez-Ruiz CA
Arch Bronconeumol 2023 Oct;59(10):651-661. Epub 2023 Jul 28 doi: 10.1016/j.arbres.2023.07.024. PMID: 37567792
Treatment of nicotine dependence needs be strengthened in primary health care.
Ekblad MO
Scand J Prim Health Care 2022 Sep;40(3):329-330. Epub 2023 Jan 2 doi: 10.1080/02813432.2022.2159638. PMID: 36593588Free PMC Article
Treatment of Tobacco Smoking: A Review.
Rigotti NA, Kruse GR, Livingstone-Banks J, Hartmann-Boyce J
JAMA 2022 Feb 8;327(6):566-577. doi: 10.1001/jama.2022.0395. PMID: 35133411

Recent clinical studies

Etiology

Association of nicotine dependence and gut microbiota: a bidirectional two-sample Mendelian randomization study.
Chen Y, Zhao M, Ji K, Li J, Wang S, Lu L, Chen Z, Zeng J
Front Immunol 2023;14:1244272. Epub 2023 Nov 7 doi: 10.3389/fimmu.2023.1244272. PMID: 38022531Free PMC Article
Biochemical and genetic biomarkers associated with nicotine dependence in Mexican smokers.
Borrego-Soto G, Perez-Paramo YX, Hernández-Cabrera F, Alvarado-Monroy FM, Borrego G, Robles-Zamora A, Lazarus P, Rojas-Martinez A
Pharmacol Res Perspect 2023 Oct;11(5):e01142. doi: 10.1002/prp2.1142. PMID: 37787014Free PMC Article
Nicotine Dependence and Postpartum Depression: A Multicenter Research Network Study.
Wiener RC
Subst Use Misuse 2023;58(13):1691-1695. Epub 2023 Aug 6 doi: 10.1080/10826084.2023.2244063. PMID: 37545109
Family functioning and nicotine dependence among smoking fathers: a cross-sectional study.
Guo Y, Liu DY, Wang YJ, Huang MJ, Jiang N, Hou Q, Feng B, Wu WY, Wu YB, Qi F, Sun XY
BMC Public Health 2023 Apr 6;23(1):658. doi: 10.1186/s12889-023-15475-4. PMID: 37024859Free PMC Article
Minority Stress and Nicotine Use and Dependence among Sexual Minority Youth.
Mann I, Jenzer T, Miranda R Jr, Mereish EH
Subst Use Misuse 2021;56(14):2264-2268. Epub 2021 Sep 14 doi: 10.1080/10826084.2021.1972315. PMID: 34519262Free PMC Article

Diagnosis

Association of nicotine dependence and gut microbiota: a bidirectional two-sample Mendelian randomization study.
Chen Y, Zhao M, Ji K, Li J, Wang S, Lu L, Chen Z, Zeng J
Front Immunol 2023;14:1244272. Epub 2023 Nov 7 doi: 10.3389/fimmu.2023.1244272. PMID: 38022531Free PMC Article
Anhedonia in Nicotine Dependence.
Gilbert DG, Stone BM
Curr Top Behav Neurosci 2022;58:167-184. doi: 10.1007/7854_2022_320. PMID: 35507287
Targeting Nicotine Addiction.
Carr E
Clin J Oncol Nurs 2018 Jun 1;22(3):243-244. doi: 10.1188/18.CJON.243-244. PMID: 29781460
Assessing nicotine dependence.
Rustin TA
Am Fam Physician 2000 Aug 1;62(3):579-84, 591-2. PMID: 10950214
Cigarette smoking.
Bergen AW, Caporaso N
J Natl Cancer Inst 1999 Aug 18;91(16):1365-75. doi: 10.1093/jnci/91.16.1365. PMID: 10451441

