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Agenesis of central incisor

MedGen UID:
381532
•Concept ID:
C1855000
•
Finding
Synonyms: Absent central incisor; Absent central incisors
 
HPO: HP:0006289

Definition

Agenesis of one or more central incisors, i.e., of lower secondary incisor, lower primary incisor, upper secondary incisor, or of upper central primary incisor. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAgenesis of central incisor

Conditions with this feature

Mohr syndrome
MedGen UID:
10077
•Concept ID:
C0026363
•
Disease or Syndrome
Orofaciodigital syndrome II (OFD2), also known as Mohr syndrome, is characterized by cleft lip/palate, lobulated tongue with nodules, dental anomalies including tooth agenesis, maxillary hypoplasia, conductive hearing loss, and poly-, syn-, and brachydactyly. Mesomelic shortening of the limbs has also been observed (Mohr, 1941; Gorlin, 1982; Monroe et al., 2016).
See: Condition Record
Central incisors, absence of
MedGen UID:
337110
•Concept ID:
C1844886
•
Finding
See: Condition Record
Central incisors, absence of
Mohr syndrome

Professional guidelines

PubMed

Management of excessive gingival display using botulinum toxin type A: a descriptive study.
Andriola FO, Chieza GS, Cavagni J, Freddo AL, Corsetti A
Toxicon 2021 Jun;196:56-62. Epub 2021 Mar 29 doi: 10.1016/j.toxicon.2021.03.016. PMID: 33794266
Nine Novel PAX9 Mutations and a Distinct Tooth Agenesis Genotype-Phenotype.
Wong SW, Han D, Zhang H, Liu Y, Zhang X, Miao MZ, Wang Y, Zhao N, Zeng L, Bai B, Wang YX, Liu H, Frazier-Bowers SA, Feng H
J Dent Res 2018 Feb;97(2):155-162. Epub 2017 Sep 14 doi: 10.1177/0022034517729322. PMID: 28910570Free PMC Article
Impacted central incisors: factors affecting prognosis and treatment duration.
Chaushu S, Becker T, Becker A
Am J Orthod Dentofacial Orthop 2015 Mar;147(3):355-62. doi: 10.1016/j.ajodo.2014.11.019. PMID: 25726403

Recent clinical studies

Etiology

DISP1 deficiency: Monoallelic and biallelic variants cause a spectrum of midline craniofacial malformations.
Lavillaureix A, Rollier P, Kim A, Panasenkava V, De Tayrac M, Carré W, Guyodo H, Faoucher M, Poirel E, Akloul L, Quélin C, Whalen S, Bos J, Broekema M, van Hagen JM, Grand K, Allen-Sharpley M, Magness E, McLean SD, Kayserili H, Altunoglu U, En Qi Chong A, Xue S, Jeanne M, Almontashiri N, Habhab W, Vanlerberghe C, Faivre L, Viora-Dupont E, Philippe C, Safraou H, Laffargue F, Mittendorf L, Abou Jamra R, Patil SJ, Dalal A, Sarma AS, Keren B, Reversade B, Dubourg C, Odent S, Dupé V
Genet Med 2024 Jul;26(7):101126. Epub 2024 Mar 24 doi: 10.1016/j.gim.2024.101126. PMID: 38529886
Closure of maxillary lateral incisor agenesis space in unilateral cleft lip and palate: a digital model assessment.
Manfio ASC, Garib D, Flores-Mir C, Lauris JRP, Teixeira R, Almeida ALPF
Dental Press J Orthod 2023;28(1):e2321331. Epub 2023 Apr 14 doi: 10.1590/2177-6709.28.1.e2321331.oar. PMID: 37075417Free PMC Article
Surgical removal versus retention for the management of asymptomatic disease-free impacted wisdom teeth.
Ghaeminia H, Nienhuijs ME, Toedtling V, Perry J, Tummers M, Hoppenreijs TJ, Van der Sanden WJ, Mettes TG
Cochrane Database Syst Rev 2020 May 4;5(5):CD003879. doi: 10.1002/14651858.CD003879.pub5. PMID: 32368796Free PMC Article
A study of prevalence and distribution of tooth agenesis.
Bozga A, Stanciu RP, Mănuc D
J Med Life 2014 Oct-Dec;7(4):551-4. PMID: 25713620Free PMC Article
Natal teeth.
Leung AK
Am J Dis Child 1986 Mar;140(3):249-51. doi: 10.1001/archpedi.1986.02140170075033. PMID: 3946356

