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Brachydactyly, type A2, with microcephaly

MedGen UID:
395250
Concept ID:
C1859393
Disease or Syndrome
Synonym: Brachydactyly, Type A2, With Microcephaly
 
Monarch Initiative: MONDO:0008883
OMIM®: 211369

Clinical features

From HPO
Type A2 brachydactyly
MedGen UID:
318690
Concept ID:
C1832702
Congenital Abnormality
Brachydactyly type A2 is an autosomal dominant disorder characterized by malformations of the middle phalanx of the index finger and by anomalies of the second toe (summary by Su et al., 2011).
Absent middle phalanx of 2nd finger
MedGen UID:
867078
Concept ID:
C4021436
Finding
Absence of the middle phalanx of the index (2nd) finger.
Clinodactyly of the 2nd toe
MedGen UID:
867260
Concept ID:
C4021620
Anatomical Abnormality
Bending or curvature of a second toe in the tibial direction (i.e., towards the big toe).
Thumbs hypoplastic with bulbous tips
MedGen UID:
870692
Concept ID:
C4025146
Finding
Seizure
MedGen UID:
20693
Concept ID:
C0036572
Sign or Symptom
A seizure is an intermittent abnormality of nervous system physiology characterized by a transient occurrence of signs and/or symptoms due to abnormal excessive or synchronous neuronal activity in the brain.
Microcephaly
MedGen UID:
1644158
Concept ID:
C4551563
Finding
Head circumference below 2 standard deviations below the mean for age and gender.
Diabetes mellitus
MedGen UID:
8350
Concept ID:
C0011849
Disease or Syndrome
A group of abnormalities characterized by hyperglycemia and glucose intolerance.

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