Therapy

Association of nicotine dependence and gut microbiota: a bidirectional two-sample Mendelian randomization study.
Chen Y, Zhao M, Ji K, Li J, Wang S, Lu L, Chen Z, Zeng J
Front Immunol 2023;14:1244272. Epub 2023 Nov 7 doi: 10.3389/fimmu.2023.1244272. PMID: 38022531Free PMC Article
Cytisinicline for Smoking Cessation: A Randomized Clinical Trial.
Rigotti NA, Benowitz NL, Prochaska J, Leischow S, Nides M, Blumenstein B, Clarke A, Cain D, Jacobs C
JAMA 2023 Jul 11;330(2):152-160. doi: 10.1001/jama.2023.10042. PMID: 37432430Free PMC Article
Treatment of Tobacco Smoking: A Review.
Rigotti NA, Kruse GR, Livingstone-Banks J, Hartmann-Boyce J
JAMA 2022 Feb 8;327(6):566-577. doi: 10.1001/jama.2022.0395. PMID: 35133411
Effectiveness of a Vaping Cessation Text Message Program Among Young Adult e-Cigarette Users: A Randomized Clinical Trial.
Graham AL, Amato MS, Cha S, Jacobs MA, Bottcher MM, Papandonatos GD
JAMA Intern Med 2021 Jul 1;181(7):923-930. doi: 10.1001/jamainternmed.2021.1793. PMID: 33999133Free PMC Article
Interventions for improving medication-taking ability and adherence in older adults prescribed multiple medications.
Cross AJ, Elliott RA, Petrie K, Kuruvilla L, George J
Cochrane Database Syst Rev 2020 May 8;5(5):CD012419. doi: 10.1002/14651858.CD012419.pub2. PMID: 32383493Free PMC Article

Prognosis

Association of nicotine dependence and gut microbiota: a bidirectional two-sample Mendelian randomization study.
Chen Y, Zhao M, Ji K, Li J, Wang S, Lu L, Chen Z, Zeng J
Front Immunol 2023;14:1244272. Epub 2023 Nov 7 doi: 10.3389/fimmu.2023.1244272. PMID: 38022531Free PMC Article
Nicotine dependence and insula subregions: functional connectivity and cue-induced activation.
Ghahremani DG, Pochon JF, Diaz MP, Tyndale RF, Dean AC, London ED
Neuropsychopharmacology 2023 May;48(6):936-945. Epub 2023 Mar 3 doi: 10.1038/s41386-023-01528-0. PMID: 36869233Free PMC Article
Predictors of Nicotine Dependence Among Adult Male Midwakh and Cigarette Smokers.
Al Sharbatti S, Shaikh RB, Sreedharan J, Muttappallymyalil J, Weizman M
Sultan Qaboos Univ Med J 2022 May;22(2):212-217. Epub 2022 May 26 doi: 10.18295/squmj.4.2021.064. PMID: 35673287Free PMC Article
Translational Research on Nicotine Dependence.
Falcone M, Lee B, Lerman C, Blendy JA
Curr Top Behav Neurosci 2016;28:121-50. doi: 10.1007/7854_2015_5005. PMID: 26873019
Familial Risk and Heritability of Cancer Among Twins in Nordic Countries.
Mucci LA, Hjelmborg JB, Harris JR, Czene K, Havelick DJ, Scheike T, Graff RE, Holst K, Möller S, Unger RH, McIntosh C, Nuttall E, Brandt I, Penney KL, Hartman M, Kraft P, Parmigiani G, Christensen K, Koskenvuo M, Holm NV, Heikkilä K, Pukkala E, Skytthe A, Adami HO, Kaprio J; Nordic Twin Study of Cancer (NorTwinCan) Collaboration
JAMA 2016 Jan 5;315(1):68-76. doi: 10.1001/jama.2015.17703. PMID: 26746459Free PMC Article

