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Peripheral T-cell lymphoma

MedGen UID:
38240
•Concept ID:
C0079774
•
Neoplastic Process
Synonym: Primary cutaneous peripheral T-cell lymphoma not otherwise specified
SNOMED CT: Peripheral T-cell lymphoma (clinical) (109977009); Peripheral T-cell lymphoma (109977009); Mature T-cell lymphoma (1163404000); Peripheral T-cell lymphoma (1163404000); T-cell lymphoma (1163404000)
Modes of inheritance:
Not genetically inherited
MedGen UID:
988794
•Concept ID:
CN307044
•
Finding
Source: Orphanet
clinical entity without genetic inheritance.
See: This record
Not genetically inherited (Orphanet)
 
Monarch Initiative: MONDO:0019476
Orphanet: ORPHA86885

Definition

An extremely rare, primary cutaneous T-cell lymphoma disorder characterized by solitary, or multifocal and diffuse, cutaneous lesions, ranging from tumor-like patches, plaques, papules, nodules, and/or erythroderma, located on any area of the body, which rapidly progress and may become ulcerated and/or infected. Systemic involvement may be associated. [from ORDO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVPeripheral T-cell lymphoma
Follow this link to review classifications for Peripheral T-cell lymphoma in Orphanet.

Professional guidelines

PubMed

Aggressive T-cell lymphomas: 2024: Updates on diagnosis, risk stratification, and management.
Ong SY, Zain JM
Am J Hematol 2024 Mar;99(3):439-456. Epub 2024 Feb 2 doi: 10.1002/ajh.27165. PMID: 38304959
Epigenetic alterations and advancement of treatment in peripheral T-cell lymphoma.
Zhang P, Zhang M
Clin Epigenetics 2020 Nov 7;12(1):169. doi: 10.1186/s13148-020-00962-x. PMID: 33160401Free PMC Article
Angioimmunoblastic T-cell lymphoma management.
Mosalpuria K, Bociek RG, Vose JM
Semin Hematol 2014 Jan;51(1):52-8. Epub 2013 Nov 14 doi: 10.1053/j.seminhematol.2013.11.008. PMID: 24468316

Curated

NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines®), T-Cell Lymphomas, 2024

Recent clinical studies

Etiology

Aggressive T-cell lymphomas: 2024: Updates on diagnosis, risk stratification, and management.
Ong SY, Zain JM
Am J Hematol 2024 Mar;99(3):439-456. Epub 2024 Feb 2 doi: 10.1002/ajh.27165. PMID: 38304959
Therapeutic challenges in peripheral T-cell lymphoma.
Luan Y, Li X, Luan Y, Luo J, Dong Q, Ye S, Li Y, Li Y, Jia L, Yang J, Yang DH
Mol Cancer 2024 Jan 4;23(1):2. doi: 10.1186/s12943-023-01904-w. PMID: 38178117Free PMC Article
T-Cell Lymphomas, Version 2.2022, NCCN Clinical Practice Guidelines in Oncology.
Horwitz SM, Ansell S, Ai WZ, Barnes J, Barta SK, Brammer J, Clemens MW, Dogan A, Foss F, Ghione P, Goodman AM, Guitart J, Halwani A, Haverkos BM, Hoppe RT, Jacobsen E, Jagadeesh D, Jones A, Kallam A, Kim YH, Kumar K, Mehta-Shah N, Olsen EA, Rajguru SA, Rozati S, Said J, Shaver A, Shea L, Shinohara MM, Sokol L, Torres-Cabala C, Wilcox R, Wu P, Zain J, Dwyer M, Sundar H
J Natl Compr Canc Netw 2022 Mar;20(3):285-308. doi: 10.6004/jnccn.2022.0015. PMID: 35276674
Epigenetic alterations and advancement of treatment in peripheral T-cell lymphoma.
Zhang P, Zhang M
Clin Epigenetics 2020 Nov 7;12(1):169. doi: 10.1186/s13148-020-00962-x. PMID: 33160401Free PMC Article
Gene expression signatures delineate biological and prognostic subgroups in peripheral T-cell lymphoma.
Iqbal J, Wright G, Wang C, Rosenwald A, Gascoyne RD, Weisenburger DD, Greiner TC, Smith L, Guo S, Wilcox RA, Teh BT, Lim ST, Tan SY, Rimsza LM, Jaffe ES, Campo E, Martinez A, Delabie J, Braziel RM, Cook JR, Tubbs RR, Ott G, Geissinger E, Gaulard P, Piccaluga PP, Pileri SA, Au WY, Nakamura S, Seto M, Berger F, de Leval L, Connors JM, Armitage J, Vose J, Chan WC, Staudt LM; Lymphoma Leukemia Molecular Profiling Project and the International Peripheral T-cell Lymphoma Project
Blood 2014 May 8;123(19):2915-23. Epub 2014 Mar 14 doi: 10.1182/blood-2013-11-536359. PMID: 24632715Free PMC Article

