U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Vulvar basaloid squamous cell carcinoma

MedGen UID:
384496
•Concept ID:
C2211850
•
Neoplastic Process
Synonyms: Vulvar Basaloid Carcinoma; vulvar basaloid carcinoma; Vulvar Basaloid Squamous Cell Carcinoma; vulvar basaloid squamous cell carcinoma
 
Monarch Initiative: MONDO:0004090

Definition

A squamous cell carcinoma that arises from the vulva and is characterized by the presence of nests of malignant basaloid cells with a scant amount of cytoplasm. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVVulvar basaloid squamous cell carcinoma

Professional guidelines

PubMed

Diagnostic Criteria for Differentiated Vulvar Intraepithelial Neoplasia and Vulvar Aberrant Maturation.
Heller DS, Day T, Allbritton JI, Scurry J, Radici G, Welch K, Preti M; ISSVD Difficult Pathologic Diagnoses Committee
J Low Genit Tract Dis 2021 Jan 1;25(1):57-70. doi: 10.1097/LGT.0000000000000572. PMID: 33105449Free PMC Article
Worldwide human papillomavirus genotype attribution in over 2000 cases of intraepithelial and invasive lesions of the vulva.
de Sanjosé S, Alemany L, Ordi J, Tous S, Alejo M, Bigby SM, Joura EA, Maldonado P, Laco J, Bravo IG, Vidal A, Guimerà N, Cross P, Wain GV, Petry KU, Mariani L, Bergeron C, Mandys V, Sica AR, Félix A, Usubutun A, Seoud M, Hernández-Suárez G, Nowakowski AM, Wilson G, Dalstein V, Hampl M, Kasamatsu ES, Lombardi LE, Tinoco L, Alvarado-Cabrero I, Perrotta M, Bhatla N, Agorastos T, Lynch CF, Goodman MT, Shin HR, Viarheichyk H, Jach R, Cruz MO, Velasco J, Molina C, Bornstein J, Ferrera A, Domingo EJ, Chou CY, Banjo AF, Castellsagué X, Pawlita M, Lloveras B, Quint WG, Muñoz N, Bosch FX; HPV VVAP study group
Eur J Cancer 2013 Nov;49(16):3450-61. Epub 2013 Jul 22 doi: 10.1016/j.ejca.2013.06.033. PMID: 23886586

Recent clinical studies

Etiology

Incidence and Clinicopathologic Characteristics of Human Papillomavirus-independent Invasive Squamous Cell Carcinomas of the Cervix: A Morphologic, Immunohistochemical, and Human Papilloma-Virologic Study of 670 Cases.
Stolnicu S, Allison D, Praiss AM, Tessier-Cloutier B, Momeni Boroujeni A, Flynn J, Iasonos A, Serrette R, Hoang L, Patrichi A, Terinte C, Pesci A, Mateoiu C, Lastra RR, Kiyokawa T, Ali-Fehmi R, Kheil M, Oliva E, Devins KM, Abu-Rustum NR, Soslow RA
Am J Surg Pathol 2023 Dec 1;47(12):1376-1389. Epub 2023 Sep 13 doi: 10.1097/PAS.0000000000002122. PMID: 37702216Free PMC Article
Reducing the radicality of surgery for vulvar cancer: are smaller margins safer?
Milliken S, May J, Sanderson PA, Congiu MA, D'Oria O, Golia D'Augè T, Caruso G, DI Donato V, Benedetti Panici P, Giannini A
Minerva Obstet Gynecol 2021 Apr;73(2):160-165. Epub 2020 Dec 11 doi: 10.23736/S2724-606X.20.04743-7. PMID: 33306289
Diagnostic Criteria for Differentiated Vulvar Intraepithelial Neoplasia and Vulvar Aberrant Maturation.
Heller DS, Day T, Allbritton JI, Scurry J, Radici G, Welch K, Preti M; ISSVD Difficult Pathologic Diagnoses Committee
J Low Genit Tract Dis 2021 Jan 1;25(1):57-70. doi: 10.1097/LGT.0000000000000572. PMID: 33105449Free PMC Article
Putative precancerous lesions of vulvar squamous cell carcinoma.
Jenkins TM, Mills AM
Semin Diagn Pathol 2021 Jan;38(1):27-36. Epub 2020 Sep 6 doi: 10.1053/j.semdp.2020.09.006. PMID: 32948383
Human Papillomavirus-Independent Squamous Lesions of the Vulva.
Watkins JC
Surg Pathol Clin 2019 Jun;12(2):249-261. Epub 2019 Apr 5 doi: 10.1016/j.path.2019.01.001. PMID: 31097103

