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Sick Newborn

MedGen UID:
417237
•Concept ID:
C2825562
•
Finding

Definition

A neonate that is unwell. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVSick Newborn

Professional guidelines

PubMed

Expert consensus statement 'Neonatologist-performed Echocardiography (NoPE)'-training and accreditation in UK.
Singh Y, Gupta S, Groves AM, Gandhi A, Thomson J, Qureshi S, Simpson JM
Eur J Pediatr 2016 Feb;175(2):281-7. Epub 2015 Sep 12 doi: 10.1007/s00431-015-2633-2. PMID: 26362538
Diagnosis and management of hypotension in neonates.
Farrugia R, Rojas H, Rabe H
Future Cardiol 2013 Sep;9(5):669-79. doi: 10.2217/fca.13.59. PMID: 24020669
Withholding or withdrawal of life sustaining treatment for newborn infants.
Aladangady N, de Rooy L
Early Hum Dev 2012 Feb;88(2):65-9. Epub 2012 Jan 17 doi: 10.1016/j.earlhumdev.2012.01.002. PMID: 22261290

Recent clinical studies

Etiology

Use of human milk and fortification in the NICU.
Adamkin DH
J Perinatol 2023 May;43(5):551-559. Epub 2022 Oct 18 doi: 10.1038/s41372-022-01532-0. PMID: 36257977
Prophylactic postnatal corticosteroids: Early hydrocortisone.
Baud O, Watterberg KL
Semin Fetal Neonatal Med 2019 Jun;24(3):202-206. Epub 2019 Apr 20 doi: 10.1016/j.siny.2019.04.007. PMID: 31043325
Introduction to neonatologist-performed echocardiography.
Groves AM, Singh Y, Dempsey E, Molnar Z, Austin T, El-Khuffash A, de Boode WP; European Special Interest Group ‘Neonatologist Performed Echocardiography’ (NPE)
Pediatr Res 2018 Jul;84(Suppl 1):1-12. doi: 10.1038/s41390-018-0076-y. PMID: 30072808Free PMC Article
Ethics of drug studies in the newborn.
Ward RM, Sherwin CM
Paediatr Drugs 2015 Feb;17(1):37-42. doi: 10.1007/s40272-014-0099-8. PMID: 25354989
Perinatal galactose metabolism.
Kliegman RM, Sparks JW
J Pediatr 1985 Dec;107(6):831-41. doi: 10.1016/s0022-3476(85)80173-6. PMID: 3906069

Diagnosis

Neonatal inpatient dataset for small and sick newborn care in low- and middle-income countries: systematic development and multi-country operationalisation with NEST360.
Cross JH, Bohne C, Ngwala SK, Shabani J, Wainaina J, Dosunmu O, Kassim I, Penzias RE, Tillya R, Gathara D, Zimba E, Ezeaka VC, Odedere O, Chiume M, Salim N, Kawaza K, Lufesi N, Irimu G, Tongo OO, Malla L, Paton C, Day LT, Oden M, Richards-Kortum R, Molyneux EM, Ohuma EO, Lawn JE; with NEST360 Neonatal Inpatient Dataset Learning Group
BMC Pediatr 2023 Nov 15;23(Suppl 2):567. doi: 10.1186/s12887-023-04341-2. PMID: 37968588Free PMC Article
ALPS-Neo pain and stress assessment scale for neonates-A measure for procedural pain.
Vederhus BJ, Olsen MS, Eide GE, Storm H, Guthe HJ
Acta Paediatr 2023 Jun;112(6):1220-1225. Epub 2023 Mar 28 doi: 10.1111/apa.16759. PMID: 36938888
The healthy and sick newborn.
Stanton BF
Pediatr Clin North Am 2015 Apr;62(2):xiii. Epub 2015 Feb 26 doi: 10.1016/j.pcl.2015.01.002. PMID: 25836714
Diagnosis and management of hypotension in neonates.
Farrugia R, Rojas H, Rabe H
Future Cardiol 2013 Sep;9(5):669-79. doi: 10.2217/fca.13.59. PMID: 24020669
Mitochondrial hepatopathies in the newborn period.
Fellman V, Kotarsky H
Semin Fetal Neonatal Med 2011 Aug;16(4):222-8. Epub 2011 Jun 15 doi: 10.1016/j.siny.2011.05.002. PMID: 21680270

