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Ranula

MedGen UID:
389212
•Concept ID:
C2242813
•
Disease or Syndrome
Synonym: Ranulas
SNOMED CT: Ranula (14919007); Ranula of floor of mouth (14919007); Sublingual cyst (14919007)
 
HPO: HP:0030706

Definition

A ranula is a mucocele that occurs in the floor of the mouth and usually involve the major salivary glands. Specifically, the ranula originates in the body of the sublingual gland, in the ducts of the sublingual gland, in the Wharton's duct of the submandibular gland or infrequently from the minor salivary glands at this location. [from HPO]

Professional guidelines

PubMed

Management of Mucoceles, Sialoceles, and Ranulas.
Bowers EMR, Schaitkin B
Otolaryngol Clin North Am 2021 Jun;54(3):543-551. doi: 10.1016/j.otc.2021.03.002. PMID: 34024482
Diagnosis and management of salivary lesions of the neck.
Carlson ER
Atlas Oral Maxillofac Surg Clin North Am 2015 Mar;23(1):49-61. Epub 2015 Jan 9 doi: 10.1016/j.cxom.2014.10.005. PMID: 25707565
Primary treatment of pediatric plunging ranula with nonsurgical sclerotherapy using OK-432 (Picibanil).
Roh JL, Kim HS
Int J Pediatr Otorhinolaryngol 2008 Sep;72(9):1405-10. Epub 2008 Jul 9 doi: 10.1016/j.ijporl.2008.06.003. PMID: 18617276

Recent clinical studies

Etiology

Ranula in children: Retrospective study of 25 years and literature review of the plunging variable.
Bachesk AB, Bin LR, Iwaki IV, Iwaki Filho L
Int J Pediatr Otorhinolaryngol 2021 Sep;148:110810. Epub 2021 Jun 23 doi: 10.1016/j.ijporl.2021.110810. PMID: 34242981
Plunging Ranula.
Liman ARUA, Tuang GJ, Mansor M
Ear Nose Throat J 2021 Dec;100(10_suppl):1004S-1005S. Epub 2020 Jun 11 doi: 10.1177/0145561320927828. PMID: 32525702
Congenital Ranula: A Case Report and Literature Review.
Pontes FSC, de Souza LL, Pedrinha VF, Pontes HAR
J Clin Pediatr Dent 2018;42(6):454-457. Epub 2018 Aug 7 doi: 10.17796/1053-4625-42.6.9. PMID: 30085866
Plunging ranula: congenital or acquired?
Morton RP, Ahmad Z, Jain P
Otolaryngol Head Neck Surg 2010 Jan;142(1):104-7. doi: 10.1016/j.otohns.2009.10.014. PMID: 20096232
Primary treatment of pediatric plunging ranula with nonsurgical sclerotherapy using OK-432 (Picibanil).
Roh JL, Kim HS
Int J Pediatr Otorhinolaryngol 2008 Sep;72(9):1405-10. Epub 2008 Jul 9 doi: 10.1016/j.ijporl.2008.06.003. PMID: 18617276

Diagnosis

Imaging of Pediatric Salivary Glands.
Friedman E, Patiño MO, Udayasankar UK
Neuroimaging Clin N Am 2018 May;28(2):209-226. Epub 2018 Mar 7 doi: 10.1016/j.nic.2018.01.005. PMID: 29622115
Salivary gland disorders.
Mandel L
Med Clin North Am 2014 Nov;98(6):1407-49. Epub 2014 Oct 18 doi: 10.1016/j.mcna.2014.08.008. PMID: 25443682
Plunging ranula.
Kalra V, Mirza K, Malhotra A
J Radiol Case Rep 2011;5(6):18-24. Epub 2011 Jun 1 doi: 10.3941/jrcr.v5i6.682. PMID: 22470797Free PMC Article
Congenital neck masses.
Rosa PA, Hirsch DL, Dierks EJ
Oral Maxillofac Surg Clin North Am 2008 Aug;20(3):339-52. doi: 10.1016/j.coms.2008.03.003. PMID: 18603195
Non-nodal neck masses.
Woodruff WW, Kennedy TL
Semin Ultrasound CT MR 1997 Jun;18(3):182-204. doi: 10.1016/s0887-2171(97)90019-6. PMID: 9253083

Therapy

What is new in management of pediatric ranula?
Zhi K, Gao L, Ren W
Curr Opin Otolaryngol Head Neck Surg 2014 Dec;22(6):525-9. doi: 10.1097/MOO.0000000000000103. PMID: 25211709
OK-432 treatment of ranula extending to the parapharyngeal space.
Ohta N, Fukase S, Suzuki Y, Kurakami K, Aoyagi M, Kakehata S
Acta Otolaryngol 2014 Feb;134(2):206-10. Epub 2013 Nov 21 doi: 10.3109/00016489.2013.847285. PMID: 24256037
Review of unusual intraoperative and postoperative complications associated with endosseous implant placement.
Wanner L, Manegold-Brauer G, Brauer HU
Quintessence Int 2013 Nov-Dec;44(10):773-81. doi: 10.3290/j.qi.a29936. PMID: 23772438
Primary treatment of pediatric plunging ranula with nonsurgical sclerotherapy using OK-432 (Picibanil).
Roh JL, Kim HS
Int J Pediatr Otorhinolaryngol 2008 Sep;72(9):1405-10. Epub 2008 Jul 9 doi: 10.1016/j.ijporl.2008.06.003. PMID: 18617276
Myxofibrosarcoma of the neck.
Udaka T, Yamamoto H, Shiomori T, Fujimura T, Suzuki H
J Laryngol Otol 2006 Oct;120(10):872-4. doi: 10.1017/S0022215106001113. PMID: 17038234

