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Lichen planopilaris

MedGen UID:
44150
•Concept ID:
C0023645
•
Disease or Syndrome
Synonyms: Follicular lichen planus; Lichen planus follicularis
SNOMED CT: Lichen planopilaris (64540004); Lichen planus follicularis (64540004)
Modes of inheritance:
Not genetically inherited
MedGen UID:
988794
•Concept ID:
CN307044
•
Finding
Source: Orphanet
clinical entity without genetic inheritance.
See: This record
Not genetically inherited (Orphanet)
 
Monarch Initiative: MONDO:0018879
Orphanet: ORPHA525

Definition

A rare cutaneous variant of lichen planus which affects hair follicles. It may occur on its own or in association with more common forms of lichen planus, usually classical type and/or oral lichen planus. [from ORDO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • Lichen planopilaris
Follow this link to review classifications for Lichen planopilaris in Orphanet.

Professional guidelines

PubMed

A Practical Approach to the Diagnosis and Management of Classic Lichen Planopilaris.
Svigos K, Yin L, Fried L, Lo Sicco K, Shapiro J
Am J Clin Dermatol 2021 Sep;22(5):681-692. Epub 2021 Aug 4 doi: 10.1007/s40257-021-00630-7. PMID: 34347282
Oral minoxidil treatment for hair loss: A review of efficacy and safety.
Randolph M, Tosti A
J Am Acad Dermatol 2021 Mar;84(3):737-746. Epub 2020 Jul 2 doi: 10.1016/j.jaad.2020.06.1009. PMID: 32622136
The Diagnosis and Treatment of Hair and Scalp Diseases.
Wolff H, Fischer TW, Blume-Peytavi U
Dtsch Arztebl Int 2016 May 27;113(21):377-86. doi: 10.3238/arztebl.2016.0377. PMID: 27504707Free PMC Article

Recent clinical studies

Etiology

Prevalence and Treatment Patterns in Patients With Lichen Planopilaris.
Pelet Del Toro N, Strunk A, Garg A, Han G
JAMA Dermatol 2024 Aug 1;160(8):865-868. doi: 10.1001/jamadermatol.2024.1445. PMID: 38865116Free PMC Article
Treatment of lichen planopilaris with baricitinib: A retrospective study.
Moussa A, Bhoyrul B, Asfour L, Kazmi A, Eisman S, Sinclair RD
J Am Acad Dermatol 2022 Sep;87(3):663-666. Epub 2022 Feb 22 doi: 10.1016/j.jaad.2022.02.027. PMID: 35202778
Safety of low-dose oral minoxidil for hair loss: A multicenter study of 1404 patients.
Vañó-Galván S, Pirmez R, Hermosa-Gelbard A, Moreno-Arrones ÓM, Saceda-Corralo D, Rodrigues-Barata R, Jimenez-Cauhe J, Koh WL, Poa JE, Jerjen R, Trindade de Carvalho L, John JM, Salas-Callo CI, Vincenzi C, Yin L, Lo-Sicco K, Waskiel-Burnat A, Starace M, Zamorano JL, Jaén-Olasolo P, Piraccini BM, Rudnicka L, Shapiro J, Tosti A, Sinclair R, Bhoyrul B
J Am Acad Dermatol 2021 Jun;84(6):1644-1651. Epub 2021 Feb 24 doi: 10.1016/j.jaad.2021.02.054. PMID: 33639244
The uses of naltrexone in dermatologic conditions.
Lee B, Elston DM
J Am Acad Dermatol 2019 Jun;80(6):1746-1752. Epub 2018 Dec 21 doi: 10.1016/j.jaad.2018.12.031. PMID: 30582992
Primary scarring alopecias.
Rigopoulos D, Stamatios G, Ioannides D
Curr Probl Dermatol 2015;47:76-86. Epub 2015 Feb 20 doi: 10.1159/000369407. PMID: 26370646

