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Ludwig angina

MedGen UID:
44205
•Concept ID:
C0024081
•
Disease or Syndrome
Synonym: Ludwig's angina
SNOMED CT: Ludwig angina (196542004); Ludwig's angina (196542004)
 
Monarch Initiative: MONDO:0006576

Definition

Severe cellulitis of the submaxillary space with secondary involvement of the sublingual and submental space. It usually results from infection in the lower molar area or from a penetrating injury to the mouth floor. (From Dorland, 27th ed) [from MONDO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVLudwig angina

Professional guidelines

PubMed

Management of pediatric head and neck infections in the emergency department.
Abudinen-Vasquez S, Marin MN
Pediatr Emerg Med Pract 2020 Nov;17(11):1-24. Epub 2020 Nov 2 PMID: 33105074
Characteristics and management of patients requiring hospitalization for treatment of odontogenic infections.
Gonçalves L, Lauriti L, Yamamoto MK, Luz JG
J Craniofac Surg 2013;24(5):e458-62. doi: 10.1097/SCS.0b013e3182902e95. PMID: 24036813
Ludwig angina: a review of current airway management.
Marple BF
Arch Otolaryngol Head Neck Surg 1999 May;125(5):596-9. doi: 10.1001/archotol.125.5.596. PMID: 10326823

Recent clinical studies

Etiology

Major complications after tongue-tie release: A case report and systematic review.
Solis-Pazmino P, Kim GS, Lincango-Naranjo E, Prokop L, Ponce OJ, Truong MT
Int J Pediatr Otorhinolaryngol 2020 Nov;138:110356. Epub 2020 Sep 1 doi: 10.1016/j.ijporl.2020.110356. PMID: 32927351
Should we consider IgG hypogammaglobulinemia a risk factor for severe complications of Ludwig angina?: A case report and review of the literature.
Baez-Pravia OV, Díaz-Cámara M, De La O, Pey C, Ontañón Martín M, Jimenez Hiscock L, Morató Bellido B, Córdoba Sánchez ÁL
Medicine (Baltimore) 2017 Nov;96(47):e8708. doi: 10.1097/MD.0000000000008708. PMID: 29381958Free PMC Article
Longitudinal discharge trends and outcomes after hospitalization for mouth cellulitis and Ludwig angina.
Allareddy V, Rampa S, Nalliah RP, Allareddy V
Oral Surg Oral Med Oral Pathol Oral Radiol 2014 Nov;118(5):524-31. Epub 2014 Jun 14 doi: 10.1016/j.oooo.2014.06.003. PMID: 25216950
Characteristics and management of patients requiring hospitalization for treatment of odontogenic infections.
Gonçalves L, Lauriti L, Yamamoto MK, Luz JG
J Craniofac Surg 2013;24(5):e458-62. doi: 10.1097/SCS.0b013e3182902e95. PMID: 24036813
Is surgical airway necessary for airway management in deep neck infections and Ludwig angina?
Wolfe MM, Davis JW, Parks SN
J Crit Care 2011 Feb;26(1):11-4. doi: 10.1016/j.jcrc.2010.02.016. PMID: 20537506

Diagnosis

Ludwig angina and sudden death.
Tu A, Gilbert JD, Byard RW
Forensic Sci Med Pathol 2021 Sep;17(3):506-509. Epub 2021 Jan 22 doi: 10.1007/s12024-020-00350-0. PMID: 33481171
Infections of the Neck.
Li RM, Kiemeney M
Emerg Med Clin North Am 2019 Feb;37(1):95-107. doi: 10.1016/j.emc.2018.09.003. PMID: 30454783
Ludwig angina.
Kobayashi M, Watanabe K
CMAJ 2017 Feb 13;189(6):E246. Epub 2016 Dec 12 doi: 10.1503/cmaj.160279. PMID: 27956390Free PMC Article
Infections and edema.
Linkov G, Soliman AM
Anesthesiol Clin 2015 Jun;33(2):329-46. doi: 10.1016/j.anclin.2015.02.005. PMID: 25999006
Ludwig angina.
Cahill D
Am J Nurs 2002 Oct;102(10):43-4. doi: 10.1097/00000446-200210000-00020. PMID: 12394305