Therapy

Techniques to increase lumbar puncture success in newborn babies: the NeoCLEAR RCT.
Roehr CC, Marshall AS, Scrivens A, Sadarangani M, Williams R, Yong J, Linsell L, Chiocchia V, Bell JL, Stokes C, Santhanadass P, Nicoll I, Adams E, King A, Murray D, Bowler U, Stanbury K, Juszczak E; NeoCLEAR Collaborative Group
Health Technol Assess 2023 Dec;27(33):1-97. doi: 10.3310/THJY0671. PMID: 38149666Free PMC Article
Prophylactic postnatal corticosteroids: Early hydrocortisone.
Baud O, Watterberg KL
Semin Fetal Neonatal Med 2019 Jun;24(3):202-206. Epub 2019 Apr 20 doi: 10.1016/j.siny.2019.04.007. PMID: 31043325
The Goldilocks principle. Oxygen in the delivery room: When is it too little, too much, and just right?
Kapadia V, Rabi Y, Oei JL
Semin Fetal Neonatal Med 2018 Oct;23(5):347-354. Epub 2018 Jun 30 doi: 10.1016/j.siny.2018.06.003. PMID: 29983332
Ethics of drug studies in the newborn.
Ward RM, Sherwin CM
Paediatr Drugs 2015 Feb;17(1):37-42. doi: 10.1007/s40272-014-0099-8. PMID: 25354989
Thrombocytopenia in the newborn.
Ramasethu J
Curr Hematol Rep 2004 Mar;3(2):134-42. PMID: 14965490

Prognosis

Investment case for small and sick newborn care in Tanzania: systematic analyses.
Kamuyu R, Tarus A, Bundala F, Msemo G, Shamba D, Paul C, Tillya R, Murless-Collins S, Oden M, Richards-Kortum R, Powell-Jackson T, Kumar MB, Salim N, Lawn JE
BMC Pediatr 2023 Dec 14;23(Suppl 2):632. doi: 10.1186/s12887-023-04414-2. PMID: 38098013Free PMC Article
Ending Preventable Neonatal Deaths: Multicountry Evidence to Inform Accelerated Progress to the Sustainable Development Goal by 2030.
Lawn JE, Bhutta ZA, Ezeaka C, Saugstad O
Neonatology 2023;120(4):491-499. Epub 2023 May 16 doi: 10.1159/000530496. PMID: 37231868Free PMC Article
Continuum of care for maternal, newborn, and child health: from slogan to service delivery.
Kerber KJ, de Graft-Johnson JE, Bhutta ZA, Okong P, Starrs A, Lawn JE
Lancet 2007 Oct 13;370(9595):1358-69. doi: 10.1016/S0140-6736(07)61578-5. PMID: 17933651
An update on ECMO.
Tulenko DR
Neonatal Netw 2004 Jul-Aug;23(4):11-8. doi: 10.1891/0730-0832.23.4.11. PMID: 15317374
Perinatal galactose metabolism.
Kliegman RM, Sparks JW
J Pediatr 1985 Dec;107(6):831-41. doi: 10.1016/s0022-3476(85)80173-6. PMID: 3906069

Clinical prediction guides

Neonatal inpatient dataset for small and sick newborn care in low- and middle-income countries: systematic development and multi-country operationalisation with NEST360.
Cross JH, Bohne C, Ngwala SK, Shabani J, Wainaina J, Dosunmu O, Kassim I, Penzias RE, Tillya R, Gathara D, Zimba E, Ezeaka VC, Odedere O, Chiume M, Salim N, Kawaza K, Lufesi N, Irimu G, Tongo OO, Malla L, Paton C, Day LT, Oden M, Richards-Kortum R, Molyneux EM, Ohuma EO, Lawn JE; with NEST360 Neonatal Inpatient Dataset Learning Group
BMC Pediatr 2023 Nov 15;23(Suppl 2):567. doi: 10.1186/s12887-023-04341-2. PMID: 37968588Free PMC Article
ALPS-Neo pain and stress assessment scale for neonates-A measure for procedural pain.
Vederhus BJ, Olsen MS, Eide GE, Storm H, Guthe HJ
Acta Paediatr 2023 Jun;112(6):1220-1225. Epub 2023 Mar 28 doi: 10.1111/apa.16759. PMID: 36938888
Quality of care assessment for small and sick newborns and young infants in Pakistan: findings from a cross-sectional study.
Pradhan NA, Ali SA, Roujani S, Ali A, Hussain SS, Rizwan S, Ariff S, Saleem S, Siddiqi S
BMC Pediatr 2022 Jan 29;22(1):68. doi: 10.1186/s12887-022-03108-5. PMID: 35093035Free PMC Article
Efficacy and acceptability of an "App on sick newborn care" in physicians from newborn units.
Prakash V, Thukral A, Sankar MJ, Agarwal RK, Paul VK, Deorari AK
BMC Med Educ 2016 Mar 8;16:84. doi: 10.1186/s12909-016-0579-3. PMID: 26956397Free PMC Article
Pharmacology of diuretics in the newborn.
Chemtob S, Kaplan BS, Sherbotie JR, Aranda JV
Pediatr Clin North Am 1989 Oct;36(5):1231-50. doi: 10.1016/s0031-3955(16)36766-9. PMID: 2677940

Recent systematic reviews

Higher versus lower amino acid intake in parenteral nutrition for newborn infants.
Osborn DA, Schindler T, Jones LJ, Sinn JK, Bolisetty S
Cochrane Database Syst Rev 2018 Mar 5;3(3):CD005949. doi: 10.1002/14651858.CD005949.pub2. PMID: 29505664Free PMC Article

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