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Hypocapnia

MedGen UID:
39035
•Concept ID:
C0085383
•
Finding; Sign or Symptom
Synonym: Hypocapnias
SNOMED CT: Hypocapnia (61031008); Hypocapnemia (61031008); Hypocarbia (61031008)
 
HPO: HP:0012417

Definition

Abnormally reduced blood carbon dioxide (CO2) level. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVHypocapnia

Professional guidelines

PubMed

Decompressive craniectomy for the treatment of high intracranial pressure in closed traumatic brain injury.
Sahuquillo J, Dennis JA
Cochrane Database Syst Rev 2019 Dec 31;12(12):CD003983. doi: 10.1002/14651858.CD003983.pub3. PMID: 31887790Free PMC Article
Respiratory management during therapeutic hypothermia for hypoxic-ischemic encephalopathy.
Szakmar E, Jermendy A, El-Dib M
J Perinatol 2019 Jun;39(6):763-773. Epub 2019 Mar 11 doi: 10.1038/s41372-019-0349-2. PMID: 30858610
Hyperbaric oxygen treatment for air or gas embolism.
Moon RE
Undersea Hyperb Med 2014 Mar-Apr;41(2):159-66. PMID: 24851554

Recent clinical studies

Etiology

Prevalence of cerebral edema among diabetic ketoacidosis patients.
González Pannia P, Balboa R, Navarro R, Nocita MF, Ferraro M, Mannucci C
Arch Argent Pediatr 2020 Oct;118(5):332-336. doi: 10.5546/aap.2020.eng.332. PMID: 32924396
Pulmonary Embolism and Gas Exchange.
Fernandes CJ, Luppino Assad AP, Alves-Jr JL, Jardim C, de Souza R
Respiration 2019;98(3):253-262. Epub 2019 Aug 7 doi: 10.1159/000501342. PMID: 31390642
Anaesthetic considerations for surgery in newborns.
Houck CS, Vinson AE
Arch Dis Child Fetal Neonatal Ed 2017 Jul;102(4):F359-F363. Epub 2017 Mar 10 doi: 10.1136/archdischild-2016-311800. PMID: 28283552
Dysfunctional breathing: a review of the literature and proposal for classification.
Boulding R, Stacey R, Niven R, Fowler SJ
Eur Respir Rev 2016 Sep;25(141):287-94. doi: 10.1183/16000617.0088-2015. PMID: 27581828Free PMC Article
Permissive hypercapnia.
Thome UH, Carlo WA
Semin Neonatol 2002 Oct;7(5):409-19. doi: 10.1053/siny.2002.0135. PMID: 12464503

Diagnosis

Respiratory Acidosis and Respiratory Alkalosis: Core Curriculum 2023.
Palmer BF, Clegg DJ
Am J Kidney Dis 2023 Sep;82(3):347-359. Epub 2023 Jun 21 doi: 10.1053/j.ajkd.2023.02.004. PMID: 37341662
Neurotrauma Update.
Salasky VR, Chang WW
Emerg Med Clin North Am 2023 Feb;41(1):19-33. doi: 10.1016/j.emc.2022.09.014. PMID: 36424041
The physiological basis of pulmonary arterial hypertension.
Naeije R, Richter MJ, Rubin LJ
Eur Respir J 2022 Jun;59(6) Epub 2022 Jun 16 doi: 10.1183/13993003.02334-2021. PMID: 34737219Free PMC Article
Prevalence of cerebral edema among diabetic ketoacidosis patients.
González Pannia P, Balboa R, Navarro R, Nocita MF, Ferraro M, Mannucci C
Arch Argent Pediatr 2020 Oct;118(5):332-336. doi: 10.5546/aap.2020.eng.332. PMID: 32924396
Dysfunctional breathing: a review of the literature and proposal for classification.
Boulding R, Stacey R, Niven R, Fowler SJ
Eur Respir Rev 2016 Sep;25(141):287-94. doi: 10.1183/16000617.0088-2015. PMID: 27581828Free PMC Article

Therapy

Neurotrauma Update.
Salasky VR, Chang WW
Emerg Med Clin North Am 2023 Feb;41(1):19-33. doi: 10.1016/j.emc.2022.09.014. PMID: 36424041
Prevalence of cerebral edema among diabetic ketoacidosis patients.
González Pannia P, Balboa R, Navarro R, Nocita MF, Ferraro M, Mannucci C
Arch Argent Pediatr 2020 Oct;118(5):332-336. doi: 10.5546/aap.2020.eng.332. PMID: 32924396
Decompressive craniectomy for the treatment of high intracranial pressure in closed traumatic brain injury.
Sahuquillo J, Dennis JA
Cochrane Database Syst Rev 2019 Dec 31;12(12):CD003983. doi: 10.1002/14651858.CD003983.pub3. PMID: 31887790Free PMC Article
Permissive hypercapnia.
Thome UH, Carlo WA
Semin Neonatol 2002 Oct;7(5):409-19. doi: 10.1053/siny.2002.0135. PMID: 12464503
Hypocapnia.
Laffey JG, Kavanagh BP
N Engl J Med 2002 Jul 4;347(1):43-53. doi: 10.1056/NEJMra012457. PMID: 12097540