Therapy

Ludwig's angina and steroid use: A narrative review.
Tami A, Othman S, Sudhakar A, McKinnon BJ
Am J Otolaryngol 2020 May-Jun;41(3):102411. Epub 2020 Feb 1 doi: 10.1016/j.amjoto.2020.102411. PMID: 32035654
Pseudo-Ludwig angina.
Tiu A, Lapumnuaypol K
Cleve Clin J Med 2019 Sep;86(9):577-578. doi: 10.3949/ccjm.86a.19014. PMID: 31498770
Ludwig angina.
Kobayashi M, Watanabe K
CMAJ 2017 Feb 13;189(6):E246. Epub 2016 Dec 12 doi: 10.1503/cmaj.160279. PMID: 27956390Free PMC Article
Extracranial head and neck infections.
Jaworsky D, Reynolds S, Chow AW
Crit Care Clin 2013 Jul;29(3):443-63. doi: 10.1016/j.ccc.2013.03.003. PMID: 23830648
Ludwig angina.
Cahill D
Am J Nurs 2002 Oct;102(10):43-4. doi: 10.1097/00000446-200210000-00020. PMID: 12394305

Prognosis

Ludwig's angina: A diagnostic and surgical priority.
Vallée M, Gaborit B, Meyer J, Malard O, Boutoille D, Raffi F, Espitalier F, Asseray N
Int J Infect Dis 2020 Apr;93:160-162. Epub 2020 Jan 23 doi: 10.1016/j.ijid.2020.01.028. PMID: 31981767
Ludwig Angina after First Aid Treatment: Possible Etiologies and Prevention-Case Report.
Shemesh A, Yitzhak A, Ben Itzhak J, Azizi H, Solomonov M
J Endod 2019 Jan;45(1):79-82. Epub 2018 Nov 13 doi: 10.1016/j.joen.2018.10.001. PMID: 30446404
Mucormycosis Causing Ludwig Angina: A Unique Presentation.
McSpadden RP, Martin JR, Mehrotra S, Thorpe E
J Oral Maxillofac Surg 2017 Apr;75(4):759-762. Epub 2016 Oct 29 doi: 10.1016/j.joms.2016.10.025. PMID: 27875707
Ludwig angina progressing to fatal necrotizing fasciitis.
Blanchard A, Garza Garcia L, Palacios E, Bordlee B Jr, Neitzschman H
Ear Nose Throat J 2013 Mar;92(3):102-4. doi: 10.1177/014556131309200306. PMID: 23532644
Chronic osteomyelitis following an uncomplicated dental extraction.
Humber CC, Albilia JB, Rittenberg B
J Can Dent Assoc 2011;77:b98. PMID: 21810374

Clinical prediction guides

Post-mortem CT findings in a case of necrotizing cellulitis of the floor of the mouth (Ludwig angina).
Lee WI, Lee J, Bassed R, O'Donnell C
Forensic Sci Med Pathol 2014 Mar;10(1):109-13. Epub 2013 Oct 23 doi: 10.1007/s12024-013-9499-2. PMID: 24150965
An upper airway obstruction emergency: Ludwig angina.
Chou YK, Lee CY, Chao HH
Pediatr Emerg Care 2007 Dec;23(12):892-6. doi: 10.1097/pec.0b013e31815c9d4a. PMID: 18091599

Recent systematic reviews

Major complications after tongue-tie release: A case report and systematic review.
Solis-Pazmino P, Kim GS, Lincango-Naranjo E, Prokop L, Ponce OJ, Truong MT
Int J Pediatr Otorhinolaryngol 2020 Nov;138:110356. Epub 2020 Sep 1 doi: 10.1016/j.ijporl.2020.110356. PMID: 32927351
Ludwig's angina and steroid use: A narrative review.
Tami A, Othman S, Sudhakar A, McKinnon BJ
Am J Otolaryngol 2020 May-Jun;41(3):102411. Epub 2020 Feb 1 doi: 10.1016/j.amjoto.2020.102411. PMID: 32035654

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