Diagnosis

Update on T-Cell Lymphoma Epidemiology.
Chen JJ, Tokumori FC, Del Guzzo C, Kim J, Ruan J
Curr Hematol Malig Rep 2024 Jun;19(3):93-103. Epub 2024 Mar 7 doi: 10.1007/s11899-024-00727-w. PMID: 38451372
Recent Advances in Diagnosis and Therapy of Angioimmunoblastic T Cell Lymphoma.
Mohammed Saleh MF, Kotb A, Abdallah GEM, Muhsen IN, El Fakih R, Aljurf M
Curr Oncol 2021 Dec 20;28(6):5480-5498. doi: 10.3390/curroncol28060456. PMID: 34940095Free PMC Article
Follicular T-cell lymphoma.
Lisa M, Verma PK, Nishi, Shuchismita, Hussain MA
J Cancer Res Ther 2021 Oct-Dec;17(6):1568-1571. doi: 10.4103/jcrt.JCRT_486_19. PMID: 34916399
How I Diagnose Angioimmunoblastic T-Cell Lymphoma.
Xie Y, Jaffe ES
Am J Clin Pathol 2021 Jun 17;156(1):1-14. doi: 10.1093/ajcp/aqab090. PMID: 34117736Free PMC Article
Hepatosplenic T-Cell Lymphomas.
Gowda L, Foss F
Cancer Treat Res 2019;176:185-193. doi: 10.1007/978-3-319-99716-2_9. PMID: 30596219

Therapy

Aggressive T-cell lymphomas: 2024: Updates on diagnosis, risk stratification, and management.
Ong SY, Zain JM
Am J Hematol 2024 Mar;99(3):439-456. Epub 2024 Feb 2 doi: 10.1002/ajh.27165. PMID: 38304959
Therapeutic challenges in peripheral T-cell lymphoma.
Luan Y, Li X, Luan Y, Luo J, Dong Q, Ye S, Li Y, Li Y, Jia L, Yang J, Yang DH
Mol Cancer 2024 Jan 4;23(1):2. doi: 10.1186/s12943-023-01904-w. PMID: 38178117Free PMC Article
Peripheral T-cell lymphomas.
Broccoli A, Zinzani PL
Hematol Oncol 2023 Jun;41 Suppl 1:82-87. doi: 10.1002/hon.3142. PMID: 37294962
The ECHELON-2 Trial: 5-year results of a randomized, phase III study of brentuximab vedotin with chemotherapy for CD30-positive peripheral T-cell lymphoma.
Horwitz S, O'Connor OA, Pro B, Trümper L, Iyer S, Advani R, Bartlett NL, Christensen JH, Morschhauser F, Domingo-Domenech E, Rossi G, Kim WS, Feldman T, Menne T, Belada D, Illés Á, Tobinai K, Tsukasaki K, Yeh SP, Shustov A, Hüttmann A, Savage KJ, Yuen S, Zinzani PL, Miao H, Bunn V, Fenton K, Fanale M, Puhlmann M, Illidge T
Ann Oncol 2022 Mar;33(3):288-298. Epub 2021 Dec 16 doi: 10.1016/j.annonc.2021.12.002. PMID: 34921960Free PMC Article
NK-/T-cell lymphomas.
Wang H, Fu BB, Gale RP, Liang Y
Leukemia 2021 Sep;35(9):2460-2468. Epub 2021 Jun 11 doi: 10.1038/s41375-021-01313-2. PMID: 34117356Free PMC Article

