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Microsporidiosis

MedGen UID:
39278
•Concept ID:
C0085407
•
Disease or Syndrome
Synonym: Microsporidiasis
SNOMED CT: Infection by Microspora (65883009); Infection by Microsporidia (699676006); Microsporidiosis (699676006); Infection caused by Microsporidia (699676006); Infection caused by Microspora (65883009)
Modes of inheritance:
Not genetically inherited
MedGen UID:
988794
•Concept ID:
CN307044
•
Finding
Source: Orphanet
clinical entity without genetic inheritance.
See: This record
Not genetically inherited (Orphanet)
 
Monarch Initiative: MONDO:0005846
Orphanet: ORPHA2552

Definition

Microsporidiosis is a parasitosis caused by microsporidia (protozoan parasites). [from ORDO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVMicrosporidiosis
Follow this link to review classifications for Microsporidiosis in Orphanet.

Professional guidelines

PubMed

Unusual dominant genotype NIA1 of Enterocytozoon bieneusi in children in Southern Xinjiang, China.
Qi M, Yu F, Zhao A, Zhang Y, Wei Z, Li D, Zhang L
PLoS Negl Trop Dis 2020 Jun;14(6):e0008293. Epub 2020 Jun 22 doi: 10.1371/journal.pntd.0008293. PMID: 32569279Free PMC Article
Therapeutic targets for the treatment of microsporidiosis in humans.
Han B, Weiss LM
Expert Opin Ther Targets 2018 Nov;22(11):903-915. Epub 2018 Nov 1 doi: 10.1080/14728222.2018.1538360. PMID: 30336698Free PMC Article
Prevalence and genotypes of Enterocytozoon bieneusi in China.
Wang SS, Wang RJ, Fan XC, Liu TL, Zhang LX, Zhao GH
Acta Trop 2018 Jul;183:142-152. Epub 2018 Apr 13 doi: 10.1016/j.actatropica.2018.04.017. PMID: 29660311

Recent clinical studies

Etiology

Microsporidiosis in Humans.
Han B, Pan G, Weiss LM
Clin Microbiol Rev 2021 Dec 15;34(4):e0001020. Epub 2021 Jun 30 doi: 10.1128/CMR.00010-20. PMID: 34190570Free PMC Article
Therapeutic targets for the treatment of microsporidiosis in humans.
Han B, Weiss LM
Expert Opin Ther Targets 2018 Nov;22(11):903-915. Epub 2018 Nov 1 doi: 10.1080/14728222.2018.1538360. PMID: 30336698Free PMC Article
Invertebrate host responses to microsporidia infections.
Pan G, Bao J, Ma Z, Song Y, Han B, Ran M, Li C, Zhou Z
Dev Comp Immunol 2018 Jun;83:104-113. Epub 2018 Feb 8 doi: 10.1016/j.dci.2018.02.004. PMID: 29428490
Microsporidia-host interactions.
Szumowski SC, Troemel ER
Curr Opin Microbiol 2015 Aug;26:10-6. Epub 2015 Apr 4 doi: 10.1016/j.mib.2015.03.006. PMID: 25847674Free PMC Article
Microsporidiosis: current status.
Didier ES, Weiss LM
Curr Opin Infect Dis 2006 Oct;19(5):485-92. doi: 10.1097/01.qco.0000244055.46382.23. PMID: 16940873Free PMC Article

Diagnosis

Microsporidiosis in Humans.
Han B, Pan G, Weiss LM
Clin Microbiol Rev 2021 Dec 15;34(4):e0001020. Epub 2021 Jun 30 doi: 10.1128/CMR.00010-20. PMID: 34190570Free PMC Article
Diarrhea in the immunocompromised patient.
Krones E, Högenauer C
Gastroenterol Clin North Am 2012 Sep;41(3):677-701. Epub 2012 Jul 4 doi: 10.1016/j.gtc.2012.06.009. PMID: 22917171
Microsporidiosis: current status.
Didier ES, Weiss LM
Curr Opin Infect Dis 2006 Oct;19(5):485-92. doi: 10.1097/01.qco.0000244055.46382.23. PMID: 16940873Free PMC Article
Parasitic gastroenteritis.
La Via WV, B1P6
Pediatr Ann 1994 Oct;23(10):556-60. doi: 10.3928/0090-4481-19941001-10. PMID: 7838606
Human microsporidial infections.
Weber R, Bryan RT, Schwartz DA, Owen RL
Clin Microbiol Rev 1994 Oct;7(4):426-61. doi: 10.1128/CMR.7.4.426. PMID: 7834600Free PMC Article

Therapy

Albendazole and Mebendazole as Anti-Parasitic and Anti-Cancer Agents: an Update.
Chai JY, Jung BK, Hong SJ
Korean J Parasitol 2021 Jun;59(3):189-225. Epub 2021 Jun 21 doi: 10.3347/kjp.2021.59.3.189. PMID: 34218593Free PMC Article
Intestinal parasites including Cryptosporidium, Cyclospora, Giardia, and Microsporidia, Entamoeba histolytica, Strongyloides, Schistosomiasis, and Echinococcus: Guidelines from the American Society of Transplantation Infectious Diseases Community of Practice.
La Hoz RM, Morris MI; AST Infectious Diseases Community of Practice
Clin Transplant 2019 Sep;33(9):e13618. Epub 2019 Jun 23 doi: 10.1111/ctr.13618. PMID: 31145496
Diarrhea in the immunocompromised patient.
Krones E, Högenauer C
Gastroenterol Clin North Am 2012 Sep;41(3):677-701. Epub 2012 Jul 4 doi: 10.1016/j.gtc.2012.06.009. PMID: 22917171
Thalidomide: a re-look.
Grover JK, Vats V, Gopalakrishna R, Ramam M
Natl Med J India 2000 May-Jun;13(3):132-41. PMID: 11558112
Antiparasitic agents.
Rosenblatt JE
Mayo Clin Proc 1999 Nov;74(11):1161-75. doi: 10.4065/74.11.1161. PMID: 10560606