Prognosis

Bilateral Plunging Ranulas in South Auckland: Evidence for a Genetic Basis.
Yin T, Jain P, Ahmad Z, Harrison JD, Morton RP
Laryngoscope 2021 Jan;131(1):73-77. Epub 2020 Feb 28 doi: 10.1002/lary.28593. PMID: 32109322
Sonolocation during submandibular sialolithotomy.
Romero NJ, Fuson A, Kieliszak CR, Joshi AS
Laryngoscope 2019 Dec;129(12):2716-2720. Epub 2019 Feb 23 doi: 10.1002/lary.27816. PMID: 30801712
Patient with synchronous bilateral plunging ranulae.
Yin T, Jain P, Ahmad Z, Morton RP
ANZ J Surg 2019 Nov;89(11):E533-E535. Epub 2018 Oct 15 doi: 10.1111/ans.14865. PMID: 30321905
Congenital ranula.
Licéaga R, González C, Licéaga C, Vargas G
J Clin Pediatr Dent 2010 Spring;34(3):263-6. doi: 10.17796/jcpd.34.3.n3t6x8148g1756vl. PMID: 20578666
Myxofibrosarcoma of the neck.
Udaka T, Yamamoto H, Shiomori T, Fujimura T, Suzuki H
J Laryngol Otol 2006 Oct;120(10):872-4. doi: 10.1017/S0022215106001113. PMID: 17038234

Clinical prediction guides

Congenital Ranula: A Case Report and Literature Review.
Pontes FSC, de Souza LL, Pedrinha VF, Pontes HAR
J Clin Pediatr Dent 2018;42(6):454-457. Epub 2018 Aug 7 doi: 10.17796/1053-4625-42.6.9. PMID: 30085866
What is new in management of pediatric ranula?
Zhi K, Gao L, Ren W
Curr Opin Otolaryngol Head Neck Surg 2014 Dec;22(6):525-9. doi: 10.1097/MOO.0000000000000103. PMID: 25211709
Salivary gland diseases: infections, sialolithiasis and mucoceles.
Delli K, Spijkervet FK, Vissink A
Monogr Oral Sci 2014;24:135-48. Epub 2014 May 23 doi: 10.1159/000358794. PMID: 24862601
Oral ranula in an HIV-positive patient: case report and literature review.
Kinshuck AJ, Schober M, Kokai G, Clarke R
BMJ Case Rep 2012 Jul 10;2012 doi: 10.1136/bcr-06-2011-4407. PMID: 22783004Free PMC Article
Primary treatment of pediatric plunging ranula with nonsurgical sclerotherapy using OK-432 (Picibanil).
Roh JL, Kim HS
Int J Pediatr Otorhinolaryngol 2008 Sep;72(9):1405-10. Epub 2008 Jul 9 doi: 10.1016/j.ijporl.2008.06.003. PMID: 18617276

Recent systematic reviews

Sclerotherapy for Benign Cystic Lesions of the Head and Neck: Systematic Review of 474 Cases.
Talmor G, Nguyen B, Mir G, Badash I, Kaye R, Caloway C
Otolaryngol Head Neck Surg 2021 Dec;165(6):775-783. Epub 2021 Mar 23 doi: 10.1177/01945998211000448. PMID: 33755513
Diagnosis and management of congenital floor of mouth masses: A systematic review.
Lucas JP, Allen M, Siegel B, Gonik N
Int J Pediatr Otorhinolaryngol 2021 Jan;140:110541. Epub 2020 Dec 1 doi: 10.1016/j.ijporl.2020.110541. PMID: 33296834
Comparison of outcomes of treatment for ranula: a proportion meta-analysis.
Chung YS, Cho Y, Kim BH
Br J Oral Maxillofac Surg 2019 Sep;57(7):620-626. Epub 2019 Jun 22 doi: 10.1016/j.bjoms.2019.06.005. PMID: 31239229
Pediatric primary Sjögren syndrome presenting with bilateral ranulas: A case report and systematic review of the literature.
Means C, Aldape MA, King E
Int J Pediatr Otorhinolaryngol 2017 Oct;101:11-19. Epub 2017 Jul 19 doi: 10.1016/j.ijporl.2017.07.019. PMID: 28964279
Surgical approaches to the submandibular gland: a review of literature.
Beahm DD, Peleaz L, Nuss DW, Schaitkin B, Sedlmayr JC, Rivera-Serrano CM, Zanation AM, Walvekar RR
Int J Surg 2009 Dec;7(6):503-9. Epub 2009 Sep 24 doi: 10.1016/j.ijsu.2009.09.006. PMID: 19782158

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