Diagnosis

Incidence and Clinicopathologic Characteristics of Human Papillomavirus-independent Invasive Squamous Cell Carcinomas of the Cervix: A Morphologic, Immunohistochemical, and Human Papilloma-Virologic Study of 670 Cases.
Stolnicu S, Allison D, Praiss AM, Tessier-Cloutier B, Momeni Boroujeni A, Flynn J, Iasonos A, Serrette R, Hoang L, Patrichi A, Terinte C, Pesci A, Mateoiu C, Lastra RR, Kiyokawa T, Ali-Fehmi R, Kheil M, Oliva E, Devins KM, Abu-Rustum NR, Soslow RA
Am J Surg Pathol 2023 Dec 1;47(12):1376-1389. Epub 2023 Sep 13 doi: 10.1097/PAS.0000000000002122. PMID: 37702216Free PMC Article
Diagnostic Criteria for Differentiated Vulvar Intraepithelial Neoplasia and Vulvar Aberrant Maturation.
Heller DS, Day T, Allbritton JI, Scurry J, Radici G, Welch K, Preti M; ISSVD Difficult Pathologic Diagnoses Committee
J Low Genit Tract Dis 2021 Jan 1;25(1):57-70. doi: 10.1097/LGT.0000000000000572. PMID: 33105449Free PMC Article
Putative precancerous lesions of vulvar squamous cell carcinoma.
Jenkins TM, Mills AM
Semin Diagn Pathol 2021 Jan;38(1):27-36. Epub 2020 Sep 6 doi: 10.1053/j.semdp.2020.09.006. PMID: 32948383
Clinicopathologic Diagnosis of Differentiated Vulvar Intraepithelial Neoplasia and Vulvar Aberrant Maturation.
Day T, Marzol A, Pagano R, Jaaback K, Scurry J
J Low Genit Tract Dis 2020 Oct;24(4):392-398. doi: 10.1097/LGT.0000000000000569. PMID: 32976294Free PMC Article
Human Papillomavirus-Independent Squamous Lesions of the Vulva.
Watkins JC
Surg Pathol Clin 2019 Jun;12(2):249-261. Epub 2019 Apr 5 doi: 10.1016/j.path.2019.01.001. PMID: 31097103

Therapy

Is Vulvovaginal Lichen Planus Associated With Squamous Cell Carcinoma?
Day T, Otton G, Jaaback K, Weigner J, Scurry J
J Low Genit Tract Dis 2018 Apr;22(2):159-165. doi: 10.1097/LGT.0000000000000384. PMID: 29470358Free PMC Article
Usual vulval intraepithelial neoplasia in HIV-positive women - a case series.
Toby M, Conway K, Sethi G, Lewis F
Int J STD AIDS 2016 Dec;27(14):1253-1256. Epub 2015 Oct 14 doi: 10.1177/0956462415611513. PMID: 26472432
A case of usual (basaloid)-type vulvar intraepithelial neoplasia that failed to respond to imiquimod cream: clinical implications.
Shiozaki T, Tabata T, Toriyabe K, Motohashi T, Kondo E, Tanida K, Okugawa T, Sagawa N
Int J Clin Oncol 2011 Oct;16(5):610-2. Epub 2011 Jan 21 doi: 10.1007/s10147-010-0180-4. PMID: 21249413
Human papillomavirus-specific serologic response in vulvar neoplasia.
Sun Y, Hildesheim A, Brinton LA, Nasca PC, Trimble CL, Kurman RJ, Viscidi RP, Shah KV
Gynecol Oncol 1996 Nov;63(2):200-3. doi: 10.1006/gyno.1996.0306. PMID: 8910627

