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Pyogenic granuloma

MedGen UID:
39085
•Concept ID:
C0085653
•
Neoplastic Process
Synonyms: Lobular capillary hemangioma; PG
SNOMED CT: PG - Pyogenic granuloma (39629007); Capillary hemangioma of granulation tissue type (17372009); Lobular capillary hemangioma (17372009); Granuloma pyogenicum (17372009); Pyogenic granuloma (17372009); Granuloma telangiectaticum (17372009); Pyogenic granuloma (200722003)
 
Monarch Initiative: MONDO:0022096

Definition

A friable, benign vascular neoplasm with lobular capillary architecture that presents as a raised red skin growth. [from NCI]

Professional guidelines

PubMed

S2k guideline: Laser therapy of the skin.
Paasch U, Zidane M, Baron JM, Bund T, Cappius HJ, Drosner M, Feise K, Fischer T, Gauglitz G, Gerber PA, Grunewald S, Herberger K, Jung A, Karsai S, Kautz G, Philipp C, Schädel D, Seitz AT, Nast A
J Dtsch Dermatol Ges 2022 Sep;20(9):1248-1267. Epub 2022 Sep 13 doi: 10.1111/ddg.14879. PMID: 36098675
Pyogenic granulomas in childhood: New treatment modalities.
Patrizi A, Gurioli C, Dika E
Dermatol Ther 2015 Sep-Oct;28(5):332. Epub 2015 May 27 doi: 10.1111/dth.12237. PMID: 25818498
Management of hemangiomas and other vascular tumors.
Greene AK
Clin Plast Surg 2011 Jan;38(1):45-63. doi: 10.1016/j.cps.2010.08.001. PMID: 21095471

Recent clinical studies

Etiology

Polidocanol Sclerotherapy for the Treatment of Pyogenic Granuloma in Children.
Li J, Wu C, Song D, Wang L, Guo L
Dermatol Surg 2021 Jun 1;47(6):802-804. doi: 10.1097/DSS.0000000000002967. PMID: 33625133
Benign oral mucosal lesions: Clinical and pathological findings.
Maymone MBC, Greer RO, Burdine LK, Dao-Cheng A, Venkatesh S, Sahitya PC, Maymone AC, Kesecker J, Vashi NA
J Am Acad Dermatol 2019 Jul;81(1):43-56. Epub 2018 Nov 14 doi: 10.1016/j.jaad.2018.09.061. PMID: 30447312
Periodontal health and gingival diseases and conditions on an intact and a reduced periodontium: Consensus report of workgroup 1 of the 2017 World Workshop on the Classification of Periodontal and Peri-Implant Diseases and Conditions.
Chapple ILC, Mealey BL, Van Dyke TE, Bartold PM, Dommisch H, Eickholz P, Geisinger ML, Genco RJ, Glogauer M, Goldstein M, Griffin TJ, Holmstrup P, Johnson GK, Kapila Y, Lang NP, Meyle J, Murakami S, Plemons J, Romito GA, Shapira L, Tatakis DN, Teughels W, Trombelli L, Walter C, Wimmer G, Xenoudi P, Yoshie H
J Periodontol 2018 Jun;89 Suppl 1:S74-S84. doi: 10.1002/JPER.17-0719. PMID: 29926944
Pyogenic granuloma.
Lin RL, Janniger CK
Cutis 2004 Oct;74(4):229-33. PMID: 15551715
Bacillary angiomatosis.
Batsakis JG, Ro JY, Frauenhoffer EE
Ann Otol Rhinol Laryngol 1995 Aug;104(8):668-72. doi: 10.1177/000348949510400815. PMID: 7543738

Diagnosis

Pyogenic Granuloma.
Komakech D, Ssenkumba B
N Engl J Med 2022 Nov 24;387(21):1979. doi: 10.1056/NEJMicm2204602. PMID: 36416770
Vascular Anomalies: Other Vascular Tumors.
Atherton K, Hinen H
Dermatol Clin 2022 Oct;40(4):401-423. Epub 2022 Sep 16 doi: 10.1016/j.det.2022.06.011. PMID: 36243428
Duodenal Pyogenic Granuloma.
Paleti S, Fischer EG, Rustagi T
Clin Gastroenterol Hepatol 2021 Jul;19(7):e73. Epub 2020 Apr 30 doi: 10.1016/j.cgh.2020.04.064. PMID: 32360803
Congenital Vascular Tumors.
Goss JA, Greene AK
Otolaryngol Clin North Am 2018 Feb;51(1):89-97. doi: 10.1016/j.otc.2017.09.008. PMID: 29217070
Pyogenic granuloma.
Lin RL, Janniger CK
Cutis 2004 Oct;74(4):229-33. PMID: 15551715

