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Visceral leishmaniasis

MedGen UID:
44098
•Concept ID:
C0023290
•
Disease or Syndrome
Synonym: Kala-azar susceptibility
SNOMED CT: Visceral leishmaniasis (186803007); Indian visceral leishmaniasis (186803007); Dum Dum fever (186803007); Burdwan fever (186803007); Dum-dum fever (186803007); Mediterranean leishmaniasis (186803007); Kala-azar (186803007); Mard el bicha (186803007); Sirkari disease (186803007); VL - Visceral leishmaniasis (186803007)
 
Monarch Initiative: MONDO:0005445
OMIM® Phenotypic series: PS608207

Definition

A chronic parasitic infection affecting the viscera and caused by Leishmania donovani. Signs and symptoms include fever, anorexia, fatigue, lymphadenopathy, anemia, and hepatosplenomegaly. If left untreated it may lead to death. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVVisceral leishmaniasis

Professional guidelines

PubMed

Visceral Leishmaniasis: Recent Advances in Diagnostics and Treatment Regimens.
van Griensven J, Diro E
Infect Dis Clin North Am 2019 Mar;33(1):79-99. doi: 10.1016/j.idc.2018.10.005. PMID: 30712769
Visceral Leishmaniasis-Optimum Treatment Options in Children.
Sundar S, Agarwal D
Pediatr Infect Dis J 2018 May;37(5):492-494. doi: 10.1097/INF.0000000000001885. PMID: 29280784Free PMC Article
Drug resistance and treatment failure in leishmaniasis: A 21st century challenge.
Ponte-Sucre A, Gamarro F, Dujardin JC, Barrett MP, López-Vélez R, García-Hernández R, Pountain AW, Mwenechanya R, Papadopoulou B
PLoS Negl Trop Dis 2017 Dec;11(12):e0006052. Epub 2017 Dec 14 doi: 10.1371/journal.pntd.0006052. PMID: 29240765Free PMC Article

Recent clinical studies

Etiology

Nano- and Microformulations to Advance Therapies for Visceral Leishmaniasis.
Varma DM, Redding EA, Bachelder EM, Ainslie KM
ACS Biomater Sci Eng 2021 May 10;7(5):1725-1741. Epub 2020 Oct 14 doi: 10.1021/acsbiomaterials.0c01132. PMID: 33966377Free PMC Article
Molecular Tracking of the Leishmania Parasite.
Moulik S, Sengupta S, Chatterjee M
Front Cell Infect Microbiol 2021;11:623437. Epub 2021 Feb 22 doi: 10.3389/fcimb.2021.623437. PMID: 33692966Free PMC Article
Histological Disorganization of Spleen Compartments and Severe Visceral Leishmaniasis.
Hermida MD, de Melo CVB, Lima IDS, Oliveira GGS, Dos-Santos WLC
Front Cell Infect Microbiol 2018;8:394. Epub 2018 Nov 13 doi: 10.3389/fcimb.2018.00394. PMID: 30483481Free PMC Article
New insights into leishmaniasis in the immunosuppressed.
Akuffo H, Costa C, van Griensven J, Burza S, Moreno J, Herrero M
PLoS Negl Trop Dis 2018 May;12(5):e0006375. Epub 2018 May 10 doi: 10.1371/journal.pntd.0006375. PMID: 29746470Free PMC Article
Treatment Options for Visceral Leishmaniasis and HIV Coinfection.
Monge-Maillo B, López-Vélez R
AIDS Rev 2016 Jan-Mar;18(1):32-43. PMID: 26936761

