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Hemangioendothelioma

MedGen UID:
42384
•Concept ID:
C0018915
•
Neoplastic Process
Synonyms: Endothelioma, Vascular; Endotheliomas, Vascular; Hemangio Endothelioma; Hemangio-Endothelioma; Hemangio-Endotheliomas; Hemangioendotheliomas; Vascular Endothelioma; Vascular Endotheliomas
SNOMED CT: Hemangioendothelioma (66229009); Angioendothelioma (66229009); Hemangioendothelioma (403980002)
 
Monarch Initiative: MONDO:0021121

Definition

A vascular proliferation characterized by the presence of prominent endothelial cells and the formation of vascular channels. Hemangioendotheliomas may display borderline or low grade characteristics. [from NCI]

Professional guidelines

PubMed

Additive value of transarterial embolization to systemic sirolimus treatment in kaposiform hemangioendothelioma.
Brill R, Uller W, Huf V, Müller-Wille R, Schmid I, Pohl A, Häberle B, Perkowski S, Funke K, Till AM, Lauten M, Neumann J, Güttel C, Heid E, Ziermann F, Schmid A, Hüsemann D, Meyer L, Sporns PB, Schinner R, Schmidt VF, Ricke J, Rössler J, Kapp FG, Wohlgemuth WA, Wildgruber M
Int J Cancer 2021 May 1;148(9):2345-2351. Epub 2020 Dec 3 doi: 10.1002/ijc.33406. PMID: 33231291
Epithelioid Hemangioendothelioma: Update on Diagnosis and Treatment.
Rosenberg A, Agulnik M
Curr Treat Options Oncol 2018 Mar 15;19(4):19. doi: 10.1007/s11864-018-0536-y. PMID: 29546487
Management of hemangiomas and other vascular tumors.
Greene AK
Clin Plast Surg 2011 Jan;38(1):45-63. doi: 10.1016/j.cps.2010.08.001. PMID: 21095471

Recent clinical studies

Etiology

Epithelioid hemangioendothelioma, an ultra-rare cancer: a consensus paper from the community of experts.
Stacchiotti S, Miah AB, Frezza AM, Messiou C, Morosi C, Caraceni A, Antonescu CR, Bajpai J, Baldini E, Bauer S, Biagini R, Bielack S, Blay JY, Bonvalot S, Boukovinas I, Bovee JVMG, Boye K, Brodowicz T, Callegaro D, De Alava E, Deoras-Sutliff M, Dufresne A, Eriksson M, Errani C, Fedenko A, Ferraresi V, Ferrari A, Fletcher CDM, Garcia Del Muro X, Gelderblom H, Gladdy RA, Gouin F, Grignani G, Gutkovich J, Haas R, Hindi N, Hohenberger P, Huang P, Joensuu H, Jones RL, Jungels C, Kasper B, Kawai A, Le Cesne A, Le Grange F, Leithner A, Leonard H, Lopez Pousa A, Martin Broto J, Merimsky O, Merriam P, Miceli R, Mir O, Molinari M, Montemurro M, Oldani G, Palmerini E, Pantaleo MA, Patel S, Piperno-Neumann S, Raut CP, Ravi V, Razak ARA, Reichardt P, Rubin BP, Rutkowski P, Safwat AA, Sangalli C, Sapisochin G, Sbaraglia M, Scheipl S, Schöffski P, Strauss D, Strauss SJ, Sundby Hall K, Tap WD, Trama A, Tweddle A, van der Graaf WTA, Van De Sande MAJ, Van Houdt W, van Oortmerssen G, Wagner AJ, Wartenberg M, Wood J, Zaffaroni N, Zimmermann C, Casali PG, Dei Tos AP, Gronchi A
ESMO Open 2021 Jun;6(3):100170. Epub 2021 Jun 2 doi: 10.1016/j.esmoop.2021.100170. PMID: 34090171Free PMC Article
Benign esophageal tumors.
Ha C, Regan J, Cetindag IB, Ali A, Mellinger JD
Surg Clin North Am 2015 Jun;95(3):491-514. Epub 2015 Mar 21 doi: 10.1016/j.suc.2015.02.005. PMID: 25965126
Kasabach-Merritt phenomenon.
Kelly M
Pediatr Clin North Am 2010 Oct;57(5):1085-9. Epub 2010 Aug 21 doi: 10.1016/j.pcl.2010.07.006. PMID: 20888459
Malignant liver tumors.
Suriawinata AA, Thung SN
Clin Liver Dis 2002 May;6(2):527-54, ix. doi: 10.1016/s1089-3261(02)00005-3. PMID: 12122869
Hepatic hemangiomas.
Hobbs KE
World J Surg 1990 Jul-Aug;14(4):468-71. doi: 10.1007/BF01658669. PMID: 2200208