Prognosis

Carbon dioxide and MAPK signalling: towards therapy for inflammation.
Gałgańska H, Jarmuszkiewicz W, Gałgański Ł
Cell Commun Signal 2023 Oct 10;21(1):280. doi: 10.1186/s12964-023-01306-x. PMID: 37817178Free PMC Article
Neurotrauma Update.
Salasky VR, Chang WW
Emerg Med Clin North Am 2023 Feb;41(1):19-33. doi: 10.1016/j.emc.2022.09.014. PMID: 36424041
Dysfunctional breathing: a review of the literature and proposal for classification.
Boulding R, Stacey R, Niven R, Fowler SJ
Eur Respir Rev 2016 Sep;25(141):287-94. doi: 10.1183/16000617.0088-2015. PMID: 27581828Free PMC Article
Central Sleep Apnea at High Altitude.
Burgess KR, Ainslie PN
Adv Exp Med Biol 2016;903:275-83. doi: 10.1007/978-1-4899-7678-9_19. PMID: 27343103
Ventilatory targets after cardiac arrest.
Sutherasan Y, Vargas M, Brunetti I, Pelosi P
Minerva Anestesiol 2015 Jan;81(1):39-51. Epub 2014 Mar 19 PMID: 24642487

Clinical prediction guides

High ventilation breathwork practices: An overview of their effects, mechanisms, and considerations for clinical applications.
Fincham GW, Kartar A, Uthaug MV, Anderson B, Hall L, Nagai Y, Critchley H, Colasanti A
Neurosci Biobehav Rev 2023 Dec;155:105453. Epub 2023 Nov 2 doi: 10.1016/j.neubiorev.2023.105453. PMID: 37923236
Neurotrauma Update.
Salasky VR, Chang WW
Emerg Med Clin North Am 2023 Feb;41(1):19-33. doi: 10.1016/j.emc.2022.09.014. PMID: 36424041
Hyperventilation and electroconvulsive therapy: A literature review.
Gómez-Arnau J, de Arriba-Arnau A, Correas-Lauffer J, Urretavizcaya M
Gen Hosp Psychiatry 2018 Jan-Feb;50:54-62. Epub 2017 Sep 23 doi: 10.1016/j.genhosppsych.2017.09.003. PMID: 29054017
Dysfunctional breathing: a review of the literature and proposal for classification.
Boulding R, Stacey R, Niven R, Fowler SJ
Eur Respir Rev 2016 Sep;25(141):287-94. doi: 10.1183/16000617.0088-2015. PMID: 27581828Free PMC Article
Brain perfusion in sepsis.
Taccone FS, Scolletta S, Franchi F, Donadello K, Oddo M
Curr Vasc Pharmacol 2013 Mar 1;11(2):170-86. doi: 10.2174/1570161111311020007. PMID: 23506496

Recent systematic reviews

Carbon dioxide levels in neonates: what are safe parameters?
Wong SK, Chim M, Allen J, Butler A, Tyrrell J, Hurley T, McGovern M, Omer M, Lagan N, Meehan J, Cummins EP, Molloy EJ
Pediatr Res 2022 Apr;91(5):1049-1056. Epub 2021 Jul 6 doi: 10.1038/s41390-021-01473-y. PMID: 34230621Free PMC Article
Oxygenation and ventilation targets after cardiac arrest: A systematic review and meta-analysis.
Holmberg MJ, Nicholson T, Nolan JP, Schexnayder S, Reynolds J, Nation K, Welsford M, Morley P, Soar J, Berg KM; Adult Pediatric Advanced Life Support Task Forces at the International Liaison Committee on Resuscitation (ILCOR)
Resuscitation 2020 Jul;152:107-115. Epub 2020 May 8 doi: 10.1016/j.resuscitation.2020.04.031. PMID: 32389599
Decompressive craniectomy for the treatment of high intracranial pressure in closed traumatic brain injury.
Sahuquillo J, Dennis JA
Cochrane Database Syst Rev 2019 Dec 31;12(12):CD003983. doi: 10.1002/14651858.CD003983.pub3. PMID: 31887790Free PMC Article
Effects of PaCO2 derangements on clinical outcomes after cerebral injury: A systematic review.
Roberts BW, Karagiannis P, Coletta M, Kilgannon JH, Chansky ME, Trzeciak S
Resuscitation 2015 Jun;91:32-41. Epub 2015 Mar 28 doi: 10.1016/j.resuscitation.2015.03.015. PMID: 25828950
Hypoxic hypoxia at moderate altitudes: review of the state of the science.
Petrassi FA, Hodkinson PD, Walters PL, Gaydos SJ
Aviat Space Environ Med 2012 Oct;83(10):975-84. doi: 10.3357/asem.3315.2012. PMID: 23066620

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