Diagnosis

Managing visceral leishmaniasis.
Bansal N, Jain A
BMJ 2023 Oct 16;383:2213. doi: 10.1136/bmj.p2213. PMID: 37844956
Diagnosing visceral leishmaniasis.
Bansal N, Jain A
BMJ 2023 Oct 16;383:e076715. doi: 10.1136/bmj-2023-076715. PMID: 37844918
Visceral Leishmaniasis: Kala-azar.
Safavi M, Eshaghi H, Hajihassani Z
Diagn Cytopathol 2021 Mar;49(3):446-448. Epub 2020 Nov 22 doi: 10.1002/dc.24671. PMID: 33225605
Visceral Leishmaniasis: Recent Advances in Diagnostics and Treatment Regimens.
van Griensven J, Diro E
Infect Dis Clin North Am 2019 Mar;33(1):79-99. doi: 10.1016/j.idc.2018.10.005. PMID: 30712769
Visceral leishmaniasis.
van Griensven J, Diro E
Infect Dis Clin North Am 2012 Jun;26(2):309-22. Epub 2012 Apr 24 doi: 10.1016/j.idc.2012.03.005. PMID: 22632641

Therapy

Intestinal leishmaniasis.
Chattopadhyay A, Mittal S, Gupta K, Dhir V, Jain S
Clin Microbiol Infect 2020 Oct;26(10):1345-1346. Epub 2020 May 18 doi: 10.1016/j.cmi.2020.05.003. PMID: 32439594
Visceral Leishmaniasis: Recent Advances in Diagnostics and Treatment Regimens.
van Griensven J, Diro E
Infect Dis Clin North Am 2019 Mar;33(1):79-99. doi: 10.1016/j.idc.2018.10.005. PMID: 30712769
Peptide Vaccines for Leishmaniasis.
De Brito RCF, Cardoso JMO, Reis LES, Vieira JF, Mathias FAS, Roatt BM, Aguiar-Soares RDDO, Ruiz JC, Resende DM, Reis AB
Front Immunol 2018;9:1043. Epub 2018 May 11 doi: 10.3389/fimmu.2018.01043. PMID: 29868006Free PMC Article
Chemotherapy of leishmaniasis: present challenges.
Uliana SRB, Trinconi CT, Coelho AC
Parasitology 2018 Apr;145(4):464-480. Epub 2017 Jan 20 doi: 10.1017/S0031182016002523. PMID: 28103966
Visceral leishmaniasis.
van Griensven J, Diro E
Infect Dis Clin North Am 2012 Jun;26(2):309-22. Epub 2012 Apr 24 doi: 10.1016/j.idc.2012.03.005. PMID: 22632641

Prognosis

Visceral leishmaniasis elimination in India: progress and the road ahead.
Singh OP, Sundar S
Expert Rev Anti Infect Ther 2022 Nov;20(11):1381-1388. Epub 2022 Sep 25 doi: 10.1080/14787210.2022.2126352. PMID: 36111688
Promising nanotherapy in treating leishmaniasis.
de Souza A, Marins DSS, Mathias SL, Monteiro LM, Yukuyama MN, Scarim CB, Löbenberg R, Bou-Chacra NA
Int J Pharm 2018 Aug 25;547(1-2):421-431. Epub 2018 Jun 8 doi: 10.1016/j.ijpharm.2018.06.018. PMID: 29886097
Visceral leishmaniasis and leishmaniasis-HIV coinfection: comparative study.
Coutinho JVSC, Santos FSD, Ribeiro RDSP, Oliveira IBB, Dantas VB, Santos ABFS, Tauhata JR
Rev Soc Bras Med Trop 2017 Sep-Oct;50(5):670-674. doi: 10.1590/0037-8682-0193-2017. PMID: 29160515
Visceral Leishmaniasis and HIV coinfection in East Africa.
Diro E, Lynen L, Ritmeijer K, Boelaert M, Hailu A, van Griensven J
PLoS Negl Trop Dis 2014 Jun;8(6):e2869. Epub 2014 Jun 26 doi: 10.1371/journal.pntd.0002869. PMID: 24968313Free PMC Article
Leishmaniases in Greece.
Ntais P, Sifaki-Pistola D, Christodoulou V, Messaritakis I, Pratlong F, Poupalos G, Antoniou M
Am J Trop Med Hyg 2013 Nov;89(5):906-15. Epub 2013 Sep 23 doi: 10.4269/ajtmh.13-0070. PMID: 24062479Free PMC Article

