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Group B streptococcal infection

MedGen UID:
378336
•Concept ID:
C2020625
•
Disease or Syndrome
Synonyms: Group B Strep Infection; Group B Streptococcal Infection; Group B Streptococcal Infections
SNOMED CT: Streptococcus agalactiae infection (426933007); Infection due to Streptococcus group B (426933007)
 
Monarch Initiative: MONDO:0700218

Definition

Group B Streptococcus, also known as Streptococcus agalactiae, colonizes the vaginal and gastrointestinal tracts of up to 45% of healthy women and may infect neonates in utero or during delivery, causing neonatal sepsis in 1-2% of colonized neonates. GBS infection may also occur in nonpregnant (particularly elderly) adults with underlying medical conditions, presenting as urinary tract infection, pneumonia, or soft-tissue infection. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVGroup B streptococcal infection

Professional guidelines

PubMed

Progress in Diagnosis and Treatment of Neonatal Sepsis: A Review Article.
Yadav P, Yadav SK
JNMA J Nepal Med Assoc 2022 Mar 11;60(247):318-324. doi: 10.31729/jnma.7324. PMID: 35633256Free PMC Article
Perinatal Management of Group B Streptococcal Infection: Clinical Update.
Howard ED
J Perinat Neonatal Nurs 2019 Oct/Dec;33(4):280-282. doi: 10.1097/JPN.0000000000000445. PMID: 31651622
Group B streptococcal infection in older patients. Spectrum of disease and management strategies.
Farley MM
Drugs Aging 1995 Apr;6(4):293-300. doi: 10.2165/00002512-199506040-00004. PMID: 7613018

Curated

UK NICE Guideline NG195, Neonatal infection: antibiotics for prevention and treatment, 2021

Recent clinical studies

Etiology

Progress in Diagnosis and Treatment of Neonatal Sepsis: A Review Article.
Yadav P, Yadav SK
JNMA J Nepal Med Assoc 2022 Mar 11;60(247):318-324. doi: 10.31729/jnma.7324. PMID: 35633256Free PMC Article
Anaphylactic shock in pregnancy: a case study and review of the literature.
Chaudhuri K, Gonzales J, Jesurun CA, Ambat MT, Mandal-Chaudhuri S
Int J Obstet Anesth 2008 Oct;17(4):350-7. doi: 10.1016/j.ijoa.2008.05.002. PMID: 18691872
Management of UTIs during pregnancy.
Morgan KL
MCN Am J Matern Child Nurs 2004 Jul-Aug;29(4):254-8. doi: 10.1097/00005721-200407000-00011. PMID: 15238753
Bacterial meningitis--a five year review 1975--1979.
Nadarajah M
Ann Acad Med Singap 1981 Jan;10(1):11-3. PMID: 6792976
Group B streptococci: a new threat to the newborn.
Hammersen G, Bartholomé K, Oppermann HC, Wille L, Lutz P
Eur J Pediatr 1977 Oct 12;126(3):189-97. doi: 10.1007/BF00442201. PMID: 334549

Diagnosis

Progress in Diagnosis and Treatment of Neonatal Sepsis: A Review Article.
Yadav P, Yadav SK
JNMA J Nepal Med Assoc 2022 Mar 11;60(247):318-324. doi: 10.31729/jnma.7324. PMID: 35633256Free PMC Article
Myth: Group B streptococcal infection in pregnancy: comprehended and conquered.
Steer PJ, Plumb J
Semin Fetal Neonatal Med 2011 Oct;16(5):254-8. Epub 2011 Apr 13 doi: 10.1016/j.siny.2011.03.005. PMID: 21493170
Anaphylactic shock in pregnancy: a case study and review of the literature.
Chaudhuri K, Gonzales J, Jesurun CA, Ambat MT, Mandal-Chaudhuri S
Int J Obstet Anesth 2008 Oct;17(4):350-7. doi: 10.1016/j.ijoa.2008.05.002. PMID: 18691872
Management of UTIs during pregnancy.
Morgan KL
MCN Am J Matern Child Nurs 2004 Jul-Aug;29(4):254-8. doi: 10.1097/00005721-200407000-00011. PMID: 15238753
Group B streptococci: a new threat to the newborn.
Hammersen G, Bartholomé K, Oppermann HC, Wille L, Lutz P
Eur J Pediatr 1977 Oct 12;126(3):189-97. doi: 10.1007/BF00442201. PMID: 334549