Clinical prediction guides

Association of nicotine dependence and gut microbiota: a bidirectional two-sample Mendelian randomization study.
Chen Y, Zhao M, Ji K, Li J, Wang S, Lu L, Chen Z, Zeng J
Front Immunol 2023;14:1244272. Epub 2023 Nov 7 doi: 10.3389/fimmu.2023.1244272. PMID: 38022531Free PMC Article
Biochemical and genetic biomarkers associated with nicotine dependence in Mexican smokers.
Borrego-Soto G, Perez-Paramo YX, Hernández-Cabrera F, Alvarado-Monroy FM, Borrego G, Robles-Zamora A, Lazarus P, Rojas-Martinez A
Pharmacol Res Perspect 2023 Oct;11(5):e01142. doi: 10.1002/prp2.1142. PMID: 37787014Free PMC Article
Nicotine Dependence and Postpartum Depression: A Multicenter Research Network Study.
Wiener RC
Subst Use Misuse 2023;58(13):1691-1695. Epub 2023 Aug 6 doi: 10.1080/10826084.2023.2244063. PMID: 37545109
Nicotine dependence and insula subregions: functional connectivity and cue-induced activation.
Ghahremani DG, Pochon JF, Diaz MP, Tyndale RF, Dean AC, London ED
Neuropsychopharmacology 2023 May;48(6):936-945. Epub 2023 Mar 3 doi: 10.1038/s41386-023-01528-0. PMID: 36869233Free PMC Article
Multiethnic Prediction of Nicotine Biomarkers and Association With Nicotine Dependence.
Bergen AW, McMahan CS, McGee S, Ervin CM, Tindle HA, Le Marchand L, Murphy SE, Stram DO, Patel YM, Park SL, Baurley JW
Nicotine Tob Res 2021 Nov 5;23(12):2162-2169. doi: 10.1093/ntr/ntab124. PMID: 34313775Free PMC Article

Recent systematic reviews

Clinical Practice Guideline of Spanish Society of Pneumology and Thoracic Surgery (SEPAR) on Pharmacological Treatment of Tobacco Dependence 2023.
Rábade-Castedo C, de Granda-Orive JI, Riesco-Miranda JA, De Higes-Martínez E, Ramos-Pinedo Á, Cabrera-César E, Signes-Costa Miñana J, García Rueda M, Pastor-Esplá E, Jiménez-Ruiz CA
Arch Bronconeumol 2023 Oct;59(10):651-661. Epub 2023 Jul 28 doi: 10.1016/j.arbres.2023.07.024. PMID: 37567792
Interventions for improving medication-taking ability and adherence in older adults prescribed multiple medications.
Cross AJ, Elliott RA, Petrie K, Kuruvilla L, George J
Cochrane Database Syst Rev 2020 May 8;5(5):CD012419. doi: 10.1002/14651858.CD012419.pub2. PMID: 32383493Free PMC Article
Cigarette smoking and depression comorbidity: systematic review and proposed theoretical model.
Mathew AR, Hogarth L, Leventhal AM, Cook JW, Hitsman B
Addiction 2017 Mar;112(3):401-412. Epub 2016 Oct 26 doi: 10.1111/add.13604. PMID: 27628300Free PMC Article
E-cigarettes and smoking cessation in real-world and clinical settings: a systematic review and meta-analysis.
Kalkhoran S, Glantz SA
Lancet Respir Med 2016 Feb;4(2):116-28. Epub 2016 Jan 14 doi: 10.1016/S2213-2600(15)00521-4. PMID: 26776875Free PMC Article
Cigarette smoking, nicotine dependence and anxiety disorders: a systematic review of population-based, epidemiological studies.
Moylan S, Jacka FN, Pasco JA, Berk M
BMC Med 2012 Oct 19;10:123. doi: 10.1186/1741-7015-10-123. PMID: 23083451Free PMC Article

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Consumer resources

    Reviews

    Related information

    • GTR
      Related information in GTR
    • GTR(Clinical)
      Clinical tests in GTR
    • MeSH
      Related Medical Subject Headings
    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...