Diagnosis

Scarring Alopecia.
Larrondo J, McMichael AJ
Dermatol Clin 2023 Jul;41(3):519-537. Epub 2023 Apr 14 doi: 10.1016/j.det.2023.02.007. PMID: 37236719
Lichen planopilaris and frontal fibrosing alopecia: review and update of diagnostic and therapeutic features.
Fechine COC, Valente NYS, Romiti R
An Bras Dermatol 2022 May-Jun;97(3):348-357. Epub 2022 Apr 2 doi: 10.1016/j.abd.2021.08.008. PMID: 35379508Free PMC Article
A Practical Approach to the Diagnosis and Management of Classic Lichen Planopilaris.
Svigos K, Yin L, Fried L, Lo Sicco K, Shapiro J
Am J Clin Dermatol 2021 Sep;22(5):681-692. Epub 2021 Aug 4 doi: 10.1007/s40257-021-00630-7. PMID: 34347282
Common causes of hair loss - clinical manifestations, trichoscopy and therapy.
Alessandrini A, Bruni F, Piraccini BM, Starace M
J Eur Acad Dermatol Venereol 2021 Mar;35(3):629-640. Epub 2021 Jan 8 doi: 10.1111/jdv.17079. PMID: 33290611
Fibrosing alopecia in a pattern distribution.
Griggs J, Trüeb RM, Gavazzoni Dias MFR, Hordinsky M, Tosti A
J Am Acad Dermatol 2021 Dec;85(6):1557-1564. Epub 2020 Jan 8 doi: 10.1016/j.jaad.2019.12.056. PMID: 31926219

Therapy

Janus-kinase inhibitors in dermatology: A review of their use in psoriasis, vitiligo, systemic lupus erythematosus, hidradenitis suppurativa, dermatomyositis, lichen planus, lichen planopilaris, sarcoidosis and graft-versus-host disease.
Huang MY, Armstrong AW
Indian J Dermatol Venereol Leprol 2023 [SEASON];90(1):30-40. doi: 10.25259/IJDVL_15_2023. PMID: 38031699
JAK inhibitors in lichen planus: a review of pathogenesis and treatments.
Motamed-Sanaye A, Khazaee YF, Shokrgozar M, Alishahi M, Ahramiyanpour N, Amani M
J Dermatolog Treat 2022 Dec;33(8):3098-3103. Epub 2022 Aug 29 doi: 10.1080/09546634.2022.2116926. PMID: 35997540
Treatment of lichen planopilaris with baricitinib: A retrospective study.
Moussa A, Bhoyrul B, Asfour L, Kazmi A, Eisman S, Sinclair RD
J Am Acad Dermatol 2022 Sep;87(3):663-666. Epub 2022 Feb 22 doi: 10.1016/j.jaad.2022.02.027. PMID: 35202778
Safety of low-dose oral minoxidil for hair loss: A multicenter study of 1404 patients.
Vañó-Galván S, Pirmez R, Hermosa-Gelbard A, Moreno-Arrones ÓM, Saceda-Corralo D, Rodrigues-Barata R, Jimenez-Cauhe J, Koh WL, Poa JE, Jerjen R, Trindade de Carvalho L, John JM, Salas-Callo CI, Vincenzi C, Yin L, Lo-Sicco K, Waskiel-Burnat A, Starace M, Zamorano JL, Jaén-Olasolo P, Piraccini BM, Rudnicka L, Shapiro J, Tosti A, Sinclair R, Bhoyrul B
J Am Acad Dermatol 2021 Jun;84(6):1644-1651. Epub 2021 Feb 24 doi: 10.1016/j.jaad.2021.02.054. PMID: 33639244
Oral minoxidil treatment for hair loss: A review of efficacy and safety.
Randolph M, Tosti A
J Am Acad Dermatol 2021 Mar;84(3):737-746. Epub 2020 Jul 2 doi: 10.1016/j.jaad.2020.06.1009. PMID: 32622136

Prognosis

Frontal Fibrosing Alopecia - a review and a practical guide for clinicians.
Kępińska K, Jałowska M, Bowszyc-Dmochowska M
Ann Agric Environ Med 2022 Jun 24;29(2):169-184. Epub 2021 Aug 31 doi: 10.26444/aaem/141324. PMID: 35767748
Update on trichoscopy: Integration of the terminology by systematic approach and a proposal of a diagnostic flowchart.
Kinoshita-Ise M, Sachdeva M
J Dermatol 2022 Jan;49(1):4-18. Epub 2021 Nov 22 doi: 10.1111/1346-8138.16233. PMID: 34806223
Common causes of hair loss - clinical manifestations, trichoscopy and therapy.
Alessandrini A, Bruni F, Piraccini BM, Starace M
J Eur Acad Dermatol Venereol 2021 Mar;35(3):629-640. Epub 2021 Jan 8 doi: 10.1111/jdv.17079. PMID: 33290611
The uses of naltrexone in dermatologic conditions.
Lee B, Elston DM
J Am Acad Dermatol 2019 Jun;80(6):1746-1752. Epub 2018 Dec 21 doi: 10.1016/j.jaad.2018.12.031. PMID: 30582992
Evaluation and diagnosis of the hair loss patient: part I. History and clinical examination.
Mubki T, Rudnicka L, Olszewska M, Shapiro J
J Am Acad Dermatol 2014 Sep;71(3):415.e1-415.e15. doi: 10.1016/j.jaad.2014.04.070. PMID: 25128118