Therapy

Breast milk and Group B streptococcal infection: vector of transmission or vehicle for protection?
Le Doare K, Kampmann B
Vaccine 2014 May 30;32(26):3128-32. Epub 2014 Apr 13 doi: 10.1016/j.vaccine.2014.04.020. PMID: 24736004Free PMC Article
Neonatal infections: group B streptococcus.
Heath PT, Jardine LA
BMJ Clin Evid 2014 Feb 28;2014 PMID: 24580886Free PMC Article
Myth: Group B streptococcal infection in pregnancy: comprehended and conquered.
Steer PJ, Plumb J
Semin Fetal Neonatal Med 2011 Oct;16(5):254-8. Epub 2011 Apr 13 doi: 10.1016/j.siny.2011.03.005. PMID: 21493170
Anaphylactic shock in pregnancy: a case study and review of the literature.
Chaudhuri K, Gonzales J, Jesurun CA, Ambat MT, Mandal-Chaudhuri S
Int J Obstet Anesth 2008 Oct;17(4):350-7. doi: 10.1016/j.ijoa.2008.05.002. PMID: 18691872
Management of UTIs during pregnancy.
Morgan KL
MCN Am J Matern Child Nurs 2004 Jul-Aug;29(4):254-8. doi: 10.1097/00005721-200407000-00011. PMID: 15238753

Prognosis

Progress in Diagnosis and Treatment of Neonatal Sepsis: A Review Article.
Yadav P, Yadav SK
JNMA J Nepal Med Assoc 2022 Mar 11;60(247):318-324. doi: 10.31729/jnma.7324. PMID: 35633256Free PMC Article
Burden of Adults Hospitalized With Group B Streptococcal Infection.
McLaughlin JM, Peyrani P, Furmanek S, Khan FL, Quinn A, Jodar L, Ramirez J, Swerdlow DL
J Infect Dis 2021 Oct 13;224(7):1170-1178. doi: 10.1093/infdis/jiaa110. PMID: 32188975Free PMC Article
Management of UTIs during pregnancy.
Morgan KL
MCN Am J Matern Child Nurs 2004 Jul-Aug;29(4):254-8. doi: 10.1097/00005721-200407000-00011. PMID: 15238753
Group B streptococcus. Is it time for a screening program?
Paes BA
Can Fam Physician 1995 Feb;41:273-8, 281-5. PMID: 7735001Free PMC Article
Group B streptococci: a new threat to the newborn.
Hammersen G, Bartholomé K, Oppermann HC, Wille L, Lutz P
Eur J Pediatr 1977 Oct 12;126(3):189-97. doi: 10.1007/BF00442201. PMID: 334549

Clinical prediction guides

Effectiveness of intrapartum antibiotic prophylaxis for early-onset group B Streptococcal infection: An integrative review.
Braye K, Ferguson J, Davis D, Catling C, Monk A, Foureur M
Women Birth 2018 Aug;31(4):244-253. Epub 2017 Nov 10 doi: 10.1016/j.wombi.2017.10.012. PMID: 29129472
Group B streptococcal infection and activation of human astrocytes.
Stoner TD, Weston TA, Trejo J, Doran KS
PLoS One 2015;10(6):e0128431. Epub 2015 Jun 1 doi: 10.1371/journal.pone.0128431. PMID: 26030618Free PMC Article
Neonatal infections: group B streptococcus.
Heath PT, Jardine LA
BMJ Clin Evid 2010 Sep 27;2010 PMID: 21418675Free PMC Article
Increasing incidence of neonatal septicemia: causative organism and predisposing risk factors.
Bennet R, Eriksson M, Zetterström R
Acta Paediatr Scand 1981 Mar;70(2):207-10. doi: 10.1111/j.1651-2227.1981.tb05543.x. PMID: 7234404
Group B streptococci: a new threat to the newborn.
Hammersen G, Bartholomé K, Oppermann HC, Wille L, Lutz P
Eur J Pediatr 1977 Oct 12;126(3):189-97. doi: 10.1007/BF00442201. PMID: 334549

Recent systematic reviews

Epidemiology of group B streptococcal infection in pregnant women and diseased infants in mainland China.
Huang J, Lin XZ, Zhu Y, Chen C
Pediatr Neonatol 2019 Oct;60(5):487-495. Epub 2019 Jul 26 doi: 10.1016/j.pedneo.2019.07.001. PMID: 31445795
Effectiveness of intrapartum antibiotic prophylaxis for early-onset group B Streptococcal infection: An integrative review.
Braye K, Ferguson J, Davis D, Catling C, Monk A, Foureur M
Women Birth 2018 Aug;31(4):244-253. Epub 2017 Nov 10 doi: 10.1016/j.wombi.2017.10.012. PMID: 29129472
Vaginal chlorhexidine during labour to prevent early-onset neonatal group B streptococcal infection.
Ohlsson A, Shah VS, Stade BC
Cochrane Database Syst Rev 2014 Dec 14;2014(12):CD003520. doi: 10.1002/14651858.CD003520.pub3. PMID: 25504106Free PMC Article
Neonatal infections: group B streptococcus.
Heath PT, Jardine LA
BMJ Clin Evid 2014 Feb 28;2014 PMID: 24580886Free PMC Article
Neonatal infections: group B streptococcus.
Heath PT, Jardine LA
BMJ Clin Evid 2010 Sep 27;2010 PMID: 21418675Free PMC Article

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    Curated

    • NICE, 2021
      UK NICE Guideline NG195, Neonatal infection: antibiotics for prevention and treatment, 2021

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    Reviews

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