Prognosis

Peripheral T-cell lymphomas.
Broccoli A, Zinzani PL
Hematol Oncol 2023 Jun;41 Suppl 1:82-87. doi: 10.1002/hon.3142. PMID: 37294962
Recent Advances in Diagnosis and Therapy of Angioimmunoblastic T Cell Lymphoma.
Mohammed Saleh MF, Kotb A, Abdallah GEM, Muhsen IN, El Fakih R, Aljurf M
Curr Oncol 2021 Dec 20;28(6):5480-5498. doi: 10.3390/curroncol28060456. PMID: 34940095Free PMC Article
NK-/T-cell lymphomas.
Wang H, Fu BB, Gale RP, Liang Y
Leukemia 2021 Sep;35(9):2460-2468. Epub 2021 Jun 11 doi: 10.1038/s41375-021-01313-2. PMID: 34117356Free PMC Article
Epigenetic alterations and advancement of treatment in peripheral T-cell lymphoma.
Zhang P, Zhang M
Clin Epigenetics 2020 Nov 7;12(1):169. doi: 10.1186/s13148-020-00962-x. PMID: 33160401Free PMC Article
Reproducing the molecular subclassification of peripheral T-cell lymphoma-NOS by immunohistochemistry.
Amador C, Greiner TC, Heavican TB, Smith LM, Galvis KT, Lone W, Bouska A, D'Amore F, Pedersen MB, Pileri S, Agostinelli C, Feldman AL, Rosenwald A, Ott G, Mottok A, Savage KJ, de Leval L, Gaulard P, Lim ST, Ong CK, Ondrejka SL, Song J, Campo E, Jaffe ES, Staudt LM, Rimsza LM, Vose J, Weisenburger DD, Chan WC, Iqbal J
Blood 2019 Dec 12;134(24):2159-2170. doi: 10.1182/blood.2019000779. PMID: 31562134Free PMC Article

