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Collapsing Glomerulopathy

MedGen UID:
412719
•Concept ID:
C2749515
•
Disease or Syndrome
Synonym: Collapsing glomerulopathy

Definition

Segmental or global glomerulopathy with tuft wrinkling, collapse and contraction without increased matrix or cells, but with adjacent podocyte hypertrophy and hyperplasia. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVCollapsing Glomerulopathy

Professional guidelines

PubMed

Idiopathic collapsing glomerulopathy is associated with APOL1 high-risk genotypes or Mendelian variants in most affected individuals in a highly admixed population.
Neves PD, Watanabe A, Watanabe EH, Narcizo AM, Nunes K, Lerario AM, Ferreira FM, Cavalcante LB, Wongboonsin J, Malheiros DM, Jorge LB, Sampson MG, Noronha IL, Onuchic LF
Kidney Int 2024 Mar;105(3):593-607. Epub 2023 Dec 22 doi: 10.1016/j.kint.2023.11.028. PMID: 38143038
Treatment potential in APOL1-associated nephropathy.
Friedman DJ, Ma L, Freedman BI
Curr Opin Nephrol Hypertens 2022 Sep 1;31(5):442-448. Epub 2022 Jul 11 doi: 10.1097/MNH.0000000000000816. [Epub ahead of print] PMID: 35894278
HIV-associated nephropathies: epidemiology, pathology, mechanisms and treatment.
Rosenberg AZ, Naicker S, Winkler CA, Kopp JB
Nat Rev Nephrol 2015 Mar;11(3):150-60. Epub 2015 Feb 17 doi: 10.1038/nrneph.2015.9. PMID: 25686569

Recent clinical studies

Etiology

Collapsing Glomerulopathy.
Koirala A, Akilesh S, Jefferson JA
Adv Kidney Dis Health 2024 Jul;31(4):290-298. doi: 10.1053/j.akdh.2024.03.008. PMID: 39084754Free PMC Article
Digital spatial profiling of collapsing glomerulopathy.
Smith KD, Prince DK, Henriksen KJ, Nicosia RF, Alpers CE, Akilesh S
Kidney Int 2022 May;101(5):1017-1026. Epub 2022 Feb 26 doi: 10.1016/j.kint.2022.01.033. PMID: 35227689Free PMC Article
Acute Kidney Injury in COVID-19.
Głowacka M, Lipka S, Młynarska E, Franczyk B, Rysz J
Int J Mol Sci 2021 Jul 28;22(15) doi: 10.3390/ijms22158081. PMID: 34360866Free PMC Article
COVID-19-Associated Glomerular Disease.
Shetty AA, Tawhari I, Safar-Boueri L, Seif N, Alahmadi A, Gargiulo R, Aggarwal V, Usman I, Kisselev S, Gharavi AG, Kanwar Y, Quaggin SE
J Am Soc Nephrol 2021 Jan;32(1):33-40. Epub 2020 Nov 19 doi: 10.1681/ASN.2020060804. PMID: 33214201Free PMC Article
Collapsing glomerulopathy: update.
Morales E, Alonso M, Gutiérrez E
Med Clin (Barc) 2019 May 3;152(9):361-367. Epub 2018 Dec 13 doi: 10.1016/j.medcli.2018.10.021. PMID: 30554809

Diagnosis

Autoinflammatory diseases and the kidney.
Hegazy MT, Fayed A, Nuzzolese R, Sota J, Ragab G
Immunol Res 2023 Aug;71(4):578-587. Epub 2023 Mar 29 doi: 10.1007/s12026-023-09375-3. PMID: 36991303Free PMC Article
Collapsing glomerulopathy: unraveling varied pathogeneses.
Smith KD, Akilesh S
Curr Opin Nephrol Hypertens 2023 May 1;32(3):213-222. Epub 2023 Feb 9 doi: 10.1097/MNH.0000000000000873. PMID: 36811644
Type I interferon-related kidney disorders.
Lodi L, Mastrolia MV, Bello F, Rossi GM, Angelotti ML, Crow YJ, Romagnani P, Vaglio A
Kidney Int 2022 Jun;101(6):1142-1159. Epub 2022 Mar 24 doi: 10.1016/j.kint.2022.02.031. PMID: 35339535
COVID-19-Associated Glomerular Disease.
Shetty AA, Tawhari I, Safar-Boueri L, Seif N, Alahmadi A, Gargiulo R, Aggarwal V, Usman I, Kisselev S, Gharavi AG, Kanwar Y, Quaggin SE
J Am Soc Nephrol 2021 Jan;32(1):33-40. Epub 2020 Nov 19 doi: 10.1681/ASN.2020060804. PMID: 33214201Free PMC Article
Collapsing glomerulopathy: update.
Morales E, Alonso M, Gutiérrez E
Med Clin (Barc) 2019 May 3;152(9):361-367. Epub 2018 Dec 13 doi: 10.1016/j.medcli.2018.10.021. PMID: 30554809