Diagnosis

Pseudomyogenic Hemangioendothelioma (Epithelioid Sarcoma-Like Hemangioendothelioma).
Caballero GA, Roitman PD
Arch Pathol Lab Med 2020 Apr;144(4):529-533. Epub 2019 Apr 24 doi: 10.5858/arpa.2018-0395-RS. PMID: 31017450
Pseudomyogenic hemangioendothelioma.
Horan NA, DiMaio DJ
Cutis 2017 Dec;100(6):E13-E16. PMID: 29360904
Diagnostically Challenging Epithelioid Vascular Tumors.
Ko JS, Billings SD
Surg Pathol Clin 2015 Sep;8(3):331-51. doi: 10.1016/j.path.2015.05.001. PMID: 26297060
Hepatic epithelioid hemangioendothelioma.
Uchimura K, Nakamuta M, Osoegawa M, Takeaki S, Nishi H, Iwamoto H, Enjoji M, Nawata H
J Clin Gastroenterol 2001 May-Jun;32(5):431-4. doi: 10.1097/00004836-200105000-00015. PMID: 11319317
The hemangioma.
MACOMBER WB, WANG MK
GP 1953 Nov;8(5):41-9. PMID: 13107859

Therapy

Kasabach-Merritt phenomenon.
Kelly M
Pediatr Clin North Am 2010 Oct;57(5):1085-9. Epub 2010 Aug 21 doi: 10.1016/j.pcl.2010.07.006. PMID: 20888459
Pleural epithelioid hemangioendothelioma.
Lee YJ, Chung MJ, Jeong KC, Hahn CH, Hong KP, Kim YJ, Kim YT
Yonsei Med J 2008 Dec 31;49(6):1036-40. doi: 10.3349/ymj.2008.49.6.1036. PMID: 19108030Free PMC Article
The "skinny aorta".
Israel G, Krinsky G, Lee V
Clin Imaging 2002 Mar-Apr;26(2):116-21. doi: 10.1016/s0899-7071(01)00368-0. PMID: 11852219
Malignant hemangioendothelioma.
Ihda H, Tokura Y, Fushimi M, Yokote R, Hashizume H, Shirahama S, Iwatsuki K, Murakami K, Takigawa M
Int J Dermatol 1995 Nov;34(11):811-6. doi: 10.1111/j.1365-4362.1995.tb04406.x. PMID: 8543420
Angioendotheliomatosis.
Berger TG, Dawson NA
J Am Acad Dermatol 1988 Feb;18(2 Pt 2):407-12. doi: 10.1016/s0190-9622(88)70058-4. PMID: 3278019