Diagnosis

Deep phenotyping of the neuroimaging and skeletal features in KBG syndrome: a study of 53 patients and review of the literature.
Peluso F, Caraffi SG, Contrò G, Valeri L, Napoli M, Carboni G, Seth A, Zuntini R, Coccia E, Astrea G, Bisgaard AM, Ivanovski I, Maitz S, Brischoux-Boucher E, Carter MT, Dentici ML, Devriendt K, Bellini M, Digilio MC, Doja A, Dyment DA, Farholt S, Ferreira CR, Wolfe LA, Gahl WA, Gnazzo M, Goel H, Grønborg SW, Hammer T, Iughetti L, Kleefstra T, Koolen DA, Lepri FR, Lemire G, Louro P, McCullagh G, Madeo SF, Milone A, Milone R, Nielsen JEK, Novelli A, Ockeloen CW, Pascarella R, Pippucci T, Ricca I, Robertson SP, Sawyer S, Falkenberg Smeland M, Stegmann S, Stumpel CT, Goel A, Taylor JM, Barbuti D, Soresina A, Bedeschi MF, Battini R, Cavalli A, Fusco C, Iascone M, Van Maldergem L, Venkateswaran S, Zuffardi O, Vergano S, Garavelli L, Bayat A
J Med Genet 2023 Nov 27;60(12):1224-1234. doi: 10.1136/jmg-2023-109141. PMID: 37586838Free PMC Article
Sonography of fetal holoprosencephaly: a guide to recognize the lesser varieties.
Montaguti E, Cariello L, Brunelli E, Youssef A, Livi A, Salsi G, Pilu G
J Matern Fetal Neonatal Med 2022 Dec;35(25):9717-9723. Epub 2022 Mar 10 doi: 10.1080/14767058.2022.2050900. PMID: 35272544
Molar incisor hypomineralization: Analysis of asymmetry of lesions.
Biondi AM, Córtese SG, Babino L, Toscano MA
Acta Odontol Latinoam 2019 Apr 1;32(1):44-48. PMID: 31206574
CT and MRI of congenital nasal lesions in syndromic conditions.
Ginat DT, Robson CD
Pediatr Radiol 2015 Jul;45(7):1056-65. Epub 2015 Jan 9 doi: 10.1007/s00247-014-3239-y. PMID: 25573243
KBG syndrome.
Brancati F, Sarkozy A, Dallapiccola B
Orphanet J Rare Dis 2006 Dec 12;1:50. doi: 10.1186/1750-1172-1-50. PMID: 17163996Free PMC Article

Therapy

Prevalence and Etiological Factors of Dental Trauma among 12- and 15-Year-Old Schoolchildren of Lebanon: A National Study.
Abdel Malak C, Chakar C, Romanos A, Rachidi S
ScientificWorldJournal 2021;2021:5587431. Epub 2021 Mar 5 doi: 10.1155/2021/5587431. PMID: 33746633Free PMC Article
Surgical removal versus retention for the management of asymptomatic disease-free impacted wisdom teeth.
Ghaeminia H, Nienhuijs ME, Toedtling V, Perry J, Tummers M, Hoppenreijs TJ, Van der Sanden WJ, Mettes TG
Cochrane Database Syst Rev 2020 May 4;5(5):CD003879. doi: 10.1002/14651858.CD003879.pub5. PMID: 32368796Free PMC Article
Cephalometric Findings in Nine Individuals With Richieri-Costa-Pereira Syndrome.
Pinto RO, Peixoto AP, Pinto ADS, Richieri-Costa A, Zechi-Ceide RM, Ozawa TO, Dalben GDS
J Craniofac Surg 2018 Sep;29(6):1596-1600. doi: 10.1097/SCS.0000000000004588. PMID: 29863549
Prosthetic replacement vs space closure for maxillary lateral incisor agenesis: A systematic review.
Silveira GS, de Almeida NV, Pereira DM, Mattos CT, Mucha JN
Am J Orthod Dentofacial Orthop 2016 Aug;150(2):228-37. doi: 10.1016/j.ajodo.2016.01.018. PMID: 27476355
Effectiveness of TAD-anchored maxillary protraction in late mixed dentition.
Feng X, Li J, Li Y, Zhao Z, Zhao S, Wang J
Angle Orthod 2012 Nov;82(6):1107-14. Epub 2012 Mar 29 doi: 10.2319/111411-705.1. PMID: 22458766Free PMC Article

