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Pulmonary nodular lymphoid hyperplasia

MedGen UID:
401226
•Concept ID:
C1867419
•
Disease or Syndrome
Synonym: Pulmonary nodular lymphoid hyperplasia, familial
 
Monarch Initiative: MONDO:0008348
OMIM®: 178610
Orphanet: ORPHA60026

Definition

Pulmonary nodular lymphoid hyperplasia (PNHL) is a reactive lymphoid proliferation manifesting as solitary or multiple nodules in the lung. [from ORDO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVPulmonary nodular lymphoid hyperplasia
Follow this link to review classifications for Pulmonary nodular lymphoid hyperplasia in Orphanet.

Professional guidelines

PubMed

Differential diagnosis of IgG4-positive plasma cells in the lung.
Mukhopadhyay S
Semin Diagn Pathol 2024 Mar;41(2):72-78. Epub 2023 Nov 15 doi: 10.1053/j.semdp.2023.11.006. PMID: 37993385
Primary Pulmonary Lymphoid Lesions: Radiologic and Pathologic Findings.
Sirajuddin A, Raparia K, Lewis VA, Franks TJ, Dhand S, Galvin JR, White CS
Radiographics 2016 Jan-Feb;36(1):53-70. doi: 10.1148/rg.2016140339. PMID: 26761531

Recent clinical studies

Etiology

No definite clinical features of immunoglobulin G4-related disease in patients with pulmonary nodular lymphoid hyperplasia.
Bois MC, Sekiguchi H, Ryu JH, Yi ES
Hum Pathol 2017 Jan;59:80-86. Epub 2016 Oct 5 doi: 10.1016/j.humpath.2016.09.016. PMID: 27720730
A case of pulmonary nodular lymphoid hyperplasia with a resected cavity, followed by spontaneous regression of the remaining lesions.
Miyoshi S, Hamada H, Katayama H, Hamaguchi N, Irifune K, Ito R, Ohtsuki Y, Yoshino T, Higaki J
Intern Med 2010;49(15):1617-21. Epub 2010 Aug 2 doi: 10.2169/internalmedicine.49.3487. PMID: 20686301

Diagnosis

Suspected Aspergillus nodule histologically consistent with pulmonary nodular lymphoid hyperplasia:a case report.
Morizumi S, Morishita A, Nishiyama M, Takahashi K, Sumitomo K, Hino H, Naruse K, Takeuchi E, Sakiyama S, Shinohara T
J Med Invest 2023;70(3.4):499-502. doi: 10.2152/jmi.70.499. PMID: 37940538
Pulmonary Nodular Lymphoid Hyperplasia Evaluated with Bronchoalveolar Lavage Fluid Findings: A Case Report and Review of the Literature on Japanese Patients.
Moriyama S, Kido T, Sakamoto N, Fuchigami M, Tokito T, Okuno D, Miyamura T, Nakashima S, Hara A, Ishimoto H, Imaizumi Y, Tsuruda K, Yanagihara K, Fukuoka J, Mukae H
Intern Med 2023;62(1):95-102. Epub 2023 Jan 1 doi: 10.2169/internalmedicine.9310-21. PMID: 36596475Free PMC Article
Pulmonary nodular lymphoid hyperplasia in a 53-year-old man with malignant sign: a case report.
Yang Z, Wei L, Li X, Liu X
J Cardiothorac Surg 2021 Oct 9;16(1):289. doi: 10.1186/s13019-021-01672-y. PMID: 34627304Free PMC Article
Pulmonary nodular lymphoid hyperplasia and Sjögren's syndrome: a case report and literature review.
Darder A, Losada Lopez I, Gomez-Bellvert C, Rodriguez A, Cisneros E, Gonzalez-Moreno J
Rheumatol Int 2021 Nov;41(11):2041-2044. Epub 2021 Jun 13 doi: 10.1007/s00296-021-04915-2. PMID: 34120218
Pulmonary Nodular Lymphoid Hyperplasia.
Yell M, Rosado FG
Arch Pathol Lab Med 2019 Sep;143(9):1149-1153. Epub 2019 Feb 6 doi: 10.5858/arpa.2018-0188-RS. PMID: 30720334

Prognosis

Pulmonary nodular lymphoid hyperplasia in pediatric patients with Hodgkin lymphoma.
Quarello P, Bianchi M, Gambella A, Molinaro L, Tirtei E, Rosa GD, Arena V, Fagioli F
Pediatr Hematol Oncol 2020 Aug;37(5):424-430. Epub 2020 Mar 5 doi: 10.1080/08880018.2020.1735590. PMID: 32131663
Rare case of nodular lymphoid hyperplasia of left lung in the patient with previous pulmonary tuberculosis.
Kuzyk PV, Savchyna МА, Gychka SG
Exp Oncol 2018 Dec;40(4):332-335. PMID: 30593758
A case of pulmonary nodular lymphoid hyperplasia with a resected cavity, followed by spontaneous regression of the remaining lesions.
Miyoshi S, Hamada H, Katayama H, Hamaguchi N, Irifune K, Ito R, Ohtsuki Y, Yoshino T, Higaki J
Intern Med 2010;49(15):1617-21. Epub 2010 Aug 2 doi: 10.2169/internalmedicine.49.3487. PMID: 20686301

Clinical prediction guides

Suspected Aspergillus nodule histologically consistent with pulmonary nodular lymphoid hyperplasia:a case report.
Morizumi S, Morishita A, Nishiyama M, Takahashi K, Sumitomo K, Hino H, Naruse K, Takeuchi E, Sakiyama S, Shinohara T
J Med Invest 2023;70(3.4):499-502. doi: 10.2152/jmi.70.499. PMID: 37940538
Pulmonary nodular lymphoid hyperplasia in a 53-year-old man with malignant sign: a case report.
Yang Z, Wei L, Li X, Liu X
J Cardiothorac Surg 2021 Oct 9;16(1):289. doi: 10.1186/s13019-021-01672-y. PMID: 34627304Free PMC Article

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