Therapy

Podocytopathies related to either COVID-19 infection or its vaccination, our experience and literature review.
Pokharel A, Anderson JD, Deebajah M, Blatt NB, Reddy G, Garlapaty V, Li W, Kanaan HD, Zhang PL
Ultrastruct Pathol 2023 Sep 3;47(5):373-381. Epub 2023 Jul 18 doi: 10.1080/01913123.2023.2237565. PMID: 37463165
The association between adult-onset Still's disease and collapsing glomerulopathy: a case report.
Orentas M, Patel N, Rodby R, Hassan S
J Med Case Rep 2022 Oct 14;16(1):370. doi: 10.1186/s13256-022-03606-1. PMID: 36229843Free PMC Article
Type I interferon-related kidney disorders.
Lodi L, Mastrolia MV, Bello F, Rossi GM, Angelotti ML, Crow YJ, Romagnani P, Vaglio A
Kidney Int 2022 Jun;101(6):1142-1159. Epub 2022 Mar 24 doi: 10.1016/j.kint.2022.02.031. PMID: 35339535
Clofarabine-induced kidney toxicity.
Jhaveri KD, Chidella S, Allen SL, Fishbane S
J Oncol Pharm Pract 2014 Aug;20(4):305-8. Epub 2013 Sep 29 doi: 10.1177/1078155213504976. PMID: 24081220
Parvovirus-B19-associated complications in renal transplant recipients.
Waldman M, Kopp JB
Nat Clin Pract Nephrol 2007 Oct;3(10):540-50. doi: 10.1038/ncpneph0609. PMID: 17895931

Prognosis

Collapsing Glomerulopathy.
Koirala A, Akilesh S, Jefferson JA
Adv Kidney Dis Health 2024 Jul;31(4):290-298. doi: 10.1053/j.akdh.2024.03.008. PMID: 39084754Free PMC Article
Digital spatial profiling of collapsing glomerulopathy.
Smith KD, Prince DK, Henriksen KJ, Nicosia RF, Alpers CE, Akilesh S
Kidney Int 2022 May;101(5):1017-1026. Epub 2022 Feb 26 doi: 10.1016/j.kint.2022.01.033. PMID: 35227689Free PMC Article
COVID-19-Associated Glomerular Disease.
Shetty AA, Tawhari I, Safar-Boueri L, Seif N, Alahmadi A, Gargiulo R, Aggarwal V, Usman I, Kisselev S, Gharavi AG, Kanwar Y, Quaggin SE
J Am Soc Nephrol 2021 Jan;32(1):33-40. Epub 2020 Nov 19 doi: 10.1681/ASN.2020060804. PMID: 33214201Free PMC Article
Collapsing glomerulopathy: update.
Morales E, Alonso M, Gutiérrez E
Med Clin (Barc) 2019 May 3;152(9):361-367. Epub 2018 Dec 13 doi: 10.1016/j.medcli.2018.10.021. PMID: 30554809
Collapsing glomerulopathy.
Schwimmer JA, Markowitz GS, Valeri A, Appel GB
Semin Nephrol 2003 Mar;23(2):209-18. doi: 10.1053/snep.2003.50019. PMID: 12704581

Clinical prediction guides

Type I interferon-related kidney disorders.
Lodi L, Mastrolia MV, Bello F, Rossi GM, Angelotti ML, Crow YJ, Romagnani P, Vaglio A
Kidney Int 2022 Jun;101(6):1142-1159. Epub 2022 Mar 24 doi: 10.1016/j.kint.2022.02.031. PMID: 35339535
Spectrum of Kidney Injury Following COVID-19 Disease: Renal Biopsy Findings in a Single Italian Pathology Service.
Gambella A, Barreca A, Biancone L, Roccatello D, Peruzzi L, Besso L, Licata C, Attanasio A, Papotti M, Cassoni P
Biomolecules 2022 Feb 12;12(2) doi: 10.3390/biom12020298. PMID: 35204798Free PMC Article
Evidence For and Against Direct Kidney Infection by SARS-CoV-2 in Patients with COVID-19.
Hassler L, Reyes F, Sparks MA, Welling P, Batlle D
Clin J Am Soc Nephrol 2021 Nov;16(11):1755-1765. Epub 2021 Jun 14 doi: 10.2215/CJN.04560421. PMID: 34127485Free PMC Article
Malaria, Collapsing Glomerulopathy, and Focal and Segmental Glomerulosclerosis.
Amoura A, Moktefi A, Halfon M, Karras A, Rafat C, Gibier JB, Gleeson PJ, Servais A, Argy N, Maillé P, Belenfant X, Gueutin V, Delpierre A, Tricot L, El Karoui K, Jourde-Chiche N, Houze S, Sahali D, Audard V
Clin J Am Soc Nephrol 2020 Jul 1;15(7):964-972. Epub 2020 May 22 doi: 10.2215/CJN.00590120. PMID: 32444394Free PMC Article
Clofarabine-induced kidney toxicity.
Jhaveri KD, Chidella S, Allen SL, Fishbane S
J Oncol Pharm Pract 2014 Aug;20(4):305-8. Epub 2013 Sep 29 doi: 10.1177/1078155213504976. PMID: 24081220

Recent systematic reviews

Renal manifestations in adult-onset Still's disease: a systematic review.
Arya PVA, Marnet E, Rondla M, Tan JW, Unnikrishnan D, Buller G
Rheumatol Int 2024 Jul;44(7):1209-1218. Epub 2024 Apr 16 doi: 10.1007/s00296-024-05578-5. PMID: 38625385
Renal Histopathological Changes in Coronavirus Disease 2019 Patients: A Systematic Review and Meta-analysis of Individual Patient Data.
Vishwajeet V, Krishna H, Ghatak S, Elhence PA, Ambwani S, Varthya SB
Saudi J Kidney Dis Transpl 2021 Nov-Dec;32(6):1523-1544. doi: 10.4103/1319-2442.352410. PMID: 35946265
Collapsing glomerulopathy in collagen vascular-like disease.
Nasr R, Johns C, Gertner E
Lupus 2014;23(1):75-80. Epub 2013 Nov 27 doi: 10.1177/0961203313513509. PMID: 24285096

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