Prognosis

Prognosis of Maxillary Central Incisors in Patients with Bilateral Cleft Lip/Palate.
Green MA, Ritchie C, Flanagan S, Nuzzi L, Padwa BL
Cleft Palate Craniofac J 2024 Sep;61(9):1543-1547. Epub 2023 May 9 doi: 10.1177/10556656231175337. PMID: 37160755
The solitary median maxillary central incisor (SMMCI) syndrome: Associations, prenatal diagnosis, and outcomes.
Garcia Rodriguez R, Garcia Cruz L, Novoa Medina Y, Garcia Delgado R, Perez Gonzalez J, Palma Milla C, Lopez Siles J, Medina Castellano M, Garcia Hernandez JA, Santana Rodriguez A
Prenat Diagn 2019 May;39(6):415-419. Epub 2019 Apr 26 doi: 10.1002/pd.5451. PMID: 30900264
Impacted and transmigrant mandibular canines incidence, aetiology, and treatment: a systematic review.
Dalessandri D, Parrini S, Rubiano R, Gallone D, Migliorati M
Eur J Orthod 2017 Apr 1;39(2):161-169. doi: 10.1093/ejo/cjw027. PMID: 27036134
Impacted central incisors: factors affecting prognosis and treatment duration.
Chaushu S, Becker T, Becker A
Am J Orthod Dentofacial Orthop 2015 Mar;147(3):355-62. doi: 10.1016/j.ajodo.2014.11.019. PMID: 25726403
Solitary median maxillary central incisor (SMMCI) syndrome.
Hall RK
Orphanet J Rare Dis 2006 Apr 9;1:12. doi: 10.1186/1750-1172-1-12. PMID: 16722608Free PMC Article

Clinical prediction guides

KBG syndrome: Clinical features and molecular findings in seven unrelated Korean families with a review of the literature.
Choi Y, Choi J, Do H, Hwang S, Seo GH, Choi IH, Keum C, Choi JH, Kang M, Kim GH, Yoo HW, Lee BH
Mol Genet Genomic Med 2023 Apr;11(4):e2127. Epub 2022 Dec 23 doi: 10.1002/mgg3.2127. PMID: 36564961Free PMC Article
Does primary trauma lead to developmental defects in permanent teeth?
Gibbison R, Crozier R
Evid Based Dent 2022 Sep;23(3):112-113. Epub 2022 Sep 23 doi: 10.1038/s41432-022-0808-z. PMID: 36151286
Molar incisor hypomineralization: Analysis of asymmetry of lesions.
Biondi AM, Córtese SG, Babino L, Toscano MA
Acta Odontol Latinoam 2019 Apr 1;32(1):44-48. PMID: 31206574
A study of prevalence and distribution of tooth agenesis.
Bozga A, Stanciu RP, Mănuc D
J Med Life 2014 Oct-Dec;7(4):551-4. PMID: 25713620Free PMC Article
KBG syndrome.
Brancati F, Sarkozy A, Dallapiccola B
Orphanet J Rare Dis 2006 Dec 12;1:50. doi: 10.1186/1750-1172-1-50. PMID: 17163996Free PMC Article

Recent systematic reviews

Laser Surgical Approach of Upper Labial Frenulum: A Systematic Review.
Inchingolo AM, Malcangi G, Ferrara I, Viapiano F, Netti A, Buongiorno S, Latini G, Azzollini D, De Leonardis N, de Ruvo E, Mancini A, Rapone B, Venere DD, Patano A, Avantario P, Tartaglia GM, Lorusso F, Scarano A, Sauro S, Fatone MC, Bordea IR, Inchingolo F, Inchingolo AD, Dipalma G
Int J Environ Res Public Health 2023 Jan 11;20(2) doi: 10.3390/ijerph20021302. PMID: 36674058Free PMC Article
Does primary trauma lead to developmental defects in permanent teeth?
Gibbison R, Crozier R
Evid Based Dent 2022 Sep;23(3):112-113. Epub 2022 Sep 23 doi: 10.1038/s41432-022-0808-z. PMID: 36151286
Surgical removal versus retention for the management of asymptomatic disease-free impacted wisdom teeth.
Ghaeminia H, Nienhuijs ME, Toedtling V, Perry J, Tummers M, Hoppenreijs TJ, Van der Sanden WJ, Mettes TG
Cochrane Database Syst Rev 2020 May 4;5(5):CD003879. doi: 10.1002/14651858.CD003879.pub5. PMID: 32368796Free PMC Article
Impacted and transmigrant mandibular canines incidence, aetiology, and treatment: a systematic review.
Dalessandri D, Parrini S, Rubiano R, Gallone D, Migliorati M
Eur J Orthod 2017 Apr 1;39(2):161-169. doi: 10.1093/ejo/cjw027. PMID: 27036134
Prosthetic replacement vs space closure for maxillary lateral incisor agenesis: A systematic review.
Silveira GS, de Almeida NV, Pereira DM, Mattos CT, Mucha JN
Am J Orthod Dentofacial Orthop 2016 Aug;150(2):228-37. doi: 10.1016/j.ajodo.2016.01.018. PMID: 27476355

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