Clinical prediction guides

Clinical Characterization and Treatment Response of Folliculitis Decalvans Lichen Planopilaris Phenotypic Spectrum: A Unicentre Retrospective Series of 31 Patients.
Melián-Olivera A, Moreno-Arrones Ó, Burgos-Blasco P, Hermosa-Gelbard Á, Jaén-Olasolo P, Vañó-Galván S, Saceda-Corralo D
Acta Derm Venereol 2024 Feb 19;104:adv12373. doi: 10.2340/actadv.v104.12373. PMID: 38372472Free PMC Article
Update on trichoscopy: Integration of the terminology by systematic approach and a proposal of a diagnostic flowchart.
Kinoshita-Ise M, Sachdeva M
J Dermatol 2022 Jan;49(1):4-18. Epub 2021 Nov 22 doi: 10.1111/1346-8138.16233. PMID: 34806223
Safety of low-dose oral minoxidil for hair loss: A multicenter study of 1404 patients.
Vañó-Galván S, Pirmez R, Hermosa-Gelbard A, Moreno-Arrones ÓM, Saceda-Corralo D, Rodrigues-Barata R, Jimenez-Cauhe J, Koh WL, Poa JE, Jerjen R, Trindade de Carvalho L, John JM, Salas-Callo CI, Vincenzi C, Yin L, Lo-Sicco K, Waskiel-Burnat A, Starace M, Zamorano JL, Jaén-Olasolo P, Piraccini BM, Rudnicka L, Shapiro J, Tosti A, Sinclair R, Bhoyrul B
J Am Acad Dermatol 2021 Jun;84(6):1644-1651. Epub 2021 Feb 24 doi: 10.1016/j.jaad.2021.02.054. PMID: 33639244
Sunscreen and frontal fibrosing alopecia: A review.
Robinson G, McMichael A, Wang SQ, Lim HW
J Am Acad Dermatol 2020 Mar;82(3):723-728. Epub 2019 Oct 22 doi: 10.1016/j.jaad.2019.09.085. PMID: 31654665
Special Stains and Immunohistochemical Stains in Hair Pathology.
LaSenna C, Miteva M
Am J Dermatopathol 2016 May;38(5):327-37. doi: 10.1097/DAD.0000000000000418. PMID: 27097238

Recent systematic reviews

A Systematic Review and Bayesian Network Meta-Analysis of Medical Therapies for Lichen Planopilaris.
Husein-ElAhmed H, Husein-ElAhmed S
Dermatology 2024;240(1):103-110. Epub 2023 Oct 18 doi: 10.1159/000534364. PMID: 37852211
Frontal fibrosing alopecia and personal care product use: a systematic review and meta-analysis.
Kam O, Na S, Guo W, Tejeda CI, Kaufmann T
Arch Dermatol Res 2023 Oct;315(8):2313-2331. Epub 2023 Apr 4 doi: 10.1007/s00403-023-02604-7. PMID: 37014396
Update on trichoscopy: Integration of the terminology by systematic approach and a proposal of a diagnostic flowchart.
Kinoshita-Ise M, Sachdeva M
J Dermatol 2022 Jan;49(1):4-18. Epub 2021 Nov 22 doi: 10.1111/1346-8138.16233. PMID: 34806223
Mycophenolate mofetil and lichen planopilaris: systematic review and meta-analysis.
Mostafa N, Phan K, Smith S
J Dermatolog Treat 2022 Feb;33(1):369-372. Epub 2020 Apr 23 doi: 10.1080/09546634.2020.1755416. PMID: 32281437
Hair Transplantation in Frontal Fibrosing Alopecia and Lichen Planopilaris: A Systematic Review.
Lee JA, Levy DA, Patel KG, Brennan E, Oyer SL
Laryngoscope 2021 Jan;131(1):59-66. Epub 2020 Feb 11 doi: 10.1002/lary.28551. PMID: 32045028

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