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Oral leukoedema

MedGen UID:: 44132
•Concept ID:: C0023523
•: Disease or Syndrome

Synonyms:	Leukoedema, Oral; Leukoedemas, Oral; Oral Leukoedema; Oral Leukoedemas
SNOMED CT:	Oral leukoedema (67795000); Leukedema of mouth (67795000)

Monarch Initiative:	MONDO:0006880

Definition

A disorder of the buccal mucosa resembling early leukoplakia, characterized by the presence of filmy opalescence of the mucosa in the early stages to a whitish gray cast with a coarsely wrinkled surface in the later stages, associated with intracellular edema of the spinous or malpighian layer. (Dorland, 27th ed) [from MONDO]

Term Hierarchy

GTR
MeSH

CClinical test, RResearch test, OOMIM, GGeneReviews, VClinVar

CROGVOral leukoedema

Mouth disorder
- Mouth disorder
  - Mouth disorder
    - Mouth disorder
      - Mouth disorder
        Mouth disorder
        Oral leukoedema

Professional guidelines

PubMed

Genetic and developmental disorders of the oral mucosa: Epidemiology; molecular mechanisms; diagnostic criteria; management.

Pinna R, Cocco F, Campus G, Conti G, Milia E, Sardella A, Cagetti MG
Periodontol 2000 2019 Jun;80(1):12-27. doi: 10.1111/prd.12261. PMID: 31090139

White lesions in the oral cavity: clinical presentation, diagnosis, and treatment.

Jones KB, Jordan R
Semin Cutan Med Surg 2015 Dec;34(4):161-70. doi: 10.12788/j.sder.2015.0180. PMID: 26650693

Normal variations of oral anatomy and common oral soft tissue lesions: evaluation and management.

Madani FM, Kuperstein AS
Med Clin North Am 2014 Nov;98(6):1281-98. Epub 2014 Sep 22 doi: 10.1016/j.mcna.2014.08.004. PMID: 25443677

See all (4)

Recent clinical studies

Etiology

Prevalence of oral mucosal lesions among tobacco users.

Chandra P, Govindraju P
Oral Health Prev Dent 2012;10(2):149-53. PMID: 22763594

Oral Candida species and betel quid-associated oral lesions in Padaung women of Northern Thailand.

Reichart PA, Khongkhunthian P, Samaranayake LP, Yau J, Patanaporn V, Scheifele C
Mycoses 2005 Mar;48(2):132-6. doi: 10.1111/j.1439-0507.2004.01071.x. PMID: 15743432

Betel quid-associated oral lesions and oral Candida species in a female Cambodian cohort.

Reichart PA, Schmidtberg W, Samaranayake LP, Scheifele C
J Oral Pathol Med 2002 Sep;31(8):468-72. doi: 10.1034/j.1600-0714.2002.00009.x. PMID: 12220354

Leukoedema: a review of the literature.

Martin JL
J Natl Med Assoc 1992 Nov;84(11):938-40. PMID: 1460680 Free PMC Article

Oral leukoplakia and other white lesions of the oral mucosa related to dermatological disorders.

Bánóczy J
J Cutan Pathol 1983 Aug;10(4):238-56. doi: 10.1111/j.1600-0560.1983.tb01490.x. PMID: 6350389

See all (18)

Diagnosis

Normal variations of oral anatomy and common oral soft tissue lesions: evaluation and management.

Madani FM, Kuperstein AS
Med Clin North Am 2014 Nov;98(6):1281-98. Epub 2014 Sep 22 doi: 10.1016/j.mcna.2014.08.004. PMID: 25443677

Pediatric soft tissue oral lesions.

Pinto A, Haberland CM, Baker S
Dent Clin North Am 2014 Apr;58(2):437-53. Epub 2014 Jan 31 doi: 10.1016/j.cden.2013.12.003. PMID: 24655531

Betel chewer's mucosa--a review.

Reichart PA, Phillipsen HP
J Oral Pathol Med 1998 Jul;27(6):239-42. doi: 10.1111/j.1600-0714.1998.tb01949.x. PMID: 9707274

Oral leukoedema.

Waitzer S, Fisher BK
Arch Dermatol 1984 Feb;120(2):264-6. PMID: 6696486

Oral leukoplakia and other white lesions of the oral mucosa related to dermatological disorders.

Bánóczy J
J Cutan Pathol 1983 Aug;10(4):238-56. doi: 10.1111/j.1600-0560.1983.tb01490.x. PMID: 6350389

See all (18)

Therapy

Oral leukoedema with mucosal desquamation caused by toothpaste containing sodium lauryl sulfate.

Macdonald JB, Tobin CA, Hurley MY
Cutis 2016 Jan;97(1):E4-5. PMID: 26919363

Effect of cannabis usage on the oral environment: a review.

Versteeg PA, Slot DE, van der Velden U, van der Weijden GA
Int J Dent Hyg 2008 Nov;6(4):315-20. doi: 10.1111/j.1601-5037.2008.00301.x. PMID: 19138182

Cannabis abuse and oral health care: review and suggestions for management.

Darling MR
SADJ 2003 Jun;58(5):189-90. PMID: 14596260

Betel quid-associated oral lesions and oral Candida species in a female Cambodian cohort.

Reichart PA, Schmidtberg W, Samaranayake LP, Scheifele C
J Oral Pathol Med 2002 Sep;31(8):468-72. doi: 10.1034/j.1600-0714.2002.00009.x. PMID: 12220354

The influence of cigarette consumption and smoking machine yields of tar and nicotine on the nicotine uptake and oral mucosal lesions in smokers.

Andersson G, Vala EK, Curvall M
J Oral Pathol Med 1997 Mar;26(3):117-23. doi: 10.1111/j.1600-0714.1997.tb00033.x. PMID: 9083935

See all (11)

Prognosis

Normal variations of oral anatomy and common oral soft tissue lesions: evaluation and management.

Madani FM, Kuperstein AS
Med Clin North Am 2014 Nov;98(6):1281-98. Epub 2014 Sep 22 doi: 10.1016/j.mcna.2014.08.004. PMID: 25443677

Leukoedema: an epidemiological study in white and African Americans.

Martin JL
J Tenn Dent Assoc 1997 Jan;77(1):18-21. PMID: 9520752

Effect of cessation of tobacco use on the incidence of oral mucosal lesions in a 10-yr follow-up study of 12,212 users.

Gupta PC, Murti PR, Bhonsle RB, Mehta FS, Pindborg JJ
Oral Dis 1995 Mar;1(1):54-8. doi: 10.1111/j.1601-0825.1995.tb00158.x. PMID: 7553382

Pseudo oral hairy leukoplakia in a renal allograft recipient.

Euvrard S, Kanitakis J, Pouteil-Noble C, Chardonnet Y, Touraine JL, Thivolet J
J Am Acad Dermatol 1994 Feb;30(2 Pt 2):300-3. doi: 10.1016/s0190-9622(94)70027-3. PMID: 8294586

Incidence rates of oral cancer and natural history of oral precancerous lesions in a 10-year follow-up study of Indian villagers.

Gupta PC, Mehta FS, Daftary DK, Pindborg JJ, Bhonsle RB, Jalnawalla PN, Sinor PN, Pitkar VK, Murti PR, Irani RR, Shah HT, Kadam PM, Iyer KS, Iyer HM, Hegde AK, Chandrashekar GK, Shiroff BC, Sahiar BE, Mehta MN
Community Dent Oral Epidemiol 1980;8(6):283-333. doi: 10.1111/j.1600-0528.1980.tb01302.x. PMID: 6937277

See all (5)