Prognosis

Incidence and Clinicopathologic Characteristics of Human Papillomavirus-independent Invasive Squamous Cell Carcinomas of the Cervix: A Morphologic, Immunohistochemical, and Human Papilloma-Virologic Study of 670 Cases.
Stolnicu S, Allison D, Praiss AM, Tessier-Cloutier B, Momeni Boroujeni A, Flynn J, Iasonos A, Serrette R, Hoang L, Patrichi A, Terinte C, Pesci A, Mateoiu C, Lastra RR, Kiyokawa T, Ali-Fehmi R, Kheil M, Oliva E, Devins KM, Abu-Rustum NR, Soslow RA
Am J Surg Pathol 2023 Dec 1;47(12):1376-1389. Epub 2023 Sep 13 doi: 10.1097/PAS.0000000000002122. PMID: 37702216Free PMC Article
Reducing the radicality of surgery for vulvar cancer: are smaller margins safer?
Milliken S, May J, Sanderson PA, Congiu MA, D'Oria O, Golia D'Augè T, Caruso G, DI Donato V, Benedetti Panici P, Giannini A
Minerva Obstet Gynecol 2021 Apr;73(2):160-165. Epub 2020 Dec 11 doi: 10.23736/S2724-606X.20.04743-7. PMID: 33306289
Putative precancerous lesions of vulvar squamous cell carcinoma.
Jenkins TM, Mills AM
Semin Diagn Pathol 2021 Jan;38(1):27-36. Epub 2020 Sep 6 doi: 10.1053/j.semdp.2020.09.006. PMID: 32948383
Human Papillomavirus-Independent Squamous Lesions of the Vulva.
Watkins JC
Surg Pathol Clin 2019 Jun;12(2):249-261. Epub 2019 Apr 5 doi: 10.1016/j.path.2019.01.001. PMID: 31097103
Pathways of vulvar intraepithelial neoplasia and squamous cell carcinoma.
Del Pino M, Rodriguez-Carunchio L, Ordi J
Histopathology 2013 Jan;62(1):161-75. Epub 2012 Nov 27 doi: 10.1111/his.12034. PMID: 23190170

Clinical prediction guides

Incidence and Clinicopathologic Characteristics of Human Papillomavirus-independent Invasive Squamous Cell Carcinomas of the Cervix: A Morphologic, Immunohistochemical, and Human Papilloma-Virologic Study of 670 Cases.
Stolnicu S, Allison D, Praiss AM, Tessier-Cloutier B, Momeni Boroujeni A, Flynn J, Iasonos A, Serrette R, Hoang L, Patrichi A, Terinte C, Pesci A, Mateoiu C, Lastra RR, Kiyokawa T, Ali-Fehmi R, Kheil M, Oliva E, Devins KM, Abu-Rustum NR, Soslow RA
Am J Surg Pathol 2023 Dec 1;47(12):1376-1389. Epub 2023 Sep 13 doi: 10.1097/PAS.0000000000002122. PMID: 37702216Free PMC Article
Reducing the radicality of surgery for vulvar cancer: are smaller margins safer?
Milliken S, May J, Sanderson PA, Congiu MA, D'Oria O, Golia D'Augè T, Caruso G, DI Donato V, Benedetti Panici P, Giannini A
Minerva Obstet Gynecol 2021 Apr;73(2):160-165. Epub 2020 Dec 11 doi: 10.23736/S2724-606X.20.04743-7. PMID: 33306289
Clinicopathologic Diagnosis of Differentiated Vulvar Intraepithelial Neoplasia and Vulvar Aberrant Maturation.
Day T, Marzol A, Pagano R, Jaaback K, Scurry J
J Low Genit Tract Dis 2020 Oct;24(4):392-398. doi: 10.1097/LGT.0000000000000569. PMID: 32976294Free PMC Article
p16 Immunostaining Allows for Accurate Subclassification of Vulvar Squamous Cell Carcinoma Into HPV-Associated and HPV-Independent Cases.
Cheng AS, Karnezis AN, Jordan S, Singh N, McAlpine JN, Gilks CB
Int J Gynecol Pathol 2016 Jul;35(4):385-93. doi: 10.1097/PGP.0000000000000263. PMID: 26630231
p16 overexpression identifies HPV-positive vulvar squamous cell carcinomas.
Santos M, Landolfi S, Olivella A, Lloveras B, Klaustermeier J, Suárez H, Alòs L, Puig-Tintoré LM, Campo E, Ordi J
Am J Surg Pathol 2006 Nov;30(11):1347-56. doi: 10.1097/01.pas.0000213251.82940.bf. PMID: 17063073

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Consumer resources

    Reviews

    Related information

    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...