Clinical prediction guides

Elucidating the role played by bone marrow in visceral leishmaniasis.
Veras PST, de Santana MBR, Brodskyn CI, Fraga DBM, Solcà MS, De Menezes JPB, Leite BMM, Teixeira HMP
Front Cell Infect Microbiol 2023;13:1261074. Epub 2023 Oct 4 doi: 10.3389/fcimb.2023.1261074. PMID: 37860064Free PMC Article
Linear and conformational determinants of visceral leishmaniasis diagnostic antigens rK28 and rK39.
Simonson P, Bhattacharyya T, El-Safi S, Miles MA
Parasit Vectors 2022 Oct 22;15(1):387. doi: 10.1186/s13071-022-05495-1. PMID: 36273150Free PMC Article
Prevalence, severity, and pathogeneses of anemia in visceral leishmaniasis.
Goto Y, Cheng J, Omachi S, Morimoto A
Parasitol Res 2017 Feb;116(2):457-464. Epub 2016 Nov 7 doi: 10.1007/s00436-016-5313-x. PMID: 27822583
Laboratory diagnosis of human visceral leishmaniasis.
Sakkas H, Gartzonika C, Levidiotou S
J Vector Borne Dis 2016 Mar;53(1):8-16. PMID: 27004573
Visceral Leishmaniasis and HIV coinfection in East Africa.
Diro E, Lynen L, Ritmeijer K, Boelaert M, Hailu A, van Griensven J
PLoS Negl Trop Dis 2014 Jun;8(6):e2869. Epub 2014 Jun 26 doi: 10.1371/journal.pntd.0002869. PMID: 24968313Free PMC Article

Recent systematic reviews

Prevalence of visceral leishmaniasis among people with HIV: a systematic review and meta-analysis.
Kantzanou M, Karalexi MA, Theodoridou K, Kostares E, Kostare G, Loka T, Vrioni G, Tsakris A
Eur J Clin Microbiol Infect Dis 2023 Jan;42(1):1-12. Epub 2022 Nov 24 doi: 10.1007/s10096-022-04530-4. PMID: 36427170Free PMC Article
Indoor residual spraying for the control of visceral leishmaniasis: A systematic review.
Faber C, Montenegro Quiñonez C, Horstick O, Rahman KM, Runge-Ranzinger S
PLoS Negl Trop Dis 2022 May;16(5):e0010391. Epub 2022 May 19 doi: 10.1371/journal.pntd.0010391. PMID: 35587498Free PMC Article
Leishmaniasis and Trace Element Alterations: a Systematic Review.
Taghipour A, Abdoli A, Ramezani A, Abolghazi A, Mofazzal Jahromi MA, Maani S, Heidar Nejadi SM, Rasti S, Shams M, Ghasemi E
Biol Trace Elem Res 2021 Oct;199(10):3918-3938. Epub 2021 Jan 6 doi: 10.1007/s12011-020-02505-0. PMID: 33405078
Prevalence of human visceral leishmaniasis in Iran: A systematic review and meta-analysis.
Rostamian M, Bashiri H, Yousefinejad V, Bozorgomid A, Sohrabi N, Raeghi S, Khodayari MT, Ghadiri K, Rezaeian S
Comp Immunol Microbiol Infect Dis 2021 Apr;75:101604. Epub 2020 Dec 14 doi: 10.1016/j.cimid.2020.101604. PMID: 33388595
Canine visceral leishmaniasis in Iran: A systematic review and meta-analysis.
Shokri A, Fakhar M, Teshnizi SH
Acta Trop 2017 Jan;165:76-89. Epub 2016 Aug 26 doi: 10.1016/j.actatropica.2016.08.020. PMID: 27570207

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