Therapy

RF - FTopical Timolol in Dermatology.
Lopez-Bernal T, Aranegui B
Actas Dermosifiliogr 2023 Apr;114(4):334-335. Epub 2022 Sep 17 doi: 10.1016/j.ad.2021.09.014. PMID: 36126701
Polidocanol Sclerotherapy in Pyogenic Granulomas.
Khurana A, Mathachan SR
Dermatol Surg 2022 Jan 1;48(1):72-75. doi: 10.1097/DSS.0000000000003308. PMID: 34816819
Topical beta-blockers in dermatologic therapy.
Filoni A, Ambrogio F, De Marco A, Pacifico A, Bonamonte D
Dermatol Ther 2021 Jul;34(4):e15016. Epub 2021 Jun 21 doi: 10.1111/dth.15016. PMID: 34075667Free PMC Article
Laryngeal Contact Ulcer.
Barrena BG, Miller TM, Nelson BL
Head Neck Pathol 2020 Dec;14(4):1032-1035. Epub 2020 May 7 doi: 10.1007/s12105-020-01167-7. PMID: 32383044Free PMC Article
The "silver-nitrate-oma".
McBride TJ, Rand B, Dhillon SS
Hand Surg 2012;17(1):129-30. doi: 10.1142/S0218810412720136. PMID: 22351550

Prognosis

Nail tumors.
Richert B, Lecerf P, Caucanas M, André J
Clin Dermatol 2013 Sep-Oct;31(5):602-17. doi: 10.1016/j.clindermatol.2013.06.014. PMID: 24079590
Kaposi sarcoma.
Radu O, Pantanowitz L
Arch Pathol Lab Med 2013 Feb;137(2):289-94. doi: 10.5858/arpa.2012-0101-RS. PMID: 23368874
Pyogenic granuloma.
Lin RL, Janniger CK
Cutis 2004 Oct;74(4):229-33. PMID: 15551715
Pyogenic granulomas.
Jennings BJ
J Am Optom Assoc 1987 Aug;58(8):664-73. PMID: 3624762
Subungual epidermoid carcinoma.
Mikhail GR
J Am Acad Dermatol 1984 Aug;11(2 Pt 1):291-8. doi: 10.1016/s0190-9622(84)70165-4. PMID: 6480930

Clinical prediction guides

How Traumatic is Intravitreal Ozurdex Injection?
Gulyesil FF, Dogan M, Sabaner MC, Gobeka HH
Ocul Immunol Inflamm 2023 Oct;31(8):1569-1571. Epub 2021 Apr 7 doi: 10.1080/09273948.2021.1896009. PMID: 33826471
Polidocanol Sclerotherapy for the Treatment of Pyogenic Granuloma in Children.
Li J, Wu C, Song D, Wang L, Guo L
Dermatol Surg 2021 Jun 1;47(6):802-804. doi: 10.1097/DSS.0000000000002967. PMID: 33625133
Dermatopathological characteristics of dermatofibromas from dermatoscopic clues.
Genc Y, Akay BN, Okcu Heper A, Rosendahl C, Erdem C
Int J Dermatol 2020 Jan;59(1):66-75. Epub 2019 Jul 1 doi: 10.1111/ijd.14559. PMID: 31264200
Oral tissues and orthodontic treatment: common side effects.
Farronato G, Giannini L, Galbiati G, Cannalire P, Martinelli G, Tubertini I, Maspero C
Minerva Stomatol 2013 Nov-Dec;62(11-12):431-46. PMID: 24270203
Treatment options for cutaneous pyogenic granulomas: a review.
Lee J, Sinno H, Tahiri Y, Gilardino MS
J Plast Reconstr Aesthet Surg 2011 Sep;64(9):1216-20. Epub 2011 Feb 11 doi: 10.1016/j.bjps.2010.12.021. PMID: 21316320

Recent systematic reviews

Acitretin-induced periungual pyogenic granulomas and review.
Thomas M, Shon W, Truong AK
Dermatol Online J 2021 Jul 15;27(7) doi: 10.5070/D327754369. PMID: 34391333
Cutaneous presentations of omphalomesenteric duct remnant: A systematic review of the literature.
Solomon-Cohen E, Lapidoth M, Snast I, Ben-Amitai D, Zidan O, Friedland R, Moshe M, Mimouni D, Leshem YA, Hodak E, Levi A
J Am Acad Dermatol 2019 Nov;81(5):1120-1126. Epub 2019 Feb 21 doi: 10.1016/j.jaad.2019.02.033. PMID: 30797849
Prevalence of oral mucosal disorders during pregnancy: A systematic review and meta-analysis.
Bett JVS, Batistella EÂ, Melo G, Munhoz EA, Silva CAB, Guerra ENDS, Porporatti AL, De Luca Canto G
J Oral Pathol Med 2019 Apr;48(4):270-277. Epub 2019 Feb 12 doi: 10.1111/jop.12831. PMID: 30673134
Therapeutic approaches to pyogenic granuloma: an updated review.
Plachouri KM, Georgiou S
Int J Dermatol 2019 Jun;58(6):642-648. Epub 2018 Oct 21 doi: 10.1111/ijd.14268. PMID: 30345507
Conjunctival autograft for pterygium.
Clearfield E, Muthappan V, Wang X, Kuo IC
Cochrane Database Syst Rev 2016 Feb 11;2(2):CD011349. doi: 10.1002/14651858.CD011349.pub2. PMID: 26867004Free PMC Article

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