Clinical prediction guides

PD-1 instructs a tumor-suppressive metabolic program that restricts glycolysis and restrains AP-1 activity in T cell lymphoma.
Wartewig T, Daniels J, Schulz M, Hameister E, Joshi A, Park J, Morrish E, Venkatasubramani AV, Cernilogar FM, van Heijster FHA, Hundshammer C, Schneider H, Konstantinidis F, Gabler JV, Klement C, Kurniawan H, Law C, Lee Y, Choi S, Guitart J, Forne I, Giustinani J, Müschen M, Jain S, Weinstock DM, Rad R, Ortonne N, Schilling F, Schotta G, Imhof A, Brenner D, Choi J, Ruland J
Nat Cancer 2023 Oct;4(10):1508-1525. Epub 2023 Sep 18 doi: 10.1038/s43018-023-00635-7. PMID: 37723306Free PMC Article
NK-/T-cell lymphomas.
Wang H, Fu BB, Gale RP, Liang Y
Leukemia 2021 Sep;35(9):2460-2468. Epub 2021 Jun 11 doi: 10.1038/s41375-021-01313-2. PMID: 34117356Free PMC Article
Epigenetic alterations and advancement of treatment in peripheral T-cell lymphoma.
Zhang P, Zhang M
Clin Epigenetics 2020 Nov 7;12(1):169. doi: 10.1186/s13148-020-00962-x. PMID: 33160401Free PMC Article
Reproducing the molecular subclassification of peripheral T-cell lymphoma-NOS by immunohistochemistry.
Amador C, Greiner TC, Heavican TB, Smith LM, Galvis KT, Lone W, Bouska A, D'Amore F, Pedersen MB, Pileri S, Agostinelli C, Feldman AL, Rosenwald A, Ott G, Mottok A, Savage KJ, de Leval L, Gaulard P, Lim ST, Ong CK, Ondrejka SL, Song J, Campo E, Jaffe ES, Staudt LM, Rimsza LM, Vose J, Weisenburger DD, Chan WC, Iqbal J
Blood 2019 Dec 12;134(24):2159-2170. doi: 10.1182/blood.2019000779. PMID: 31562134Free PMC Article
Gene expression signatures delineate biological and prognostic subgroups in peripheral T-cell lymphoma.
Iqbal J, Wright G, Wang C, Rosenwald A, Gascoyne RD, Weisenburger DD, Greiner TC, Smith L, Guo S, Wilcox RA, Teh BT, Lim ST, Tan SY, Rimsza LM, Jaffe ES, Campo E, Martinez A, Delabie J, Braziel RM, Cook JR, Tubbs RR, Ott G, Geissinger E, Gaulard P, Piccaluga PP, Pileri SA, Au WY, Nakamura S, Seto M, Berger F, de Leval L, Connors JM, Armitage J, Vose J, Chan WC, Staudt LM; Lymphoma Leukemia Molecular Profiling Project and the International Peripheral T-cell Lymphoma Project
Blood 2014 May 8;123(19):2915-23. Epub 2014 Mar 14 doi: 10.1182/blood-2013-11-536359. PMID: 24632715Free PMC Article

Recent systematic reviews

The efficiency of autologous stem cell transplantation as the first-line treatment for nodal peripheral T-cell lymphoma: results of a systematic review and meta-analysis.
Zhai Y, Wang J, Jiang Y, Wu W, Lv Y, Xu H, Tian L, Sun H, Zhao Z, Li L
Expert Rev Hematol 2022 Mar;15(3):265-272. Epub 2022 Feb 21 doi: 10.1080/17474086.2022.2042247. PMID: 35152814
The clinical and economic burden of peripheral T-cell lymphoma: a systematic literature review.
Ashaye AO, Burnett H, Abogunrin S, Panchmatia H, Ovcinnikova O, Dalal M
Future Oncol 2022 Feb;18(4):519-535. Epub 2021 Dec 1 doi: 10.2217/fon-2021-1032. PMID: 34851173
Comparison of first-line treatments of peripheral T-cell lymphoma according to regimen: A systematic review and meta-analysis.
Kim J, Cho J, Byeon S, Kim WS, Kim SJ
Hematol Oncol 2021 Dec;39(5):664-673. Epub 2021 Sep 6 doi: 10.1002/hon.2924. PMID: 34487565
Comparison of Allogeneic Stem Cell Transplant and Autologous Stem Cell Transplant in Refractory or Relapsed Peripheral T-Cell Lymphoma: A Systematic Review and Meta-analysis.
Du J, Yu D, Han X, Zhu L, Huang Z
JAMA Netw Open 2021 May 3;4(5):e219807. doi: 10.1001/jamanetworkopen.2021.9807. PMID: 34042995Free PMC Article
Allogeneic stem-cell transplantation for peripheral T-cell lymphoma: a systemic review and meta-analysis.
Wei J, Xu J, Cao Y, Zhou J, Zhang Y
Acta Haematol 2015;133(2):136-44. Epub 2014 Sep 20 doi: 10.1159/000358579. PMID: 25247746

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      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Curated

    • NCCN, 2024
      NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines®), T-Cell Lymphomas, 2024

    Reviews

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