Prognosis

Microsporidial myositis in adult-onset immunodeficiency: case-based review.
Sundaram TG, Aggarwal A, Ganguly S, Iangngap EK, Marak RSK, Gupta L
Rheumatol Int 2019 Nov;39(11):1995-2003. Epub 2019 Sep 9 doi: 10.1007/s00296-019-04439-w. PMID: 31501996
Anncaliia algerae microsporidial myositis.
Watts MR, Chan RC, Cheong EY, Brammah S, Clezy KR, Tong C, Marriott D, Webb CE, Chacko B, Tobias V, Outhred AC, Field AS, Prowse MV, Bertouch JV, Stark D, Reddel SW
Emerg Infect Dis 2014 Feb;20(2):185-91. doi: 10.3201/eid2002.131126. PMID: 24447398Free PMC Article
Clinical spectrum of microsporidial keratoconjunctivitis.
Tham AC, Sanjay S
Clin Exp Ophthalmol 2012 Jul;40(5):512-8. Epub 2011 Dec 6 doi: 10.1111/j.1442-9071.2011.02712.x. PMID: 22003887
The ecology and evolution of microsporidian parasites.
Smith JE
Parasitology 2009 Dec;136(14):1901-14. doi: 10.1017/S0031182009991818. PMID: 19995469
Microsporidiosis as an AIDS-related opportunistic infection.
Bryan RT
Clin Infect Dis 1995 Aug;21 Suppl 1:S62-5. doi: 10.1093/clinids/21.supplement_1.s62. PMID: 8547514

Clinical prediction guides

Epidemiological and clinical study of microsporidiosis in French kidney transplant recipients from 2005 to 2019: TRANS-SPORE registry.
Dumond C, Aulagnon F, Etienne I, Heng AE, Bougnoux ME, Favennec L, Kamar N, Iriart X, Pereira B, Büchler M, Desoubeaux G, Kaminski H, Lussac-Sorton F, Gargala G, Anglicheau D, Poirier P, Scemla A, Garrouste C; French Microsporidiosis Network
Transpl Infect Dis 2021 Oct;23(5):e13708. Epub 2021 Aug 5 doi: 10.1111/tid.13708. PMID: 34324771
HIV/AIDS-associated opportunistic protozoal diarrhea.
Agholi M, Hatam GR, Motazedian MH
AIDS Res Hum Retroviruses 2013 Jan;29(1):35-41. Epub 2012 Sep 11 doi: 10.1089/AID.2012.0119. PMID: 22873400Free PMC Article
The ecology and evolution of microsporidian parasites.
Smith JE
Parasitology 2009 Dec;136(14):1901-14. doi: 10.1017/S0031182009991818. PMID: 19995469
Thalidomide: a re-look.
Grover JK, Vats V, Gopalakrishna R, Ramam M
Natl Med J India 2000 May-Jun;13(3):132-41. PMID: 11558112
Human microsporidial infections.
Weber R, Bryan RT, Schwartz DA, Owen RL
Clin Microbiol Rev 1994 Oct;7(4):426-61. doi: 10.1128/CMR.7.4.426. PMID: 7834600Free PMC Article

Recent systematic reviews

Global prevalence and risk factors of Enterocytozoon bieneusi infection in humans: a systematic review and meta-analysis.
Wang Y, Li XM, Yang X, Wang XY, Wei YJ, Cai Y, Geng HL, Yang XB, Yu HL, Cao H, Jiang J
Parasite 2024;31:9. Epub 2024 Feb 9 doi: 10.1051/parasite/2024007. PMID: 38345479Free PMC Article
Global prevalence and genotype distribution of Microsporidia spp. in various consumables: a systematic review and meta-analysis.
Rezaeian S, Taghipour A, Bahadory S, Mogharab V, Abdoli A
J Water Health 2023 Jul;21(7):895-914. doi: 10.2166/wh.2023.042. PMID: 37515561
Prevalence and related factors of Enterocytozoon bieneusi in cattle: A global systematic review and meta-analysis.
Qin Y, Chen C, Qin YF, Yang XB, Li MH, Meng XZ, Zhao ZY, Ma N, Cai Y, Zhang Y, Zhao Q
Prev Vet Med 2022 Nov;208:105775. Epub 2022 Oct 6 doi: 10.1016/j.prevetmed.2022.105775. PMID: 36265298
The prevalence of microsporidia in China : A systematic review and meta-analysis.
Qiu L, Xia W, Li W, Ping J, Ding S, Liu H
Sci Rep 2019 Feb 28;9(1):3174. doi: 10.1038/s41598-019-39290-3. PMID: 30816168Free PMC Article
Prevalence of Cryptosporidium, microsporidia and Isospora infection in HIV-infected people: a global systematic review and meta-analysis.
Wang ZD, Liu Q, Liu HH, Li S, Zhang L, Zhao YK, Zhu XQ
Parasit Vectors 2018 Jan 9;11(1):28. doi: 10.1186/s13071-017-2558-x. PMID: 29316950Free PMC Article

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