Prognosis

Epithelioid hemangioendothelioma-its history, clinical features, molecular biology and current therapy.
Tsuchihashi K, Baba E
Jpn J Clin Oncol 2024 Jul 7;54(7):739-747. doi: 10.1093/jjco/hyae037. PMID: 38555494
Pseudomyogenic Hemangioendothelioma (Epithelioid Sarcoma-Like Hemangioendothelioma).
Caballero GA, Roitman PD
Arch Pathol Lab Med 2020 Apr;144(4):529-533. Epub 2019 Apr 24 doi: 10.5858/arpa.2018-0395-RS. PMID: 31017450
Pulmonary epithelioid hemangioendothelioma.
Mizuno Y, Iwata H, Shirahashi K, Hirose Y, Takemura H
Gen Thorac Cardiovasc Surg 2011 Apr;59(4):297-300. Epub 2011 Apr 12 doi: 10.1007/s11748-010-0651-6. PMID: 21484560
Pleural epithelioid hemangioendothelioma.
Lee YJ, Chung MJ, Jeong KC, Hahn CH, Hong KP, Kim YJ, Kim YT
Yonsei Med J 2008 Dec 31;49(6):1036-40. doi: 10.3349/ymj.2008.49.6.1036. PMID: 19108030Free PMC Article
Angioendotheliomatosis.
Berger TG, Dawson NA
J Am Acad Dermatol 1988 Feb;18(2 Pt 2):407-12. doi: 10.1016/s0190-9622(88)70058-4. PMID: 3278019

Clinical prediction guides

Treating rare tumors with liver transplantation.
Melehy A, Agopian V
Curr Opin Organ Transplant 2024 Feb 1;29(1):30-36. Epub 2023 Oct 18 doi: 10.1097/MOT.0000000000001118. PMID: 37851086
Hepatic epithelioid hemangioendothelioma: A clinocopathological correlation.
Mundada AD, Deodhar K, Ramadwar M, Bal M, Kumar R
Indian J Pathol Microbiol 2022 Jan-Mar;65(1):133-136. doi: 10.4103/ijpm.ijpm_350_21. PMID: 35074978
Pulmonary epithelioid hemangioendothelioma.
Rosengarten D, Kramer MR, Amir G, Fuks L, Berkman N
Isr Med Assoc J 2011 Nov;13(11):676-9. PMID: 22279701
Pulmonary epithelioid hemangioendothelioma.
Mizuno Y, Iwata H, Shirahashi K, Hirose Y, Takemura H
Gen Thorac Cardiovasc Surg 2011 Apr;59(4):297-300. Epub 2011 Apr 12 doi: 10.1007/s11748-010-0651-6. PMID: 21484560
Retiform haemangioendothelioma.
Fukunaga M, Endo Y, Masui F, Yoshikawa T, Ishikawa E, Ushigome S
Virchows Arch 1996 Jul;428(4-5):301-4. doi: 10.1007/BF00196705. PMID: 8764941

Recent systematic reviews

The use of mTOR inhibitors for the treatment of kaposiform hemangioendothelioma. A systematic review.
Maza-Morales M, Valdés-Loperena S, Durán-McKinster LC, García-Romero MT
Pediatr Dermatol 2023 May-Jun;40(3):440-445. Epub 2023 Jan 30 doi: 10.1111/pde.15262. PMID: 36716766
Adult primary liver sarcoma: systematic review.
Martins ACA, Costa Neto DCD, Silva JDDE, Moraes YM, LeÃo CS, Martins C
Rev Col Bras Cir 2020;47:e20202647. Epub 2020 Nov 30 doi: 10.1590/0100-6991e-20202647. PMID: 33263653
Treatment of kaposiform hemangioendothelioma and tufted angioma.
Liu XH, Li JY, Qu XH, Yan WL, Zhang L, Yang C, Zheng JW
Int J Cancer 2016 Oct 1;139(7):1658-66. Epub 2016 Jun 28 doi: 10.1002/ijc.30216. PMID: 27252149
Primary Thyroid Sarcoma: A Systematic Review.
Surov A, Gottschling S, Wienke A, Meyer HJ, Spielmann RP, Dralle H
Anticancer Res 2015 Oct;35(10):5185-91. PMID: 26408676
Liver transplantation for benign hepatic tumors: a systematic review.
Ercolani G, Grazi GL, Pinna AD
Dig Surg 2010;27(1):68-75. Epub 2010 Apr 1 doi: 10.1159/000268628. PMID: 20357454

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